A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.
Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies
Events
Oct. 14 webinar: Health Effects and Sources of Melamine Exposure [CHE]
Regulations/Policy
Toward harmonizing global pesticide regulations for surface freshwaters in support of protecting human health.
Trans-disciplinary diagnosis for an in-depth reform of regulatory expertise in the field of environmental toxicology and security.
Methods/Tools/Screening
Systematic Review Methodologies and Endocrine Disrupting Chemicals: Improving Evaluations of the Plastic Monomer Bisphenol A.
Transcriptomics and Other Omics Approaches to Investigate Effects of Xenobiotics on the Placenta.
Nontargeted Analysis Study Reporting Tool: A Framework to Improve Research Transparency and Reproducibility.
Assessment of four rounds of interlaboratory tests within the UNEP-coordinated POPs projects.
Commentaries/Conference Summaries
The Need for Chemical Simplification As a Logical Consequence of Ever-Increasing Chemical Pollution.
Beyond Cholinesterase Inhibition: Developmental Neurotoxicity of Organophosphate Ester Flame Retardants and Plasticizers.
Exposure Monitoring Toward Environmental Justice.
Air pollution-time to address the silent killer.
Youth in Action: Local Teens Help Assess Chemical Exposures from Household Cleaning Products. [Science Selection in EHP]
Reviews
Numerous EDCs
Implications of environmental toxicants on ovarian follicles: how it can adversely affect the female fertility?
BPA/Phenols
Impact of bisphenol A (BPA) on cells and tissues at the human materno-fetal interface.
Relationship between endocrine disruptors and obesity with a focus on bisphenol A: a narrative review.
Phthalates
Update about the disrupting-effects of phthalates on the human reproductive system.
Flame Retardants
A global systematic review on the concentration of organophosphate esters in water resources: Meta-analysis, and probabilistic risk assessment.
Pesticides
Revisiting pesticide pollution: The case of fluorinated pesticides.
Potentially Toxic Elements
Comprehensive Review of Cadmium Toxicity Mechanisms in Male Reproduction and Therapeutic Strategies.
Cadmium exposure and risk of diabetes and prediabetes: A systematic review and dose-response meta-analysis.
Advantages of omics technology for evaluating cadmium toxicity in zebrafish.
Arsenic-protein interactions as a mechanism of arsenic toxicity.
DNA methylation changes induced by prenatal toxic metal exposure: An overview of epidemiological evidence.
Microplastics
Microplastics in the Food Chain: Food Safety and Environmental Aspects.
Effects of micro(nano)plastics on higher plants and the rhizosphere environment.
Are research methods shaping our understanding of microplastic pollution? A literature review on the seawater and sediment bodies of the Mediterranean Sea.
Challenges and opportunities in sustainable management of microplastics and nanoplastics in the environment.
Tiered testing of micro- and nanoplastics using intestinal in vitro models to support hazard assessments.
Pharmaceuticals/Personal Care Products
Proximate causes and ultimate effects of common antidepressants, fluoxetine and venlafaxine, on fish behavior.
Miscellaneous
A Schema of Toxic Stress Informed by Racism, Transgenerational Stress, and Disadvantage.
Is micronucleus assay in oral exfoliated cells a suitable tool for biomonitoring children exposed to environmental pollutants? A systematic review.
A comprehensive review on current technologies for removal of endocrine disrupting chemicals from wastewaters.
Human Health Studies
Numerous Chemicals/Mixtures
Genome-wide gene-bisphenol A, F and triclosan interaction analyses on urinary oxidative stress markers.
Metabolome-wide association study of serum exogenous chemical residues in a cohort with 5 major chronic diseases.
Phthalates
Phthalates and attributable mortality: A population-based longitudinal cohort study and cost analysis
Urinary and seminal plasma concentrations of phthalate metabolites in relation to spermatogenesis-related miRNA106a among men from an infertility clinic.
Effect of childhood phthalates exposure on the risk of overweight and obesity: A nested case-control study in China.
Perfluoroalkyl Substances
Umbilical cord serum concentrations of perfluorooctane sulfonate, perfluorooctanoic acid, and the body mass index changes from birth to 5 1/2 years of age.
Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease.
Associations between Novel and Legacy Per- and Polyfluoroalkyl Substances in Human Serum and Thyroid Cancer: A Case and Healthy Population in Shandong Province, East China.
Associations between both legacy and alternative per- and polyfluoroalkyl substances and glucose-homeostasis: The Isomers of C8 health project in China.
Maternal Levels of Perfluoroalkyl Substances (PFAS) during Early Pregnancy in Relation to Preeclampsia Subtypes and Biomarkers of Preeclampsia Risk.
Exposure to perfluoroalkyl substances in early pregnancy and the risk of hypertensive disorders of pregnancy: A nested case-control study in Guangxi, China.
Pesticides
Concurrent urinary organophosphate metabolites and acetylcholinesterase activity in Ecuadorian adolescents.
Potentially Toxic Elements
Integrating SNPs-based genetic risk factor with blood epigenomic response of differentially arsenic-exposed rural subjects reveals disease-associated signaling pathways.
Influence of serum ferritin combined with blood cadmium concentrations on blood pressure and hypertension: From the Korean National Health and Nutrition Examination Survey.
Combined association of early exposure to long-chain n-3 polyunsaturated fatty acids, mercury and selenium with cognitive performance in 1-year-old infants.
Associations between urinary heavy metal concentrations and blood pressure in residents of Asian countries.
Changes in DNA methylation in APOE and ACKR3 genes in multiple sclerosis patients and the relationship with their heavy metal blood levels.
Metal(loid)s and Human Semen Quality: the LIFE Study.
Air Pollution
In utero exposure to near-roadway air pollution and autism spectrum disorder in children.
Exposure to air pollution is associated with congenital anomalies in the population born by in vitro fertilization.
Exploring health in the UK Biobank: associations with sociodemographic characteristics, psychosocial factors, lifestyle and environmental exposures.
Pharmaceuticals/Personal Care Products
Organic UV filters mixture exposure and childhood adiposity: A prospective follow-up study in China.
Association between gestational hair dye use and allergies at 3 years old: the Japan environment and Children’s study.
Miscellaneous
Relationship between Blood Trihalomethane Concentrations and Serum Thyroid Function Measures in U.S. Adults.
Association between high-risk pregnancy and environmental contaminants in the Metropolitan Region of Baixada Santista, Brazil.
FOXE1 polymorphisms and chronic exposure to nitrates in drinking water cause metabolic dysfunction, thyroid abnormalities, and genotoxic damage in women.
Laboratory Studies
BPA/Phenols
Perinatal Exposure of Bisphenol A Differently Affects Dendritic Spines of Male and Female Grown-Up Adult Hippocampal Neurons.
Binding and activity of bisphenol analogues to human peroxisome proliferator-activated receptor β/δ.
Disrupted metabolic pathways and potential human diseases induced by bisphenol S.
Bisphenol A induces miR-708-5p through an ER stress-mediated mechanism altering neuronatin and neuropeptide Y expression in hypothalamic neuronal models.
Effects of Bisphenols on RACK1 Expression and Their Immunological Implications in THP-1 Cells.
1,8-cineole alleviates bisphenol A-induced apoptosis and necroptosis in bursa of Fabricius in chicken through regulating oxidative stress and PI3K/AKT pathway.
Evaluate the bisphenol A-induced redox state in cells, zebrafish and in vivo with a hydrogen peroxide turn-on fluorescent probe.
Gestational and lactational exposure to BPA or BPS has minimal effects on skeletal outcomes in adult female mice.
Phthalates
MEHP induces alteration of mitochondrial function and inhibition of steroid biosynthesis in ma-10 mouse tumor leydig cells.
Exposure to Di-(2-ethylhexyl) phthalate reduces secretion of GDNF via interfering with estrogen pathway and downregulating ERK/c-fos signaling pathway in astrocytes.
In vitro genotoxicity of dibutyl phthalate on A549 lung cells at air-liquid interface in exposure concentrations relevant at workplaces.
Parabens/Triclosan/Antimicrobials
Exposure to Propylparaben During Pregnancy and Lactation Induces Long-Term Alterations to the Mammary Gland in Mice.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
Polychlorinated environmental toxicants affect sphingolipid metabolism during neurogenesis in vitro.
Perfluoroalkyl Substances
Perfluorohexane sulfonate induces memory impairment and downregulation of neuroproteins via NMDA receptor-mediated PKC-ERK/AMPK signaling pathway.
Flame Retardants
Reproductive stimulation and energy allocation variation of BDE-47 and its derivatives on Daphnia magna.
High-fat diet exacerbated BDE-209-induced hepatocyte apoptosis via intensifying the transfer of Ca2+ from endoplasmic reticulum to mitochondria.
Insulin-like growth factor reduced against decabromodiphenyl ether-209-induced neurodevelopmental toxicity in vivo and in vitro.
Insights into the sex-dependent reproductive toxicity of 2-ethylhexyl diphenyl phosphate on zebrafish (Danio rerio).
Organotins
Tributyltin protects against ovariectomy-induced trabecular bone loss in C57BL/6J mice with an attenuated effect in high fat fed mice.
Effects of tributyltin on retinoid X receptor gene expression and global DNA methylation during intracapsular development of the gastropod Tritia mutabilis (Linnaeus, 1758).
Pesticides
Potential neurotoxicity, immunotoxicity, and carcinogenicity induced by metribuzin and tebuconazole exposure in earthworms (Eisenia fetida) revealed by transcriptome analysis.
Effects of low-concentration glyphosate and aminomethyl phosphonic acid on zebrafish embryo development.
Attenuating effect of Prosopis cineraria against paraquat-induced toxicity in prepubertal mice, Mus musculus.
Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling.
Assessment of transplacental and lactational genotoxicity of tembotrione in Wistar rats at different developmental stages by alkaline comet assay.
Interaction between herbicides applied in mixtures alters the conception of its environmental impact.
Transient exposure to sublethal concentrations of a pesticide mixture (chlorpyrifos-difenoconazole) caused different responses in fish species from different trophic levels of the same community.
Alterations in small RNA profiles in liver following a subchronic exposure to a low-dose pesticide mixture in Sprague-Dawley rats.
Modulations of blood biochemical parameters of golden mahseer, Tor putitora following exposures to single and mixed organophosphate.
The Keap1/Nrf2-ARE signaling pathway is involved in atrazine induced dopaminergic neurons degeneration via microglia activation.
The Effects of Metallothionein in Paraquat-induced Parkinson Disease Model of Zebrafish.
Bio-uptake, tissue distribution and metabolism of a neonicotinoid insecticide clothianidin in zebrafish.
An NMR-based metabolomics study on sea anemones Exaiptasia diaphana (Rapp, 1829) with atrazine exposure.
Evaluation of Placental Transfer and Tissue Distribution of cis– and Trans-Permethrin in Pregnant Rats and Fetuses Using a Physiological-Based Pharmacokinetic Model.
Thifluzamide exposure induced neuro-endocrine disrupting effects in zebrafish (Danio rerio).
Multigenerational effects modify the tolerance of mosquito larvae to chlorpyrifos but not to a heat spike and do not change their synergism.
Potentially Toxic Elements
Resveratrol Attenuates Learning, Memory, and Social Interaction Impairments in Rats Exposed to Arsenic.
Evidence of melatonin ameliorative effects on the blood-testis barrier and sperm quality alterations induced by cadmium in the rat testis.
Increased expression of TCF3, transcription factor 3, is a defense response against methylmercury toxicity in mouse neuronal C17.2 cells.
Arsenic-fluoride co-exposure induced endoplasmic reticulum stress resulting in apoptosis in rat heart and H9c2 cells.
Long-Term Toxicity of Gadolinium to the Freshwater Crustacean Daphnia magna.
Microplastics
In vitro evaluation of nanoplastics using human lung epithelial cells, microarray analysis and co-culture model.
Photoaging enhanced the adverse effects of polyamide microplastics on the growth, intestinal health, and lipid absorption in developing zebrafish.
Exposure to nanoplastics impairs collective contractility of neonatal cardiomyocytes under electrical synchronization.
Microglial phagocytosis of polystyrene microplastics results in immune alteration and apoptosis in vitro and in vivo.
Polystyrene microplastics disturb maternal-fetal immune balance and cause reproductive toxicity in pregnant mice.
Nanoplastics aggravate the toxicity of arsenic to AGS cells by disrupting ABC transporter and cytoskeleton.
No prominent toxicity of polyethylene microplastics observed in neonatal mice following intratracheal instillation to dams during gestational and neonatal period.
Pharmaceuticals/Personal Care Products
Inhalation and ingestion of Synthetic musks in pregnant women: In silico spontaneous abortion risk evaluation and control.
Uptake, elimination, and toxicokinetics of selected pharmaceuticals in multiple tissues of Nile tilapia (Oreochromis niloticus) exposed to environmentally relevant concentrations.
Biological effects of the antihypertensive losartan under different ocean acidification scenarios.
Mixtures
The discovery of combined toxicity effects and mechanisms of hexaconazole and arsenic to mice based on untargeted metabolomics.
Exposure/Environment Studies
BPA/Phenols
A sensitive environmental forensic method that determines bisphenol S and A exposure within receipt-handling through fingerprint analysis.
Spatiotemporal distribution, source apportionment and risk assessment of typical hormones and phenolic endocrine disrupting chemicals in environmental and biological samples from the mariculture areas in the Pearl River Delta, China.
Phthalates
Production, Use, and Fate of Phthalic Acid Esters for Polyvinyl Chloride Products in China.
Initial phthalates fingerprint and hydrochemical signature as key factors controlling phthalates concentration trends in PET-bottled waters during long storage times.
Parabens/Triclosan/Antimicrobials
Biomonitoring parabens in dogs using fur sample analysis – Preliminary studies.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
Health risk assessment of exposure to organochlorine pesticides in the general population in Seoul, Korea over 12 years: A cross-sectional epidemiological study.
Brominated and chlorinated contaminants in food (PCDD/Fs, PCBs, PBDD/Fs PBDEs): Simultaneous determination and occurrence in Italian produce.
Analysis of organochlorine pesticides residues in fish from Edko Lake (North of Egypt) using eco-friendly method and their health implications for humans.
Perfluoroalkyl Substances
Dietary predictors of prenatal per- and poly-fluoroalkyl substances exposure.
Concentration profiles of per- and polyfluoroalkyl substances in major sources to the environment.
Perfluoroalkyl Substances in the Western Tropical Atlantic Ocean.
Quality assurance and quality control of solid phase extraction for PFAS in water and novel analytical techniques for PFAS analysis.
Perfluoroalkyl substances in water, sediment, and fish from a subtropical river of China: Environmental behaviors and potential risk.
Flame Retardants
Formal waste treatment facilities as a source of halogenated flame retardants and organophosphate esters to the environment: A critical review with particular focus on outdoor air and soil.
Correlating seasonal changes of naturally produced brominated compounds to biomarkers in perch from the Baltic Sea.
Pesticides
Development of a Bayesian network for probabilistic risk assessment of pesticides.
Preschool-Age Children’s Pesticide Exposures in Child Care Centers and at Home in Northern California.
New-generation pesticides are prevalent in California’s central coast streams.
Prioritization of Pesticides for Assessment of Risk to Aquatic Ecosystems in Canada and Identification of Knowledge Gaps.
Current use pesticides in soil and air from two agricultural sites in South Africa: Implications for environmental fate and human exposure.
Comprehensive analyses of agrochemicals affecting aquatic ecosystems: A case study of Odonata communities and macrophytes in Saga Plain, northern Kyushu, Japan.
Potentially Toxic Elements
Serum metal levels in a population of Spanish pregnant women.
Urinary heavy metals in residents from a typical city in South China: human exposure and health risks.
Urinary level of heavy metals in people working in smoking cafés.
Temporal change and the influence of climate and weather factors on mercury concentrations in Hudson Bay polar bears, caribou, and seabird eggs.
How does Three Gorges Dam regulate heavy metal footprints in the largest freshwater lake of China.
Mixtures/Numerous Chemicals
Substances of emerging concern in Baltic Sea water: Review on methodological advances for the environmental assessment and proposal for future monitoring.
Extensive rain events have a more substantial impact than advanced effluent treatment on the endocrine-disrupting activity in an effluent-dominated small river.
Contaminant exposure as an additional stressor to bats affected by white-nose syndrome: current evidence and knowledge gaps.
Miscellaneous
Ecological and human health risks of manure-borne steroid estrogens: A 20-year global synthesis study.
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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.
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