EDC Science Weekly, Oct. 7-12, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Science highlights

Events

Regulations/Policy

PFASs-restriction proposal commentary on ECHA’s Annex XV restriction report, proposal for a restriction, March 2023.

Cosmetic UV filters in the environment-state of the art in EU regulations, science and possible knowledge gaps.

A review on the fate and effects of contaminants in biosolids applied on land: Hazards and government regulatory policies.

European nanomaterial legislation in the past 20 years – Closing the final gaps.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Evaluation of new alternative methods for the identification of estrogenic, androgenic and steroidogenic effects: a comparative in vitro/in silico study.

A battery of in silico models application for pesticides exerting reproductive health effects: Assessment of performance and prioritization of mechanistic studies.

Enhancing developmental and reproductive toxicity knowledge: A new AOP stemming from glutathione depletion.

The ToxCast pipeline: updates to curve-fitting approaches and database structure.

More tools, reports, and resources

Commentaries

Per- and polyfluoroalkyl substances (PFAS) at the interface of biological and environmental systems. [intro to a collection of articles in Biointerphases]

Climate change and cancer: the Environmental Justice perspective.

Reviews

Numerous Chemicals/Mixtures

Pollution and endometriosis: A deep dive into the environmental impacts on women’s health.

Associations of per- and polyfluoroalkyl substances, polychlorinated biphenyl, organochlorine pesticides, and polybrominated diphenyl ethers with oxidative stress markers: A systematic review and meta-analysis.

Toxic ties: Unraveling the complex relationship between endocrine disrupting chemicals and chronic kidney disease.

The Impact of Environmental Toxins on Cardiovascular Diseases.

A metabolomic perspective on the mechanisms by which environmental pollutants and lifestyle lead to male infertility.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Association between exposure to persistent organic pollutants and pubertal timing in boys and girls: A systematic review and meta-analysis.

Physical exercise and persistent organic pollutants.

PFAS

Per- and polyfluoroalkyl substances and cardiometabolic diseases: a review.

Flame Retardants

An overview of current knowledge on organophosphate di-esters in environment: Analytical methods, sources, occurrence, and behavior.

Metals/Metalloids

Translational toxicology of metal(loid) species: linking their bioinorganic chemistry in the bloodstream to organ damage onset.

Microplastics/Nanomaterials/Plastics

The effects of industrial chemicals bonded to plastic materials in newborns: A systematic review.

Leaching of chemicals from microplastics: A review of chemical types, leaching mechanisms and influencing factors.

Pharmaceuticals/Personal Care Products

Pharmaceuticals and Personal Care Products in the Aquatic Environment: How Can Regions at Risk be Identified in the Future?

Human Health Studies

Phthalates

A mixture of urinary phthalate metabolite concentrations during pregnancy and offspring Social Responsiveness Scale (SRS) scores.

Associations of urinary di(2-ethylhexyl) phthalate metabolites with lipid profiles among US general adult population.

The Link between Exposure to Phthalates and Type 2 Diabetes Mellitus: A Study Based on NHANES Data and Bioinformatic Analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Accumulation of organophosphorus pollutants in adipose tissue of obese women – metabolic alterations.

Polybrominated biphenyls (PBBs) and prevalence of autoimmune disorders among members of the Michigan PBB registry.

Assessing Metabolic Differences Associated with Exposure to Polybrominated Biphenyl and Polychlorinated Biphenyls in the Michigan PBB Registry.

PFAS

Serum per- and polyfluoroalkyl substance concentrations and longitudinal change in post-infection and post-vaccination SARS-CoV-2 antibodies.

Prenatal exposure to poly- and perfluoroalkyl substances and the incidence of asthma in early childhood.

Gestational hypertension, preeclampsia, and gestational diabetes mellitus after high exposure to perfluoroalkyl substances from drinking water in Ronneby, Sweden.

Correlation analysis between per-fluoroalkyl and poly-fluoroalkyl substances exposure and depressive symptoms in adults: NHANES 2005-2018.

Legacy perfluoro-alkyl substances impair LDL-cholesterol uptake independently from PCSK9-function.

A co-twin control study of in utero exposure to poly- and perfluoroalkyl substances and associations with neonatal thyroid-stimulating hormone.

Per- and Poly-fluoroalkyl Substances and Bile Acid Profiles in Pregnant Women.

Pesticides

Childhood Exposure to Pyrethroids and Neurodevelopment in Canadian Preschoolers.

Association of occupational exposure to pesticides with overweight in farmers in southern Brazil.

Urinary Glyphosate, 2,4-D and DEET Biomarkers in Relation to Neurobehavioral Performance in Ecuadorian Adolescents in the ESPINA Cohort.

Bioinformatics analysis of the potential mechanisms of Alzheimer’s disease induced by exposure to combined triazine herbicides.

Metals/Metalloids

Nickel as a potential disruptor of thyroid function: benchmark modelling of human data.

Comparison of circulating and excreted metals and of autoimmunity between two Great Plains Tribal communities.

Association of Exposure to Heavy Metal Mixtures with Systemic Immune-Inflammation Index Among US Adults in NHANES 2011-2016.

Investigation of the relationship between heavy metals in the blood and depression in people with different body mass indices using the NHANES database: A cross-sectional study.

Cardiovascular risk factors and kidney function among automobile mechanic and their association with serum heavy metals in Southwest Nigeria: A cross-sectional study.

Microplastics/Nanomaterials

Identification and analysis of microplastics in human lower limb joints.

Air Pollution

Multiple myeloma risk in relation to long-term air pollution exposure – A pooled analysis of four European cohorts.

Effects of the abdominal fat distribution on the relationship between exposure to air pollutants and thyroid hormones among Korean adult males.

Pharmaceuticals/Personal Care Products

Hair relaxer use and risk of uterine cancer in the Black Women’s Health Study.

Miscellaneous

Understanding the role of environmental and socioeconomic factors in the geographic variation of breast cancer risk in the US-wide sister study.

Laboratory Studies

Numerous Chemicals/Mixtures

Impact of chemical mixtures from wastewater treatment plant effluents on human immune cell activation: An effect-based analysis.

Changes in toxicity after mixing imidacloprid and cadmium: enhanced, diminished, or both? From a perspective of oxidative stress, lipid metabolism, and amino acid metabolism in mice.

A complex mixture of polycyclic aromatic compounds causes embryotoxic, behavioral, and molecular effects in zebrafish larvae (Danio rerio), and in vitro bioassays.

BPA/Phenols

Hormone effects of eighteen bisphenol analogues and their effects on cellular homeostasis and the typical signal pathways.

Omega-3 fatty acid ameliorates bisphenol F-induced testicular toxicity by modulating Nrf2/NFkB pathway and apoptotic signaling.

Exposure to nonylphenol in early life causes behavioural deficits related with autism spectrum disorders in rats.

Phthalates

Butyl benzyl phthalate exposure impact on the gut health of Metaphire guillelmi.

Preconception and developmental DEHP exposure alter liver metabolism in a sex-dependent manner in adult mouse offspring.

Influence of different concentrations of plasticizer diethyl phthalate (DEP) on toxicity of Lactuca sativa seeds, Artemia salina and Zebrafish.

The effects of short-term and long-term phthalate exposures on ovarian follicle growth dynamics and hormone levels in female mice.

Investigation of the effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq.

Migration study of phthalates from non-food plastic containers used in food preservation.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Protective effect of didymin against 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-induced reproductive toxicity in male rats.

Rhamnazin ameliorates 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-evoked testicular toxicity by restoring biochemical, spermatogenic and histological profile in male albino rats.

PFAS

Perfluorooctanoic acid-induced metabolic disorder via enhancing metabolism of glutamine and fatty acids in human intestinal cells.

Deficiency of spns1 Exacerbates Per- and Polyfluoroalkyl Substances Mediated Hepatic Toxicity and Steatosis in Zebrafish (Danio rerio).

PFOS-induced dyslipidemia and impaired cholinergic neurotransmission in developing zebrafish: Insight into its mechanisms.

Sublethal perfluorooctanoic acid and perfluorooctanesulfonic acid delay C. elegans larval development and population growth but do not alter egg hatching.

Flame Retardants

1,2-bis(2,4,6-tribromophenoxy) ethane, a novel brominated flame retardant, disrupts intestinal barrier function via the IRX3/NOS2 axis in rat small intestine.

Persistent immune injury induced by short-term decabromodiphenyl ether (BDE-209) exposure to female middle-aged Balb/c mice.

Pesticides

Effects of glyphosate exposure on western, diet-induced non-alcoholic fatty liver disease in mice.

Influence of chlorpyrifos exposure on UVB irradiation induced toxicity in human skin cells.

Sex-specific neurobehavioral and biochemical effects of developmental exposure to Malathion in offspring mice.

Toxicity assessment of carvacrol and its acetylated derivative in early staged zebrafish (Danio rerio): Safer alternatives to fipronil-based pesticides?

Impacts of isolated or mixed Roundup® Original DI and Boral® 500 SC herbicides on the survival and metamorphosis of Melanophryniscus admirabilis tadpoles.

Biochemical and gene expression alterations due to individual exposure of atrazine, dichlorvos, and imidacloprid and their combination in zebrafish.

Metals/Metalloids

The disruption of blood-brain barrier induced by long-term arsenic exposure is associated with the increase of MMP-9 and MMP-2: The characteristics are similar to those caused by senescence.

Impact of Chronic Exposure to Arsenate through Drinking Water on the Intestinal Barrier.

Microplastics/Nanomaterials

Co-exposure to cadmium and microplastics promotes liver fibrosis through the hemichannels -ATP-P2X7 pathway.

Polystyrene nanoparticle exposure accelerates ovarian cancer development in mice by altering the tumor microenvironment.

Environmentally persistent free radicals on photoaged nanopolystyrene induce neurotoxicity by affecting dopamine, glutamate, serotonin and GABA in Caenorhabditis elegans.

Dietary exposure to polystyrene microplastics exacerbates liver damage in fulminant hepatic failure via ROS production and neutrophil extracellular trap formation.

Leaching of triphenyl phosphate and tri-n-butyl phosphate from polystyrene microplastics: influence of plastic properties and simulated digestive fluids.

Air Pollution

Gestational exposure to ambient fine particulate matter disrupts maternal hepatic lipid metabolism.

Different airborne particulates trigger distinct immune pathways leading to peanut allergy in a mouse model.

Miscellaneous

BaP/BPDE suppressed endothelial cell angiogenesis to induce miscarriage by promoting MARCHF1/GPX4-mediated ferroptosis.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Dietary intake of metals, metalloids, and persistent organic pollutants in Spanish pregnant women. ECLIPSES study.

Assessment of 18 endocrine disrupting chemicals in tap water samples from Klang Valley, Malaysia.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Prenatal and Early Postnatal Exposure to Persistent Organic Pollutants (POPs): What Is the Correlation between Dioxins and Long-Chain Per- and Polyfluorinated Alkyl Substances (PFAS)?

Diet, lifestyle and contaminants in three east Greenland Inuit municipalities.

Varying Diet Composition Causes Striking Differences in Legacy and Emerging Contaminant Concentrations in Killer Whales across the North Atlantic.

PFAS

Elevated Levels of Ultrashort- and Short-Chain Perfluoroalkyl Acids in US Homes and People.

Estimation of the Half-Lives of Recently Detected Per- and Polyfluorinated Alkyl Ethers in an Exposed Community.

Nontarget Screening and Fate of Emerging Per- and Polyfluoroalkyl Substances in Wastewater Treatment Plants in Tianjin, China.

Characteristic and health risk of per- and polyfluoroalkyl substances from cosmetics via dermal exposure.

Combustion of high-calorific industrial waste in conventional brick kilns: An emerging source of PFAS emissions to agricultural soils.

Emerging and legacy perfluoroalkyl and polyfluoroalkyl substances (PFAS) in surface water around three international airports in China.

Dynamic exposure and body burden models for per- and polyfluoroalkyl substances (PFAS) enable management of food safety risks in cattle.

Flame Retardants

Tissue distribution and trophic transfer of organophosphate triesters and diesters in three marine mammals of the Liaodong Bay and the Northern Yellow Sea.

Brominated flame retardants and natural organobrominated compounds in a vulnerable delphinid species along the Brazilian coast.

Pesticides

Effects of an organic diet intervention on the levels of organophosphorus metabolites in an adult cohort.

Urinary pesticide mixture patterns and exposure determinants in the adult population from the Netherlands and Switzerland: Application of a suspect screening approach.

Air Pollution

Concentration identification and endpoint-oriented health risk assessments on a broad-spectrum of organic compounds in atmospheric fine particles: A sampling experimental study in Beijing, China.

Pharmaceuticals/Personal Care Products

Occurrence, time trends, and human exposure of siloxanes and synthetic musk compounds in indoor dust from Korean homes.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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