EDC Science Weekly, Oct. 4-10, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Finding non-fluorinated alternatives to fluorinated gases used as refrigerants.
Impact of Real-life Environmental Exposures on Reproduction: Endocrine-disrupting chemicals, reproductive aging, and menopause.
Mixed contaminant exposure in tapwater and the potential implications for human-health in disadvantaged communities in California.

Science summaries and highlights

Events

Oct. 15 workshop: State-of-the-Science and the Future of Cumulative Impact Assessment [National Academies]

Oct. 17 webinar: Male autism spectrum disorder & prenatal BPA exposure [EDC Strategies Partnership]

Oct. 28: Swiss Symposium on Endocrine Disrupting Chemicals [Food Packaging Forum and ETH Zurich]

Oct. 29-30: 6th Annual Forum on Endocrine Disruptors [European Commission]

Nov. 5-6 conference: State of the science on development and use of NAMs for chemical safety testing [U.S. EPA]

Nov. 21 webinar: Introduction to ECHA’s guidance on new CLP hazard classes [ECHA]

Dec. 3 webinar: Fluoride, Neurodevelopment, and Cognition: A National Toxicology Program monograph [EDC Strategies Partnership]

More events

Methods/Tools/Screening

Assessing the impact of different assumptions on the size of a Mixture Assessment Factor (MAF) for chemical mixtures in surface waters using data from three recent monitoring studies.

Cross-Species Molecular Docking Method to Support Predictions of Species Susceptibility to Chemical Effects.

Screening

Profiling the endocrine disrupting properties of triazines, triazoles and short-chain PFAS.

Standardization and optimization of the hiPSC-based PluriLum assay for detection of embryonic and developmental toxicants.

A High-Throughput Screening Approach for Evaluating the Binding Affinity of Environmental Pollutants to Nuclear Receptors.

Tools

Development of a comprehensive open access “molecules with androgenic activity resource (MAAR)” to facilitate risk assessment of chemicals.

Plastics in human diets: development and evaluation of the 24-h Dietary Recall – Plastic Exposure and the Dietary Plastics Score.

Commentaries

A Twin Transition in Regulatory Toxicology-moving towards Chemicals 2.0 and phasing out animal testing.

Animal-free safety assessment of chemicals: an innovation system perspective.

Editorial: New approach methods in immunology. [intro to a research topic in Frontiers in Immunology]

How do plastics, including microplastics and plastic-associated chemicals, affect human health?

NNI Nanoinformatics Conference 2023: Movement Toward a Common Infrastructure for Federal nanoEHS Data Computational Toxicology: Short Communication.

More EDC policy and regulations open for comment

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Impact of Real-life Environmental Exposures on Reproduction: Endocrine-disrupting chemicals, reproductive aging, and menopause.

Prioritization of chemical food safety hazards in the European feed supply chain.

Rodent reproductive behavior among males and females after exposure to endocrine-disrupting chemicals.

Decoding Adverse Effects of Organic Contaminants in the Aquatic Environment: A Meta-analysis of Species Sensitivity, Hazard Prediction, and Ecological Risk Assessment.

Emerging micropollutants – Environmental impact and source-controlled approaches: Current State and Future Prospects.

PFAS

Finding non-fluorinated alternatives to fluorinated gases used as refrigerants.

Effects of per- and polyfluoroalkyl substances on the liver: Human-relevant mechanisms of toxicity.

Effect of Co-exposure to Additional Substances on the Bioconcentration of Per(poly)fluoroalkyl Substances: A Meta-Analysis Based on Hydroponic Experimental Evidence.

Comprehensive analysis of PFAS presence from environment to plate.

Pesticides

Impact of pesticides exposure and type 2 diabetes risk: a systematic review and meta-analysis.

Overview of human health effects related to glyphosate exposure.

Maternal exposure to glyphosate increased the risk of adverse neurodevelopmental outcomes in rodent offspring: A systematic review.

Metals/Metalloids

Heavy metal contamination of the Nigerian environment from e-waste management: A systematic review of exposure pathway and attendant pathophysiological implications.

Microplastics/Nanomaterials

Mechanistic insight of neurodegeneration due to micro/nano-plastic-induced gut dysbiosis.

Innovative mechanisms of micro- and nanoplastic-induced brain injury: Emphasis on the microbiota-gut-brain axis.

A review of airborne micro- and nano-plastics: Sampling methods, analytical techniques, and exposure risks.

Coupling polyethylene microplastics with other pollutants: Exploring their combined effects on plant health and technologies for mitigating toxicity.

Interactions between microplastics (MPs) and trace/toxic metals in marine environments: implications and insights-a comprehensive review.

Air Pollution

Satellite data for environmental justice: a scoping review of the literature in the United States.

Miscellaneous

Toxicokinetic Profiles and Potential Endocrine Disruption Effects at the Reproductive Level Promoted by Siloxanes Used in Consumer Products.

The Metabolic Programming of Pubertal Onset.

Relevance of gut microbiome research in food safety assessment.

Human Health Studies

Phthalates

Oxidative stress as a potential mechanism linking gestational phthalates exposure to cognitive development in infancy.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations between polychlorinated biphenyls and cancer risk among type 2 diabetes: The modifying effects of lifestyle.

The Interplay of Persistent Organic Pollutants and Mediterranean Diet in Association With the Risk of Gestational Diabetes Mellitus.

PFAS

Thyrotoxic Effects of Mixed Exposure to Perfluorinated Compounds: Integrating Population-Based, Toxicogenomic, Animal, and Cellular Evidence to Elucidate Molecular Mechanisms and Identify Potential Effector Targets.

County-level associations between drinking water PFAS contamination and COVID-19 mortality in the United States.

Prenatal exposure to per- and polyfluoroalkyl substances, genetic factors, and autistic traits: Evidence from the Shanghai birth cohort.

Pesticides

Comparative study of oxidative stress in cancer patients occupationally exposed to the mixture of pesticides.

Prevalence of Chronic Kidney Disease and its Association with Pesticide Exposure in Bargarh District, Odisha, India.

Metals/Metalloids

Environmental pollution impact on the severity of some rheumatic diseases: a comparative analytical study on inflammatory and non-inflammatory samples.

Bladder cancer associated with elevated heavy metals: Investigation of probable carcinogenic pathways through mitochondrial dysfunction, oxidative stress and mitogen-activated protein kinase.

Microplastics/Nanomaterials

Blood-brain barrier damage accelerates the accumulation of micro- and nanoplastics in the human central nervous system.

Investigating Exposure and Hazards of Micro- and Nanoplastics During Pregnancy and Early Life (AURORA Project): Protocol for an Interdisciplinary Study.

Air Pollution

Research on the causal relationship between fine particulate matter and type 2 diabetes mellitus: A two-sample multivariable mendelian randomization study.

Global and national burden of type 2 diabetes mellitus attributable to PM2.5 air pollution: An analysis of the GBD study from 1990 to 2019.

Increased Stillbirth Rates and Exposure to Environmental Risk Factors for Stillbirth in Counties with Higher Social Vulnerability: United States, 2015-2018.

Inequities in air pollution on stroke mortality among Older Americans: a U.S. nationwide analysis.

Association of ambient air pollution with cognitive functioning and markers of structural brain damage: The Maastricht study.

Miscellaneous

Prenatal polycyclic aromatic hydrocarbon exposure and neurodevelopment among children in Puerto Rico.

Laboratory Studies

Numerous Chemicals/Mixtures

Identification of endocrine-disrupting chemicals targeting key OP-associated genes via bioinformatics and machine learning. [osteoporosis and PFNA, cadmium, BPA, etc.]

BPA/Phenols

Bisphenol AP inhibits mouse oocyte maturation in vitro by disrupting cytoskeleton architecture and cell cycle processes.

An in vitro approach reveals molecular mechanisms underlying endocrine disruptor-induced epimutagenesis. [BPS]

Tetra aniline-based polymers ameliorate BPA-induced cardiotoxicity in Sprague Dawley rats, in silico and in vivo analysis.

Individual and combined antagonism of aryl hydrocarbon receptor (AhR) and estrogen receptors (ERs) offers distinct level of protection against Bisphenol A (BPA)-induced pancreatic islet cell toxicity in mice.

The effect of bisphenol A on the Notch (Notch2 and Jagged2) signaling pathway in the follicular development of the neonatal rat ovary.

Phthalates

Di(2-ethylhexyl) phthalate disrupts circadian rhythm associated with changes in metabolites and cytochrome P450 gene expression in Caenorhabditis elegans.

Parabens/Triclosan/Antimicrobials

Triclocarban disrupts the activation and differentiation of human CD8⁺ T cells by suppressing the vitamin D receptor signaling.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Inhalation of 2,2′,5,5′-tetrachlorobiphenyl (PCB52) causes changes to the gut microbiome throughout the gastrointestinal tract.

Effects of 28-Day Nose-Only Inhalation of PCB52 (2,2′,5,5′-Tetrachlorobiphenyl) on the Brain Transcriptome.

PFAS

Perfluorooctanoic acid (PFOA) induces cardiotoxicity by activating the Keap1/Nrf2 pathway in zebrafish (Danio rerio) embryos.

Possible mechanisms for adverse effects on zebrafish sperm and testes associated with low-level chronic PFOA exposure.

Environmentally relevant level of PFDA exacerbates intestinal inflammation by activating the cGAS/STING/NF-κB signaling pathway.

Novel insights into the mechanisms of bioaccumulation and tissue-specific distribution of hexafluoropropylene oxide homologues, novel PFOA alternatives, in zebrafish (Danio rerio).

Flame Retardants

The Role of Human Adiponectin Receptor 1 in 2-Ethylhexyl Diphenyl Phosphate Induced Lipid Metabolic Disruption.

Adipogenic Effects of Cresyl Diphenyl Phosphate (Triphenyl Phosphate Alternative) through Peroxisome Proliferator-Activated Receptor Gamma Pathway: A Comprehensive Study Integrating In Vitro, In Vivo, and In Silico from Molecule to Health Risk.

Pesticides

Cocktail effects of clothianidin and imidacloprid in zebrafish embryonic development, with high and low concentrations of mixtures.

Combined effects of glyphosate and chemical hypoxia in zebrafish: a new toxicological point of view.

Microplastics/Nanomaterials

Sorption of PFOS onto polystyrene microplastics potentiates synergistic toxic effects during zebrafish embryogenesis and neurodevelopment.

Examining the Relationship Between Polystyrene Microplastics and Male Fertility: Insights From an In Vivo Study and In Vitro Sertoli Cell Culture.

Changes in global methylation patterns of Mytilus galloprovincialis exposed to microplastics.

Distinctive toxic repercussions of polystyrene nano plastic towards aquatic non target species Nitrobacter vulgaris, Scenedesmus sp and Daphnia magna.

Miscellaneous

The Interaction of Myeloperoxidase with the Industrial Contaminant 6-PPD: A Potential Pathway for Reactive Metabolites.

Typical Tire Additives in River Water: Leaching, Transformation, and Environmental Risk Assessment.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Mixed contaminant exposure in tapwater and the potential implications for human-health in disadvantaged communities in California.

Determining personal exposure to high production volume chemicals (HPVCs) and polycyclic aromatic hydrocarbons (PAHs) with silicone wristbands: A pilot study.

Dietary exposure to metals/metalloids and persistent organic pollutants in Spanish preschool and primary school children.

Exposure to bisphenols, parabens, and benzophenones in colostrum breast milk of Panamanian women: A pilot study from the PA-MAMI cohort.

BPA/Phenols

Detecting Bisphenol A Leaching from Four Different Commercially Available Clear Aligner Sheets: An Ex Vivo Study.

Phthalates

Increasing the Recycling of PVC Flooring Requires Phthalate Removal for Ensuring Consumers’ Safety: A Cross-Checked Substance Flow Analysis of Plasticizers for Switzerland.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Determination of PCB and PAH tissue levels in bottlenose dolphins that stranded in the Mississippi sound before and after the unusual mortality event in 2019.

Legacy persistent organic pollutants among multiple cetacean species in the Northwest Atlantic.

PFAS

Aggregated health risk assessment of perfluoroalkyl acids migrated from convenience food contact materials.

From wastewater to feed: Understanding per- and polyfluoroalkyl substances occurrence in wastewater-irrigated crops.

Indoor air concentrations of PM_2.5 quartz fiber filter-collected ionic PFAS and emissions to outdoor air: findings from the IPA campaign.

Uptake of Per- and Polyfluoroalkyl Substances in Mixed Forages on Biosolid-Amended Farm Fields.

Pesticides

Sociodemographic and Dietary Determinants of Glyphosate Exposure in a NYC-based Pregnancy Cohort.

Metals/Metalloids

Factors influencing metal concentrations in hair and nails during longitudinal follow-up of apprentice welders.

Unexpected anthropogenic emission decreases explain recent atmospheric mercury concentration declines.

Microplastics/Nanomaterials

Microplastics and per- and polyfluoroalkyl substances (PFAS) in landfill-wastewater treatment systems: A field study.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!