EDC Science Weekly, Oct. 28 – Nov. 3, 2022 – HEEDS

EDC Science Weekly, Oct. 28 – Nov. 3, 2022

Post author:HEEDS
Post published:November 3, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events,Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Nov. 4: Untangling Complex Exposures and Health Effects (Superfund Research Program)

Webinar Nov. 16: Protecting Brain Development in Children: Phthalates in Food & the Critical Need for Policy Reform (CHE Alaska)

Webinar Nov. 30: PFAS Health Effects: National Academy of Sciences, Engineering, and Medicine’s Recommendations for At-Risk Populations (CHE Alaska)

Webinar Dec. 2: CHE Café: What’s Next in Environmental Health?

Methods/Tools/Screening

Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations.

Advancing exposure data analytics and repositories as part of the European Exposure Science Strategy 2020-2030

Mixture Risk Assessment of Complex Real-Life Mixtures-The PANORAMIX Project.

Navigating Transcriptomic Connectivity Mapping Workflows to Link Chemicals with Bioactivities.

Developing an Exposure Burden Score for Chemical Mixtures Using Item Response Theory, with Applications to PFAS Mixtures.

Pharmacophore Modeling Using Machine Learning for Screening the Blood-Brain Barrier Permeation of Xenobiotics.

Guidance on the use of the benchmark dose approach in risk assessment.

ChemFOnt: the chemical functional ontology resource.

Proposed schemes on more integrative ecological risk assessment of pesticides.

Applicability of generic PBK modelling in chemical hazard assessment: A case study with IndusChemFate

Neuronal differentiation reporter mice as a new methodology for detecting in vivo developmental neurotoxicity.

Commentaries

Breach of Security? Placental Uptake of Micro- and Nanoplastic Particles. [Science Selection in EHP]

Scientists and scientific organizations need to play a greater role in science diplomacy.

Climate, Pollution, and Children’s Health. [a video from NEJM]

In Memoriam: Jane Ellen Simmons.

Correspondence on “Toxic Substances Control Act (TSCA) Implementation: How the Amended Law Has Failed to Protect Vulnerable Populations from Toxic Chemicals in the United States”.

Rebuttal to Correspondence: “Toxic Substances Control Act (TSCA) Implementation: How the Amended Law Has Failed to Protect Vulnerable Populations from Toxic Chemicals in the United States”.

Reviews

Numerous Chemicals/Mixtures

Additives in Children’s Nutrition-A Review of Current Events. [bisphenols, phthalates, PFAS, pesticides…]

Added flavors: potential contributors to body weight gain and obesity?

[Endocrine Disrupting Chemicals]. [in German]

BPA/Phenols

Association of urinary bisphenol A concentrations with in vitro fertilisation outcomes: a systematic review and meta-analysis protocol.

Phthalates

Cumulative risk assessment of five phthalates in European children and adolescents.

Phthalates cause a low-renin phenotype commonly found in premature infants with idiopathic neonatal hypertension.

Perfluoroalkyl Substances

The Need for Testing Isomer Profiles of Perfluoroalkyl Substances to Evaluate Treatment Processes.

Pesticides

Pesticides as endocrine disruptors: programming for obesity and diabetes.

Pesticides and Their Impairing Effects on Epithelial Barrier Integrity, Dysbiosis, Disruption of the AhR Signaling Pathway and Development of Immune-Mediated Inflammatory Diseases.

Pesticide data program: 30 years of food residue data and trends.

Harmful health effects of pesticides used on museum textile artifacts – overview.

Metals/Metalloids

Aluminum, Arsenic, Beryllium, Cadmium, Chromium, Cobalt, Copper, Iron, Lead, Mercury, Molybdenum, Nickel, Platinum, Thallium, Titanium, Vanadium, and Zinc: Molecular Aspects in Experimental Liver Injury.

Neuron Protection by EDTA May Explain the Successful Outcomes of Toxic Metal Chelation Therapy in Neurodegenerative Diseases

Estimating the burden of diseases attributable to lead exposure in the North Africa and Middle East region, 1990-2019: a systematic analysis for the Global Burden of Disease study 2019.

Microplastics/Nanomaterials

Impact of Micro- and Nanoplastics on Mitochondria.

Are Ingested or Inhaled Microplastics Involved in Nonalcoholic Fatty Liver Disease?

Microplastics as Contaminants in Water Bodies and Their Threat to the Aquatic Animals: A Mini-Review.

Air Pollution

Air Pollution, Oxidative Stress, and the Risk of Development of Type 1 Diabetes.

Association between Air Pollution and Type 2 Diabetes Mellitus in Developing Countries: A Systematic Review and Meta-Analysis.

Miscellaneous

Animal evidence considered in determination of cannabis smoke and Δ⁹ -tetrahydrocannabinol as causing reproductive toxicity (developmental endpoint); Part I. Somatic development.

Animal evidence considered in determination of cannabis smoke and Δ9 -tetrahydrocannabinol (Δ9 -THC) as causing reproductive toxicity (developmental endpoint); Part II. Neurodevelopmental effects

Animal evidence considered in determination of cannabis smoke and Δ⁹ -tetrahydrocannabinol as causing reproductive toxicity (developmental endpoint): Part III. Proposed neurodevelopmental mechanisms of action.

Human Health Studies

Numerous Chemicals/Mixtures

Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls.

Phthalates

The Joint Effect of Perceived Psychosocial Stress and Phthalate Exposure on Hormonal Concentrations during the Early Stage of Pregnancy: A Cross-Sectional Study.

Maternal urine phthalate metabolite exposure and miscarriage risk: a nested case-control study of the Zunyi Birth Cohort.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Correlation between Lindane Use and the Incidence of Thyroid Cancer in the United States: An Ecological Study.

Cancer Risk following Residential Exposure to Airborne Polychlorinated Biphenyls: A Danish Register-Based Cohort Study.

Perfluoroalkyl Substances

Perfluorinated compounds in adults and their association with fasting glucose and incident diabetes: a prospective cohort study.

Associations of perfluoroalkyl substances with adipocytokines in umbilical cord serum: A mixtures approach.

Gestational exposure to perfluoroalkyl substances is associated with placental DNA methylation and birth size.

Serum concentrations of perfluoro-1-heptane sulfonate (PFHpS) among US adults: variabilities across different stages of kidney function.

Flame Retardants

Exploratory analysis of the association between organophosphate ester mixtures with high blood pressure of children and adolescents aged 8-17 years: cross-sectional findings from the National Health and Nutrition Examination Survey.

Pesticides

Residential proximity to croplands at birth and childhood leukaemia.

Associations of single and multiple organophosphate pesticide exposure with female infertility in the USA: data from the 2015-2018 National Health and Nutrition Examination Survey.

Lung Cancer in the French West Indies: Role of Sugarcane Work and Other Occupational Exposures.

Metals/Metalloids

Prenatal Co-Exposure to Manganese, Mercury, and Lead, and Neurodevelopment in Children during the First Year of Life.

Fluoride exposure and blood cell markers of inflammation in children and adolescents in the United States: NHANES, 2013-2016.

Lead exposure as a causative factor for metabolic associated fatty liver disease (MAFLD) and a lead exposure related nomogram for MAFLD prevalence.

A 30-year follow-up study in a former cadmium-polluted area of Japan: the relationship between cadmium exposure and β₂-microglobulin in the urine of Japanese people.

Air Pollution

Association Between Ambient Air Pollution and Birth Weight by Maternal Individual- and Neighborhood-Level Stressors.

Ambient air pollution associated with incidence and dynamic progression of type 2 diabetes: a trajectory analysis of a population-based cohort.

Is there a casual relation between air pollution and dementia?

Miscellaneous

The Influence of Parental Environmental Exposure and Nutrient Restriction on the Early Life of Offspring Growth in Gambia-A Pilot Study.

Long-term exposure to low concentrations of polycyclic aromatic hydrocarbons and alterations in platelet indices: A longitudinal study in China.

Laboratory Studies

Numerous Chemicals/Mixtures

Identification of endocrine-disrupting chemicals targeting the genes and pathways of genital anomalies in males. [incl phthalates]

BPA/Phenols

Bisphenol Exposure Disrupts Cytoskeletal Organization and Development of Pre-Implantation Embryos.

Bisphenol A (BPA) induces apoptosis of mouse Leydig cells via oxidative stress.

Prenatal exposure to a low dose of BPS causes sex-dependent alterations to vascular endothelial function in adult offspring.

Individual and Combined Effect of Bisphenol A and Bisphenol AF on Prostate Cell Proliferation through NF-κB Signaling Pathway.

Disturbance in Some Fertility Biomarkers Induced and Changes in Testis Architecture by Chronic Exposure to Various Dosages of Each of Nonylphenol or Bisphenol A and Their Mix.

Prostate histological investigation in rats exposed to bisphenol a and phytochemicals during the perinatal period and subjected to hormonal stimulus in adulthood.

Fetal Myocardial Expression of GLUT1: Roles of BPA Exposure and Cord Blood Exosomes in a Rat Model.

Endocrine disruptors affect the expression of estrogen receptor genes and proteins in the white cloud mountain minnow Tanichthys albonubes (Teleostei: Cyprinidae).

Phthalates

Alteration of the N⁶-methyladenosine epitranscriptomic profile in synthetic phthalate-treated human induced pluripotent stem cell-derived endothelial cells.

Sex and gametogenesis stage are strong drivers of gene expression in Mytilus edulis exposed to environmentally relevant plasticiser levels and pH 7.7.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Early Life Polychlorinated Biphenyl 126 Exposure Disrupts Gut Microbiota and Metabolic Homeostasis in Mice Fed with High-Fat Diet in Adulthood.

Perfluoroalkyl Substances

Toxic effects and transcriptional responses in zebrafish liver cells following perfluorooctanoic acid exposure.

Comparison of developmental toxicity induced by PFOA, HFPO-DA, and HFPO-TA in zebrafish embryos.

Adverse PFAS effects on mouse oocyte in vitro maturation are associated with carbon-chain length and inclusion of a sulfonate group.

1α,25-dihydroxyvitamin D₃ supplementation alleviates perfluorooctanesulfonate acid-induced reproductive injury in male mice: Modulation of Nrf2 mediated oxidative stress response.

Evaluation of the Transformation and Leaching Behavior of Two Polyfluoroalkyl Phosphate Diesters in a Field Lysimeter Study.

Organotins

Low-dose tributyltin triggers human chondrocyte senescence and mouse articular cartilage aging.

Pesticides

Olive Leaf Extract Attenuates Chlorpyrifos-Induced Neuro- and Reproductive Toxicity in Male Albino Rats.

Toxic Effects Induced by Diuron and Its Metabolites in Caenorhabditis elegans.

Paraquat is an agonist of STIM1 and increases intracellular calcium levels.

Metals/Metalloids

Estimation of Metabolic Effects upon Cadmium Exposure during Pregnancy Using Tensor Decomposition

Arsenic Induces GSK3β-Dependent p-Tau, Neuronal Apoptosis, and Cognitive Impairment via an Interdependent Hippocampal ERα and IL-1/IL-1R1 Mechanism in Female Rats.

Microplastics/Nanomaterials

Interactions of Ingested Polystyrene Microplastics with Heavy Metals (Cadmium or Silver) as Environmental Pollutants: A Comprehensive In Vivo Study Using Drosophila melanogaster.

Comparison of metabolome profiles in zebrafish (Danio rerio) intestine induced by polystyrene microplastics with different sizes.

Exposure/Environment Studies

Phthalates

Occurrence and Risk Assessment of Personal PM_2.5-Bound Phthalates Exposure for Adults in Hong Kong.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Infant Exposure to PCBs and PBDEs Revealed by Hair and Human Milk Analysis: Evaluation of Hair as an Alternative Biomatrix.

Metals/Metalloids

Unequal airborne exposure to toxic metals associated with race, ethnicity, and segregation in the USA.

Effects of heavy pollution in different water bodies on male rainbow trout (Oncorhynchus mykiss) reproductive health.

Microplastics/Nanomaterials

Microplastic Contamination of Chicken Meat and Fish through Plastic Cutting Boards.

Quantitative Assessment of Full Size Microplastics in Bottled and Tap Water Samples in Hong Kong.

Field measurements reveal exposure risk to microplastic ingestion by filter-feeding megafauna.

Air Pollution

How do the stay-at-home (SAH) orders affect air quality? Evidence from the northeastern USA.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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EHN EHN

Lou Guillette Jr. Memorial Symposium
by Sarah Howard on December 16, 2024 at 3:52 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on December 16, 2024 at 3:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Webinar: EDC exposure and gonadal function: consequences and interventions
by Sarah Howard on December 16, 2024 at 3:36 pm
This two part webinar series is sponsored by the Endocrine Society's Special Interest Group (SIG) on endocrine disrupting chemicals (EDCs). The first webinar is scheduled for Jan. 30, 2025, and the second for Feb. 13.

EHN EHN

The plastics crisis: A neuropsychiatric problem hidden in plain sight
by EHN Curators on December 18, 2024 at 7:47 pm
The impact of plastics on health is an area of increasing concern.
Scientists lay out new framework to identify toxics contributing to metabolic disorders
by Katherine McMahon,Sarah Howard on December 17, 2024 at 10:00 am
A new consensus statement published in Nature Reviews Endocrinology proposes a set of 12 characteristics that can be used to identify metabolic-disrupting agents - chemicals, pharmaceuticals, and environmental hazards that increase the risk of metabolic disorders like diabetes and obesity. “This approach will enable a more comprehensive mechanistic understanding of how environmental chemicals and other agents disrupt metabolism and cause adverse outcomes.”
2024 Lou Guillette Jr Outstanding Young Investigator Award Winner: Dr. Chris Kassotis
by Sarah Howard on December 16, 2024 at 4:00 pm
Chris Kassotis, Ph.D., is the 2024 winner of the Lou Guillette, Jr. Outstanding Young Investigator Award, sponsored by Healthy Environment and Endocrine Disruptor Strategies (HEEDS). The award, in honor of scientist and mentor Lou Guillette, Jr., is given to an early-career scientist working in some aspect of endocrine disruptor research. The Kassotis lab focuses on understanding endocrine disrupting chemicals (EDCs) and mixtures, and their potential impacts on human and animal health, with a particular focus on metabolic health. He takes on critical public health issues, such as the health effects of chemicals found in fracking fluids and in artificial turf.

EHN EHN

Pesticide industry fights state efforts to regulate PFAS in farming
by EHN Curators on December 19, 2024 at 11:21 am
Pesticide trade groups are using lobbyists and grassroots networks to delay state laws aimed at curbing PFAS contamination in food and water, citing economic concerns. Lisa Held reports for Civil Eats.
Safe drinking water law marks 50 years, but challenges persist
by EHN Curators on December 19, 2024 at 11:19 am
Fifty years after the Safe Drinking Water Act became law, millions still lack reliable access to clean water, particularly in marginalized communities and small towns. Brett Walton reports for Circle of Blue.
RFK Jr. plans to eliminate fluoride in water, but states hold the power
by EHN Curators on December 18, 2024 at 11:47 am
President-elect Donald Trump's health appointee, Robert F. Kennedy Jr., aims to end fluoride in drinking water nationwide, but many states maintain mandates that the federal government cannot override. Hannah Recht reports for The Washington Post.