A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.
Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies
Highlights: Exposure to EDCs in Europe; mixture toxicity; what is the “safe” dose for PFOA?
More science highlights
Events
The Gordon Research Conference on Environmental Endocrine Disruptors will take place on June 23-28, 2024 in beautiful Tuscany, Italy. The conference is preceded on June 22-23 by the Gordon Research Seminar on EDCs, a fun and useful experience for early stage researchers in the field of endocrine disruption. Applications are now open; first come first served!
Starting soon, Nov. 2, 2pm ET: The Launch of the Center to Advance Toxicology and Chemical Hazard Assessment (CATCHA) + EaRTHinar [PRHE EaRTH Center]
Webinar Nov. 9, 3pm ET: Indoor air phthalates and volatile organic compounds in NY nail salons [Philadelphia Regional Center for Children’s Environmental Health]
Webinar Nov. 16, 1pm ET: PFAS and Testicular Cancer: A Study of U.S. Air Force Servicemen [Sponsored by the EDC Strategies Partnership]
More events
Regulations/Policy
Range of the perfluorooctanoate (PFOA) safe dose for human health: An international collaboration
More EDC policy and regulations open for comment
Methods/Tools/Screening
Acceptance criteria for new approach methods in toxicology and human health-relevant life science research – part I.
ToxAIcology – The evolving role of artificial intelligence in advancing toxicology and modernizing regulatory science.
Usage of model combination in computational toxicology.
Effect-Directed Analysis Based on Transthyretin Binding Activity of Per- and Polyfluoroalkyl Substances (PFAS) in a Contaminated Sediment Extract.
Rapid enzymatic activity model (REAM) to decipher the toxic action of per- and polyfluoroalkyl substances.
Xenobiotic Exposure and Migraine-Associated Signaling: A Multimethod Experimental Study Exploring Cellular Assays in Combination with Ex Vivo and In Vivo Mouse Models.
Using in silico tools to predict flame retardant metabolites for more informative exposomics-based approaches.
Uncovering the Common Factors of Chemical Exposure and Behavior: Evaluating Behavioral Effects Across a Testing Battery Using Factor Analysis. [flame retardants]
More tools, reports, and resources
Commentaries
Mixture toxicity: A hot topic in toxicology and chemical risk assessment
Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned. and related Invited Perspective: How Far Have We Come? Revisiting a 2009 Report on Occupational Cancer Research Recommendations.
Air Pollution and Parkinson Disease: Increasing Our Risk Each Breath We Take?
Reviews
Numerous Chemicals/Mixtures
Endocrine Disruptors: Focus on the Adrenal Cortex.
Endocrine disrupting chemicals and male fertility: from physiological to molecular effects.
Food packaging and endocrine disruptors.
A bibliometric analysis of emerging contaminants (ECs) (2001-2021): Evolution of hotspots and research trends.
BPA/Phenols
Multilevel meta-analysis and dose-response analysis for bisphenol A (BPA) exposure on metabolic and neurobehavioral effects.
Effects of Endocrine Disrupting Chemicals (EDCs) on Skeletal System Development: A Review. [BPA]
Phthalates
Exposure to low doses of phthalates in male rodents: Effects on reproductive and cognitive behaviors.
Parabens/Triclosan/Antimicrobials
Environmental Endocrinology: Parabens Hazardous Effects on Hypothalamic-Pituitary-Thyroid Axis.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
A review of food contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin and its toxicity associated with metabolic disorders.
PFAS
Exposure to perfluoroalkyl and polyfluoroalkyl substances and pediatric obesity: a systematic review and meta-analysis.
Flame Retardants
Exposure to PBDEs and maternal and infant health outcomes: Systematic review.
Mechanisms of Organophosphate Toxicity and the Role of Acetylcholinesterase Inhibition.
Organophosphate esters (OPEs) and novel brominated flame retardants (NBFRs) in indoor dust: A systematic review on concentration, spatial distribution, sources, and human exposure.
Pesticides
Airborne Pesticides from Agricultural Practices: A Critical Review of Pathways, Influencing Factors, and Human Health Implications.
Dithiocarbamates: Properties, Methodological Approaches and Challenges to Their Control.
Investigation of the Persistence, Toxicological Effects, and Ecological Issues of S-Triazine Herbicides and Their Biodegradation Using Emerging Technologies: A Review.
Dietary pesticide exposure and non-communicable diseases and mortality: a systematic review of prospective studies among adults.
Metals/Metalloids
Arsenic in Drinking Water and Diabetes.
Interaction of Heavy Metal Lead with Gut Microbiota: Implications for Autism Spectrum Disorder.
Microplastics/Nanomaterials
Journey of micronanoplastics with blood components.
Impact of Fibrous Microplastic Pollution on Commercial Seafood and Consumer Health: A Review.
Miscellaneous
A mini review on 6PPD quinone: A new threat to aquaculture and fisheries.
Human Health Studies
BPA/Phenols
Mitigating the impact of bisphenol A exposure on mortality: Is diet the key? A cohort study based on NHANES.
Phthalates
Individual and combined effects of phthalate metabolites on eczema in the United States population.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
Identification of PCB congeners and their thresholds associated with diabetes using decision tree analysis.
Effects of defoliant exposure and medication use on the development of Parkinson’s disease in veterans.
Plasma Levels of Organochlorine Pesticides and Tumor Necrosis Factor-Alpha: A Potential Risk Factor for Developing Acquired Aplastic Anemia in the North Indian Population.
PFAS
Prenatal exposure to per- and polyfluoroalkyl substances and DNA methylation in the placenta: A prospective cohort study.
Per- and Polyfluoroalkyl Substances and Anti-Müllerian Hormone Concentrations in Two Preconception Cohort Studies.
Cardiometabolic health and per and polyfluoroalkyl substances in an Inuit population.
Per- and polyfluoroalkyl substances (PFAS) exposure and thyroid cancer risk.
Prediagnostic serum concentrations of per- and polyfluoroalkyl substances and risk of papillary thyroid cancer in the Finnish Maternity Cohort.
Early life exposure to F-53B induces neurobehavioral changes in developing children and disturbs dopamine-dependent synaptic signaling in weaning mice.
Associations of exposure to per- and polyfluoroalkyl substances mixture with the numbers of lymph nodes in colorectal cancer patients.
Associations between prenatal exposure to per- and polyfluoroalkyl substances and wheezing and asthma symptoms in 4-year-old children: The Japan environment and Children’s study.
Retraction notice to “Prenatal and early postnatal exposure to perfluoroalkyl substances and bone mineral content and density in the odense child cohort” [Environ. Int. 167 (2022) 107417].
Flame Retardants
Reproductive hormones, organophosphate esters and semen quality: Exploring associations and mediation effects among men from an infertility clinic.
Exposure to organophosphate flame retardants and plasticizers is positively associated with wheeze and FeNO and eosinophil levels among school-aged children: The Hokkaido study.
Pesticides
Agricultural intensification and childhood cancer in Brazil.
Investigating the relationship between non-occupational pesticide exposure and metabolomic biomarkers.
Genomic Instability and Cytotoxicity Evaluation of Two Communities Exposed to Pesticides in the Mexicali Valley by the L-CBMN Assay.
Metals/Metalloids
Association Between Arsenic Toxicity, AS3MT Gene Polymorphism and Onset of Type 2 Diabetes.
Urinary arsenic metabolism, genetic susceptibility, and their interaction on type 2 diabetes.
Adequate Intake of Dietary Fiber May Relieve the Detrimental Impact of Blood Lead on Dyslipidemia among US Adults: A Study of Data from the National Health and Nutrition Examination Survey Database.
A systematic analysis of chronic kidney disease burden attributable to lead exposure based on the global burden of disease study 2019.
Joint effects between cadmium exposure and dietary antioxidant quality score on osteoporosis and bone mineral density.
Associations of blood lead, cadmium, and mercury with resistant hypertension among adults in NHANES, 1999-2018.
Kindergarten dust heavy metal(loid) exposure associates with growth retardation in children.
Air Pollution
Duration-sensitive association between air pollution exposure and changes in cardiometabolic biomarkers: Evidence from a predominantly African American cohort.
Recent ambient temperature and fine particulate matter (PM2.5) exposure is associated with urinary kidney injury biomarkers in children.
Pharmaceuticals/Personal Care Products
The associations between high-levels of urine benzophenone-type UV filters (BPs) and changes in serum lipid concentrations.
Miscellaneous
Single and Joint Associations of Polycyclic Aromatic Hydrocarbon Exposure with Liver Function during Early Pregnancy.
Effects of polycyclic aromatic hydrocarbon exposure and telomere length and their interaction on blood lipids in coal miners.
Laboratory Studies
Numerous Chemicals/Mixtures
Multiple Early Life Stressors as Risk Factors for Neurodevelopmental Abnormalities in the F1 Wistar Rats.
Epigenetic mutagen-like environmental chemicals alter neural differentiation of human induced pluripotent stem cells.
BPA/Phenols
Impact of bisphenol A on cell viability and inflammatory cytokine production in human cervical epithelial cells.
Phthalates
Prenatal Di-methoxyethyl phthalate exposure impairs cortical neurogenesis and synaptic activity in the mice.
Influence of phthalate and non-phthalate plasticizers on reproductive endocrine system-related gene expression profiles in Japanese medaka (Oryzias latipes).
Acetyl Tributyl Citrate Exposure at Seemingly Safe Concentrations Induces Adverse Effects in Different Genders of Type 2 Diabetes Mice, Especially Brain Tissue. [phthalate substitute]
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
No effects of the antiandrogens cyproterone acetate (CPA), flutamide and p,p’-DDE on early sexual differentiation but CPA-induced retardation of embryonic development in the domestic fowl (Gallus gallus domesticus).
PFAS
Gestational GenX and PFOA exposures induce hepatotoxicity, metabolic pathway, and microbiome shifts in weanling mice.
Perfluorooctanoic Acid Promotes Recruitment and Exocytosis of Rodlet Cells in the Renal Hematopoietic Tissue of Common Carp.
Rutin ameliorate PFOA induced renal damage by reducing oxidative stress and improving lipid metabolism.
Organotins
Trimethyltin chloride exposure induces apoptosis and necrosis and impairs islet function through autophagic interference.
Pesticides
2,4-Dichlorophenol Shows Estrogenic Endocrine Disruptor Activity by Altering Male Rat Sexual Behavior.
Short-Term Transcriptomic Points of Departure Are Consistent with Chronic Points of Departure for Three Organophosphate Pesticides across Mouse and Fathead Minnow.
Waterborne Tebuconazole Exposure Induces Male-Biased Sex Differentiation in Zebrafish (Danio rerio) Larvae via Aromatase Inhibition.
Transcriptome Profiling of Etridiazole-Exposed Zebrafish (Danio rerio) Embryos Reveals Pathways Associated with Cardiac and Ocular Toxicities.
Long-Term Effects of Perinatal Exposure to a Glyphosate-Based Herbicide on Melatonin Levels and Oxidative Brain Damage in Adult Male Rats.
Metals/Metalloids
The Role of the Nuclear Receptor FXR in Arsenic-Induced Glucose Intolerance in Mice.
Effect of Long-Term Low-Dose Arsenic Exposure on DNA Methylation and Gene Expression in Human Liver Cells.
Assessing the mechanisms and adjunctive therapy for arsenic-induced liver injury in rats.
Effects of Gestational and Lactational Lead Exposure and High Fat Diet Feeding on Cerebellar Development of Postnatal Rat Offspring.
Microplastics/Nanomaterials
Effects of Microplastic (MP) Exposure at Environmentally Relevant Doses on the Structure, Function, and Transcriptome of the Kidney in Mice.
Gut microbiota combined with metabolome dissects long-term nanoplastics exposure-induced disturbed spermatogenesis.
DNA damage and molecular level effects induced by polystyrene (PS) nanoplastics (NPs) after Chironomus riparius (Diptera) larvae.
Air Pollution
Identifying the Relationship between PM2.5 and Hyperlipidemia Using Mendelian Randomization, RNA-seq Data and Model Mice Subjected to Air Pollution.
Exposure to different PM2.5 extracts induces gliosis and changes behavior in male rats similar to autism spectrum disorders features.
Global Air Pollutant Phenanthrene and Arrhythmic Outcomes in a Mouse Model. [see related Invited Perspective: The Silent Threat-Air Pollution’s Link to Arrhythmias.]
Pharmaceuticals/Personal Care Products
Experimental exploration of estrogenic effects of norethindrone and 17α-ethinylestradiol on zebrafish (Danio rerio) gonads.
Effects of norethindrone on the growth, behavior, and thyroid endocrine system of adult female western mosquitofish (Gambusia affinis).
Exposure/Environment Studies
Numerous Chemicals/Mixtures
Time Patterns in Internal Human Exposure Data to Bisphenols, Phthalates, DINCH, Organophosphate Flame Retardants, Cadmium and Polyaromatic Hydrocarbons in Europe.
Contamination of Bisphenol A, Nonylphenol, Octylphenol, and Estrone in Major Rivers of Mega Manila, Philippines.
BPA/Phenols
Transfer of Bisphenol A and Trace Metals from Plastic Packaging to Mineral Water in Ouagadougou, Burkina Faso.
Phthalates
Case Study of Diesters of o-Phthalic Acid in Surface Waters with Background Levels of Pollution.
Parabens/Triclosan/Antimicrobials
Exposure estimates of parabens from personal care products compared with biomonitoring data in human hair from Northeast China.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
Estimation of dietary intake of polychlorinated dibenzo-p-dioxins and dibenzofurans and dioxin-like polychlorinated biphenyls from the Thai total diet study in 2019.
Serum PCDD/F levels in metropolitan populations living near a municipal solid waste incinerator in Eastern China.
Differential gene expression and developmental pathologies associated with persistent organic pollutants in sentinel fish in Troutman Lake, Sivuqaq, Alaska.
Impacts of a warming climate on concentrations of organochlorines in a fasting high arctic marine bird: Direct vs. indirect effects?
PFAS
Is it raining PFAS in France? An analysis of 52 PFAS at ng/L levels in French rainwaters during Autumn season.
Incidence of Perfluoroalkyl Substances in Commercial Eggs and Their Impact on Consumer’s Safety.
Elaborating the Occurrence and Distribution of Per- and Polyfluoroalkyl Substances in Rivers and Sediment around a Typical Aging Landfill in China.
Pesticides
Biomonitoring of glyphosate and aminomethylphosphonic acid: Current insights and future perspectives.
Serum butyrylcholinesterase activity in healthy dogs with and without exposure to diazinon.
Metals/Metalloids
Urinary fluoride levels and metal co-exposures among pregnant women in Los Angeles, California.
Broad-Scale Assessment of Methylmercury in Adult Amphibians.
Microplastics/Nanomaterials
Human Health Risk Assessment Of Potentially Toxic Elements And Microplastics Accumulation In Products From The Danube River Basin Fish Market.
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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.
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