A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.
Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies
Highlights
Science summaries and highlights
Events
Nov. 5-6 conference: State of the science on development and use of NAMs for chemical safety testing [U.S. EPA]
Nov. 6 panel discussion: Analysis of Governments’ Authority to Mitigate Micro- and Nanoplastic Releases to Inform the Global Plastics Treaty Negotiations [University of Wollongong, Minderoo Foundation, Geneva Environment Network]
Nov. 7: Plastic Treaty Talks: Designing an Effective Treaty [Center for International Environmental Law, Geneva Environment Network]
Nov. 12 webinar: Plastics Treaty Negotiations: Who has a seat at the table? [CHE-Alaska]
Nov. 13 webinar: The Overturning of Chevron Deference: Impacts on Environmental Health Decision Making [CHE and UCSF’s EaRTH Center]
Nov. 21 webinar: Introduction to ECHA’s guidance on new CLP hazard classes [ECHA]
Dec. 3 webinar: Fluoride, Neurodevelopment, and Cognition: A National Toxicology Program monograph [EDC Strategies Partnership]
Dec. 9 webinar, save the date: Behind the Scenes at EPA: What’s going wrong? [CHE and UCSF’s EaRTH Center]
April 27-29, 2025 conference: Break the Cycle of Children’s Environmental Health Disparities [call for student research projects due Nov. 1]
May 21 – June 4, 2025 course: Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO) [applications due Jan 10, financial aid is available]
In case you missed it: Recordings of the talks at the Oct. 28 Swiss Symposium on Endocrine Disrupting Chemicals are online.
More events
Regulations/Policy
Chemicals 2.0 and Why We Need to Bypass the Gold Standard in Regulatory Toxicology.
More EDC policy and regulations open for comment
Methods/Tools/Screening
Computational Tools to Facilitate Early Warning of New Emerging Risk Chemicals.
In silico models for the screening of human transthyretin disruptors.
Bridging the gap: Innovative human-based in vitro approaches for nanomaterials hazard assessment and their role in safe and sustainable by design, risk assessment, and life cycle assessment.
Reproductive toxicology: keeping up with our changing world.
High-throughput prediction of oral acute toxicity in Rat and Mouse of over 100,000 polychlorinated persistent organic pollutants (PC-POPs) by interpretable data fusion-driven machine learning global models.
AquaticTox: A Web-Based Tool for Aquatic Toxicity Evaluation Based on Ensemble Learning to Facilitate the Screening of Green Chemicals.
Advancing Toxicity Predictions: A Review on in Vitro to in Vivo Extrapolation in Next-Generation Risk Assessment.
Commentaries
Words Matter: Reflective Science Communication and Tradeoffs in Environmental Health Research.
Gestational exposure to PFAS, the “Forever Chemicals,” May Have “Forever” Health Impacts.
Forever Chemicals, Endless Testing? Expert Advice to Be Prepared for Per- and Polyfluoroalkyl Substances.
Environmental Toxicology and Metabolism. [intro to a special issue in Metabolites]
A Bigger Big Picture: Insights on Environmental Chemicals and Dyslipidemia through Combined “Omic” Analyses. [science selection in EHP]
A shot in the foot: Could chemical control of malaria vectors threaten food security?
Plastic exposure may be associated with the deposition of microplastics in reproductive tissues and adverse clinical outcomes.
New Identities of Micro- and Nanoplastics Formed from Biological Effects (Bio-MNPs).
Endocrine-Disrupting Chemicals: Do Polyphenols Advantage or Counteract Their Activity?
Reviews/Meta-Analyses
Numerous Chemicals/Mixtures
The ENDOMIX perspective: how everyday chemical mixtures impact human health and reproduction by targeting the immune system†.
Impact of human-relevant doses of endocrine disrupting chemical and drug mixtures on testis development and function
Short-Half-Life Chemicals: Maternal Exposure and Offspring Health Consequences-The Case of Synthetic Phenols, Parabens, and Phthalates.
Breast Cancer-Related Chemical Exposures in Firefighters.
Investigating the role of food pollutants in autism spectrum disorder: a comprehensive analysis of heavy metals, pesticides, and mycotoxins.
PFAS
The Global Threat from the Irreversible Accumulation of Trifluoroacetic Acid (TFA).
Perfluoroalkyl and polyfluoroalkyl substances and Cancer risk: results from a dose-response Meta-analysis.
Neurotoxicity of per- and polyfluoroalkyl substances: Evidence and future directions.
Polyfluoroalkyl-Substances Detection in Junk Food Packing Materials Using Various Analytical Methods: A Review.
Flame Retardants
Update of the risk assessment of brominated phenols and their derivatives in food.
Pesticides
The Impact of Neonicotinoid Pesticides on Reproductive Health.
Metals/Metalloids
Association between Maternal Exposure to Arsenic during Pregnancy and Risk of Preterm Birth: A Systematic Review and Meta-Analysis.
Microplastics/Nanomaterials
Microplastics and nanoplastics in cardiovascular disease-a narrative review with worrying links.
Micro(nano)plastic and Related Chemicals: Emerging Contaminants in Environment, Food and Health Impacts.
Health Implications of Widespread Micro- and Nanoplastic Exposure: Environmental Prevalence, Mechanisms, and Biological Impact on Humans.
Reproductive and developmental implications of micro- and nanoplastic internalization: Recent advances and perspectives.
Toxic effects of microplastic and nanoplastic on the reproduction of teleost fish in aquatic environments.
Comprehensive systematic review and meta-analysis of microplastic prevalence and abundance in freshwater fish species: the effect of fish species habitat, feeding behavior, and Fulton’s condition factor.
Pharmaceuticals/Personal Care Products
Environmental contamination and risks of organic UV filters: Source, discharge, analytical methods and implications for ecological and human health.
Miscellaneous
Mapping Research Trends in One Health: A Comprehensive Review.
Polyphenols Regulate the Activity of Endocrine-Disrupting Chemicals, Having Both Positive and Negative Effects.
Human Health Studies
Numerous Chemicals/Mixtures
Association of per- and polyfluoroalkylated substances/heavy metals and bone health in children and adolescents.
Linking EDC-laden Food Consumption and Modern Lifestyle Habits with Preeclampsia: A Non-Animal Approach to Identifying Early Diagnostic Biomarkers Through Biochemical Alterations.
BPA/Phenols
Dietary bisphenols exposure as an influencing factor of body mass index.
Parabens/Triclosan/Antimicrobials
Insights into Triclosan-Induced Endocrine Disruption: Evidence from the National Health and Nutrition Examination Survey and Zebrafish Models.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
A decrease in serum dihydrotestosterone levels in 9-year-old Vietnamese children from a dioxin exposure area.
Relationships among Dioxin-like Mitochondria Inhibitor Substances (MIS)-Mediated Mitochondria Dysfunction, Obesity, and Lung Function in a Korean Cohort.
Gender- and Age-Group Specific Association of Persistent Organic Pollutants (POPs) Exposure with Diabetes Mellitus: Korean National Environmental Health Survey (KoNEHS) 2015-2017.
PFAS
Associations between maternal per- and polyfluoroalkyl substances exposure and lipid levels in maternal and cord blood: The Japan Environment and Children’s Study.
Associations between gestational exposure to perfluoroalkyl substances, fetal growth, and the mediation effect of thyroid hormones.
Prenatal exposure to per- and polyfluoroalkyl substances, fetoplacental hemodynamics, and fetal growth.
Associations of per- and polyfluoroalkyl substances with human milk metabolomic profiles in a rural North American cohort.
Relationship Between Perfluoroalkyl Acids in Human Serum and Sjogren’s Syndrome: A Case-Control Study of Populations in Hangzhou, China.
TLR4 as a Potential Target of Me-PFOSA-AcOH Leading to Cardiovascular Diseases: Evidence from NHANES 2013-2018 and Molecular Docking.
Flame Retardants
Gestational organophosphate esters (OPEs) and executive function in adolescence: The HOME Study.
Pesticides
Gestational organophosphate pesticide exposure and childhood cardiovascular outcomes.
Metals/Metalloids
Urinary metals are associated with obesity in U.S. children and adolescents: A cross-sectional study.
Combined Effects of Environmental Metals and Physiological Stress on Lipid Dysregulation.
Hematological, cardiovascular and oxidative DNA damage markers associated with heavy metal exposure in electronic waste (e-waste) workers of Bangladesh.
Association between Arsenic Methylation in Early Pregnancy and Gestational Diabetes Mellitus: A Prospective Cohort Study.
Air Pollution
Airborne ultrafine particle concentrations and brain cancer incidence in Canada’s two largest cities.
Effects of PM2.5 and Its Components on Disease Severity in Patients with Schizophrenia and the Mediating Role of Thyroid Hormones.
Miscellaneous
Cancer Incidence among Marines and Navy Personnel and Civilian Workers Exposed to Industrial Solvents in Drinking Water at US Marine Corps Base Camp Lejeune: A Cohort Study. see related Invited Perspective: Insights into Exposure to Industrial Solvents and Cancer Risk at Camp Lejeune.
One-Year Impact of Occupational Exposure to Polycyclic Aromatic Hydrocarbons on Sperm Quality.
Association of deployment characteristics and exposures with persistent ill health among 1990-1991 Gulf War veterans in the VA Million Veteran Program.
Laboratory Studies
BPA/Phenols
Determination of Bisphenol Compounds and the Bioaccumulation after Co-Exposure with Polyethylene Microplastics in Zebrafish.
Bisphenol F-induced precocious genesis of aggressive neurobehavioral response is associated with heightened monoamine oxidase activity and neurodegeneration in zebrafish brain.
Lower-dose vs high-dose oral bisphenol S action of lipid metabolism in liver of male SD rat via mediating different SREBP isoforms.
Environmental pollution by plasticizers and the relationship to vector dengue mosquito Aedes aegypti: Bisphenol A (BPA) affect the development and viral immune pathway response.
Integrative transcriptomic profiling uncovers immune and functional responses to bisphenol a across multiple tissues in male mice.
Insights into the accumulation and hepatobiliary transport of bisphenols (BPs) in liver and bile.
Maternal exposure to 4-tert-octylphenol causes alterations in the morphology and function of microglia in the offspring mouse brain.
Subchronic exposure to nonylphenol ethoxylate (NPE) induces cardiotoxicity and oxidative stress in American bullfrog tadpoles: a mechanistic approach.
Phthalates
Exposure to phthalate plasticizer compromises normal brain function in an adult vertebrate.
Novel Insights into Ethanol-Soluble Oyster Peptide-Zinc-Chelating Agents: Structural Characterization, Chelation Mechanism, and Potential Protection on MEHP-Induced Leydig Cells.
Di-(2-ethylhexyl) Phthalate Exposure Induces Developmental Toxicity in the Mouse Fetal Heart via Mitochondrial Dysfunction.
Prenatal exposure to di-n-butyl phthalate promotes RIPK1-regulated necroptosis of uroepithelial cells and induces hypospadias through the epithelial-mesenchymal transition process in newborn male rats.
Parabens/Triclosan/Antimicrobials
Aromatase as a novel target of parabens in human and rat placentas: 3D-quantitative structure-activity relationship and docking analysis.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
Effects of the organochlorine pesticide metabolite p,p’-DDE on the gastrointestinal lipidome in fish: A novel toxicity pathway for a legacy pollutant.
PFAS
6:2 Chlorinated polyfluoroalkyl ether sulfonate (F-53B) induced nephrotoxicity associated with oxidative stress, inflammation and fibrosis in mice.
Long-chain perfluoroalkylether carboxylic acids PFO5DoA and PFO4DA alter glucose, bile acid, and thyroid hormone homeostasis in fetal rats from 5-day maternal oral exposure.
Effects of Perfluorinated Alkyl Substances (PFAS) on Amphibian Body and Liver Conditions: Is Lipid Metabolism Being Perturbed throughout Metamorphosis?
Adverse Outcomes Following Exposure to Perfluorooctanesulfonamide (PFOSA) in Larval Zebrafish (Danio rerio): A Neurotoxic and Behavioral Perspective.
PFOS sub-chronic exposure selectively activates Aβ clearance pathway to improve the cognitive ability of AD mice.
Combined environmental relevant exposure to perfluorooctanoic acid and zinc sulfate enhances apoptosis through binding with endogenous antioxidants in Daphnia magna.
Mechanistic insights into the neurotoxicity of F53B: Effects on metabolic dysregulation and apoptosis of dopaminergic neurons.
Flame Retardants
Spherical covalent-organic framework-assisted laser desorption ionization mass spectrometry reveals the promotional effect of triphenyl phosphate on breast cancer in mice.
Histone Methylation-Mediated Reproductive Toxicity to Consumer Product Chemicals in Caenorhabditis elegans: An Epigenetic Adverse Outcome Pathway (AOP).
Toxicological Effects and Mechanisms of 2,2′,4,4′-Tetrabromodiphenyl Ether (BDE-47) on Marine Organisms.
Eco-friendly flame retardant comprising chitosan-based effectively enhances the flame retardancy of wood with low weight percent gain.
Pesticides
Effects of diuron and two of its metabolites in biochemical markers and behavior of zebrafish larvae.
Considering Safe and Sustainable by Design alternatives – Environmental Hazards of an agriculture Nano-enabled pesticide to non-target species.
Individual and combined effects of commercial glyphosate, atrazine and 2,4-D herbicides on the gerbil ventral prostate.
Glyphosate formulations cause mortality and diverse sublethal defects during embryonic development of the amphibian Xenopus laevis.
Effects of glyphosate based herbicide exposure in early developmental stages of Physalaemus gracilis.
In Silico, In Vitro, and In Vivo Studies Indicate the Endocrine-Disrupting Effects of Cyproconazole Stereoisomers.
Comparative Cytotoxicity and Mitochondrial Disruption in H9c2 Cardiomyocytes Induced by Common Pesticides.
Network toxicology and molecular docking to investigative the non-acetylcholinesterase mechanisms and targets of cardiotoxicity injury induced by organophosphorus pesticides.
Adolescent Exposure to Organophosphate Insecticide Malathion Induces Spermatogenesis Dysfunction in Mice by Activating the HIF-1/MAPK/PI3K Pathway.
Microplastics/Nanomaterials
Effects of Polyvinyl Chloride Microplastics on the Reproductive System, Intestinal Structure, and Microflora in Male and Female Mice.
In Vitro and In Vivo Genotoxicity of Polystyrene Microplastics: Evaluation of a Possible Synergistic Action with Bisphenol A.
Effects of polystyrene nano- and microplastics on human breast epithelial cells and human breast cancer cells.
Perfluorobutanoic acid weakens the heterogeneous aggregation of microplastics and microalgae: Perspective from physicochemical properties, extracellular polymeric substances secretion and DLVO theory.
The adsorption of drugs on nanoplastics has severe biological impact.
Rapid Generation of Microplastics and Plastic-Derived Dissolved Organic Matter from Food Packaging Films under Simulated Aging Conditions.
Miscellaneous
Estro-Androgenic Disrupting Effects of Halogenated Disinfection Byproducts: A Comprehensive Evaluation and Comparison.
A transcriptomics-based analysis of mechanisms involved in the neurobehavioral effects of 6PPD-quinone on early life stages of zebrafish.
Exposure/Environment Studies
Numerous Chemicals/Mixtures
Emerging organic contaminants in sewage sludge: Current status, technological challenges and regulatory perspectives.
Phthalates
Phthalate Esters in Different Types of Cosmetic Products: A Five-Year Quality Control Survey.
Current Phthalate Exposure Risks of Rural Population in the Northwest China: Evidence from an Internal Exposure Study.
PFAS
Personal care product use and per- and polyfluoroalkyl substances in pregnant and lactating people in the Maternal-Infant Research on Environmental Chemicals study.
Kinetics of 15 per- and polyfluoroalkyl substances (PFAS) after single oral application as a mixture – A pilot investigation in a male volunteer.
Predictions of groundwater PFAS occurrence at drinking water supply depths in the United States.
City-scale impacts of PFAS from normal and elevated temperature landfill leachates on wastewater treatment plant influent.
Non-target screening reveals 124 PFAS at an AFFF-impacted field site in Germany specified by novel systematic terminology.
Non-targeted analysis reveals hundreds of per- and polyfluoroalkyl substances (PFAS) in UK freshwater in the vicinity of a fluorochemical plant.
Large scale study on PFASs levels in fruits, vegetables and soil from allotments and gardens contaminated by atmospheric deposition from a Dutch fluorochemical production plant.
Legacy and Novel Per- and Polyfluoroalkyl Substances in Surface Soils across China: Source Tracking and Main Drivers for the Spatial Variation.
Flame Retardants
Occurrence of legacy and emerging organophosphate flame retardants (OPFRs) on silicone wristbands: Comparison within couples.
Occurrence and Distribution of Organophosphate Flame Retardants in Tap Water System-Implications for Human Exposure from Shanghai, China.
Identification and seasonal variation of PM2.5-bound organophosphate flame retardants from industrial parks and the associated human health risk.
Organophosphate esters in vehicle interior dust from Chinese urban areas: What are the influencing factors of the occurrence?
From the depths to the apex: Tracing the organophosphate ester journey through marine food webs.
Brominated flame retardants in Caretta caretta sea turtles from the Adriatic Sea.
Pesticides
A preliminary estimate of the environmental burden of disease associated with exposure to pyrethroid insecticides and ADHD in Europe based on human biomonitoring.
Current-use pesticide exposures in remote Inuit communities.
Microplastics/Nanomaterials
Internal and external microplastic exposure in young adults: A pilot study involving 26 college students in Changsha, China.
Microplastic contamination in Chinese topsoil from 1980 to 2050.
Are Microfibers a Threat to Marine Invertebrates? A Sea Urchin Toxicity Assessment.
Unscrambling why plastics aren’t detectable in chicken eggs.
Combined contamination of tire and road wear microplastics with heavy metals in expressway tunnels: occurrence characteristics and risk assessment.
Microplastic accumulation and transport in agricultural soils with long-term sewage sludge amendments.
Air Pollution
P-phenylenediamines (PPDs) and 6PPD-quinone in tunnel PM2.5: From the perspective of characterization, emission factors, and health risks.
Who is Willing to Learn About Inequality? Predictors of Choice Exposure to Messaging About Racial Disparities in Air Pollution Effects Among Black and White U.S. Residents.
Miscellaneous
Race and Superfund site remediation.
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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.
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