EDC Science Weekly, Oct. 21 – 27, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Nov 2: New “Presumptive Contamination” Model Maps PFAS Exposure (EDC Strategies Partnership)

In person and online event Nov 12: Celebrating 20 Years of Amplifying Science for Health (Collaborative on Health and the Environment (CHE))

Regulations/Policy

Improving governance of “forever chemicals” in the US and beyond

Environmental Health: A Position Paper From the American College of Physicians.

REACHing for solutions: Essential revisions to the EU chemicals regulation to modernise safety assessment.

Location-specific strategies for eliminating US national racial-ethnic PM2.5 exposure inequality

Methods/Tools/Screening

Health information for human biomonitoring studies.

Toxicological and Exposure Database Inventory: A review. [Link to TEDI here]

Cytotoxicity evaluation and mechanism of endocrine-disrupting chemicals by the embryoid body test.

Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods.

The NORMAN Suspect List Exchange (NORMAN-SLE): facilitating European and worldwide collaboration on suspect screening in high resolution mass spectrometry.

Defining the Biologically Plausible Taxonomic Domain of Applicability of an Adverse Outcome Pathway: A Case Study Linking Nicotinic Acetylcholine Receptor Activation to Colony Death.

Emerging trends in the methodology of environmental toxicology: 3D cell culture and its applications.

Exposure Prioritization (Ex Priori): A Screening-Level High-Throughput Chemical Prioritization Tool.

Identification of environmental factors that promote intestinal inflammation.

In silico model-based exploration of the applicability of parallel artificial membrane permeability assay (PAMPA) to screen chemicals of environmental concern.

In silico prediction of parkinsonian motor deficits-related neurotoxicants based on the adverse outcome pathway concept.

Case Study in 21^st Century Ecotoxicology: Using in Vitro Aromatase Inhibition Data to Predict Reproductive Outcomes in Fish, In Vivo.

Elucidating effects of environmental exposure using human-induced pluripotent stem cell disease modeling.

Toxicity by descent: A comparative approach for chemical hazard assessment

Commentaries

Exploring environmenATL justice and data analytics in an environmental studies lab course.

Environmental Microplastics and the Lung.

Editorial: Endocrine disruption in marine invertebrates [intro to a research topic in Frontiers in Endocrinology]

Editorial: Environmental Impacts of Pesticides: Environmental Fate, Ecotoxicology, Risk Assessment and Remediation [intro to a research topic in Frontiers in Environmental Science]

Hypothesis: Metformin is a potential reproductive toxicant

Reviews

Numerous Chemicals/Mixtures

Environmental toxicants and placental function.

Reprogramming of glycolysis by chemical carcinogens during tumor development.

Pet cats, the better sentinels for indoor organic pollutants

BPA/Phenols/Phthalates

Lifestyle interventions to reduce endocrine-disrupting phthalate and phenol exposures among reproductive age men and women: A review and future steps.

Pesticides

Exposure to pesticides and pediatric Wilms’ tumor. A meta-analysis on pre-conception and pregnancy parental exposure with an IARC/WHO commentary.

Influence of Rural Environmental Factors in Asthma.

Signaling pathways involved in paraquat-induced pulmonary toxicity: Molecular mechanisms and potential therapeutic drugs.

Enantioselectivity in the toxicological effects of chiral pesticides: A review.

Metals/Metalloids

A hypoxia-driven occurrence of chronic kidney disease and osteoporosis in COPD individuals: new insights into environmental cadmium exposure.

Effects of selenium supplementation on glycaemic control markers in healthy rodents: A systematic review and meta-analysis.

Carcinogenic effects of heavy metals by inducing dysregulation of microRNAs: A review.

Exposure to heavy metals and red blood cell parameters in children: A systematic review of observational studies.

Metals Exposures and DNA Methylation: Current Evidence and Future Directions.

Microplastics/Nanomaterials

Characterization and regulation of microplastic pollution for protecting planetary and human health.

Microplastic exposure in aquatic invertebrates can cause significant negative effects compared to natural particles – A meta-analysis.

Microplastic in the Baltic Sea: A review of distribution processes, sources, analysis methods and regulatory policies.

Elucidating the consequences of the co-exposure of microplastics jointly to other pollutants in bivalves: A review.

Exposure to Microplastics during Early Developmental Stage: Review of Current Evidence.

Nanoplastics and Microplastics May Be Damaging Our Livers.

Air Pollution

Association of Ambient Air Pollution with Blood pressure in Adolescence: A Systematic-Review and Meta-analysis.

Air Pollution, Depressive and Anxiety Disorders, and Brain Effects: A Systematic Review.

Human Health Studies

BPA/Phenols/Phthalates

Urinary phthalate metabolite and BPA concentrations in women with cervical cancer.

Trimester two gestational exposure to bisphenol A and adherence to mediterranean diet are associated with adolescent offspring oxidative stress and metabolic syndrome risk in a sex-specific manner.

Serum concentrations of phthalate metabolites in pregnant women and their association with gestational diabetes mellitus and blood glucose levels.

Parabens/Triclosan/Antimicrobials

Early life exposure to triclosan from antimicrobial daily necessities may increase the potential risk of autism spectrum disorder: A multicenter study in China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Mixtures of persistent organic pollutants and ovarian function in women undergoing IVF.

Perfluoroalkyl Substances

Prenatal exposure to perfluorooctane sulfonate alternatives and associations with neonatal thyroid stimulating hormone concentration: A birth cohort study.

Sex-specific associations between legacy and novel per- and polyfluoroalkyl substances and telomere length in newborns in Wuhan, China: Mixture and single pollutant associations.

Association between perfluoroalkyl substances concentration and bone mineral density in the US adolescents aged 12-19 years in NHANES 2005-2010.

Pesticides

Association between organophosphorus pesticide exposure and depression risk in adults: A cross-sectional study with NHANES data.

Organophosphate pesticide exposure and biomarkers of liver injury/liver function.

Metals/Metalloids

Neuropsychological effects and cognitive deficits associated with exposure to mercury and arsenic in children and adolescents of the Mojana region, Colombia.

Association of paternal cadmium and other heavy metal exposure to birth outcomes using propensity score matching.

Associations between prenatal multiple plasma metal exposure and newborn telomere length: Effect modification by maternal age and infant sex.

Microcystin-LR Combined with Cadmium Exposures and the Risk of Chronic Kidney Disease: A Case-Control Study in Central China.

The NOAEL Equivalent of Environmental Cadmium Exposure Associated with GFR Reduction and Chronic Kidney Disease.

Testing the Limit: Evaluating Drinking Water Arsenic Regulatory Levels Based on Adverse Pregnancy Outcomes in Bangladesh.

Association and risk of circulating inflammatory markers with hyperglycemia in coal-burning arsenicosis.

The Association between Mercury and Lead Exposure and Liver and Kidney Function in Pregnant Surinamese Women Enrolled in the Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH) Environmental Epidemiologic Cohort Study.

Puzzling relationship between levels of toxic metals in blood and serum levels of reproductive hormones: Benchmark dose approach in cross-sectional study.

Exposure to multiple trace elements and thyroid cancer risk in Chinese adults: A case-control study.

Microplastics/Nanomaterials

The Association Between Microplastics and Microbiota in Placentas and Meconium: The First Evidence in Humans.

Air Pollution

Ambient fine particulate matter exposures and human early placental inflammation.

Association between long-term ambient ozone exposure and attention-deficit/hyperactivity disorder symptoms among Chinese children.

Short-term effect of air pollution on childhood epilepsy in eastern China: A space-time-stratified case-crossover and pooled analysis.

Miscellaneous

Cohort profile: the ECHO prenatal and early childhood pathways to health consortium (ECHO-PATHWAYS).

Maternal exposure to urinary polycyclic aromatic hydrocarbons (PAH) in pregnancy and childhood asthma in a pooled multi-cohort study.

Laboratory Studies

Numerous Chemicals/Mixtures

Evaluation of female masculinization in Pomacea canaliculata (Caenogastropoda, Ampullariidae) induced by tributyltin, heavy metals, and uranium in culture water.

Cumulative Risk Meets Inter-Individual Variability: Probabilistic Concentration Addition of Complex Mixture Exposures in a Population-Based Human In Vitro Model.

The combined effect of titanium dioxide nanoparticles and cypermethrin on male reproductive toxicity in rats.

Acute toxicity of pesticide mixtures to honey bees is generally additive, and well predicted by Concentration Addition.

Modulation of DNA Methylation/Demethylation Reactions Induced by Nutraceuticals and Pollutants of Exposome Can Promote a C > T Mutation in the Breast Cancer Predisposing Gene PALB2. [folate, Diuron, glyphosate, PFOA, iron, zinc, and ascorbic acid]

BPA/Phenols

Structural and energetic basis of interaction between human estrogen-related receptor γ and environmental endocrine disruptors from multiple molecular dynamics simulations and free energy predictions.

4,4′-(9-Fluorenylidene)dianiline (BAFL) is antiestrogenic and has adverse effects on female development in CD-1 mice.

Neuroprotective effect of Biochanin a against Bisphenol A-induced prenatal neurotoxicity in zebrafish by modulating oxidative stress and locomotory defects.

Phthalates

Maternal rodent exposure to di-(2-ethylhexyl) phthalate decreases muscle mass in the offspring by increasing myostatin.

The influence of perinatal maternal exposure to dibutyl phthalate on glucolipid metabolism in adult female offspring.

Exposure to environmentally relevant doses of plasticizers alters maternal behavior and related neuroendocrine processes in primiparous and multiparous female mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Aryl hydrocarbon receptor knockout and antibody blockade of programmed cell death Ligand1 increase co-stimulatory molecules on THP-1 and specific cytokine response of human T cells.

Exposure of zebrafish to an environmental mixture of persistent organic pollutants triggers an increase in anxiety-like syndrome but does not affect boldness in unexposed offspring.

Induction of cardiotoxicity in zebrafish embryos by 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene through the JAK-STAT and NOTCH signaling pathways.

Ryanodine receptor-active non-dioxin-like polychlorinated biphenyls cause neurobehavioral deficits in larval zebrafish.

Perfluoroalkyl Substances

Effects of legacy and emerging per- and polyfluoroalkyl substances on PPARα/β/γ regulation and osteogenic/adipogenic differentiation.

Exposure to a mixture of per-and polyfluoroalkyl substances modulates pulmonary expression of ACE2 and circulating hormones and cytokines.

The human fecal microbiome contributes to the biotransformation of the PFAS surfactant 8:2 monosubstituted polyfluoroalkyl phosphate ester.

Investigation of the Binding Fraction of PFAS in Human Plasma and Underlying Mechanisms Based on Machine Learning and Molecular Dynamics Simulation.

Effects of trace PFOA on microbial community and metabolisms: Microbial selectivity, regulations and risks.

Flame Retardants

Thyroid hormone activities of neutral and anionic hydroxylated polybrominated diphenyl ethers to thyroid receptor β: A molecular dynamics study.

Developmental toxicity assessments for TBBPA and its commonly used analogs with a human embryonic stem cell liver differentiation model.

Tetrabromobisphenol a exacerbates the overall radioactive hazard to zebrafish (Danio rerio).

PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis.

Developmental exposure to indoor flame retardants and hypothalamic molecular signatures: Sex-dependent reprogramming of lipid homeostasis.

Maternal transfer and apical and physiological effects of dietary hexabromocyclododecane exposure in parental fathead minnows (Pimephales promelas).

The effect of 2,2′,4,4′-Tetrabromodiphenyl ether (BDE-47) on locomotor behaviour and muscle physiology of the sea cucumber Apostichopus japonicus.

Polybrominated diphenyl ethers interact with the key protein involved in carbohydrate metabolism in rice.

Pesticides

Using the Honey Bee (Apis mellifera L.) Cell Line, AmE-711, to Evaluate Insecticide Toxicity.

Selected Biochemical Markers Change after Oral Administration of Pesticide Mixtures in Honey Bees.

Role of the gut-microbiota-metabolite axis in the rotenone model of early-stage Parkinson’s Disease.

Fenpropathrin exposure induces neurotoxicity in zebrafish embryos.

Abamectin promotes behavior changes and liver injury in zebrafish.

Perinatal exposure to glyphosate-based herbicides impairs progeny health and placental angiogenesis by disturbing mitochondrial function.

Developmental toxicity of prometryn induces mitochondrial dysfunction, oxidative stress, and failure of organogenesis in zebrafish (Danio rerio).

Hypothesis-driven dragging of transcriptomic data to analyze proven targeted pathways in Rhinella arenarum larvae exposed to organophosphorus pesticides.

Complementary biological and computational approaches identify distinct mechanisms of chlorpyrifos versus chlorpyrifos oxon induced dopaminergic neurotoxicity.

The potential immunotoxicity of emamectin benzoate on the human THP-1 macrophages.

Differences in neurotoxic outcomes of organophosphorus pesticides revealed via multi-dimensional screening in adult and regenerating planarians.

Glyphosate and its formulations Roundup Bioflow and RangerPro alter bacterial and fungal community composition in the rat caecum microbiome.

Stereoselective toxicity, bioaccumulation, and metabolic pathways of triazole fungicide cyproconazole in zebrafish.

Chronic toxic effects of isoflucypram on reproduction and intestinal energy metabolism in zebrafish (Danio rerio).

Explicit Consideration of Temperature Improves Predictions of Toxicokinetic-Toxicodynamic Models for Flupyradifurone and Imidacloprid in Gammarus pulex.

Metals/Metalloids

Lead exposure exacerbates adverse effects of HFD on metabolic function via disruption of gut microbiome, leading to compromised barrier function and inflammation.

Multi-omics provide mechanistic insight into the Pb-induced changes in tadpole fitness-related traits and environmental water quality.

Lead exposure promotes the inflammation via the circRNA-05280/miR-146a/IRAK1 axis in mammary gland.

Acute arsenic exposure exacerbates lipopolysaccharide-induced lung injury possibly by compromising the integrity of the lung epithelial barrier in rats.

Juvenile arsenic exposure aggravates goblet cell hyperplasia and airway mucus secretion in ovalbumin-sensitized mice.

The ROS/NF-κB/HK2 axis is involved in the arsenic-induced Warburg effect in human L-02 hepatocytes.

Protective efficacy of Coriandrum sativum seeds against arsenic induced toxicity in Swiss albino mice.

Electrochemical detection mechanism of estrogen effect induced by cadmium: The regulation of purine metabolism by the estrogen effect of cadmium.

White adipose tissue as a target for cadmium toxicity.

An electron microscopic and biochemical study of the potential protective effect of ginger against Cadmium-induced testicular pathology in rats.

Banana peel ameliorated hepato-renal damage and exerted anti-inflammatory and anti-apoptotic effects in metal mixture mediated hepatic nephropathy by activation of Nrf2/ Hmox-1 and inhibition of Nfkb pathway.

Microplastics/Nanomaterials

Effects of chronic exposure of naturally weathered microplastics on oxidative stress level, behaviour, and mitochondrial function of adult zebrafish (Danio rerio).

Leaching behavior and evaluation of zebrafish embryo toxicity of microplastics and phthalates in take-away plastic containers.

Polystyrene microplastic ingestion induces the damage in digestive gland of Amphioctopus fangsiao at the physiological, inflammatory, metabolome and transcriptomic levels.

Neuro- and hepato-toxicity of polystyrene nanoplastics and polybrominated diphenyl ethers on early life stages of zebrafish.

Accumulation of microplastics and Tcep pollutants in agricultural soil: Exploring the links between metabolites and gut microbiota in earthworm homeostasis.

Long-Term Exposure to Environmentally Relevant Doses of Large Polystyrene Microplastics Disturbs Lipid Homeostasis via Bowel Function Interference.

Bioinspired engineered nickel nanoparticles with multifunctional attributes for reproductive toxicity.

Toxicity of nanomixtures to human macrophages: Joint action of silver and polystyrene nanoparticles.

Zinc Oxide Particles Can Cause Ovarian Toxicity by Oxidative Stress in Female Mice Model.

Acute, sub-chronic and chronic exposures to TiO₂ and Ag nanoparticles differentially affects neuronal function in vitro.

Exposure to Environmentally Relevant Concentrations of Polystyrene Microplastics Increases Hexavalent Chromium Toxicity in Aquatic Animals.

Pharmaceuticals/Personal Care Products

Acute toxicity characterization of organic UV-filters and chronic exposure revealing multigenerational effects in Daphnia magna.

Miscellaneous

The gut microbiota metabolite glycochenodeoxycholate activates TFR-ACSL4-mediated ferroptosis to promote the development of environmental toxin-linked MAFLD.

Animal performance and biochemical parameters are sex-dependent in peripubertal rats exposed to deoxynivalenol.

The environmental pollutant 3-methyl-4-nitrophenol reduces the regulatory T cells in the intestine.

Chlorinated Polycyclic Aromatic Hydrocarbons Induce Immunosuppression in THP-1 Macrophages Characterized by Disrupted Amino Acid Metabolism.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Contaminants of emerging concerns (CECs) in a municipal wastewater treatment plant in Indonesia.

BPA/Phenols

Evaluation of Bisphenol A in Pregnant Women from 10 Caribbean Countries.

Phthalates

Is e-waste a source of phthalate and novel non-phthalate plasticizers? A comparison study on indoor dust.

Determination and risk assessment of phthalates in face masks. An Italian study.

Phthalate esters and plastic debris abundance in the Red Sea and Sharm Obhur and their ecological risk level.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Seasonal trends of PCBs in air over Washington DC reveal localized urban sources and the influence of Anacostia River.

Polybrominated dibenzo-p-dioxins/furans and their chlorinated analogues in sediments from a historical hotspot for both brominated flame retardants and organochlorine pesticides.

Polychlorinated biphenyls and polychlorinated dibenzo-p-dioxins and furans in imported canned fish in Nigeria and risk assessment.

Temporal trends of persistent organic pollutants biotransport by Pacific salmon in the Northwest Pacific (2008-2018).

Soil ingestion, a key determinant of exposure to environmental contaminants. The case study of chlordecone exposure in free-range pigs in the French West Indies.

Perfluoroalkyl Substances

Occurrences of legacy and emerging per- and polyfluoroalkyl substances in human milk in China: Results of the third National Human Milk Survey (2017-2020).

Associations between dietary profiles and perfluoroalkyl acids in Inuit youth and adults.

Blood concentrations of per- and polyfluoroalkyl substances are associated with autoimmune-like effects in American alligators from Wilmington, North Carolina

PFAS and Precursor Bioaccumulation in Freshwater Recreational Fish: Implications for Fish Advisories.

On-line solid phase extraction-ultra high performance liquid chromatography-quadrupole/Orbitrap high resolution mass spectrometry determination of per- and polyfluoroalkyl substances in human serum.

Differing behavioral changes in crayfish and bluegill under short- and long-chain PFAS exposures: Field study in Northern Michigan, USA.

Perfluoroalkyl acids in the aquatic environment of a fluorine industry-impacted region: Spatiotemporal distribution, partition behavior, source, and risk assessment.

Occurrence, spatial distribution, and sources of PFASs in the water and sediment from lakes in the Tibetan Plateau.

Comprehensive profiles of per- and polyfluoroalkyl substances in Chinese and African municipal wastewater treatment plants: New implications for removal efficiency.

Formation of perfluorocarboxylic acids (PFCAs) from thermolysis of Teflon model compound.

Occurrence and bioconcentration of per- and polyfluoroalkyl substances and conversion of oxidizable precursors in the waters of coastal tourist resorts in China.

Retention of PFOS and PFOA Mixtures by Trapped Gas Bubbles in Porous Media.

Flame Retardants

Bioaccumulation and Biomagnification of Hexabromocyclododecane in Marine Biota from China: A Review.

Pesticides

Higher proportion of agricultural land use around the residence is associated with higher urinary concentrations of AMPA, a glyphosate metabolite.

Glyphosate and AMPA in Human Urine of HBM4EU-Aligned Studies: Part B Adults.

Biotransformation and oxidative stress responses in fish (Astyanax aeneus) inhabiting a Caribbean estuary contaminated with pesticide residues from agricultural runoff.

Metals/Metalloids

Toxic metal exposures from infant diets: Risk prevention strategies for caregivers and health care professionals.

Cadmium exposure in adults across Europe: Results from the HBM4EU Aligned Studies survey 2014-2020.

Blood Lead Levels among Non-Occupationally Exposed Pregnant Women in Southern Thailand.

Blood lead monitoring in a former mining area in Euskirchen, Germany: results of a representative random sample in 3- to 17-year-old children and minors.

Concentration of mercury in human hair and associated factors in residents of the Gulf of Trieste (North-Eastern Italy).

Could a city-dwelling bat (Pipistrellus kuhlii) serve as a bioindicator species for trace metals pollution?

Microplastics/Nanomaterials

Textile microfibers in wild Antarctic whelk Neobuccinum eatoni (Smith, 1875) from Terra Nova Bay (Ross Sea, Antarctica).

Miscellaneous

Presence of Halogenated Polycyclic Aromatic Hydrocarbons in Milk Powder and the Consequence to Human Health.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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