EDC Science Weekly, Oct. 21 – 27, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Oct. 28: Addressing Root Causes and Preventing Breast Cancer: A New Toolkit and Breast Cancer Action with a Precautionary, Prevention-Oriented Approach (CHE-Alaska)

Webinar Nov. 9: Developmental Endocrine Disruption and Neurotoxicity (HEEDS)

Virtual Town Hall Nov. 10: Eat your Peas, not PFAS: A look into the movement to make school lunch plates safe from PFAS (CEH)

Conference Nov. 11: Moving Towards Beauty Justice: Conversations for Change (NIEHS)

Conference Nov. 8-9: U.S. Developmental Origins of Adult Disease (DOHAD) Society Annual Meeting 2021

Conference Nov. 29 – Dec. 3: The Society of Toxicology of Canada 53rd Annual Symposium

Conference Jan 10-13: PPTOX VII: International Conference on Prenatal Programming and Toxicity (Abstracts due Nov 29)

Course May 25 – June 9: Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO) (Marine Biological Laboratory, Woods Hole)

June 19 – 24: Gordon Research Conference: EDCs and the Environment
June 18 – 19: Gordon Research Seminar: Harnessing Interdisciplinary Evidence for Endocrine Disruption to Improve Public Health

Regulations/Policy

Trends in the Regulation of Per- and Polyfluoroalkyl Substances (PFAS): A Scoping Review

The Environment as a Patient: A Content Analysis of Canadian Nursing Organizations and Regulatory Bodies Policies on Environmental Health.

Regulation of Sun Protection Products in the EU.

WHO Air Quality Guidelines 2021-Aiming for Healthier Air for all: A Joint Statement by Medical, Public Health, Scientific Societies and Patient Representative Organisations.

Methods/Tools/Screening

Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications

Targeted and non-targeted detection and characterization of trace organic chemicals in human serum and plasma using QuEChERS extraction.

Utilizing ion mobility spectrometry-mass spectrometry for the characterization and detection of persistent organic pollutants and their metabolites.

Strategies to improve the challenges of classic dispersive liquid-liquid microextraction for determination of the parabens in personal care products-One step closer to green analytical chemistry.

Trends in the Application of “Omics” to Ecotoxicology and Stress Ecology

Commentaries/Conference Summaries

The emergence, trajectory, and impacts of emerging contaminants publications in the Journal of Environmental Quality.

Nanoplastics: A Complex, Polluting Terra Incognita.

Editorial: Glyphosate Herbicide as Endocrine Disruptor and Probable Human Carcinogen: Current Knowledge and Future Direction.

Editorial: The 2021 European Society of Cardiology (ESC) Guidelines on the Real-World Prevention of Atherosclerotic Cardiovascular Disease (ASCVD)

Special Issue “Recent Advances in Flame-Retardant Polymers and Composites”

Reviews

Numerous EDCs

Endocrine Disrupting Chemicals and Reproductive Health in Boys and Men.

A review of environmental metabolism disrupting chemicals and effect biomarkers associating disease risks: Where exposomics meets metabolomics.

The First Thousand Days: Kidney Health and Beyond.

A Review on Environmental Contaminants-Related Fertility Threat in Male Fishes: Effects and Possible Mechanisms of Action Learned from Wildlife and Laboratory Studies.

Environmental Alterations during Embryonic Development: Studying the Impact of Stressors on Pluripotent Stem Cell-Derived Cardiomyocytes.

BPA/Phenols

Regulatory and academic studies to derive reference values for human health: The case of bisphenol S.

Phthalates

Di(2-ethylhexyl) phthalate (DEHP) and thyroid: biological mechanisms of interference and possible clinical implications.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Dichlorodiphenyltrichloroethane and the Adrenal Gland: From Toxicity to Endocrine Disruption.

Exposure to the pesticide DDT and risk of diabetes and hypertension: Systematic review and meta-analysis of prospective studies.

Perfluoroalkyl Substances

Per- and polyfluoroalkyl substances in water and wastewater: A critical review of their global occurrence and distribution.

Pesticides

Autism Spectrum Disorder and Prenatal or Early Life Exposure to Pesticides: A Short Review.

Cancer and occupational exposure to pesticides: a bibliometric study of the past 10 years.

Advances in organophosphorus pesticides pollution: Current status and challenges in ecotoxicological, sustainable agriculture, and degradation strategies.

A comprehensive review of 1,2,4-triazole fungicide toxicity in zebrafish (Danio rerio): A mitochondrial and metabolic perspective.

Potentially Toxic Elements

The Association Between Heavy Metals Exposure and Sex Hormones: a Systematic Review on Current Evidence.

Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part I-Animal Model Studies

Influence of Dietary Compounds on Arsenic Metabolism and Toxicity. Part II-Human Studies

Microplastics

Looking at the Bigger Picture-Considering the Hurdles in the Struggle against Nanoplastic Pollution.

Microplastics in freshwater: A global review of factors affecting spatial and temporal variations.

Microplastics as a vehicle of heavy metals in aquatic environments: A review of adsorption factors, mechanisms, and biological effects.

What have we known so far about microplastics in drinking water treatment? A timely review.

Pharmaceuticals/Personal Care Products

Systematic assessment of quaternary ammonium compounds for the potential to elicit developmental and reproductive effects.

Human Drug Pollution in the Aquatic System: The Biochemical Responses of Danio rerio Adults

Miscellaneous

An Alternative Explanation for Alzheimer’s Disease and Parkinson’s Disease Initiation from Specific Antibiotics, Gut Microbiota Dysbiosis and Neurotoxins.

The Blood-Brain Barrier: Much More Than a Selective Access to the Brain

Human Health Studies

Numerous Chemicals

Phthalates and Phenols, Leukocyte Telomere Length, and Breast Cancer Risk and Mortality in the Long Island Breast Cancer Study Project.

Phthalates

First- and Third-Trimester Urinary Phthalate Metabolites in the Development of Hypertensive Diseases of Pregnancy.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

In Utero Exposure to Persistent Organic Pollutants and Childhood Lipid Levels.

Association between toxic organochlorine levels in human serum and systemic lupus erythematosus.

Associations of paternal serum dioxin-like polychlorinated biphenyl concentrations on IVF success: A pilot study.

Perfluoroalkyl Substances

Per- and polyfluoroalkyl substances, epigenetic age and DNA methylation: a cross-sectional study of firefighters.

Susceptibility to COVID-19 after High Exposure to Perfluoroalkyl Substances from Contaminated Drinking Water: An Ecological Study from Ronneby, Sweden.

Flame Retardants

Reduced mitochondrial DNA copy number in occupational workers from brominated flame retardants manufacturing plants.

Pesticides

Children Environmentally Exposed to Agrochemicals in Rural Areas Present Changes in Oxidative Status and DNA Damage.

Transient central precocious puberty: a new entity among the spectrum of precocious puberty?

Association between Haematological Parameters and Exposure to a Mixture of Organophosphate and Neonicotinoid Insecticides among Male Farmworkers in Northern Thailand.

Potentially Toxic Elements

Placental cadmium, placental genetic variations, and birth size.

Urinary Metals and Maternal Circulating Extracellular Vesicle microRNA in the MADRES Pregnancy Cohort.

The Effect of Mixture of Heavy Metals on Obesity in Individuals ≥50 Years of Age.

Association between Blood Mercury Concentration and Prevalence of Borderline Hypercholesterolemia among Adolescents: The Korea National Health and Nutrition Examination Survey (KNHANES) 2010-2013 and 2016.

The effect of a high-selenium lentil diet on cardiovascular risk markers in an arsenic-exposed population.

Detailed Analysis of Neurological Symptoms and Sensory Disturbances Due to Chronic Arsenic Exposure in Toroku, Japan

Association of exposure to PM_2.5-bound metals with maternal thyroid function in early pregnancy.

The association between hemoglobin level and osteoporosis in a Chinese population with environmental lead and cadmium exposure.

Miscellaneous

Impaired semen quality, an increase of sperm morphological defects and DNA fragmentation associated with environmental pollution in urban population of young men from Western Siberia, Russia

Urinary Polycyclic Aromatic Hydrocarbon Metabolites Are Associated with Biomarkers of Chronic Endocrine Stress, Oxidative Stress, and Inflammation in Adolescents: FLEHS-4 (2016-2020)

Laboratory Studies

BPA/Phenols

Three-Generation Study of Male Rats Gestationally Exposed to High Butterfat and Bisphenol A: Impaired Spermatogenesis, Penetrance with Reduced Severity.

Effects of Bisphenol A and Its Alternatives, Bisphenol F and Tetramethyl Bisphenol F on Osteoclast Differentiation.

Bisphenol A Induces Accelerated Cell Aging in Murine Endothelium.

Bisphenol A regulates apolipoprotein A1 expression through estrogen receptors and DNA methlylation and leads to cholesterol disorder in rare minnow testis.

Metabolomics Reveals That Bisphenol Pollutants Impair Protein Synthesis-Related Pathways in Daphnia magna.

Bisphenol a Induces Autophagy Defects and AIF-Dependent Apoptosis via HO-1 and AMPK to Degenerate N2a Neurons

Protective Effects of Lignin-Carbohydrate Complexes from Wheat Stalk against Bisphenol a Neurotoxicity in Zebrafish via Oxidative Stress

Effects of electrospun fiber curcumin on bisphenol A exposed Caco-2 cells.

Phthalates

The Peculiar Estrogenicity of Diethyl Phthalate: Modulation of Estrogen Receptor α Activities in the Proliferation of Breast Cancer Cells.

Lineage-Selective Disturbance of Early Human Hematopoietic Progenitor Cell Differentiation by the Commonly Used Plasticizer Di-2-ethylhexyl Phthalate via Reactive Oxygen Species: Fatty Acid Oxidation Makes the Difference.

Effects and underlying cellular pathway involved in the impairment of the neurovascular unit following exposure of adult male mice to low doses of di(2-ethylhexyl) phthalate alone or in an environmental phthalate mixture.

Disruption of Intestinal Homeostasis Through Altered Responses of the Microbial Community, Energy Metabolites, and Immune System in Zebrafish After Chronic Exposure to DEHP.

Characterization of diphenyl phthalate as an agonist for estrogen receptor: an in vitro and in silico study.

Structural observations on spermatogenic cells of Japanese quail (Coturnix coturnix japonica) pre-pubertally exposed to dibutyl phthalate: A light and transmission electron microscopy study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Manganese mitigates against hepatorenal oxidative stress, inflammation and caspase-3 activation in rats exposed to hexachlorobenzene.

Organochlorine pesticide dieldrin upregulate proximal promoter (PII) driven CYP19A1 gene expression and increases estrogen production in granulosa cells.

In silico prediction of nuclear receptor binding to polychlorinated dibenzofurans and its implication on endocrine disruption in humans and wildlife.

Perfluoroalkyl Substances

Transcriptional Effects of Binary Combinations of PFAS in FaO Cells.

PFOS facilitates liver inflammation and steatosis: An involvement of NLRP3 inflammasome-mediated hepatocyte pyroptosis.

Flame Retardants

Persistent autism-relevant behavioral phenotype and social neuropeptide alterations in female mice offspring induced by maternal transfer of PBDE congeners in the commercial mixture DE-71.

Pesticides

Stereoselective toxicity mechanism of neonicotinoid dinotefuran in honeybees: New perspective from a spatial metabolomics study.

Effects of low-concentration glyphosate and aminomethyl phosphonic acid on zebrafish embryo development.

Body fluids from the rat exposed to chlorpyrifos induce cytotoxicity against the corresponding tissue-derived cells in vitro.

Comparative role of microplastics and microalgae as vectors for chlorpyrifos bioacumulation and related physiological and immune effects in mussels.

New insights into potential estrogen agonistic activity of triazole fungicides and coupled metabolic disturbance.

Health risks of sulfentrazone exposure during zebrafish embryo-larvae development at environmental concentration.

Imidacloprid and thiamethoxam affect synaptic transmission in zebrafish.

Toxic effects of methomyl on mouse oocytes and its possible mechanisms.

Tebuconazole Fungicide Induces Lipid Accumulation and Oxidative Stress in HepG2 Cells

Evaluation of Behavioral Changes and Tissue Damages in Common Carp (Cyprinus carpio) after Exposure to the Herbicide Glyphosate.

Epoxiconazole profoundly alters rat brain and properties of neural stem cells..

3-Indolepropionic acid upturned male reproductive function by reducing oxido-inflammatory responses and apoptosis along the hypothalamic-pituitary-gonadal axis of adult rats exposed to chlorpyrifos.

Impact of imidacloprid exposure on the biochemical responses, transcriptome, gut microbiota and growth performance of the Pacific white shrimp Litopenaeus vannamei.

Exposure of American lobster (Homarus americanus) to the pesticide chlorpyrifos results in changes in gene expression.

Susceptibility of the Non-Targeted Crustacean Eurytemora affinis to the Endocrine Disruptor Tebufenozide: A Transcriptomic Approach.

Transmission electron microscopic analysis of glyphosate induced cytotoxicity and its attenuation by N-acetyl-L-cysteine in caprine testicular germ cells in vitro.

Potentially Toxic Elements

Resveratrol ameliorates toxic effects of cadmium on placental development in mouse placenta and human trophoblast cells.

Transcription profiling of cadmium-exposed livers reveals alteration of lipid metabolism and predisposition to hepatic steatosis.

Microplastics/Nanomaterials

Effects of polypropylene, polyvinyl chloride, polyethylene terephthalate, polyurethane, high-density polyethylene, and polystyrene microplastic on Nelumbo nucifera (Lotus) in water and sediment.

TiO₂ NPs induce the reproductive toxicity in mice with gestational diabetes mellitus through the effects on the endoplasmic reticulum stress signaling pathway.

Effects of nano- and microplastics on kidney: Physicochemical properties, bioaccumulation, oxidative stress and immunoreaction.

In vitro study on the toxicity of nanoplastics with different charges to murine splenic lymphocytes.

Comparing the sorption of pyrene and its derivatives onto polystyrene microplastics: Insights from experimental and computational studies.

Pharmaceutical Products and Pesticides Toxicity Associated with Microplastics (Polyvinyl Chloride) in Artemia salina.

Long-Term Effects of Polystyrene Nanoplastics in Human Intestinal Caco-2 Cells.

Effects of oral administration of polystyrene nanoplastics on plasma glucose metabolism in mice.

Prolonged oral ingestion of microplastics induced inflammation in the liver tissues of C57BL/6J mice through polarization of macrophages and increased infiltration of natural killer cells.

Pharmaceuticals/Personal Care Products

Ecotoxicological screening of UV-filters using a battery of marine bioassays.

How temperature rise will influence the toxic impacts of 17 alpha-ethinylestradiol in Mytilus galloprovincialis?

Numerous Chemicals/Mixtures

Type 2 Diabetes Mellitus Mediation by the Disruptive Activity of Environmental Toxicants on Sex Hormone Receptors: In Silico Evaluation.

Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. (paraquat, tartrazine, triclosan)

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Several typical endocrine-disrupting chemicals in human urine from general population in China: Regional and demographic-related differences in exposure risk.

Levels of Phthalates, Bisphenol-A, Nonylphenol, and Microplastics in Fish in the Estuaries of Northern Taiwan and the Impact on Human Health.

Temporal and Geographical Variation of Intestinal Ulcers in Grey Seals ( Halichoerus grypus) and Environmental Contaminants in Baltic Biota during Four Decades

Response of biomarkers to metals, hydrocarbons and organochlorine pesticides contamination in crabs (Callinectes ornatus and C. bocourti) from two tropical estuaries (São José and São Marcos bays) of the Maranhão State (northeastern Brazil).

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) occurrence in Sparus aurata exposed to microplastic enriched diets in aquaculture facilities.

Polychlorinated biphenyl (PCB) concentrations and profiles in marine mammals from the North Atlantic Ocean.

Perfluoroalkyl Substances

How to Address Consumers’ Concerns and Information Needs about Emerging Chemical and Microbial Contaminants in Drinking Water; The Case of GenX in The Netherlands.

Target and Nontarget Screening of PFAS in Biosolids, Composts, and Other Organic Waste Products for Land Application in France.

Porphyrin-based colorimetric sensing of perfluorooctanoic acid as proof of concept for perfluoroalkyl substance detection.

Survey of legacy and emerging per- and polyfluorinated alkyl substances in Mediterranean seafood from a North African ecosystem.

Detection of long chain per- and polyfluoroalkyl substances (PFAS) in the benthic Golden tilefish (Lopholatilus chamaeleonticeps) and their association with microscopic hepatic changes

Pesticides

Pesticide residues in honeybee-collected pollen: does the EU regulation protect honeybees from pesticides?

Effects of agricultural landscape structure, insecticide residues, and pollen diversity on the life-history traits of the red mason bee Osmia bicornis.

Assessment of Environmental Pollution and Human Exposure to Pesticides by Wastewater Analysis in a Seven-Year Study in Athens, Greece.

Analysis of Multi-Pesticide Residues and Dietary Risk Assessment in Fresh Tomatoes (Lycopersicum esculentum) from Local Supermarkets of the Metropolitan Region, Chile.

Environmental risk assessment of neonicotinoids in surface water.

Herbicide-Induced Shifts in the Periphyton Community Composition Indirectly Affect Feeding Activity and Physiology of the Gastropod Grazer Physella acuta.

Potentially Toxic Elements

Levels of mercury in Moroccan breast milk and the affecting factors: CONTAMILK study.

Biological monitoring and health assessment of 21 metal(loid)s in children and adolescents in Liuzhou City, Southwest China.

Soil and plant contamination by potentially toxic and emerging elements and the associated human health risk in some Egyptian environments.

High variability of mercury content in the hair of Russia Northwest population: the role of the environment and social factors.

Total Blood Mercury Predicts Methylmercury Exposure in Fish and Shellfish Consumers.

Risk and benefit assessment of seafood consumption harvested from the Pertuis Charentais region of France.

Occurrence, potential release and health risks of heavy metals in popular take-out food containers from China.

Toxic element levels in ingredients and commercial pet foods.

Quality and human health risk assessment of uranium and other heavy metals in drinking water from Kwale County, Kenya.

Microplastics

Microplastics in fillets of Mediterranean seafood. A risk assessment study.

Microplastics in a pelagic dolphinfish (Coryphaena hippurus) from the Eastern Pacific Ocean and the implications for fish health.

Field evidence for microplastic interactions in marine benthic invertebrates.

Microplastic pollution in mountain terrains and foothills: A review on source, extraction, and distribution of microplastics in remote areas.

The microplastic pollution in beaches that served as historical nesting grounds for green turtles on Hainan Island, China.

Cell size matters: Nano- and micro-plastics preferentially drive declines of large marine phytoplankton due to co-aggregation.

Pharmaceuticals/Personal Care Products

Pharmaceuticals in source waters of 95 First Nations in Canada.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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