A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.
Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies
Highlights: BPA regulations; numerous research topics in Frontiers in Endocrinology; a few studies on bone mineral density and chemicals; Blood-cerebrospinal fluid barrier permeability of metals/metalloids; non-phthalate plasticizers as EDCs; β-HCH and autism; are there 7 million PFAS?
More science highlights
Events
The Gordon Research Conference on Environmental Endocrine Disruptors will take place on June 23-28, 2024 in beautiful Tuscany, Italy. The conference is preceded on June 22-23 by the Gordon Research Seminar on EDCs, a fun and useful experience for early stage researchers in the field of endocrine disruption. Applications are now open; first come first served!
Symposium Oct. 27: Global Environmental Health and Environmental Justice. Virtual or in-person at Duke.
Webinar Nov. 1, noon ET: Plastics & Environmental Justice: What’s Next for the Global Treaty? [with live translation into Spanish. Sponsored by CHE.]
Webinar Nov. 1, 1pm ET: Reusable Revolution: How Greenscreen certified shifts markets toward materials with preferable chemistry [Center for Environmental Health and Clean Production Action]
Webinar Nov. 9, 3pm ET: Indoor air phthalates and volatile organic compounds in NY nail salons [Philadelphia Regional Center for Children’s Environmental Health]
Webinar Nov. 16, 1pm ET: PFAS and Testicular Cancer: A Study of U.S. Air Force Servicemen [Sponsored by the EDC Strategies Partnership]
More Events
Regulations/Policy
European Medicines Agency Conflicts With the European Food Safety Authority (EFSA) on Bisphenol A Regulation. [first published in August]
Net Effects Explains the Benefits to Children from Maternal Fish Consumption Despite Methylmercury in Fish.
More EDC policy and regulations open for comment
Methods/Tools/Screening
Seminar: Extracellular Vesicles as Mediators of Environmental Stress in Human Disease.
Development and application of a systematic and quantitative weighting framework to evaluate the quality and relevance of relative potency estimates for dioxin-like compounds (DLCs) for human health risk assessment.
Per- and Polyfluoroalkyl Substances (PFAS) in PubChem: 7 Million and Growing.
Avoiding Regrettable Replacements: Can the Introduction of Novel Functional Groups Move PFAS from Recalcitrant to Reactive?
The 3Ranker: An AI-based Algorithm for Finding Non-animal Alternative Methods.
Identification of neurotoxicology (NT)/developmental neurotoxicology (DNT) adverse outcome pathways and key event linkages with in vitro DNT screening assays.
A novel method for predicting the emergence of toxicity interaction in ternary mixtures.
Towards translating in vitro measures of thyroid hormone system disruption to in vivo responses in the pregnant rat via a biologically based dose response (BBDR) model.
In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse.
The NOAA NCEI marine microplastics database.
More tools, reports, and resources
Commentaries
Time to Treat the Climate and Nature Crisis as One Indivisible Global Health Emergency [published simultaneously in numerous journals. Not EDCs but important]
Editorial: Obesogens in the XXI century: emerging health challenges volume II. [intro to a research topic in Frontiers in Endocrinology]
Editorial: Environmental stressors and metabolic disease. [intro to a research topic in Frontiers in Endocrinology]
Editorial: Environmental exposomics and metabolic disorders. [intro to a research topic in Frontiers in Endocrinology]
Mother, placenta, and fetal health: endocrine disrupting chemicals at play.
Emerging issues in aquatic toxicology – Plastic pollution.
Reviews
Numerous Chemicals/Mixtures
Hormonal Injustice: Environmental Toxicants as Drivers of Endocrine Health Disparities.
Modulation of fetoplacental growth, development and reproductive function by endocrine disrupters.
Nuclear Receptors-Mediated Endocrine Disrupting Effects of Non-Phthalate Plasticizers: A Review.
Temperature- and chemical-induced neurotoxicity in zebrafish.
BPA/Phenols
Effect of bisphenol A on the neurological system: a review update.
Bisphenol A contamination in aquatic environments: a review of sources, environmental concerns, and microbial remediation.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
Unveiling the mechanistic role of the Aryl hydrocarbon receptor in environmentally induced Breast cancer.
PFAS
Dietary exposure to per- and polyfluoroalkyl substances: Potential health impacts on human liver.
Per- and Poly-fluoroalkyl Substances (PFAS) Exposure and Risk of Kidney, Liver, and Testicular Cancers: A Systematic Review and Meta-Analysis.
Flame Retardants
Elucidating the toxicity mechanisms of organophosphate esters by adverse outcome pathway network.
Pesticides
Agricultural exposures and risk of childhood neuroblastoma: a systematic review and meta-analysis.
Neurobehavioral effects of fungicides in zebrafish: a systematic review and meta-analysis.
Atrazine: cytotoxicity, oxidative stress, apoptosis, testicular effects and chemopreventive Interventions.
Present status of insecticide impacts and eco-friendly approaches for remediation-a review.
Metals/Metalloids
Emerging roles of epigenetics in lead-induced neurotoxicity.
Microplastics/Nanomaterials
Additives of plastics: Entry into the environment and potential risks to human and ecological health.
Assessing micro- and nanoplastics toxicity using rodent models: investigating potential mitochondrial implications.
Miscellaneous
Environmental fate of aquatic pollutants and their mitigation by phycoremediation for the clean and sustainable environment: A review.
The Silent Threat: Exploring the Ecological and Ecotoxicological Impacts of Chlorinated Aniline Derivatives and the Metabolites on the Aquatic Ecosystem.
Human Health Studies
Numerous Chemicals/Mixtures
Perinatal exposure to potential endocrine disrupting chemicals and autism spectrum disorder: From Norwegian birth cohort to zebrafish studies.
Time-specific impact of mono-benzyl phthalate (MBzP) and perfluorooctanoic acid (PFOA) on breast density of a Chilean adolescent Cohort.
Phthalates
Associations between phthalate metabolites and cytokines in the follicular fluid of women undergoing in vitro fertilization.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
Association between persistent organic pollutants in human milk and the infant growth and development throughout the first year postpartum in a cohort from Rio de Janeiro, Brazil.
PFAS
Metabolic Perturbations Associated with an Exposure Mixture of Per- and Polyfluoroalkyl Substances in the Atlanta African American Maternal-Child Cohort.
Exposure to perfluoroalkyl substances and hyperlipidemia among adults: data from NHANES 2017-2018.
Perfluoroalkyl substances in umbilical cord blood and blood pressure in offspring: a prospective cohort study.
Prenatal and early postnatal exposure to perfluoroalkyl substances and bone mineral content and density in the Odense Child Cohort.
Neonatal per- and polyfluoroalkyl substance exposure in relation to retinoblastoma.
Flame Retardants
Organophosphate ester flame retardants and plasticizers in house dust and mental health outcomes among Canadian mothers: A nested prospective cohort study in CHILD.
Pesticides
Association of Prenatal Exposure to Organophosphate, Pyrethroid, and Neonicotinoid Insecticides with Child Neurodevelopment at 2 Years of Age: A Prospective Cohort Study.
Association between maternal urinary neonicotinoid concentrations and child development in the Japan Environment and Children’s Study.
Association of glyphosate exposure with multiple adverse outcomes and potential mediators.
Residential proximity to vines and risk of childhood embryonal tumours in France – GEOCAP case-control study, 2006-2013.
Risk of breast cancer in daughters of agricultural workers in Denmark.
Higher urinary glyphosate exposure is associated with increased risk of liver dysfunction in adults: An analysis of NHANES, 2013-2016.
High pesticide exposures events, pesticide poisoning, and shingles: A medicare-linked study of pesticide applicators in the agricultural health study.
Metals/Metalloids
Blood-cerebrospinal fluid barrier permeability of metals/metalloids and its determinants in pediatric patients.
Synergistic impact of co-exposures to whole blood metals on chronic kidney disease in general US adults: a cross‑sectional study of the National Health and Nutrition Examination Survey 2011-2020.
Association of urinary arsenic metabolism with type 2 diabetes and glucose homeostasis: Cross-sectional and longitudinal associations.
KEAP1 polymorphisms and neurodevelopmental outcomes in children with exposure to prenatal MeHg from the Seychelles Child Development Study Nutrition Cohort 2.
Exposure of environmental trace elements in prostate cancer patients: A multiple metal analysis.
Potential roles of gut microbiota in metal mixture and bone mineral density and osteoporosis risk association: an epidemiologic study in Wuhan.
Urine antimony and risk of cardiovascular disease – A prospective case-cohort study in Danish Non-Smokers.
Quantitative relationships of FAM50B and PTCHD3 methylation with reduced intelligence quotients in school aged children exposed to lead: Evidence from epidemiological and in vitro studies.
Prenatal Lead Exposure Is Associated with Reduced Abundance of Beneficial Gut Microbial Cliques in Late Childhood: An Investigation Using Microbial Co-Occurrence Analysis (MiCA).
Associations between parental and postnatal metal mixture exposure and developmental delays in a Taiwanese longitudinal birth cohort of preschool children.
Air Pollution
Identifying critical windows of air pollution exposure during preconception and gestational period on birthweight: a prospective cohort study.
Fine Particulate Matter Metal Composition, Oxidative Potential, and Adverse Birth Outcomes in Los Angeles.
Ambient Air Pollution Exposure and Cerebral White Matter Hyperintensities in Older Adults: A Cross-Sectional Analysis in the Three-City Montpellier Study.
Long-term exposure to low-level air pollution and greenness and mortality in Northern Europe. The Life-GAP project.
Air pollution and fecundability in a North American preconception cohort study.
Environmental inequalities and multimorbidity: Insights from the Southwest China multi-ethnic cohort study.
Traffic-related air pollution and Parkinson’s disease in central California.
The causal relationship between air pollution, obesity, and COVID-19 risk: a large-scale genetic correlation study.
Laboratory Studies
BPA/Phenols
Mammary gland development and EDC-driven cancer susceptibility in mesenchymal ERα knockout mice.
IVIVE-PBPK based new approach methodology for addressing early life toxicity induced by bisphenol A.
Nrf2-mediated protective effect of alpha-lipoic acid on synaptic oxidative damage and inhibition of PKC/ERK/CREB pathway in bisphenol A-exposed HT-22 cells.
Bisphenol S dysregulates thyroid hormone homeostasis; testicular survival, redox and metabolic status: Ameliorative actions of melatonin.
The Effect of Glucose on the Interaction of Bisphenol A and Bovine Hemoglobin Characterized by Spectroscopic and Molecular Docking Techniques.
Omega 3 fatty acid improves sexual and erectile function in BPF-treated rats by upregulating NO/cGMP signaling and steroidogenic enzymes activities.
Bisphenol A exposure exacerbates tracheal inflammatory injury in selenium-deficient chickens by regulating the miR-155/TRAF3/ROS pathway.
Phthalates
Chronic exposure of mice to phthalates enhances TGF beta signaling and promotes uterine fibrosis.
Subchronic exposure to Di-(2-ethylhexyl) phthalate (DEHP) elicits blood-brain barrier dysfunction and cerebral inflammation in male C57BL/6J mice.
Crosstalk between aryl hydrocarbon receptor and Wnt/β-catenin signaling pathway: Possible culprit of di (2-ethylhexyl) phthalate-mediated cardiotoxicity in zebrafish larvae.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
Targets for pollutants in rat and human pancreatic beta-cells: the effect of prolonged exposure to sub-lethal concentrations of hexachlorocyclohexane isomers on the expression of function- and survival-related proteins.
Effect of TCDD exposure in adult female and male mice on the expression of miRNA in the ovaries and testes and associated reproductive functions.
PFAS
The contribution of PFAS to thyroid hormone-displacing activity in Dutch waters: A comparison between two in vitro bioassays with chemical analysis.
Comparative Toxicological Effects of PFOS and its Alternative 6:2 Chlorinated Polyfluorinated Ether Sulfonate on Earthworms.
Organic anion transporting polypeptide 3a1 is a novel influx pump for Perfluorooctane sulfonate in Sertoli cells and contributes to its reproductive toxicity.
Carbon chain length of perfluoroalkylated carboxylic acids determines inhibitory strength on gonadal 3β-hydroxysteroid dehydrogenases in humans, rats, and mice.
Novel insights into perfluorinated compound-induced hepatotoxicity: Chronic dietary restriction exacerbates the effects of PFBS on hepatic lipid metabolism in mice.
Flame Retardants
Environmentally relevant exposure to tetrabromobisphenol A induces reproductive toxicity via regulating glucose-6-phosphate 1-dehydrogenase and sperm activation in Caenorhabditis elegans.
Insight into Tetrabromobisphenol A-Associated Liver Transcriptional Landscape via Single Cell RNA Sequencing.
Activation of LXRα attenuates 2-Ethylhexyl diphenyl phosphate (EHDPP) induced placental dysfunction.
Evaluation and Mechanistic Study of Transgenerational Neurotoxicity in Zebrafish upon Life Cycle Exposure to Decabromodiphenyl Ethane (DBDPE).
Pesticides
Long-term Neuropsychiatric Developmental Defects after Neonatal Organophosphate Exposure: Mitigation by Synthetic Neurosteroids.
Mevinphos induces developmental defects via inflammation, apoptosis, and altered MAPK and Akt signaling pathways in zebrafish.
The herbicide glyphosate inhibits hippocampal long-term potentiation and learning through activation of pro-inflammatory signaling.
The Protective Effect of Curcumin Against Cardiotoxic Effects Induced by Chronic Exposure to Chlorpyrifos.
Effects of Glyphosate, Mancozeb and Their Combinations on Mouse Neuroblastoma Cells.
Biomarkers of oral subacute toxicity of deltamethrin in exposed male Albino rats.
Trisiloxane Surfactants Negatively Affect Reproductive Behaviors and Enhance Viral replication In Honey Bees.
Rotenone impairs brain glial energetics and locomotor behavior in bumblebees.
Exposure to sublethal concentrations of imidacloprid, pyraclostrobin, and glyphosate harm the behavior and fat body cells of the stingless bee Scaptotrigona postica.
Metals/Metalloids
Low concentrations of antimony impair adipogenesis and endoplasmic reticulum homeostasis during 3T3-L1 cells differentiation.
Cadmium facilitates the formation of large lipid droplets via PLCβ2-DAG-DGKε-PA signal pathway in Leydig cells.
Lead exposure induces neuronal apoptosis via NFκB p65/RBBP4/Survivin signaling pathway.
Microplastics/Nanomaterials
Size-dependent and sex-specific negative effects of micro- and nano-sized polystyrene particles in the terrestrial invertebrate model Drosophila melanogaster.
Toxicity of co-exposure of microplastics and lead in African catfish (Clarias gariepinus).
Air Pollution
Oxidative stress and inflammation induced by air pollution-derived PM2.5 persist in the lungs of mice after cessation of their sub-chronic exposure.
Pharmaceuticals/Personal Care Products
Comparison of female rat reproductive effects of pubertal versus adult exposure to known endocrine disruptors.
Developmental estrogen exposure in mice disrupts uterine epithelial cell differentiation and causes adenocarcinoma via Wnt/β-catenin and PI3K/AKT signaling.
Effect of in utero and lactational exposure to a thyroid hormone system disrupting chemical on mouse metabolome and brain transcriptome.
Exposure/Environment Studies
Numerous Chemicals/Mixtures
Occurrence, removal, and risk assessment of emerging contaminants in aquatic products processing sewage treatment plants.
Quantitative assessment of human health risks from chemical pollution in the uMsunduzi River, South Africa.
BPA/Phenols
Bisphenol and analogues in indoor dust from E-waste recycling sites, neighboring residential homes, and urban residential homes: Implications for human exposure.
Phthalates
Occurrence, ecological and health risk assessment of phthalates in a polluted urban river used for agricultural land irrigation in central Mexico.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
The dynamics of persistent organic pollutant (POP) transfer from female bottlenose dolphins (Tursiops truncatus) to their calves during lactation.
The status of organochlorine pesticide contamination in Greek agricultural soils: the ghost of traditional agricultural history.
PFAS
Per and polyfluoroalkylated substances (PFAS) target and EOF analyses in ski wax, snowmelts, and soil from skiing areas.
Nontarget Analysis and Comprehensive Characterization of Iodinated Polyfluoroalkyl Acids in Wastewater and River Water by LC-HRMS with Cascade Precursor-Ion Exclusions and Algorithmic Approach.
Uncovering per- and polyfluoroalkyl substances (PFAS) with nontargeted ion mobility spectrometry-mass spectrometry analyses.
Flame Retardants
Canadian high arctic ice core records of organophosphate flame retardants and plasticizers.
Determinants of organophosphate esters exposure in pregnant women from East China.
Pesticides
Bioaccumulation of pesticides in fish resulting toxicities in humans through food chain and forensic aspects.
Glacier foreland insect uptake synthetic compounds: an emerging environmental concern.
Risk assessment of a Brazilian urban population due to the exposure to pyrethroid insecticides during the COVID-19 pandemic using wastewater-based epidemiology.
Metals/Metalloids
Validation of the efficiency of arsenic mitigation strategies in southwestern region of Bangladesh and development of a cost-effective adsorbent to mitigate arsenic levels.
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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.
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