EDC Science Weekly, Oct. 18-24, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Science summaries and highlights

Events

Oct. 28: Swiss Symposium on Endocrine Disrupting Chemicals [Food Packaging Forum and ETH Zurich]

Oct. 29-30: 6th Annual Forum on Endocrine Disruptors [European Commission]

Nov. 5-6 conference: State of the science on development and use of NAMs for chemical safety testing [U.S. EPA]

Nov. 12 webinar: Plastics Treaty Negotiations: Who has a seat at the table? [CHE-Alaska]

Nov. 13 webinar: The Overturning of Chevron Deference: Impacts on Environmental Health Decision Making [CHE and UCSF’s EaRTH Center]

Nov. 21 webinar: Introduction to ECHA’s guidance on new CLP hazard classes [ECHA]

Dec. 3 webinar: Fluoride, Neurodevelopment, and Cognition: A National Toxicology Program monograph [EDC Strategies Partnership]

Dec. 9 webinar, save the date: Behind the Scenes at EPA: What’s going wrong? [CHE and UCSF’s EaRTH Center]

April 27-29, 2025 conference: Break the Cycle of Children’s Environmental Health Disparities [call for student research projects due Nov. 1]

More events

Regulations/Policy

Fulfilling the criteria for CLP classification: the implications for substances under the EU chemicals legislation.

Invited Perspective: Is It Time to Revisit the Allowable Maximum Contaminant Limit for Arsenic in Public Drinking Water?

An analysis of the use of historical control data in the assessment of regulatory pesticide toxicity studies.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Analyzing high-throughput assay data to advance the rapid screening of environmental chemicals for human reproductive toxicity [and related blog]

Multiple-Criteria Decision Analysis for Assessments of Chemical Alternatives (MCDA-ACA).

Pharmaceuticals and personal care product modelling: Unleashing artificial intelligence and machine learning capabilities and impact on one health and sustainable development goals.

In vitro pharmacologic profiling aids systemic toxicity assessment of chemicals.

Improving the integration of epidemiological data into human health risk assessment: What risk assessors told us they want.

World Health Organization repository of systematic reviews on interventions in environment, climate change and health: a new resource for decision makers, intervention implementers, and researchers.

Evaluating the performance of multi-omics integration: a thyroid toxicity case study.

Leveraging biomarkers and translational medicine for preclinical safety – Lessons for advancing the validation of alternatives to animal testing.

Organoid intelligence for developmental neurotoxicity testing.

Commentaries

A toxic relationship: ultra-processed foods & plastics

Environmental Neurotoxins and a Neurodegenerative Outbreak: Diagnosis Requires Specific Sampling Knowledge.

A multidisciplinary perspective on the role of plastic pollution in the triple planetary crisis.

Arsenic in Rice: A Call to Change Feeding Substitution Practices for Pediatric Otolaryngology Patients.

Climate change influence on the trends of BFRs in the environment and food.

Key characteristics of carcinogens meet hallmarks for prevention-cutting the Gordian knot.

Commentary: Understanding IARC’s PFOA and PFOS Carcinogenicity Assessments.

Meeting report: Non-animal models: Complexity for interactions…Connecting science.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Environmental Racism and Child Health.

A critical review of wastewater-based epidemiology as a tool to evaluate the unintentional human exposure to potentially harmful chemicals.

BPA/Phenols

A critical review to identify data gaps and improve risk assessment of bisphenol A alternatives for human health.

Phthalates

Antioxidant vitamins’ modification of the adverse health effects induced by phthalate exposure: A scoping review of epidemiological and experimental studies.

Pesticides

A scoping review to determine if adverse human health effects are associated with use of organophosphates for mosquito control.

Metals/Metalloids

Epigenetic toxicity of heavy metals – implications for embryonic stem cells.

Microplastics/Nanomaterials

Sources and distributions of microplastics and the hazards to plants, animals and human health: A review.

When microplastics/plastics meet metal-organic frameworks: turning threats into opportunities.

A systematic review and quality assessment of estimated daily intake of microplastics through food.

Microplastics: an often-overlooked issue in the transition from chronic inflammation to cancer.

The whole life journey and destination of microplastics: A review.

Viruses in the era of microplastics and plastispheres: Analytical methods, advances and future directions.

Air Pollution

Association between air pollutants, thyroid disorders, and thyroid hormone levels: a scoping review of epidemiological evidence.

Pharmaceuticals/Personal Care Products

Tiny pills, big impacts: A systematic review on the endocrine disrupting effects of paediatric pharmaceuticals

Human Health Studies

BPA/Parabens/Phthalates

Exploring the role of genetic variability and exposure to bisphenols and parabens on excess body weight in Spanish children.

Toxic Beauty: Parabens and Benzophenone-type UV Filters Linked to Increased Non-Alcoholic Fatty Liver Disease Risk.

Associations between phenols, parabens, and phthalates and depressive symptoms: The role of inflammatory markers and bioinformatic insights.

EXPRESS: Association of exposure to non-persistent endocrine disruptors with sex hormones and metabolic health in US females.

Exploring diet as a source of plasticizers in pregnancy and implications for maternal second-trimester metabolic health.

Associations of 1.5- and 3-year Phthalate Exposure Levels with Early Adiposity Rebound and Overweight/Obesity in Japanese Children: An Adjunct Study of the Japan Environment and Children’s Study.

High Levels of Vitamin C Intake Modify Effects of Phthalates on Metabolic Dysfunction-associated Steatotic Liver Disease: A Nationally Representative Study.

Non-dietary exposure to phthalates in primary school children: Risk and correlation with anthropometric indices, cardiovascular and respiratory diseases.

PFAS

Early pregnancy serum PFAS are associated with alterations in the maternal lipidome.

Association between per- and polyfluoroalkyl substances and hyperuricemia: sex-specific analysis.

The potential mediating role of the gut microbiome and metabolites in the association between PFAS and kidney function in young adults: A proof-of-concept study.

Serum levels of Per- and poly-fluoroalkyl substances among middle-aged and elderly populations in Beijing and their association with dyslipidemia.

Flame Retardants

Gestational exposure to organophosphate ester flame retardants and risk of childhood obesity in the environmental influences on child health outcomes consortium.

Pesticides

Cross-Sectional Examination of Thyroid Hormones and Environmental Exposure to Multiclass Pesticides in Women of Reproductive Age in China.

Plasma pesticide residues-serum 8-OHdG among farmers/non-farmers diagnosed with lymphoma, leukaemia and breast cancers: A case-control study.

Metals/Metalloids

Long-Term Exposure to Arsenic in Community Water Supplies and Risk of Cardiovascular Disease among Women in the California Teachers Study.

Laboratory Studies

Numerous Chemicals/Mixtures

Perfluorooctane sulfonate (PFOS) and benzo[a]pyrene (BaP) synergistically induce neurotoxicity in C6 rat glioma cells via the activation of neurotransmitter and Cyp1a1-mediated steroid hormone synthesis pathways.

BPA/Phenols

Long-term exposure to environmentally relevant Bisphenol-A levels affects growth, swimming, condition factor, sex ratio and histology of juvenile zebrafish.

Mode of action exploration for prostate epithelial cell injury caused by bisphenol A.

Ferulic acid ameliorates bisphenol A (BPA)-induced Alzheimer’s disease-like pathology through Akt-ERK crosstalk pathway in male rats.

Percutaneous Absorption of Two Bisphenol A Analogues, BPAF and TGSA: Novel In Vitro Data from Human Skin.

Dysregulated proinflammatory cytokines and immune-related miRNAs in ASK cells exposed to 17⍺-Ethynyl Estradiol and 4-nonylphenol.

Phthalates

Butyl benzyl phthalate induces neurotoxicity in Eisenia fetida: Mechanisms revealed by biochemical and metabolomic analyses.

Persistent effects of di-n-butyl phthalate on liver transcriptome: impaired energy and lipid metabolic pathways.

Diethylhexyl phthalate induces immune dysregulation and is an environmental immune disruptor.

Long-term inhalation exposure: A model for phthalate accumulation in the respiratory tract.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Inhibition of HIF-2α expression in cardiomyocytes attenuates PCB126-induced cardiotoxicity associated with decreased apoptosis through the PI3K/Akt and p53 signaling pathways.

PFAS

Embryonic 6:2 Fluorotelomer Alcohol Exposure Disrupts the Blood‒Brain Barrier by Causing Endothelial‒to‒Mesenchymal Transition in the Male Mice.

Analysis of oral and inhalation toxicity of per- and polyfluoroalkylated organic compounds in rats and mice using multivariate QSAR.

Thyroid endocrine disruption effects of OBS in adult zebrafish and offspring after parental exposure at early life stage.

Flame Retardants

Tri-iso-butyl phosphate (TiBP) exposure induces neurotoxicity by triggering oxidative stress accompanied by neurotransmitter system disruptions and apoptosis in zebrafish larvae.

Organotins

Metformin Mitigates Trimethyltin-Induced Cognition Impairment and Hippocampal Neurodegeneration.

Pesticides

Chlorpyrifos and Dimethoate Exposure Impairs Female Fertility by Deregulating WNT Signaling Pathway &Uterine Receptivity.

Microplastics/Nanomaterials

Assessment of the cytotoxicity micro- and nano-plastic on human intestinal Caco-2 cells and the protective effects of catechin.

The toxic effects of exposure to fibrous and fragmented microplastic in juvenile rockfish based on two omics approach.

Life on both environment in semi-aquatic frogs: Impact of aquatic microplastic (MP) from MP enrichment to growth, immune function and physiological stress.

UV-B radiation aging changed the environmental behavior of polystyrene micro-/nanoplastics-adsorption kinetics of BDE-47, plankton toxicities and joint toxicities with BDE-47.

Microplastics originated from Plasmix-based materials caused biochemical and behavioral adverse effects on Daphnia magna.

How nanoscale plastics facilitate the evolution of antibiotic resistance?

Exposure to microplastics contaminated with pharmaceuticals and personal care products: Histological effects on Ucides cordatus.

Microplastics exacerbate tissue damage and promote carcinogenesis following liver infection in mice.

Maternal exposure to nanopolystyrene induces neurotoxicity in offspring through P53-mediated ferritinophagy and ferroptosis in the rat hippocampus.

Miscellaneous

Untargeted metabolomic analysis reveals a time-course hepatic metabolism disorder induced by short-term 6PPD exposure in rats.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Trends in NHANES Biomonitored Exposures in California and the United States following Enactment of California’s Proposition 65.

Impact of gut permeability on estimation of oral bioavailability for chemicals in commerce and the environment.

BPA/Phenols

Exposure of elementary school-aged Brazilian children to bisphenol A: association with demographic, social, and behavioral factors, and a worldwide comparison.

Comparative analysis of the bioaccumulation of bisphenol A in the blood serum and follicular fluid of women living in two areas with different environmental impacts.

PFAS

PFAS profiles in biosolids, composts, and chemical fertilizers intended for agricultural land application in Quebec (Canada).

Multi-compartment levels and distributions of per- and polyfluoroalkyl substances surrounding fluorochemical manufacturing parks in China: A review of the current literature.

Per- and poly-fluoroalkyl substances in aquatic ecosystems and wastewater treatment works in Africa: occurrence, ecological implications, and future perspectives.

PFAS Exposure is Associated with a Lower Spermatic Quality in an Arctic Seabird.

Triiodothyronine (T₃), but not resting metabolic rate correlates positively with per- and polyfluoroalkyl substances (PFAS) in Arctic terns.

Impact of local food consumption on exposure to perfluorooctanoic acid and perfluorooctane sulfonate in a contaminated community in North-Eastern Italy.

Statistical Mapping of PFOA and PFOS in Groundwater throughout the Contiguous United States.

Low-salt diets and salt-free cooking help reduce exposure to Per- and polyfluoroalkyl substances (PFAS).

Pesticides

Prenatal exposure to chlorpyrifos of French children from the Elfe cohort.

First evidence of age-dependent decreases in non-persistent pesticide mixtures in nestlings of a farmland raptor.

Metals/Metalloids

Co-occurrence and correlation of arsenic, cadmium, and lead in processed foods intended for infants and young children: evaluation of two statistical approaches adapted to censored data and their implications for risk management.

Microplastics/Nanomaterials

Bridging the knowledge gap-microplastics in focus: assessing microplastic pollution awareness among medical students.

Rapid detection of microplastics/nanoplastics directly exposed to blood during intravenous injections via mie scattering spectra.

The emission and physicochemical properties of airborne microplastics and nanoplastics generated during the mechanical recycling of plastic via shredding.

Microplastics are detected in bull epididymal sperm and polystyrene microparticles impair sperm fertilization.

A multiple biomarker approach to understand the effects of microplastics on the health status of European seabass farmed in earth ponds on the NE Atlantic coast.

Miscellaneous

Unraveling the contribution of melamine tableware for human internal exposure to melamine and its derivatives: Insights from crossover and biomonitoring studies.

Persistent Environmental Injustice due to Brake and Tire Wear Emissions and Heavy-Duty Trucks in Future California Zero-Emission Fleets.

Determination of polycyclic aromatic hydrocarbons (pahs) in mothers’ milk of kafr el-zayat district, egypt: A case study for the health risk of infants in urban regions.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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