EDC Science Weekly, Oct. 14-20, 2020

Post author:HEEDS
Post published:October 20, 2020
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar: Generation Chemical: How Environmental Exposures are Affecting Reproductive Health and Development
Oct. 29

Webinar: Environmental reproductive justice: Racial disparities in environmental pollution and chemical exposures
Nov 18

The Superfund Research Program (SRP) Progress in Research webinar series includes four webinars on Metals, Legacy and Emerging Contaminants, Vulnerable Populations, and Emerging Exposures.
Oct. 21 and 28, and Nov. 9 and 19.

Food Packaging Forum Workshop: Improving the chemical safety of food contact articles: Linking policy-making with scientific research
Oct. 21-23

Online symposium: Endocrine Disruptors – Reduce the impact on our health
Nov. 19

Call for Comments on BPA
The European Chemicals Agency (ECHA) is accepting comments on BPA and structurally-related bisphenols. Both EU-and non-EU stakeholders are encouraged to participate. Due Jan. 15, 2021.

Methods/Tools/Screening

Evaluation of a multiplexed, multispecies nuclear receptor assay for chemical hazard assessment.

High Throughput Risk and Impact Screening of Chemicals in Consumer Products.

Systematic Assessment of Exposure Variations on Observed Bioactivity in Zebrafish Chemical Screening.

Commentaries

Quantile g-Computation: A New Method for Analyzing Mixtures of Environmental Exposures. [science selection in EHP]

Matching Rodents to People: A Humanized Mouse Model of iAs Methylation. [science selection in EHP]

Airborne Particulate Matter and SARS-CoV-2 Partnership: Virus Hitchhiking, Stabilization and Immune Cell Targeting – A Hypothesis. [opinion]

Clarifying the absence of evidence regarding human health risks to microplastic particles in drinking-water: High quality robust data wanted. [letter]

Ecotoxicology, revisiting its pioneers.

WEACT mourns the loss of our friend and colleague Cecil Corbin-Mark

In Memoriam: Eula Bingham, 1929-2020.

Reviews

Numerous EDCs

The role of endocrine-disrupting chemicals in uterine fibroid pathogenesis.

Endocrine-disruptive chemicals as contaminants of emerging concern in wastewater and surface water: A review.

Environmental pollutants and the immune response.

Environmental Endocrine-Disrupting Chemical Exposure: Role in Non-Communicable Diseases.

Environmental risk factors for endometriosis: A critical evaluation of studies and recommendations from the epidemiologic perspective

Gut homeostasis and microbiota under attack: impact of the different types of food contaminants on gut health.

Toxin-Induced Parkinsonism

Mixtures

Receptor-based in vitro activities to assess human exposure to chemical mixtures and related health impacts.

BPA/Phenols

Is There a Link between Bisphenol A (BPA), a Key Endocrine Disruptor, and the Risk for SARS-CoV-2 Infection and Severe COVID-19?

Bisphenols Threaten Male Reproductive Health via Testicular Cells.

Bisphenol A, an endocrine-disruptor compound, that modulates the immune response to infections.

Impact of BPA on behavior, neurodevelopment and neurodegeneration

Phthalates

Environmental pollutants: an immunoendocrine perspective on phthalates.

Perfluoroalkyl Substances

Are Fluoropolymers Really of Low Concern for Human and Environmental Health and Separate from Other PFAS? [also see related article in C&EN: Fluoropolymers don’t deserve “low concern” label, researchers say]

Exposure to Perflouroalkyl acids and foetal and maternal thyroid status: a review.

Pesticides

A comprehensive review on chlorpyrifos toxicity with special reference to endocrine disruption: Evidence of mechanisms, exposures and mitigation strategies.

Using benchmark dose modeling for the quantitative risk assessment: Carbon nanotubes, asbestos, glyphosate.

Ecotoxicological and regulatory aspects of environmental sustainability of nanopesticides.

Potentially Toxic Elements

Neuroendocrine effects of cadmium exposure on male reproductive functions.

Maternal Arsenic Exposure and Gestational Diabetes: A Systematic Review and Meta-Analysis

Toxic metal exposure as a possible risk factor for COVID-19 and other respiratory infectious diseases.

Cadmium and Lead Exposure, Nephrotoxicity, and Mortality

The Relationship Between the Level of Copper, Lead, Mercury and Autism Disorders: A Meta-Analysis

Microplastics

Micro- and nanoplastic induced cellular toxicity in mammals: A review.

Bioaccumulation and biomagnification of microplastics in marine organisms: A review and meta-analysis of current data.

Linking effects of microplastics to ecological impacts in marine environments.

Air Pollution

Is Particulate Matter of Air Pollution a Vector of Covid-19 Pandemic?

Acute versus Chronic Exposures to Inhaled Particulate Matter and Neurocognitive Dysfunction: Pathways to Alzheimer’s Disease or a Related Dementia.

Adverse health effects associated with household air pollution: a systematic review, meta-analysis, and burden estimation study.

Miscellaneous

The Role of Environmental Exposures in Atopic Dermatitis.

Protein-affinity guided identification of chlorinated paraffin components as ubiquitous chemicals.

Acetylcholinesterase activity in fish species exposed to crude oil hydrocarbons: A review and new perspectives.

Human Health Studies

Numerous Chemicals

Endocrine disrupting chemicals during diet-induced weight loss – a post-hoc analysis of the LOWER study. [bisphenols, parabens, phthalates]

Paternal mixtures of urinary concentrations of phthalate metabolites, bisphenol A and parabens in relation to pregnancy outcomes among couples attending a fertility center.

Serially assessed bisphenol A and phthalate exposure and association with kidney function in children with chronic kidney disease in the US and Canada: A longitudinal cohort study

BPA

Association of urinary bisphenols during pregnancy with maternal, cord blood and childhood thyroid function

Phthalates

Relationship between urinary phthalate metabolites and diabetes: Korean National Environmental Health Survey (KoNEHS) cycle 3 (2015-2017).

The influence of prenatal exposure to phthalates on subsequent male growth and body composition in adolescence.

Prenatal Maternal Phthalate Exposures and Child Lipid and Adipokine Levels at Age Six: A Study from the PROGRESS Cohort of Mexico City

SGLT2 inhibitors and thiazide enhance excretion of DEHP toxic metabolites in subjects with type 2 diabetes: A randomized clinical trial

Parabens/Triclosan/Antimicrobials

Concentrations of urinary parabens and reproductive hormones in girls 6-17 years living in Canada.

Cosmetic and personal care product use, urinary levels of parabens and benzophenones, and risk of endometriosis: results from the EndEA study.

Association between Urinary Triclosan and Serum Testosterone Levels in U.S. Adult Males from NHANES, 2011-2012.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposure to Polychlorinated Biphenyls and Organochlorine Pesticides and Thyroid Cancer in Connecticut Women.

Risk of genotoxic damage in schoolchildren exposed to organochloride pesticides.

Association between type 2 diabetes and exposure to chlorinated persistent organic pollutants in Algeria: A case-control study.

Aryl-hydrocarbon receptor binding and the incidence of type 2 diabetes: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

A Model-Based Approach to Detection Limits in Studying Environmental Exposures and Human Fecundity. [DDT and fertility]

Perfluoroalkyl Substances

Novel Perfluoroalkyl Ether Carboxylic Acids (PFECAs) and Sulfonic Acids (PFESAs): Occurrence and Association with Serum Biochemical Parameters in Residents Living Near a Fluorochemical Plant in China.

Perfluoroalkyl Substances and Cognitive Function in Older Adults: Should We Consider Non-Monotonic Dose-Responses and Chronic Kidney Disease?

A Cross-Sectional Study of the Association between Perfluorinated Chemical Exposure and Cancers related to Deregulation of Estrogen Receptors

Flame Retardants

The risk and impact of organophosphate esters on the development of female-specific cancers: Comparative analysis of patients with benign and malignant tumors.

Effects of Polybrominated Diphenyl Ethers on the Human Body Exposure in E-Waste Dismantling Region.

Pesticides

Assessment of chromosomal aberrations among agricultural workers exposed to pesticides in Punjab, India.

Genotype-Environment Interaction Analysis of NQO1, CYP2E1, and NAT2 Polymorphisms and the Risk of Childhood Acute Lymphoblastic Leukemia: A Report From the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia.

Potentially Toxic Elements

Low- and moderate- levels of arsenic exposure in young adulthood and incidence of chronic kidney disease: Findings from the CARDIA Trace Element Study

Air Pollution

Association between traffic-related air pollution and hospital readmissions for rheumatoid arthritis in Hefei, China: A time-series study.

Monitoring the Impact of Air Quality on the COVID-19 Fatalities in Delhi, India: Using Machine Learning Techniques

Association between Kawasaki Disease and Prenatal Exposure to Ambient and Industrial Air Pollution: A Population-Based Cohort Study.

Identifying the Transcriptional Response of Cancer and Inflammation-Related Genes in Lung Cells in Relation to Ambient Air Chemical Mixtures in Houston, Texas.

Environmental Epigenetics of Diesel Particulate Matter Toxicogenomics

COVID-19 and its relationship to particulate matter pollution – case study from part of greater chennai, india.

Effects of air pollution on the potential transmission and mortality of COVID-19: A preliminary case-study in Tarragona Province (Catalonia, Spain)

Pharmaceuticals/Personal Care Products

Contact Dermatitis to Personal Care Products is Increasing (but Different!) in Males and Females: North American Contact Dermatitis Group (NACDG) Data, 1996-2016.

Miscellaneous

The association of liver function biomarkers with internal exposure of short- and medium-chain chlorinated paraffins in residents from Jinan, China.

Trends in the Incidence of Central Precocious Puberty and Normal Variant Puberty Among Children in Denmark, 1998 to 2017.

No relationship between prenatal or early postnatal androgen exposure and autistic traits: evidence using anogenital distance and penile length measurements at birth and 3 months of age.

A marked decrease in Preterm Deliveries during the COVID-19 Pandemic.

Ingestion and Dermal Cancer Risk Via Exposure to Polycyclic Aromatic Hydrocarbons (PAHs) Contaminated Soils in an Oil Producing Community, Niger Delta, Nigeria.

Association between urinary polycyclic aromatic hydrocarbons and hypertension in the Korean population: data from the Second Korean National Environmental Health Survey (2012-2014)

Laboratory Studies

BPA/Phenols

Bisphenol A induces apoptosis through GPER-dependent activation of the ROS/Ca²⁺-ASK1-JNK pathway in human granulosa cell line KGN.

4-Hexylphenol influences adipogenic differentiation and hepatic lipid accumulation in vitro.

Bisphenol A decreases progesterone synthesis in human ovarian granulosa cells.

Effects of Bisphenol A and S on blood coagulation: in vivo, in vitro and in silico approaches in toxicodynamic

Phthalates

Early-life and chronic exposure to di(2-ethylhexyl) phthalate enhances amyloid-β toxicity associated with an autophagy-related gene in Caenorhabditis elegans Alzheimer’s disease models

Parabens/Triclosan/Antimicrobials

Triclocarban, Triclosan, Bromochlorophene, Chlorophene, and Climbazole Effects on Nuclear Receptors: An in Silico and in Vitro Study.

Biomarkers for the toxicity of sublethal concentrations of triclosan to the early life stages of carps

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Transgenerational Disease Specific Epigenetic Sperm Biomarkers after Ancestral Exposure to Dioxin.

Effects of incremental endosulfan sulfate exposure and high fat diet on lipid metabolism, glucose homeostasis and gut microbiota in mice.

PCB126 exposure revealed alterations in m6A RNA modifications in transcripts associated with AHR activation

Microbiome analysis and predicted relative metabolomic turnover suggest bacterial heme and selenium metabolism are altered in the gastrointestinal system of zebrafish (Danio rerio) exposed to the organochlorine dieldrin.

Perfluoroalkyl Substances

Perfluorooctanesulfonic acid induced toxicity on zebrafish embryos in the presence or absence of the chorion.

Uptake and Biological Effects of Perfluorooctane Sulfonate Exposure in the Adult Eastern Oyster Crassostrea virginica.

Evaluation of Cyto-genotoxicity of Perfluorooctane Sulfonate (PFOS) to Allium cepa.

Flame Retardants

Interaction of BDE-47 with nuclear receptors (NRs) based on the cytotoxicity: In vitro investigation and molecular interaction.

Inhibition in growth and cardiotoxicity of tris (2-butoxyethyl) phosphate through down-regulating Wnt signaling pathway in early developmental stage of zebrafish (Danio rerio).

Impaired sperm quantity and motility in adult rats following gestational and lactational exposure to environmentally relevant levels of PBDE-47: A potential role of thyroid hormones disruption

Pesticides

Transgenerational effects of developmental exposure to chlorpyrifos-oxon in zebrafish (DANIO RERIO).

Protective effects of curcumin and Ganoderma lucidum on hippocampal damage caused by the organophosphate insecticide chlorpyrifos in the developing rat brain: Stereological, histopathological and immunohistochemical study.

Toxicity assessment at different experimental scenarios with glyphosate, chlorpyrifos and antibiotics in Rhinella arenarum (Anura: Bufonidae) tadpoles.

Effects of early life stage exposure of largemouth bass to atrazine or a model estrogen (17α-ethinylestradiol).

Chronic toxicity of technical atrazine to the fathead minnow (Pimephales promelas) during a full life-cycle exposure and an evaluation of the consistency of responses.

Changes induced by atrazine in Clarias gariepinus provide insight into alterations in ovarian histoarchitecture and direct effects on oogenesis .

Risk assessment and acute toxicological effects of atrazine on Nile tilapia larvae after stress.

Neurological effects of long-term exposure to low doses of pesticides mixtures in male rats: Biochemical, histological, and neurobehavioral evaluations.

Tebuconazole exposure disrupts placental function and causes fetal low birth weight in rats.

Oxidative stress and DNA damage in earthworm (Eisenia fetida) induced by triflumezopyrim exposure.

Biochemical and morphological biomarker responses in the gills of a Neotropical fish exposed to a new flavonoid metal-insecticide.

Behavioral changes occur earlier than redox alterations in developing zebrafish exposed to Mancozeb.

Genotoxic and epigenetic effects of diuron in the Pacific oyster: in vitro evidence of interaction between DNA damage and DNA methylation.

Effect of long-term treatment with a mixture of pyrethroids on the expression of genes that govern male germ cell production in rats.

Potentially Toxic Elements

Inorganic arsenic promotes luminal to basal transition and metastasis of breast cancer.

Activation of Lrrk2 and α-Synuclein in substantia nigra, striatum, and cerebellum after chronic exposure to arsenite.

Inorganic arsenic administration suppresses human neutrophil function in vitro

Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture.

Microplastics

Uptake and cellular effects of PE, PP, PET and PVC microplastic particles.

Adsorption and desorption of triclosan on biodegradable polyhydroxybutyrate microplastics.

Size matters: Zebrafish (Danio rerio) as a model to study toxicity of nanoplastics from cells to the whole organism.

Feeding behavior responses of a juvenile hybrid grouper, Epinephelus fuscoguttatus♀ × E. lanceolatus♂, to microplastics.

Behavioral and biochemical consequences of Danio rerio larvae exposure to polylactic acid bioplastic.

Physiological effects of plastic particles on mussels are mediated by food presence.

Effects of Different Microplastics on Nematodes in the Soil Environment: Tracking the Extractable Additives Using an Ecotoxicological Approach.

Air Pollution

Inflammation response, oxidative stress and DNA damage caused by urban air pollution exposure increase in the lack of DNA repair XPC protein.

Atmospheric fine particulate matter exposure exacerbates atherosclerosis in apolipoprotein E knockout mice by inhibiting autophagy in macrophages via the PI3K/Akt/mTOR signaling pathway.

Pharmaceuticals/Personal Care Products

Dioxybenzone triggers enhanced estrogenic effect via metabolic activation: in silico, in vitro and in vivo investigation.

Mixtures

Endocrine disrupting activities and geochemistry of water resources associated with unconventional oil and gas activity.

Exposure/Environment Studies

BPA/Phenols

Bisphenol A in the Canadian environment: A multimedia analysis

Phthalates

Sentinels of synthetics – a comparison of phthalate exposure between common bottlenose dolphins (Tursiops truncatus) and human reference populations.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Twenty-year trends and exposure assessment of polychlorinated dibenzodioxins and dibenzofurans in human serum from the Seoul citizens

Fish consumption is an indicator of exposure to non-dioxin like polychlorinated biphenyls in cumulative risk assessments based on a probabilistic and sensitive approach.

Bacterial communities as indicators of environmental pollution by POPs in marine sediments.

Spatial, temporal, and inter-compartmental environmental monitoring of lipophilic pollutants by virtual organisms.

Baseline survey of marine sediments collected from the Kingdom of Bahrain: PAHs, PCBs, organochlorine pesticides, perfluoroalkyl substances, dioxins, brominated flame retardants and metal contamination.

Perfluoroalkyl Substances

Perfluoroalkyl acids in pregnant women from Nunavik (Quebec, Canada): Trends in exposure and associations with country foods consumption.

Concentration, spatial distribution, and health risk assessment of PFASs in serum of teenagers, tap water and soil near a Chinese fluorochemical industrial plant

Determination and assessment of human dietary intake of per and polyfluoroalkyl substances in retail dairy milk and infant formula from South Africa

Characteristics, pollution patterns and risks of Perfluoroalkyl substances in drinking water sources of Taiwan

Flame Retardants

Legacy and novel flame retardants from indoor dust in Antarctica: sources and human exposure

Pesticides

Effect of household rice cooking on pesticide residues.

The dietary risk index system: a tool to track pesticide dietary risks.

Acute contact with imidacloprid in soil affects the nesting and survival success of a solitary wild bee, Osmia lignaria (Hymenoptera: Megachilidae).

Integrating metapopulation dynamics into a Bayesian Network Relative Risk Model: Assessing the risk of pesticides to Chinook salmon (Oncorhynchus tshawytscha) in an ecological context.

Challenges in the interpretation of anticoagulant rodenticide residues and toxicity in predatory and scavenging birds.

Potentially Toxic Elements

Arsenic Concentrations in Ground and Surface Waters across Arizona Including Native Lands

Real-Time Monitoring of Heavy Metals in Healthcare via Twistable and Washable Smartsensors.

Probabilistic human health risk assessment associated with fluoride and arsenic co-occurrence in drinking water from the metropolitan area of San Luis Potosí, Mexico.

Microplastics

Microplastics in the edible tissues of shellfishes sold for human consumption.

Do membrane filtration systems in drinking water treatment plants release nano/microplastics?

Microplastics in three typical benthic species from the Arctic: occurrence, characteristics, sources, and environmental implications.

Need for assessing the inhalation of micro(nano)plastic debris shed from masks, respirators, and home-made face coverings during the COVID-19 pandemic.

Microplastic fibres from synthetic textiles: Environmental degradation and additive chemical content.

Suspended fine particulate matter (PM_2.5), microplastics (MPs), and polycyclic aromatic hydrocarbons (PAHs) in air: Their possible relationships and health implications.

Air Pollution

Effects of COVID-19 lockdown on global air quality and health.

Air quality assessment among populous sites of major metropolitan cities in India during COVID-19 pandemic confinement.

Influence of lockdown caused by the COVID-19 pandemic on air pollution and carcinogenic content of particulate matter observed in Croatia.

Changes in ambient air quality and atmospheric composition and reactivity in the South East of the UK as a result of the COVID-19 lockdown.

Pharmaceuticals/Personal Care Products

Extended suspect screening to identify contaminants of emerging concern in riverine and coastal ecosystems and assessment of environmental risks.

Mixtures/Numerous EDCs

Tap water contamination: Multiclass endocrine disrupting compounds in different housing types in an urban settlement.

Plasma Vitellogenin Reveals Potential Seasonal Estrogenicity in Fish from On-Site Wastewater Treatment Systems in Semi-Arid Streams Influenced by Snowmelt.

Mixtures of co-occurring chemicals in freshwater systems across the continental US.

Miscellaneous

Hazardous compounds in recreational and urban recycled surfaces made from crumb rubber. Compliance with current regulation and future perspectives.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.