EDC Science Weekly, Oct. 13-19, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Science highlights

Events

Regulations/Policy

Clean Air in Europe for All: Taking Stock of the Proposed Revision to the Ambient Air Quality Directives. A Joint ERS, HEI, and ISEE Workshop Report.

Latin America and the Caribbean Code Against cancer 1st edition: Environment, occupation, and cancer.

More EDC policy and regulations open for comment

Methods/Tools/Screening

ELIXIR and Toxicology: a community in development.

Are changes in vitellogenin concentrations in fish reliable indicators of chemical-induced endocrine activity?

Quantitative structure use relationships: Highlights from a technical summit meeting.

Migration Studies and Endocrine Disrupting Activities: Chemical Safety of Cosmetic Plastic Packaging.

Analytical methods employed in the identification and quantification of per- and polyfluoroalkyl substances in human matrices – A scoping review.

Physiology-informed toxicokinetic model for the zebrafish embryo test developed for bisphenols.

Handling concentration data below the analytical limit in environmental mixture risk assessment: A case-study on pesticide river monitoring.

More tools, reports, and resources

Commentaries

Journal of Health and Pollution: Fostering Equity in Access to Environmental Health Research Evidence. [new journal by EHP]

Climate change as a threat multiplier to environmental reproductive justice.

Editorial: The physiological response of aquatic invertebrates to pollution. [Intro to a research topic in Frontiers in Physiology]

Building strong health and career trajectories through translational research.

Invited Perspective: Forging a Way Forward Amid the Enduring Impacts of Redlining. [re study, Association of Redlining and Natural Environment with Depressive Symptoms in Women in the Sister Study.]

Reviews

Numerous Chemicals/Mixtures

Endocrine disruptors: Unravelling the link between chemical exposure and Women’s reproductive health.

Endocrine disrupting chemicals and male reproductive health.

Exposure to environmental pollutants and attention-deficit/hyperactivity disorder: an overview of systematic reviews and meta-analyses.

Effect of environmental exposures on cancer risk: Emerging role of non-coding RNA shuttled by extracellular vesicles.

The environmental burden on endocrine neoplasia: a review on the documented impact of endocrine disrupting chemicals.

BPA/Phenols

Bisphenols-A Threat to the Natural Environment.

Melatonin and Vitamins as Protectors against the Reproductive Toxicity of Bisphenols: Which Is the Most Effective? A Systematic Review and Meta-Analysis.

Phthalates

Phthalate exposure and risk of metabolic syndrome components: A systematic review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated biphenyl (PCB) half-lives in humans: A systematic review.

Inflammation and cardiometabolic diseases induced by persistent organic pollutants and nutritional interventions: Effects of multi-organ interactions.

PFAS

Plasma levels of per- and polyfluoroalkyl substances (PFAS) and cardiovascular disease – Results from two independent population-based cohorts and a meta-analysis.

Establishing Chronic Toxicity Effect Levels for Zebrafish (Danio rerio) Exposed to Perfluorooctane Sulfonate (PFOS).

Flame Retardants

A meta-analysis of randomized controlled studies on the hepatoxicity induced by polybrominated diphenyl ethers (PBDEs) in rats and mice.

Microplastics/Nanomaterials

A critical review of the recent trends in source tracing of microplastics in the environment.

Microplastics and potentially toxic elements: A review of interactions, fate and bioavailability in the environment.

Environmental fate, aging, toxicity and potential remediation strategies of microplastics in soil environment: Current progress and future perspectives.

Air Pollution

Redox and inflammatory mechanisms linking air pollution particulate matter with cardiometabolic derangements.

Human Health Studies

Numerous Chemicals/Mixtures

Evaluating mixtures of urinary phthalate metabolites and serum per-/polyfluoroalkyl substances in relation to adolescent hair cortisol: The HOME Study.

Prenatal Exposure to Multiple Endocrine-Disrupting Chemicals and Childhood BMI Trajectories in the INMA Cohort Study.

[Association of phthalate and polycyclic aromatic hydrocarbon exposure during early pregnancy with premature delivery: A cohort study]. [in Chinese]

BPA/Phenols

Association of urinary bisphenols with oxidative stress and inflammatory markers and their role in obesity.

Phthalates

Association between urinary phthalate metabolites and chronic obstructive pulmonary disease incidence in US adults: results from NHANES 2007-2018.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exploration of the correlation of serum polychlorinated biphenyl levels with luteal phase hormonal parameters and infertility in women with or without polycystic ovary syndrome.

Pre- and postnatal exposure to legacy environmental contaminants and sensation seeking in Inuit adolescents from Nunavik.

PFAS

Nested Case-Control Studies Investigating Serum Perfluorooctanoate and Perfluorooctane Sulfonate Levels and Pancreatic Ductal Adenocarcinoma in Two Cohorts.

Association of per- and polyfluoroalkyl substance exposure with metabolic syndrome and its components in adults and adolescents.

Environmental exposure to legacy and emerging per- and polyfluoroalkyl substances and endometriosis in women of childbearing age.

Relative Risks of Adverse Perinatal Outcomes in Three Australian Communities Exposed to Per- and Polyfluoroalkyl Substances: Data Linkage Study.

Novel Insights into the Adverse Health Effects of per- and Polyfluoroalkyl Substances on the Kidney via Human Urine Metabolomics.

Pesticides

Neuropathy caused by pesticide exposure on farmers in Ngablak District, Magelang, Central Java, Indonesia: An electroneuromyography study.

Association of urinary organophosphate metabolites with adult asthma patients: a cross-sectional population-based study.

Association between Residential Proximity to Viticultural Areas and Childhood Acute Leukemia Risk in Mainland France: GEOCAP Case-Control Study, 2006-2013.

Metals/Metalloids

Prenatal Metal Exposure Alters the Placental Proteome in a Sex-Dependent Manner in Extremely Low Gestational Age Newborns: Links to Gestational Age.

Association between mixed urinary metal exposure and liver function: analysis of NHANES data.

Postnatal methylmercury exposure and neurodevelopmental outcomes at 7 years of age in the Seychelles Child Development Study Nutrition Cohort 2.

Toxic metal mixtures in private well water and increased risk for preterm birth in North Carolina.

Bacterial Modification of the Association Between Arsenic and Autism-Related Social Behavior Scores.

Microplastics/Nanomaterials

Occurrence of microplastics and disturbance of gut microbiota: a pilot study of preschool children in Xiamen, China.

Air Pollution

Associations between PM_2.5 and O₃ exposures and new onset type 2 diabetes in regional and national samples in the United States.

Long-term exposure to air pollution and prevalent nonalcoholic fatty liver disease.

Joint effect of heat and air pollution on mortality in 620 cities of 36 countries.

Ambient particulate matter air pollution exposure and ovarian cancer incidence in the USA: An ecological study.

Short-term exposure to PM_2.5 and 1.5 million deaths: a time-stratified case-crossover analysis in the Mexico City Metropolitan Area.

Miscellaneous

Blood Trihalomethane Concentrations and Osteoarthritis among U.S. Population Aged over 50 Years.

Laboratory Studies

Numerous Chemicals/Mixtures

The Effects of Combined Exposure to Bisphenols and Perfluoroalkyls on Human Perinatal Stem Cells and the Potential Implications for Health Outcomes.

BPA/Phenols

Potential neuroprotective effect of nanomicellar curcumin on learning and memory functions following subacute exposure to bisphenol A in adult male rats.

Cyanidin Ameliorates Bisphenol A-Induced Alzheimer’s Disease Pathology by Restoring Wnt/β-Catenin Signaling Cascade: an In Vitro Study.

Effects of prenatal bisphenol S and bisphenol F exposure on behavior of offspring mice.

Genotoxicity of bisphenol AF in rats: Detrimental to male reproductive system and probable stronger micronucleus induction potency than BPA.

A lipidomic approach to bisphenol F-induced non-alcoholic fatty liver disease-like changes: altered lipid components in a murine model.

Parental Exposure to Environmentally Relevant Concentrations of Bisphenol-A Bis(diphenyl phosphate) Impairs Vascular Development in Offspring through DNA/RNA Methylation-Dependent Transmission.

Phthalates

Dietary exposure to an environmentally relevant phthalate mixture alters follicle dynamics, hormone levels, ovarian gene expression, and pituitary gene expression in female mice.

Parabens/Triclosan/Antimicrobials

Butylparaben weakens female fertility via causing oocyte meiotic arrest and fertilization failure in mice.

PFAS

Perfluorooctanoic acid disrupts thyroid-specific genes expression and regulation via the TSH-TSHR signaling pathway in thyroid cells.

Detail study on the interaction between perfluorooctanoic acid (PFOA) with human hemoglobin (Hb).

Evaluation of the Chronic Reproductive Toxicity of a Fluorine-free Firefighting Foam and a Short-Chain Fluorinated Foam to Northern Bobwhite Quail (Colinus virginianus).

Evaluation of the Effect of Perfluorohexane Sulfonate on the Proliferation of Human Liver Cells.

Perfluorooctanoic acid (PFOA) inhibits steroidogenesis and mitochondrial function in bovine granulosa cells in vitro.

Extracellular Vesicles altered by a Per- and Polyfluoroalkyl Substance Mixture: In Vitro Dose-Dependent Release, Chemical Content, and MicroRNA Signatures involved in Liver Health.

Flame Retardants

Emerging Organophosphate Ester Resorcinol bis(Diphenyl Phosphate) Exerts Estrogenic Effects via Estrogen Receptor Pathways.

Transgenerational effects of BDE-47 to zebrafish based on histomorphometry and toxicogenomic analyses.

The endocrine disruptor DE-79 alters oxytocinergic transmission and sexual behavior expression in male rats.

Pesticides

Combined reproductive and developmental toxicity study of pesticide abamectin on male and female Wistar Hannover rats.

Complement receptor 3-mediated neurotoxic glial activation contributes to rotenone-induced cognitive decline in mice.

Chronic exposure to pesticides disrupts the bacterial and fungal co-existence and the cross-kingdom network characteristics of honey bee gut microbiome.

Testosterone restores TM3 and TM4 cell viability, reduces reactive oxygen species generation, and protects against atrazine-induced stereological changes in rat testes.

In vitro exposure to triazoles used as fungicides impairs human granulosa cells steroidogenesis.

Metals/Metalloids

Chronic Fluoride Exposure Induces Ovarian Dysfunction and Potential Association with Premature Ovarian Failure in Female Rats.

Maternal Iron Deficiency and Environmental Lead (Pb) Exposure Alter the Predictive Value of Blood Pb Levels on Brain Pb Burden in the Offspring in a Dietary Mouse Model: An Important Consideration for Cumulative Risk in Development.

Toxicity of antimony to Daphnia magna: Influence of environmental factors, development of biotic ligand approach and biochemical response at environmental relevant concentrations.

Analysis of gut bacteriome of in utero arsenic-exposed mice using 16S rRNA-based metagenomic approach.

Arsenic Exposure-Induced Acute Kidney Injury by Regulating SIRT1/PINK1/Mitophagy Axis in Mice and in HK-2 Cells.

Melatonin Attenuates Arsenic-Induced Neurotoxicity in Rats Through the Regulation of miR-34a/miR-144 in Sirt1/Nrf2 Pathway.

Microplastics/Nanomaterials

Zinc oxide nanoparticles disrupt development and function of the olfactory sensory system impairing olfaction-mediated behaviour in zebrafish.

Co-exposure to UV-aged microplastics and cadmium induces intestinal toxicity and metabolic responses in earthworms.

Polystyrene nanoplastics induce lipid metabolism disorder and alter fatty acid composition in the hepatopancreas of Pacific whiteleg shrimp (Litopenaeus vannamei).

PS-MPs or their co-exposure with cadmium impair male reproductive function through the miR-199a-5p/HIF-1α-mediated ferroptosis pathway.

Toxicity of Polystyrene Nanoplastics in the Liver and Intestine of Normal and High-Fat Diet Juvenile Zebrafish.

Air Pollution

Nitro substituent caused negative impact on occurrence and development of atherosclerotic plaque by PM_2.5-bound polycyclic aromatic compounds.

Pharmaceuticals/Personal Care Products

Intergenerational effects on fertility in male and female mice after chronic exposure to environmental doses of NSAIDs and 17α-ethinylestradiol mixtures.

Identification of Transformation Products of Organic UV Filters by Photooxidation and Their Differential Estrogenicity Assessment.

Miscellaneous

Exposure to ecologically relevant estrogen levels do not influence morphology or immune parameters in hatchling American alligators (Alligator mississippiensis).

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Non-invasive biomonitoring of infant exposure to environmental organic pollutants in north-western Spain based on hair analysis. Identification of potential sources.

Suspect and non-target screening of semi-volatile emerging contaminants in indoor dust from Danish kindergartens.

Environmental persistence, bioaccumulation, and hazards of chemicals in e-cigarette e-liquids: short-listing chemicals for risk assessments.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The deep dive of organohalogen compounds: Bioaccumulation in the top predators of mesopelagic trophic webs, pygmy and dwarf sperm whales, from the Southwestern Atlantic ocean.

PFAS

News Brief: Nearly 50% of U.S. tap water sources contain at least one PFAS.

Comparison of aggregated exposure to perfluorooctanoic acid (PFOA) from diet and personal care products with concentrations in blood using a PBPK model – Results from the Norwegian biomonitoring study in EuroMix.

From watersheds to dinner plates: Evaluating PFAS exposure through fish consumption in Southeast Michigan.

Flushing Home Plumbing Pipes Contaminated with Aqueous Film-Forming Foam Containing Per- and Polyfluoroalkyl Substances.

Biomagnification and temporal trends (1990-2021) of perfluoroalkyl substances in striped dolphins (Stenella coeruleoalba) from the NW Mediterranean sea.

Target and suspect per- and polyfluoroalkyl substances in fish from an AFFF-impacted waterway.

Environmental distribution of per- and polyfluoroalkyl substances (PFAS) on Svalbard: Local sources and long-range transport to the Arctic.

Flame Retardants

Organophosphate ester (OPE) exposure among waste recycling and administrative workers in Denmark using silicone wristbands.

Gas-particle partitioning of organophosphate esters in indoor and outdoor air and its implications for individual exposure.

Bioaccumulation of novel brominated flame retardants in crucian carp (Carassius auratus): Implications for electronic waste recycling area monitoring.

Pesticides

Occurrence of pesticide residues in indoor dust of farmworker households across Europe and Argentina.

Pesticide Exposure and Effects on Non-Apis Bees.

Further limitations of synthetic fungicide use and expansion of organic agriculture in Europe will increase environmental and health risks of chemical crop protection caused by copper containing fungicides.

Metals/Metalloids

Data-Sparse Prediction of High-Risk Schools for Lead Contamination in Drinking Water: Examples from Four U.S. States.

Microplastics/Nanomaterials

Implications of solid waste dumps on the microplastic abundance in groundwater in Kollam, India.

Unraveling the Marine Microplastic Cycle: The First Simultaneous Data Set for Air, Sea Surface Microlayer, and Underlying Water.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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