EDC Science Weekly, Oct. 11-17, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Science summaries and highlights

Events

Oct. 28: Swiss Symposium on Endocrine Disrupting Chemicals [Food Packaging Forum and ETH Zurich]

Oct. 29-30: 6th Annual Forum on Endocrine Disruptors [European Commission]

Nov. 5-6 conference: State of the science on development and use of NAMs for chemical safety testing [U.S. EPA]

Nov. 12 webinar: Plastics Treaty Negotiations: Who has a seat at the table? [CHE-Alaska]

Nov. 13 webinar: The Overturning of Chevron Deference: Impacts on Environmental Health Decision Making [CHE and UCSF’s EaRTH Center]

Nov. 21 webinar: Introduction to ECHA’s guidance on new CLP hazard classes [ECHA]

Dec. 3 webinar: Fluoride, Neurodevelopment, and Cognition: A National Toxicology Program monograph [EDC Strategies Partnership]

Dec. 9 webinar, save the date: Behind the Scenes at EPA: What’s going wrong? [CHE and UCSF’s EaRTH Center]

April 27-29, 2025 conference: Break the Cycle of Children’s Environmental Health Disparities [call for student research projects due Nov. 1]

More events

Regulations/Policy

UN plastic pollution treaty must not ignore the scourge of microplastics.

Neonicotinoid pesticides: evidence of developmental neurotoxicity from regulatory rodent studies

More EDC policy and regulations open for comment

Methods/Tools/Screening

The Virtual Human Platform for Safety Assessment (VHP4Safety) project: Next generation chemical safety assessment based on human data.

Incorporating new approach methods (NAMs) data in dose-response assessments: The future is now!

Analysis of implicit and explicit uncertainties in QSAR prediction of chemical toxicity: a case study of neurotoxicity.

How well does a single blood sample represent long-term exposure for epidemiological studies of PFOA among men in the general population?

Using Reporter Gene Assays to Screen and Identify Chemical Compounds that Modulate Estrogen Receptor Activity.

Animal Models of Autistic-like Behavior in Rodents: A Scoping Review and Call for a Comprehensive Scoring System

Commentaries

Assessing the risk of toxic metals in tampons: Legitimate concern or misleading alarm?

Regrettable Substitution? Organophosphate Flame Retardants and Macrophage Activity. [Science Selection in EHP]

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Which is the current knowledge on man-made endocrine- disrupting chemicals in follicular fluid? An overview of effects on ovarian function and reproductive health

Exploring the Hypothetical Links Between Environmental Pollutants, Diet, and the Gut-Testis Axis: The Potential Role of Microbes in Male Reproductive Health.

Environment and Health: Endocrine-Disrupting Chemicals

Endocrine disrupting effects on morphological synaptic plasticity.

Migration of Chemical Compounds from Packaging Materials into Packaged Foods: Interaction, Mechanism, Assessment, and Regulations

Phthalates

Urinary concentrations of phthalate and phthalate alternative metabolites and sperm DNA methylation: A multi-cohort and meta-analysis of men in preconception studies.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent organic pollutants exposure and risk of depression: A systematic review and meta-analysis

PFAS

Fish consumption benefits and PFAS risks: Epidemiology and public health recommendations.

Gestational diabetes mellitus in relation to serum per- and polyfluoroalkyl substances: A scoping review to evaluate the need for a new systematic review

Removal of perfluoroalkyl and polyfluoroalkyl substances from tap water by means of point-of-use treatment: A review.

Pesticides

Neonicotinoids Impact All Aspects of Bird Life: A Meta-Analysis.

Metals/Metalloids

The Role of Ferroptosis in Environmental Pollution-Induced Male Reproductive System Toxicity

Potential pathogenic roles of ferroptosis and cuproptosis in cadmium-induced or exacerbated cardiovascular complications in individuals with diabetes

Microplastics/Nanomaterials

Biological exposure to microplastics and nanoplastics and plastic additives: impairment of glycolipid metabolism and adverse effects on metabolic diseases

Potential toxicity of microplastics on vertebrate liver: A systematic review and meta-analysis.

Human Health Studies

Numerous Chemicals/Mixtures

A National Study of the Associations between Hormonal Modulators in Hydraulic Fracturing Fluid Chemicals and Birth Outcomes in the United States of America: A County-Level Analysis [see related Invited Perspective: Drilling Down into the Mechanisms Linking Oil and Gas Development to Adverse Perinatal Health Outcomes]

Association of coexposure to perfluoroalkyl and polyfluoroalkyl compounds and heavy metals with pregnancy loss and reproductive lifespan: The mediating role of cholesterol.

Associations of co-exposure to polycyclic aromatic hydrocarbons and heavy metals with sex steroid hormones among children aged 6-19 years.

The mixture of non-persistent endocrine-disrupting chemicals in relation to endometriosis.

BPA/Phenols

Unveiling connections: bisphenol A and vitamin D dynamics in breast milk among healthy lactating mothers.

The Adverse Impact of Bisphenol A Exposure on Optimal Cardiovascular Health as Measured by Life’s Essential 8 in U.S. Adults: Evidence from NHANES 2005 to 2016

Phthalates

Prenatal phthalate exposure and pubertal development in 16-year-old daughters: reproductive hormones and number of ovarian follicles.

Placental Transcriptomic Signatures of Prenatal Phthalate Exposure and Identification of Placenta-Brain Genes Associated with the Effects of Phthalate Exposure on Neurodevelopment in Children.

Association between phthalates exposure and non-alcoholic fatty liver disease under different diagnostic criteria: a cross-sectional study based on NHANES 2017 to 2018.

Urinary phthalate metabolites associated with bone mineral density in adults: Data from the NHANES 2011-2018

Exposure to Phthalates and Alternative Plasticizers in Patients with Impaired Kidney Function in Korea: Temporal Trend during 2011-2020 and Its Association with Chronic Kidney Disease

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Association of polychlorinated biphenyls with vitamin D among rural Chinese adults with normal glycaemia and type 2 diabetes mellitus

PFAS

Serum per- and polyfluoroalkyl substance (PFAS) levels and health-related biomarkers in a pilot study of skiers in New England.

Per- and poly-fluoroalkyl substances (PFAS) accelerate biological aging mediated by increased C-reactive protein.

Serum concentrations of per- and polyfluorinated substances and risk of B-cell non-Hodgkin lymphoma.

Per and poly-fluoroalkyl substances and respiratory health in an Inuit community.

Flame Retardants

Gestational exposure to organophosphate esters and autism spectrum disorder and other non-typical development in a cohort with elevated familial likelihood.

Pesticides

Pesticide exposure and oxidative stress generation are linked to poor prognosis outcomes in breast cancer women carrying the allelic variant rs7438135 in the UGT2B7 gene.

Respiratory and allergic outcomes among farmworkers exposed to pesticides in Costa Rica.

The association of glyphosate exposure with kidney stones in American adults: A nationally representative cross-sectional study.

Metals/Metalloids

Combined Exposure to Folate and Lead during Pregnancy and Autistic-Like Behaviors among Canadian Children from the MIREC Pregnancy and Birth Cohort [see related

Invited Perspective: Protect and Serve-The Potential Role of Folate in Lead Risk Reduction]

Associations of gestational and childhood exposure to lead, cadmium, and fluoride with cognitive abilities, behavior, and social communication at 4 years of age: NICE Birth Cohort Study.

Meet-in-metabonomics: Insights into associations between hair heavy metal and adverse child growth in e-waste recycling area.

Relationship between low-level arsenic exposure in drinking water and kidney cancer risk in Texas.

Association between heavy metal exposure and biomarkers for non-alcoholic fatty liver disease in Korean adolescents.

Association between multiple metal exposure and bone mineral density among Chinese adults.

Air Pollution

Exposure to Air Pollutants and Myocardial Infarction Incidence: A UK Biobank Study Exploring Gene-Environment Interaction.

Air Quality and Wheeze Symptoms in a Rural Children’s Cohort near a Drying Saline Lake.

Environmental Inequality in Estimated Cancer Risk from Airborne Toxic Exposure across United States Communities from 2011 to 2019

Laboratory Studies

Numerous Chemicals/Mixtures

Establishment of the first dermal fibroblast cell line derived from the Indo-Pacific Bottlenose Dolphin (Tursiops aduncus) and its response to pollutant exposure.

BPA/Phenols/Phthalates

Enhanced endoplasmic reticulum stress signaling disrupts porcine sertoli cell function in response to Bisphenol A exposure.

4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) exposure induces hepatotoxicity and nephrotoxicity – role of oxidative stress, mitochondrial dysfunction and pathways of cytotoxicity

Vanillic acid ameliorates diethyl phthalate and bisphenol S-induced oxidative stress and neuroinflammation in the hippocampus of experimental rats

Parabens/Triclosan/Antimicrobials

Acute toxicity assessment and QSAR modeling of zebrafish embryos exposed to methyl paraben and its halogenated byproducts.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Impaired energy expenditure following exposure to either DDT or DDE in mice may be mediated by DNA methylation changes in brown adipose.

Juvenile exposure to low-level 2,3,7,8-tetrachlorodibenzo-p–dioxin (TCDD) alters behavior and longitudinal morphometrics in zebrafish and F₁ offspring.

PFAS

Exposure to PFOA, PFOS, and PFHxS Induces Alzheimer’s Disease-like Neuropathology in Cerebral Organoids.

Unveiling the Molecular Effects of Replacement and Legacy PFASs: Transcriptomic Analysis of Zebrafish Embryos Reveals Surprising Similarities and Potencies.

Flaxseed Oil Alleviates PFOS-Induced Liver Injury by Regulating Hepatic Cholesterol Metabolism.

Diet rich in soluble dietary fibres increases excretion of perfluorooctane sulfonic acid (PFOS) in male Sprague-Dawley rats.

Contribution of gut microbiota to hepatic steatosis following F-53B exposure from the perspective of glucose and fatty acid metabolism.

Unraveling the long-term gastrointestinal impact of perinatal perfluorobutane sulfonate exposure on rat offspring: Intestinal barrier dysfunction and Th17/Treg imbalance

Stimulating Acidimicrobium sp. Strain A6 in iron-rich, acidic sediments from AFFF-impacted sites for PFAS defluorination.

Flame Retardants

2-Ethylhexyl diphenyl phosphate aggravates colitis-induced neuroinflammation and behavioral abnormalities by inhibiting the PI3K-AKT-NF-κB and Wnt/GSK3β signaling pathways.

Pesticides

Perinatal exposure to environmental chemicals that disrupt thyroid function can perturb testis development

Cytotoxicity induced by three commercial neonicotinoid insecticide formulations in differentiated human neuroblastoma SH-SY5Y cells.

Toxicity of pesticide cocktails in amphibian larvae: understanding the impact of agricultural activity on aquatic ecosystems in the Salado River basin, Argentina.

Brain single-cell transcriptomics highlights comorbidity-related cell type-specific changes of Parkinson’s disease with major depressive disorder after paraquat exposure

Oral Administration of Lactiplantibacillus plantarum CCFM8661 Alleviates Dichlorvos-Induced Toxicity in Mice

Metals/Metalloids

Intestinal microbiota dysbiosis contributes to the liver damage in subchronic arsenic-exposed mice.

Arsenic induces ferroptosis in HTR-8/SVneo cells and placental damage

Microplastics/Nanomaterials

Impact of polyethylene microplastics exposure on kallikrein-3 levels, steroidal-thyroidal hormones, and antioxidant status in murine model: protective potentials of naringin.

Inhalation of Microplastics Induces Inflammatory Injuries in Multiple Murine Organs via the Toll-like Receptor Pathway.

Sight of Aged Microplastics Adsorbing Heavy Metal Exacerbated Intestinal Injury: A Mechanistic Study of Autophagy-Mediated Toxicity Response.

Effects of microplastics separate exposure and co-exposure to 17β-estradiol on the productive performance of juvenile female Chinese mitten crab (Eriocheir sinensis).

Early-life exposure to polystyrene micro- and nanoplastics disrupts metabolic homeostasis and gut microbiota in juvenile mice with a size-dependent manner.

Toxicity of parental co-exposure of microplastic and bisphenol compounds on adult zebrafish: Multi-omics investigations on offspring.

Systemic toxicity of biodegradable polyglycolic acid microplastics on the gut-liver-brain axis in zebrafish.

Microplastic exposure linked to accelerated aging and impaired adipogenesis in fat cells.

Evaluation of size-dependent uptake, transport and cytotoxicity of polystyrene microplastic in a blood-brain barrier (BBB) model.

Polystyrene microplastics induce activation and cell death of neutrophils through strong adherence and engulfment.

Pharmaceuticals/Personal Care Products

Vertebrate endocrine disruptors induce sex-reversal in blue mussels.

Thyroid and growth hormone endocrine disruption and mechanisms of homosalate and octisalate using wild-type, thrαa-/-, and dre-miR-499-/- zebrafish embryo/larvae

Embryonal exposure to 4-methylbenzylidene camphor induces reproduction impairment in adult zebrafish (Danio rerio)

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Current exposure to environmental pollutants in the general adult population of Kinshasa, Democratic Republic of Congo (DRC): A cross-sectional study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Human bare and clothing-covered skin exposure to chlorinated paraffins for the general populations: Exposure pattern differential and significance of indirect dermal exposure via clothing-to-skin transport.

An overview on the legacy and risks of Polychlorinated Biphenyls (PCBs) and Organochlorinated Pesticides (OCPs) in the polar regions.

Examining Bald Eagle Contaminant Exposure and Reproductive Risk Above and Below Dams on Great Lakes Tributaries

PFAS

Partitioning of Neutral PFAS in Homes and Release to the Outdoor Environment: Results from the IPA Campaign.

Removal of 48 per- and polyfluoroalkyl substances (PFAS) throughout processes in domestic and general industrial wastewater treatment plants: Implications for emerging alternatives risk control. [some PFAS increased after WW treatment]

Persistent Organic Pollutants in the Antarctic Marine Environment: The Influence Impacts of Human Activity, Regulations, and Climate Change. [PFAS and HBCD]

Per- and polyfluoroalkyl substances in food and beverages: determination by LC-HRMS and occurrence in products from the Belgian market.

Toxicokinetic of Perfluorinated Compounds – A Study of Liver Sequestration in Baltic Cod (Gadus morhua callarias) and Human Dietary Exposure.

Bioaccumulation Potentials of Per-and Polyfluoroalkyl substances (PFAS) in Recreational Fisheries: Occurrence, Health Risk Assessment and Oxidative Stress Biomarkers in Coastal Biscayne Bay.

Occurrence of per- and polyfluoroalkyl substances in drinking water in China and health risk assessment based on a probabilistic approach.

Unveiling Priority Emerging PFAS in Taihu Lake Using Integrated Nontarget Screening, Target Analysis, and Risk Characterization.

Per- and poly-fluoroalkyl substances (PFAS) do not accumulate with age or affect population survival in ruddy turnstone (Arenaria interpres).

Insights into PFAS contaminants before and after sewage discharges into a marine protected harbour.

Tissue-specific distribution and fatty acid content of PFAS in the northern Bohai Sea fish: Risk-benefit assessment of legacy PFAS and emerging alternatives.

Exposure, spatial distribution, and health risks of perfluoroalkyl acids in commercial fish species in the Beibu Gulf

Pesticides

Assessment of residues from common pesticides and associated risks in Pakistan

Monitoring of 260 pesticides in extra virgin olive oil and risk assessment for consumers within the framework of the European multiannual control program

Metals/Metalloids

How much does the carcinogenic risk of inorganic arsenic exposure from rice increase with higher brown rice consumption? An estimation for five regions around the world

Microplastics/Nanomaterials

Heavy Metal Nanoparticle Detection in Human and Formula Milk

Presence of microplastics in human stomachs

An analysis of suspected microplastics in the muscle and gastrointestinal tissues of fish from Sarasota Bay, FL: exposure and implications for apex predators and seafood consumers.

Microplastics contamination in selected staple consumer food products.

Microplastics, Polycyclic Aromatic Hydrocarbons, and Heavy Metals in Milk: Analyses and Induced Health Risk Assessment

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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