A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.
Contents: Events, Regulations/
Highlights: Scientists’ Declaration for the Global Plastics Treaty: read it here and sign it here.
Events
Nov. 21 webinar: Introduction to ECHA’s guidance on new CLP hazard classes [ECHA]
Dec. 3 webinar: Fluoride, Neurodevelopment, and Cognition: A National Toxicology Program monograph [EDC Strategies Partnership]
Dec. 5 symposium: Scientific symposium and general meeting (hybrid) [Intersectoral Center for Endocrine Disruptor Analysis (ICEDA)]
Dec. 9 webinar: Behind the Scenes at EPA: What’s going wrong? [CHE, Earthjustice, and UCSF’s EaRTH Center]
April 27-29, 2025 conference: Break the Cycle of Children’s Environmental Health Disparities
May 21 – June 4, 2025 course: Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO) [applications due Jan 10, financial aid is available]
Regulations/Policy
Scientists’ Declaration for the Global Plastics Treaty: read it here and sign it here. Due Nov. 22.
Methods/Tools/Screening
Commentaries
Editorial: Environmental impacts on women’s health disparities and reproductive health: advancing environmental health equity in clinical and public health practice. [intro to a research topic in Frontiers in Reproductive Health]
Reviews/Meta-Analyses
Numerous Chemicals/Mixtures
Mitigating Dietary Bisphenol Exposure Through the Gut Microbiota: The Role of Next-Generation Probiotics in Bacterial Detoxification Environmental and occupational exposure to organochlorine pesticides associated with Parkinson’s disease risk: A systematic review and meta-analysis based on epidemiological evidence State of the Science and Regulatory Acceptability for PFAS Residual Management Options: PFAS Disposal or Destruction Options
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
PFAS
Microplastics/Nanomaterials
Human Health Studies
Numerous Chemicals/Mixtures
BPA/Phenols/Parabens
Associations between prenatal exposure to environmental phenols and child neurodevelopment at two years of age in a South African birth cohort Associations of exposure to phthalate with serum uric acid and hyperuricemia risk, and the mediating role of systemic immune inflammation Benchmark Dose for Dioxin Based on Gestational Diabetes Mellitus Using Coexposure Statistical Methods and an Optimized Physiologically Based Toxicokinetic Model Non-dioxin-like polychlorinated biphenyls (NDL-PCBs) dietary exposure is associated with an increased risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort PFAS exposure is associated with an unfavourable metabolic profile in infants six months of age
Phthalates
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
PFAS
Per-and polyfluoroalkyl substances and disrupted sleep: mediating roles of proteins Oxidative stress mediates the association of organophosphate flame retardants with metabolic obesity in U.S. adults: A combined epidemiologic and bioinformatic study Effects of urinary organophosphate flame retardants in susceptibility to attention-deficit/hyperactivity disorder in school-age children
Flame Retardants
Lifestyle factors and urine levels of organophosphorus flame retardants in endometrial cancer: insights from a case-control study Association between prenatal mercury exposure and pediatric neurodevelopment: The Japan environment and children’s study Association between urinary arsenic levels and kidney damage in US adults: NHANES 2007-2018
Metals/Metalloids
Laboratory Studies
BPA/Phenols
The Effects of Bisphenol A and its Analogs on Steroidogenesis in MA-10 Leydig Cells and KGN Granulosa Cells
MiR-204 regulates autophagy and cell viability by targeting BDNF and inhibiting the NTRK2-dependent PI3K/Akt/mTOR pathway in a human granulosa cell line exposed to bisphenol A Different paths, same destination: Bisphenol A and its substitute induce the conjugative transfer of antibiotic resistance genes
Toxicological effects of bisphenol F on growth, antioxidant response, ultrastructure, and microbial properties of the submerged macrophyte Ceratophyllum demersum L Synergistic effects of thermal stress and 4-nonylphenol on oxidative stress and immune responses in juvenile tilapia (Oreochromis niloticus) Unraveling the acute sublethal effects of acetamiprid on honey bee neurological redox equilibrium Metabolomics reveals the metabolic disturbance caused by arsenic in the mouse model of inflammatory bowel disease
Lycium barbarum polysaccharide alleviates ferroptosis in Sertoli cells through NRF2/SLC7A11/GPX4 pathway and ameliorates DEHP-induced male reproductive damage in mice.
Resveratrol alleviates Mono-2-ethylhexyl phthalate-induced mitophagy, ferroptosis, and immunological dysfunction in grass carp hepatocytes by regulating the Nrf2 pathway Potential antiandrogenic effects of parabens and benzophenone-type UV-filters by inhibition of 3α-hydroxysteroid dehydrogenases
Parabens/Triclosan/
Structural determinants of parabens in inhibiting human and rat gonadal 3β-hydroxysteroid dehydrogenase Interaction between young fecal transplantation and perfluorobutanesulfonate endocrine disrupting toxicity in aged recipients: An estrobolome perspective
PFAS
Perfluorooctanoic acid induces transgenerational modifications in reproduction, metabolism, locomotor activity, and sleep behavior in Drosophila melanogaster and deleterious effects in human cancer cells Organophosphorus Flame Retardants and Metabolic Disruption: An in Silico, in Vitro, and in Vivo Study Focusing on Adiponectin Receptors A comparative study for organophosphate triesters and diesters in mice via oral gavage exposure: Tissue distribution, excreta elimination, metabolites and toxicity TBBPA exposure causes cartilage cell damage in both in vitro and in vivo models
Flame Retardants
Maternal probiotic supplementation protects against PBDE-induced developmental, behavior and metabolic reprogramming in a sexually dimorphic manner: Role of gut microbiome Acute glyphosate and aminomethylphosphonic acid (AMPA), its major metabolite, impaired spatial orientation, navigation, learning and/or memory in female rats Exposure to organophosphate insecticides induces behavioral changes and acetylcholinesterase inhibition in Apis mellifera
Pesticides
Transcriptome analysis reveals the molecular mechanisms of neonicotinoid acetamiprid in Leydig cells
Metals/Metalloids
Microplastics/Nanomaterials
Chronic exposure to polystyrene microplastics induces renal fibrosis via ferroptosis Mechanism of vitamin C alleviating the immunotoxicity of 17α-methyltestosterone in Carassius auratus 6-PPD quinone at environmentally relevant concentrations induces immunosenescenece by causing immunosuppression during the aging process Environmental concentrations of 6PPD and 6PPD-quinone induce hepatic lipid metabolism disorders in male black-spotted frogs Characterization of Chemical Exposome in A Paired Human Preconception Pilot Study Microplastics in maternal blood, fetal appendages, and umbilical vein blood Co-exposure of Microplastics with Heavy Metals Increases Environmental Pressure in the Endangered and Rare Wildlife Reserve: A Case Study of the Zhalong Wetland Red-crowned Crane Nature Reserve, Northeast China If you enjoy this newsletter, please feel free to donate here! Thank you!
Pharmaceuticals/Personal Care Products
Miscellaneous
Metabolite identification of emerging disinfection byproduct dibromo-benzoquinone in vivo and in vitro: Multi-strategy mass-spectrometry annotation and toxicity characterization
Exposure/Environment Studies
Numerous Chemicals/Mixtures
Changes in exposure to environmental contaminants in the aftermath of Hurricane Maria among pregnant women in northern Puerto Rico Persistent organic pollutants among seafood processing workers in West Greenland Exposure to per- and polyfluoroalkyl substances (PFAS) in North Carolina homes: results from the indoor PFAS assessment (IPA) campaign Organophosphate esters and their metabolites in Beijing total diets: Occurrence, time trend, and dietary exposure assessment Chemometric assessment of bioaccumulation and contamination pathways for toxic metals in diet and environment: implications for chronic kidney disease of unknown etiology (CKDu) in Sri Lankan agricultural regions
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
PFAS
Flame Retardants
Metals/Metalloids
Microplastics/Nanomaterials
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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@