EDC Science Weekly, Nov. 23 – Dec. 1, 2022

Post author:HEEDS
Post published:December 1, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Dec. 2: CHE Café: What’s Next in Environmental Health? (Collaborative for Health and Environment (CHE))

Webinar Dec. 2: Exposure to Environmental Contaminants and Alzheimer’s Disease Risk (Duke Integrated Toxicology and Environmental Health Program; see their Spring 2023 Seminar Series)

Webinar Dec. 6: Prenatal Exposure to Phthalates, Bisphenol, and Organophosphate Pesticide Mixtures and Fetal Growth (Health and Environment Alliance (HEAL) and Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE))

Webinar Dec. 6: ChemScore 2022 (ChemSec)

Webinar Dec. 8: Embryonic BPA Exposure Causes Liver Disease in Generations of Fish (EDC Strategies Partnership and Young EDC Scientists Showcase)

Regulations/Policy

GAO Calls for Nationwide Analysis of “Forever Chemicals” [News item in JAMA]

From science to policy: How European HBM indicators help to answer policy questions related to phthalates and DINCH exposure.

Analysis of dermal exposure assessment in the US Environmental Protection Agency Toxic Substances Control Act risk evaluations of chemical manufacturing.

Childhood Lead Poisoning 1970-2022: Charting Progress and Needed Reforms.

Methods/Tools/Screening

The Use of Race in Risk Assessment Tools Contributes to Systemic Racism.

The chemical landscape of high-throughput new approach methodologies for exposure.

Novel, highly sensitive, in vivo screening method detects estrogenic activity at low doses of bisphenol A.

Approaches to mixture risk assessment of PFASs in the European population based on human hazard and biomonitoring data.

Advancing the science of a read-across framework for evaluation of data-poor chemicals incorporating systematic and new approach methods.

Experimental human placental models for studying uptake, transport and toxicity of micro- and nanoplastics.

Principal Component Pursuit for Pattern Identification in Environmental Mixtures. [see related Invited Perspective: Challenges and Opportunities for Missing Data in the Context of Environmental Mixture Methods.]

Reanalysis of Trichloroethylene and Tetrachloroethylene Metabolism to Glutathione Conjugates Using Human, Rat, and Mouse Liver in Vitro Models to Improve Precision in Risk Characterization. [see related Invited Perspective: Improved Risk Characterization for Trichloroethylene and Perchloroethylene Based on New Analyses of Glutathione Conjugation Rates.]

Cheminformatics analysis of chemicals that increase estrogen and progesterone synthesis for a breast cancer hazard assessment.

Statistical modeling of hormesis quantities in inverted U-shaped dose-response relationships by reparameterization of a bilogistic model.

Exploring chemical space in non-targeted analysis: a proposed ChemSpace tool.

Capture-SELEX of DNA Aptamers for Estradiol Specifically and Estrogenic Compounds Collectively.

Commentaries

Global plastic treaty should address chemicals.

Editorial: Chemical testing using new approach methodologies (NAMs).

Reviews

Numerous Chemicals/Mixtures

Endocrine Disruptors and Endometriosis

The Role of the Aryl Hydrocarbon Receptor (AhR) and Its Ligands in Breast Cancer.

Lack of association between endocrine disrupting chemicals and male fertility: A systematic review and meta-analysis.

BPA/Phenols

Endocrine Disrupting Compounds (Nonylphenol and Bisphenol A)-Sources, Harmfulness and Laccase-Assisted Degradation in the Aquatic Environment.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Studying the Impact of Persistent Organic Pollutants Exposure on Human Health by Proteomic Analysis: A Systematic Review.

Perfluoroalkyl Substances

What Happens In Utero Does Not Stay In Utero: a Review of Evidence for Prenatal Epigenetic Programming by Per- and Polyfluoroalkyl Substances (PFAS) in Infants, Children, and Adolescents

Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Maternal Thyroid Dysfunction, and Child Autism Spectrum Disorder.

EI/IOT of PFCs: Environmental impacts/interactions, occurrences, and toxicities of perfluorochemicals.

Flame Retardants

Mechanisms of Male Reproductive Toxicity of Polybrominated Diphenyl Ethers.

Pesticides

Xeno-Estrogenic Pesticides and the Risk of Related Human Cancers.

Effect of Gestational Pesticide Exposure on the Child’s Respiratory System: A Narrative Review.

Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish.

Towards achieving a modern science-based paradigm for agrochemical carcinogenicity assessment.

Disturbance of cellular calcium homeostasis plays a pivotal role in glyphosate-based herbicide-induced oxidative stress.

Metals/Metalloids

Recent advancements in toxicology, modern technology for detection, and remedial measures for arsenic exposure: review.

Mechanisms of Cadmium-Induced Testicular Injury: A Risk to Male Fertility.

Microplastics/Nanomaterials

Nano- and microplastics: a comprehensive review on their exposure routes, translocation, and fate in humans.

Unraveling the potential human health risks from used disposable face mask-derived micro/nanoplastics during the COVID-19 pandemic scenario: A critical review.

A systematic review of microplastics in the environment: Sampling, separation, characterization and coexistence mechanisms with pollutants.

Immunotoxicity of nanomaterials in health and disease: Current challenges and emerging approaches for identifying immune modifiers in susceptible populations.

Pharmaceuticals/Personal Care Products

Association between hair dye use and cancer in women: a systematic review and meta-analysis of case-control studies.

Diethylstilbestrol and autism

Cosmetic Preservatives: Hazardous Micropollutants in Need of Greater Attention?

Hazard and health risk assessment of exposure to pharmaceutical active compounds via toxicological evaluation by zebrafish.

Human Health Studies

Numerous Chemicals/Mixtures

Chemical mixture exposure patterns and obesity among U.S. adults in NHANES 2005-2012. [phthalates]

A pilot reverse virtual screening study suggests toxic exposures caused long-term epigenetic changes in Gulf War Illness.

Phthalates

Urinary phthalate metabolites and the risk of endometrial polyp: A pilot study from the TREE cohort.

Associations between Prenatal Exposure to Phthalates and Features of the Metabolic Syndrome in Males from Childhood into Adulthood.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent organic pollutant exposure contributes to Black/White differences in leukocyte telomere length in the National Health and Nutrition Examination Survey.

Levels of persistent organic pollutants in breast milk samples representing Finnish and Danish boys with and without hypospadias.

Perfluoroalkyl Substances

Bone mass density following developmental exposures to perfluoroalkyl substances (PFAS): a longitudinal cohort study.

Association between Perfluoroalkyl and Polyfluoroalkyl Substances and Women’s Infertility, NHANES 2013-2016.

Is the cholesterol-perfluoroalkyl substance association confounded by dietary fiber intake?: a Bayesian analysis of NHANES data with adjustment for measurement error in fiber intake.

Reduced Birth Weight and Exposure to Per- and Polyfluoroalkyl Substances: A Review of Possible Underlying Mechanisms Using the AOP-HelpFinder.

Association of exposure to per- and polyfluoroalkyl substances with hemoglobin and hematocrit during pregnancy.

Pesticides

Neonicotinoid Insecticides and Their Metabolites Can Pass through the Human Placenta Unimpeded.

Race, Toxic Exposures, and Environmental Health: The Contestation of Lupus among Farmworkers.

Metals/Metalloids

Exposure to heavy metals and hormone levels in midlife women: The study of Women’s Health Across the nation (SWAN)

Prenatal Metal Exposures and Associations with Kidney Injury Biomarkers in Children.

Mixed heavy metals exposure affects the renal function mediated by 8-OHG: A cross-sectional study in rural residents of China.

Chronic Community Exposure to Environmental Metal Mixtures Is Associated with Selected Cytokines in the Navajo Birth Cohort Study (NBCS).

Air Pollution

Association of PM_2.5 and Its Chemical Compositions with Metabolic Syndrome: A Nationwide Study in Middle-Aged and Older Chinese Adults.

Long-term exposure to nitrogen dioxide air pollution and breast cancer risk: A nested case-control within the French E3N cohort study.

Identifying pre-conception and pre-natal periods in which ambient air pollution exposure affects fetal growth in the predominately Hispanic MADRES cohort.

Miscellaneous

Prenatal polycyclic aromatic hydrocarbon (PAH) exposure in relation to placental corticotropin releasing hormone (pCRH) in the CANDLE pregnancy cohort

Association between polycyclic aromatic hydrocarbon exposure and hypertension among the U.S. adults in the NHANES 2003-2016: A cross-sectional study.

Association between aldehyde exposure and sex steroid hormones among adults.

Laboratory Studies

Numerous Chemicals/Mixtures

In vitro biochemical assessment of mixture effects of two endocrine disruptors on INS-1 cells.

Efficient in vivo and in silico assessments of antiandrogenic potential in zebrafish.

Genome and transcriptome of Chinese medaka (Oryzias sinensis) and its uses as a model fish for evaluating estrogenicity of surface water.

Speed it up: How temperature drives toxicokinetics of organic contaminants in freshwater amphipods.

BPA/Phenols

Bisphenols induce cardiotoxicity in zebrafish embryos: Role of the thyroid hormone receptor pathway.

Determination of Metabolomics Profiling in BPA-Induced Impaired Metabolism.

Brief postnatal exposure to bisphenol A affects apoptosis and gene expression in the medial prefrontal cortex and social behavior in rats with sex specificity.

Reproductive Toxicity and Teratogenicity of Fluorene-9-bisphenol on Chinese Medaka (Oryzias sinensis): A Study from Laboratory to Field.

Phthalates

m6A contributes to a pro-survival state in GC-2 cells by facilitating DNA damage repair: Novel perspectives on the mechanism underlying DEHP genotoxicity in male germ cells.

F₀ maternal di(2-ethylhexyl) phthalate (DEHP) exposure causes multigenerational effects in the uterus of F₁ and F₂ generation rats.

Di-(2-ethylhexyl) phthalate exposure induces liver injury by promoting ferroptosis via downregulation of GPX4 in pregnant mice.

Risk assessment of bisphenol analogues towards mortality, heart rate and stress-mediated gene expression in cladocerans Moina micrura.

Parabens/Triclosan/Antimicrobials

Triclosan exposure induced disturbance of gut microbiota and exaggerated experimental colitis in mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Use of different endpoints to determine the bioavailability of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and polychlorinated biphenyls (PCBs) in Sprague-Dawley rats.

2,3′,4,4′,5-Pentachlorobiphenyl induced thyroid dysfunction by increasing mitochondrial oxidative stress.

Perfluoroalkyl Substances

Long term toxicities following developmental exposure to perfluorooctanoic acid: Roles of peroxisome proliferation activated receptor alpha

Perfluorodecanoic acid promotes adipogenesis via NLRP3 inflammasome-mediated pathway in HepG2 and 3T3-L1 cells.

Exposure to Environmentally Relevant Levels of PFAS Causes Metabolic Changes in the Freshwater Amphipod Austrochiltonia subtenuis.

Insights into the Dermal Absorption, Deposition, and Elimination of Poly- and Perfluoroalkyl Substances in Rats: The Importance of Skin Exposure.

Systemic toxicity induced by topical application of perfluoroheptanoic acid (PFHpA), perfluorohexanoic acid (PFHxA), and perfluoropentanoic acid (PFPeA) in a murine model.

Transcriptional pathways linked to fetal and maternal hepatic dysfunction caused by gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) in CD-1 mice.

Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4).

Use of clinical chemistry health outcomes and PFAS chain length to predict 28-day rodent oral toxicity.

Flame Retardants

BDE-47, -99, -209 and Their Ternary Mixture Disrupt Glucose and Lipid Metabolism of Hepg2 Cells at Dietary Relevant Concentrations: Mechanistic Insight through Integrated Transcriptomics and Proteomics Analysis.

Effects of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) on reproductive and endocrine function in female zebrafish (Danio rerio).

Tetrabromobisphenol Exposure Impairs Bovine Oocyte Maturation by Inducing Mitochondrial Dysfunction.

A transcriptomic-based analysis predicts the neuroendocrine disrupting effect on adult male and female zebrafish (Danio rerio) following long-term exposure to Tetrabromobisphenol A bis(2-hydroxyethyl) ether.

Toxicokinetics and edible tissues-specific bioaccumulation of decabrominated diphenyl ethers (BDE-209) after exposure to the broilers.

Organophosphorus Flame Retardant TCPP Induces Cellular Senescence in Normal Human Skin Keratinocytes: Implication for Skin Aging.

Pesticides

Postnatal exposure to a glyphosate-based herbicide interferes with the development and growth of the mammary gland of pre-pubertal Ewe lambs.

Rotenone causes mitochondrial dysfunction and prevents maturation in porcine oocytes.

Rotenone-induced oxidative stress in THP-1 cells: biphasic effects of baicalin.

Metals/Metalloids

Sex-dependent vascular effects of cadmium sub-chronic exposure on rats.

Topiramate Reprofiling for the Attenuation of Cadmium-Induced Testicular Impairment in Rats: Role of NLRP3 Inflammasome and AMPK/mTOR-Linked Autophagy.

Arsenic Induces Blood‒Brain Barrier Disruption and Regulates T Lymphocyte Subpopulation Differentiation in the Cerebral Cortex and Hippocampus Associated with the Nrf2 Pathway In Vivo.

Toxicogenomic signatures associated with methylmercury induced developmental toxicity in the zebrafish embryos.

Microplastics/Nanomaterials

Fate and effects of microplastics in combination with pharmaceuticals and endocrine disruptors in freshwaters: Insights from a microcosm experiment.

Accelerated transformation of plastic furniture into microplastics and nanoplastics by fire

Combined exposure to di(2-ethylhexyl) phthalate and polystyrene microplastics induced renal autophagy through the ROS/AMPK/ULK1 pathway.

Polystyrene nanoplastics enhance the toxicological effects of DDE in zebrafish (Danio rerio) larvae.

Evidence on Invasion of Blood, Adipose Tissues, Nervous System and Reproductive System of Mice After a Single Oral Exposure: Nanoplastics versus Microplastics.

Polystyrene nanoplastics promote CHIP-mediated degradation of tight junction proteins by activating IRE1α/XBP1s pathway in mouse Sertoli cells.

Metabolomic analysis of combined exposure to microplastics and methylmercury in the brackish water flea Diaphanosoma celebensis.

Toxic effects and primary source of the aged micro-sized artificial turf fragments and rubber particles: Comparative studies on laboratory photoaging and actual field sampling.

Miscellaneous

Chronic effects of environmental concentrations of antifoulant diuron on two marine fish: Assessment of hormone levels, immunity, and antioxidant defense system.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Determinants of exposure to endocrine disruptors following hurricane Harvey.

Comprehensive monitoring of a special mixture of prominent endocrine disrupting chemicals in human urine using a carefully adjusted hydrolysis of conjugates.

Characterizing surface water concentrations of hundreds of organic chemicals in United States for environmental risk prioritization.

Ecological risk assessment associated with five endocrine-disrupting compounds in wastewater treatment plants of Northeast Mexico.

Phthalates

Phthalates in Glass Window Films of Chinese University Dormitories and Their Associations with Indoor Decorating Materials and Personal Care Products.

Partition of phthalates among air, PM₂ _.5 , house dust and skin in residential indoor environments.

The Potential Biomarker of Di(2-ethylhexyl) Phthalate Exposure during Catheterization.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organochlorine pesticides and polycyclic aromatic hydrocarbons in serum of Beijing population: Exposure and health risk assessment.

New emission inventory reveals termination of global dioxin declining trend.

Riparian Spiders: Sentinels of Polychlorinated Dibenzo-p-dioxin and Dibenzofuran Contaminated Sediment.

Chlorinated Persistent Organic Pollutants (PCDD/Fs and PCBs) in Loggerhead Sea Turtles Stranded along the Central Adriatic Coast.

Perfluoroalkyl Substances

Legacy and emerging poly- and perfluoroalkyl substances in wastewater treatment plant and receiving water: abundance, removal, and potential ecological risk.

The Psychological Impact of Per- and Poly-Fluoroalkyl Substances (PFAS) Pollution in the Veneto Region, Italy: A Qualitative Study with Parents.

Longitudinal measurements of per- and poly-fluoroalkyl substances (PFAS) in archived human serum samples between 1975 and 1995 in Australia.

Fast and Sensitive Analysis of Short- and Long-Chain Perfluoroalkyl Substances in Foods of Animal Origin.

Flame Retardants

Elevated concentrations of halogenated flame retardants in waste childcare articles from Ireland.

Exposure to flame retardants in European children – Results from the HBM4EU aligned studies.

Polybrominated diphenyl ethers and polycyclic aromatic hydrocarbons in dust from different indoor environments in Zagreb, Croatia: Levels and human exposure assessment.

Sediment contamination with polybrominated diphenyl ethers and alternative brominated flame retardants: case study in urban lakes of Hanoi, Vietnam.

Pesticides

Exposure of children to glyphosate in Morocco: Urinary levels and predictors of exposure.

A Human Biomonitoring Study Assessing Glyphosate and Aminomethylphosphonic Acid (AMPA) Exposures among Farm and Non-Farm Families.

Chemicals/materials of emerging concern in farmlands: sources, crop uptake and potential human health risks.

Metals/Metalloids

Detection of Relevant Heavy Metal Concentrations in Human Placental Tissue: Relationship between the Concentrations of Hg, As, Pb and Cd and the Diet of the Pregnant Woman.

Analysis of Toxic Heavy Metals in the Pellets of Owls: A Novel Approach for the Evaluation of Environmental Pollutants.

Microplastics/Nanomaterials

Microplastics and plastics-associated contaminants in food and beverages; Global trends, concentrations, and human exposure.

Miscellaneous

Characteristics of exposure to 10 polycyclic aromatic hydrocarbon metabolites among pregnant women: cohort of pregnant women in Zunyi, southwest China.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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EHN EHN

Lou Guillette Jr. Memorial Symposium
by Sarah Howard on December 16, 2024 at 3:52 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on December 16, 2024 at 3:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Webinar: EDC exposure and gonadal function: consequences and interventions
by Sarah Howard on December 16, 2024 at 3:36 pm
This two part webinar series is sponsored by the Endocrine Society's Special Interest Group (SIG) on endocrine disrupting chemicals (EDCs). The first webinar is scheduled for Jan. 30, 2025, and the second for Feb. 13.

EHN EHN

The plastics crisis: A neuropsychiatric problem hidden in plain sight
by EHN Curators on December 18, 2024 at 7:47 pm
The impact of plastics on health is an area of increasing concern.
Scientists lay out new framework to identify toxics contributing to metabolic disorders
by Katherine McMahon,Sarah Howard on December 17, 2024 at 10:00 am
A new consensus statement published in Nature Reviews Endocrinology proposes a set of 12 characteristics that can be used to identify metabolic-disrupting agents - chemicals, pharmaceuticals, and environmental hazards that increase the risk of metabolic disorders like diabetes and obesity. “This approach will enable a more comprehensive mechanistic understanding of how environmental chemicals and other agents disrupt metabolism and cause adverse outcomes.”
2024 Lou Guillette Jr Outstanding Young Investigator Award Winner: Dr. Chris Kassotis
by Sarah Howard on December 16, 2024 at 4:00 pm
Chris Kassotis, Ph.D., is the 2024 winner of the Lou Guillette, Jr. Outstanding Young Investigator Award, sponsored by Healthy Environment and Endocrine Disruptor Strategies (HEEDS). The award, in honor of scientist and mentor Lou Guillette, Jr., is given to an early-career scientist working in some aspect of endocrine disruptor research. The Kassotis lab focuses on understanding endocrine disrupting chemicals (EDCs) and mixtures, and their potential impacts on human and animal health, with a particular focus on metabolic health. He takes on critical public health issues, such as the health effects of chemicals found in fracking fluids and in artificial turf.

EHN EHN

Pesticide industry fights state efforts to regulate PFAS in farming
by EHN Curators on December 19, 2024 at 11:21 am
Pesticide trade groups are using lobbyists and grassroots networks to delay state laws aimed at curbing PFAS contamination in food and water, citing economic concerns. Lisa Held reports for Civil Eats.
Safe drinking water law marks 50 years, but challenges persist
by EHN Curators on December 19, 2024 at 11:19 am
Fifty years after the Safe Drinking Water Act became law, millions still lack reliable access to clean water, particularly in marginalized communities and small towns. Brett Walton reports for Circle of Blue.
RFK Jr. plans to eliminate fluoride in water, but states hold the power
by EHN Curators on December 18, 2024 at 11:47 am
President-elect Donald Trump's health appointee, Robert F. Kennedy Jr., aims to end fluoride in drinking water nationwide, but many states maintain mandates that the federal government cannot override. Hannah Recht reports for The Washington Post.