EDC Science Weekly, Nov. 22 – Dec. 5, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed over the past two weeks.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Science summaries and highlights

Events

Dec. 5 webinar: ECOTOX Knowledgebase and PFAS Updates [EPA]

Dec. 9 webinar: Behind the Scenes at EPA: What’s going wrong and what does it mean for our work? [CHE, Earthjustice, and UCSF’s EaRTH Center]

Mar. 14-15: Lou Guillette Jr. Symposium, in person at the University of Florida in Gainesville [HEEDS]

Apr. 27-29, 2025 conference: Break the Cycle of Children’s Environmental Health Disparities

May 21 – June 4, 2025 course: Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO) [applications due Jan 10, financial aid is available]

More events

Regulations/Policy

EPA braces for change under Trump.

Management of phthalates in Canada and beyond: can we do better to protect human health?

Systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency.

Evaluation of reproductive toxicology studies according the OECD Guidance Document 443 – claim and reality.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Advancing understanding of human variability through toxicokinetic modeling, in vitro-in vivo extrapolation, and new approach methodologies.

Human biomonitoring health-based guidance values: A case study of the HB2GV Dashboard and DEHP.

Enhancing reliability of embryo-fetal developmental toxicity studies: A proposed design of replicate studies.

Establishment of a cell culture from Daphnia magna as an in vitro model for (eco)toxicology assays: Case study using Bisphenol A as a representative cytotoxic and endocrine disrupting chemical.

Towards a risk assessment framework for micro- and nanoplastic particles for human health.

A comprehensive item bank of internal validity issues of relevance to in vitro toxicology studies

Commentaries

A plastics treaty is urgently needed, but getting it right will take time.

Plastics pollution: Talks collapse after oil producers resist limits.

A Call for Pediatric Clinicians to Address Environmental Health Concerns in Rural Settings.

Editorial: Environmental endocrine disruptors: mechanisms, implications, and advances in detection and mitigation in endocrinology. [intro to a Research Topic in Frontiers in Endocrinology]

Communicating risk in the face of data gaps: Toxic metals in tampons.

Designing a safer circular economy of chemicals.

Comprehensive risk-benefit assessment of chemicals: A case study on glyphosate.

Retraction notice to “A commentary on the paper “identification of microplastics in human placenta using laser direct infrared spectroscopy”: Reflections on identification and typing of microplastics in human biological samples” [Sci. Total Environ. 875 (2023) 162650]. [There are a number of additional retractions from this journal as well]

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Consensus on the key characteristics of metabolism disruptors.

Plastics pollution exacerbates the impacts of all planetary boundaries

Diabetes in China part 1: epidemiology and risk factors.

Exposure to Pollutants and Vaccines’ Effectiveness: A Systematic Review.

Hidden link between endocrine-disrupting chemicals and pediatric obesity.

Obesogens and Energy Homeostasis: Definition, Mechanisms of Action, Exposure and Adverse Effects on Human Health.

A review on sustainable management strategies for navigating the piling e-waste crisis and associated environmental threats.

BPA/Phenols

Impact of bisphenol A exposure on the risk of gestational diabetes: a meta-analysis of observational studies.

Phthalates

Association of Di(2-ethylhexyl) Phthalate Exposure with Reproductive Hormones in the General Population and the Susceptible Population: A Systematic Review and Meta-Analysis.

Phthalates Induced Neurotoxicity: A Mechanistic Approach.

PFAS

Latest trends in the environmental analysis of PFAS including nontarget analysis and EOF-, AOF-, and TOP-based methodologies.

Adverse outcome pathway for the neurotoxicity of Per- and polyfluoroalkyl substances: A systematic review.

Flame Retardants

Human toxicity of polybrominated diphenyl ethers (PBDEs) and their derivatives: A comprehensive review.

Molecular mechanisms of tetrabromobisphenol A (TBBPA) toxicity: Insights from various biological systems.

Pesticides

Pollution Characteristics, Environmental Issues, and Green Development of Neonicotinoid Insecticides in China: Insights from Imidacloprid.

Mechanisms of Neurotoxicity of Organophosphate Pesticides and Their Relation to Neurological Disorders.

Metals/Metalloids

Interplay Between Vitamin D Levels and Heavy Metals Exposure in Pregnancy and Childbirth: A Systematic Review.

Association of heavy metals and bio-elements blood level with metabolic syndrome: a systematic review and meta-analysis of observational studies.

Microplastics/Nanomaterials

Examining the hidden dangers: Understanding how microplastics affect pregnancy.

Environmental microplastic and phthalate esters co-contamination, interrelationships, co-toxicity and mechanisms. A review.

The Effects of Microplastics on Musculoskeletal Disorder; A Narrative Review.

Impact of microplastics exposure on liver health: A comprehensive meta-analysis.

Mechanistic paradigms of immunotoxicity, triggered by nanoparticles – a review.

Can Mammalian Reproductive Health Withstand Massive Exposure to Polystyrene Micro- and Nanoplastic Derivatives? A Systematic Review.

Plant-inspired building blocks for future plastics.

Unlocking the combined impact of microplastics and emerging contaminants on fish: A review and meta-analysis.

Potential health, environmental implication of microplastics: A review on its detection.

Miscellaneous

Additives in Processed Foods as a Potential Source of Endocrine-Disrupting Chemicals: A Review.

Advancements and Challenges in Nanoscale Zero-Valent Iron-Activated Persulfate Technology for the Removal of Endocrine-Disrupting Chemicals.

Recent and emerging food packaging alternatives: Chemical safety risks, current regulations, and analytical challenges.

Environmental occurrence, fate, human exposure, and human health risks of p-phenylenediamines and their quinones.

Human Health Studies

Numerous Chemicals/Mixtures

Reducing Exposures to Endocrine Disruptors (REED) study, a personalized at-home intervention program to reduce exposure to endocrine disrupting chemicals among a child-bearing age cohort: study protocol for a randomized controlled trial

Associations of per- and polyfluoroalkyl substances and heavy metals with blood lipid profiles in a representative sample of Korean adolescents.

Childhood exposure to non-persistent endocrine disruptors, glucocorticosteroids, and attentional function: A cross-sectional study based on the parametric g-formula.

Exploring environmental modifiers of LRRK2-associated Parkinson’s disease penetrance: An exposomics and metagenomics pilot study on household dust.

Environmental exposures and fecundability: The Norwegian Mother, Father, and Child Cohort study.

Association of environmental pollutants with asthma and allergy, and the mediating role of oxidative stress and immune markers in adolescents.

Dietary exposure to mixtures of chemicals in the first year of life and allergic and respiratory diseases up to 8 years in the French EDEN mother-child cohort.

BPA/Phenols

Exposure to alkylphenols during early pregnancy and the risk of gestational diabetes mellitus: Fetal sex-specific effects.

Prenatal bisphenol analogs exposure and placental DNA hypomethylation of genes in the PPAR signaling pathway: Insights for bisphenol analogs’ effects on infant anthropometry.

Prenatal exposure to environmental bisphenols over time and their association with childhood asthma, allergic rhinitis and atopic dermatitis in the ECHO consortium.

Phthalates

Distinct Impacts of Prenatal and Postnatal Phthalate Exposure on Behavioral and Emotional Development in Children Aged 1.5 to 3 Years.

Maternal Thyroid Hormones as Mediators between Phthalate Exposure and Neonatal Birth Weight: A Cross-Sectional Study from the Zunyi Birth Cohort.

Associations of Phthalate Exposure With Adiposity and Metabolic Syndrome in US Adolescents and Adults, NHANES 2013 to 2018.

Phthalate exposures, blood coagulation function, and assisted reproductive technology outcomes: Results from the TREE cohort study.

Associations Between Urinary Phthalate Metabolites and Decreased Serum α-Klotho Level: A Cross-Sectional Study Among US Adults in Middle and Old Age.

Adolescent urinary concentrations of phthalate metabolites and indices of overweight and cardiovascular risk in Dutch adolescents.

Parabens/Triclosan/Antimicrobials

SOCS3 Methylation Partially Mediated the Association of Exposure to Triclosan but Not Triclocarban with Type 2 Diabetes Mellitus: A Case-Control Study

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Mixtures of serum concentrations of organochlorine pesticides and breastfeeding duration.

Association between chronic long-term exposure to airborne dioxins and breast cancer.

The burden of cancer attributable to dietary dioxins and dioxin-like compounds exposure in China, 2000-2020.

Association Between Prenatal Exposure to Organochlorine Pesticides and Telomere Length in Neonatal Cord Blood.

The Interplay of Persistent Organic Pollutants and Mediterranean Diet in Association With the Risk of Gestational Diabetes Mellitus.

PFAS

Exposure to Per- and Polyfluoroalkyl Substances and Risk of Psoriasis: A Population-Based Study.

Kidney function mediates the effects of four per-and polyfluoroalkyl substances (PFAS) on atherosclerotic cardiovascular disease.

Integrated analysis of per- and polyfluoroalkyl substances and plasma lipidomics profiles in multi-ethnic Asian subjects for exposome research.

Associations of per- and polyfluoroalkyl substances and alternatives with subclinical hypothyroidism in children: A cross-sectional study in China.

Potential causal associations between perfluoroalkyl substances exposure and adverse pregnancy outcomes: A bidirectional two-sample mendelian randomization study.

Cord plasma metabolomic signatures of prenatal per- and polyfluoroalkyl substance (PFAS) exposures in the Boston Birth Cohort.

Flame Retardants

Organophosphate flame retardants associated with increased oxidative stress biomarkers and elevated FeNO levels in general population of children: The Hokkaido study.

Pesticides

Pyrethroid exposure biomarker 3-phenoxybenzoic acid (3-PBA) binds to transthyretin and is positively associated with free T3 in pregnant women.

Pesticides and risk of pancreatic adenocarcinoma in France: a nationwide spatiotemporal ecological study between 2011 and 2021.

Use of agrochemicals resulted in anemia and inflammation among farmers in Fako Division, Cameroon.

Associations between pesticide use and rheumatoid arthritis among older farmers in the Agricultural Health Study.

Metals/Metalloids

Urinary Metal Levels, Cognitive Test Performance, and Dementia in the Multi-Ethnic Study of Atherosclerosis.

Association between multiple metals exposure and metabolic dysfunction-associated fatty liver disease among Chinese adults.

Cancer incidence associations with drinking water arsenic levels and disinfection methods in Maine, USA.

Exposure to multiple metals and leukocyte telomere length in children and adolescents: The mediating effect of thyroid hormones.

Microplastics/Nanomaterials

Association between microplastics in human amniotic fluid and pregnancy outcomes: Detection and characterization using Raman spectroscopy and pyrolysis GC/MS.

Detection and Quantification of Microplastics in Endometrial Polyps and Their Role in Polyp Formation.

Air Pollution

Wildfire Smoke Exposure and Incident Dementia

Global, regional, and national mortality burden attributable to air pollution from landscape fires: a health impact assessment study.

Pharmaceuticals/Personal Care Products

Sunscreen use associated with elevated prevalence of anti-nuclear antibodies in U.S. adults.

Laboratory Studies

Numerous Chemicals/Mixtures

Effects of steroid hormones and their mixtures on western mosquitofish (Gambusia affinis).

Prenatal Exposure to a Human Relevant Mixture of Endocrine-Disrupting Chemicals Affects Mandibular Development in Mice

BPA/Phenols

Early ovarian differentiation in the tammar wallaby and the effects of exposure to bisphenol-A.

Protective effect of a novel furan hybrid chalcone against bisphenol A-induced craniofacial developmental toxicity in zebrafish embryos.

Thymoquinone inhibits Neuroinflammatory mediators and vasoconstriction injury via NF-κB dependent NeuN/GFAP/Ki-67 in hypertensive Dams and F1 male pups on exposure to a mixture of Bisphenol-A analogues.

A study on bisphenol induce renal damage and role of vitamin c as an antioxidant on bisphenol induced renal damage in wistar rats. A case control study.

Bisphenol B Exposure Promotes Melanoma Progression via Dysregulation of Lipid Metabolism in C57BL/6J Mice.

Toxic effects of chronic exposure to BPAF and perturbation of gut microbiota homeostasis in marine medaka (Oryzias melastigma).

The impact of bisphenol AF on skeletal muscle function and differentiation in vitro.

BPAP induces autism-like behavior by affecting the expression of neurodevelopmental genes in Drosophila melanogaster.

Gene Expression Modulation of Markers Involved in Bone Formation and Resorption by Bisphenol A, Bisphenol F, Bisphenol S, and Bisphenol AF

Early-life bisphenol A exposure causes detrimental age-related changes in anxiety, depression, learning, and memory in juvenile and adult male rats: Involvement of NMDAR/PSD-95-PTEN/AKT signaling pathway.

Phthalates

Adverse effects of diethyl phthalate and butyl benzyl phthalate on circadian rhythms and sleep patterns in zebrafish larvae.

Multi-omics revealed activation of TNF-α induced apoptosis signaling pathway in testis of DEHP treated prepubertal male rat.

Early-life exposure to di(2-ethylhexyl) phthalate impairs reproduction in adult female zebrafish (Danio rerio).

Parabens/Triclosan/Antimicrobials

Exposure of Porcine Oocytes to Methylparaben During In Vitro Maturation Alters the Expression of Genes Involved in Cumulus Cell Expansion and Steroidogenesis, Decreasing Hyaluronic Acid and Progesterone Synthesis.

Methyl Paraben Affects Porcine Oocyte Maturation Through Mitochondrial Dysfunction

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Dioxin-Induced PAI-1 Expression: A Novel Pathway to Pancreatic β-Cell Failure in Type 2 Diabetes

Low dose exposure to dioxins alters hepatic energy metabolism and steatotic liver disease development in a sex-specific manner.

PFAS

Specific and potent inhibition of steroid hormone pre-receptor regulator AKR1C2 by perfluorooctanoic acid: implications for androgen metabolism.

ACSL4-mediated ZIP7-VDAC3 interaction regulates endoplasmic reticulum-mitochondria iron transfer in hepatocytes under PFOS exposure.

Impact of Legacy Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoate (PFOA) on GABA Receptor-Mediated Currents in Neuron-Like Neuroblastoma Cells: Insights into Neurotoxic Mechanisms and Health Implications.

Investigating the Mechanism of Neurotoxic Effects of PFAS in Differentiated Neuronal Cells through Transcriptomics and Lipidomics Analysis.

Perfluorohexane sulfonate exposure caused multiple developmental abnormalities in early life of zebrafish.

Exploring Toxicity of Per- and Polyfluoroalkyl Substances (PFAS) Mixture Through ADMET and Toxicogenomic In Silico Analysis: Molecular Insights

Thyroid Hormone Neuroprotection Against Perfluorooctane Sulfonic Acid Cholinergic and Glutamatergic Disruption and Neurodegeneration Induction

Nicotinamide mononucleotide enhances the developmental potential of mouse early embryos exposed to perfluorooctanoic acid.

Impacts of hexafluoropropylene oxide tetrameric acid (HFPO-TeA) on neurodevelopment and GABAergic signaling in zebrafish larvae.

Flame Retardants

Distribution of Polybrominated Diphenyl Ethers (PBDEs) in Placental Tissues of Maternal and Fetal Origin in Exposed Wistar Rats and Associations with Thyroid Hormone Levels.

Exposure to brominated flame retardants in utero and through lactation delays the development of DMBA-induced mammary cancer: potential effects on subtypes?

Integrated Studies on Male Reproductive Toxicity of Decabromodiphenyl Ethane in Zebrafish Spermatozoa Ex Vivo, Male Zebrafish in Vivo, and GC-1 Cells in Vitro.

Cresyl diphenyl phosphate (a novel organophosphate ester) induces hepatic steatosis by directly binding to liver X receptor α: From molecule action to risk assessment.

Pesticides

Probing the potential mechanism of permethrin exposure on Alzheimer’s disease through enantiomer-specific network toxicology, multi-spectroscopic, and docking approaches.

Effects of environmentally relevant concentrations of glyphosate and aminomethylphosphonic acid on biotransformation and stress response proteins in the liver of zebrafish (Danio rerio).

Gender-Specific Toxic Effects of S-Metolachlor and Its Metabolite on Hibernating Lizards: Implications for Reproductive Health and Ecosystem Vulnerability.

Sex Difference in Histopathological and Steroidogenesis Metabolism of Zebrafish After Exposure to Spiromesifen.

Chlorpyrifos intermittent exposure enhances cardiovascular but not behavioural responses to contextual fear conditioning in adult rats: possible involvement of brain oxidative-nitrosative stress.

Effects of atrazine, diuron and glyphosate mixtures on zebrafish embryos: acute toxicity and oxidative stress responses.

Metals/Metalloids

Differentiated and mature neurons are more responsive to neurotoxicant exposure at both transcriptional and translational levels.

Multigenerational Impact of Chronic Exposure to Mercury Chloride on Maternal Care, Puberty, Fertility, and Hypothalamic Function in Female Mice.

Epicatechin as a promising agent against arsenic-induced neurobehavioral toxicity in NMRI mice: behavioral and biochemical alterations.

Gut microbiota perturbation and subsequent oxidative stress in gut and kidney tissues of zebrafish after individual and combined exposure to inorganic arsenic and fluoride.

Epigenetic dysregulation of H19/IGF2 in hepatic cells exposed to toxic metal mixtures in vitro.

Microplastics/Nanomaterials

Polystyrene microplastics exposure: Disruption of intestinal barrier integrity and hepatic function in infant mice.

Mitigation of polystyrene microplastic-induced hepatotoxicity in human hepatobiliary organoids through bile extraction.

Integration of transcriptomics and metabolomics reveal cytotoxic mechanisms of Polyethylene terephthalate microplastics in BEAS-2B cells.

Combined effect of polystyrene nanoparticles and chlorpyrifos to Daphnia magna.

Polystyrene microplastics induced spermatogenesis disorder via disrupting mitochondrial function through the regulation of the Sirt1-Pgc1α signaling pathway in male mice.

Female zebrafish are more affected than males under polystyrene microplastics exposure.

Nano-scale Dangers: Unravelling the Impact of Nanoplastics on Human Trophoblast Invasion.

Impacts of nanopolystyrene and/or phoxim exposure at environmentally relevant concentrations on the intestinal histopathology, intestinal microbiota, and metabolome in Eriocheir sinensis.

Polyethylene Terephthalate Microplastic Exposure Induced Reproductive Toxicity Through Oxidative Stress and p38 Signaling Pathway Activation in Male Mice.

Microplastic changes during the development of cervical cancer and its effects on the metabolomic profiles of cancer tissues.

Chronic exposure to polystyrene microplastics triggers osteoporosis by breaking the balance of osteoblast and osteoclast differentiation.

Gut-on-a-Chip Reveals Enhanced Peristalsis Reduces Nanoplastic-Induced Inflammation.

Revealing transport, uptake and damage of polystyrene microplastics using a gut-liver-on-a-chip.

Pharmaceuticals/Personal Care Products

Long-term impact of embryonic exposure to ethinylestradiol and clotrimazole on behavior and neuroplasticity in zebrafish (Danio rerio).

Miscellaneous

Acute exposure to diisopropylfluorophosphate in mice results in persistent cognitive deficits and alterations in senescence markers in the brain.

Network pharmacology and transcriptomics reveal androgen receptor as a potential protein target for 6PPD-quinone.

Chronic toxicity and intergenerational effects of N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD) exposure alone and in combination with Zn²⁺ on Daphnia magna (Cladocera).

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Study of Endocrine-Disrupting Chemicals in Infant Formulas and Baby Bottles: Data from the European LIFE-MILCH PROJECT.

The Exposure Status of Environmental Chemicals in South Korea: The Korean National Environmental Health Survey 2018-2020.

Nationwide human biomonitoring strategy in Korea: Prioritization of novel contaminants using GC/TOF-MS with suspect and non-target screening.

Comprehensive characterization of European house dust contaminants: Concentrations and profiles, geographical variability, and implications for chemical regulation and health risk.

Chemical mixtures of mercury, PCBs, PFAS/PFOS, and pesticides in freshwater fish in the US and the risks they pose for fish consumption.

BPA/Phthalates

A systematic evidence map protocol for mapping global exposure to bisphenols and their alternatives and social and environmental justice implications.

Assessment of bisphenol accumulation from disposable devices used sequentially in IVF routine procedures.

Comparison of urinary exposure profiles to phthalates and bisphenol analogues in kindergartens in Korea: Impact of environmental choices on children’s health.

Urinary profiles of bisphenol S derivatives and their exposure pathway analysis in maternal and infant populations of Beijing.

Global perspectives on indoor phthalates and alternative plasticizers: Occurrence and key transport parameters.

A comprehensive study on bisphenol A and estrogenic activity in the Paraíba do Sul River, São Paulo, Brazil.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Serum Dioxin Levels in a Subset of Participants of the East Palestine, Ohio Train Derailment Health Tracking Study.

PFAS

Per- and polyfluoroalkyl substances (PFAS): Trends in mass spectrometric analysis for human biomonitoring and exposure patterns from recent global cohort studies.

Concentrations and exposure risks of per- and polyfluoroalkyl substances in human milk from Southern China during the first 400 days of lactation.

Exploring Perfluoroalkyl Substances Contamination in Human Breast Milk: First Ghanaian Study.

Examining Potential PFAS Contamination of Private Wells from a High School in Rural Maine.

Spatial Variations in Per- and Polyfluoroalkyl Substance Concentrations in Pooled Sera from Inland, Coastal, and Island Populations.

Occurrence, migration, and assessment of human health and ecological risks of PFASs and EDCs in groundwater of Northeast China.

Photocatalytic low-temperature defluorination of PFASs.

Sources and Seasonal Variations of Per- and Polyfluoroalkyl Substances (PFAS) in Surface Snow in the Arctic.

Maternal transfer and sex-differences in brain bioaccumulation for Northern bobwhite quail (Colinus virginianus) exposed to per- and poly-fluoroalkyl substances.

Occurrence of per- and polyfluoroalkyl substances in wheat, maize, rice, and soybean from Chinese major grain producing regions.

Flame Retardants

Organophosphorus flame retardants in infant’s diets from Beijing, China: Detection and risk assessment.

Organophosphate Esters and Polybrominated Diphenyl Ethers in Vehicle Dust: Concentrations, Sources, and Health Risk Assessment.

Phosphorous flame-retardant concentration in Finnish daycares dust and children’s exposure.

Biomagnification of polybrominated diphenyl ethers and alternative halogenated flame retardants through food chains of yellowfin tuna (Thunnus albacares) and their prey from the South China Sea and the associated potential health risk.

Microplastics/Nanomaterials

Microplastics in stools and their influencing factors among young adults from three cities in China: a multicenter cross-sectional study.

Effects of polystyrene microplastics on the distribution behaviors and mechanisms of metalloid As(III) and As(V) on pipe scales in drinking water distribution systems.

Medical exposure to micro(nano)plastics: An exposure pathway with potentially significant harm to human health that should not be overlooked.

Pharmaceuticals/Personal Care Products

Pharmaceuticals in the environment: a strategy for prioritizing molecules of environmental concern.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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