EDC Science Weekly, Nov. 18 – 22, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week (distributed early this week due to Thanksgiving).

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Barriers to evidence use for sustainability: Insights from pesticide policy and practice.

Methods/Tools/Screening

Multi-omics signatures of the human early life exposome. [see the online Exposome-omics-Wide Association Study tool to query or download data from the Human Early Life Exposome (HELIX) Project]

Data curation to support toxicity assessments using the Integrated Chemical Environment.

Cancer Hazard Evaluations for Contemporary Needs: Highlights From New National Toxicology Program Evaluations and Methodological Advancements.

When a birth cohort grows up: challenges and opportunities in longitudinal developmental origins of health and disease (DOHaD) research.

Epidemiology meets toxicogenomics: Mining toxicologic evidence in support of an untargeted analysis of pesticides exposure and Parkinson’s disease.

Evaluating the utility of the Threshold of Toxicological Concern (TTC) and its exclusions in the biocompatibility assessment of extractable chemical substances from medical devices.

Commentaries

Common Misconceptions about PCBs Obscure the Crisis of Children’s Exposure in School.

Update of the WHO global air quality guidelines: Systematic reviews – An introduction. [intro to a special issue]

Clarifying a Foggy Picture: Moderate Air Pollution, Underlying Conditions, and Risk of COVID-19 Death. [Science Selection in EHP]

Reviews

Numerous Chemicals/Mixtures

The Pediatrician’s Role in Protecting Children from Environmental Hazards.

Endocrine disruptor chemicals as obesogen and diabetogen: Clinical and mechanistic evidence.

Drinking water and the implications for gender equity and empowerment: A systematic review of qualitative and quantitative evidence.

BPA/Phenols

An insight into bisphenol A, food exposure and its adverse effects on health: A review.

Perfluoroalkyl Substances

Association between per- and polyfluoroalkyl substances and semen quality.

Pesticides

Correlation between in vitro toxicity of pesticides and in vivo risk guidelines in support of complex operating site risk management: A meta-analysis.

Air Pollution

Impacts of Climate Change and Air Pollution on Neurologic Health, Disease, and Practice: A Scoping Review.

Human Health Studies

Numerous Chemicals/Mixtures

Childhood exposures to environmental chemicals and neurodevelopmental outcomes in congenital heart disease. [esp phthalates]

Effects of Lifetime Exposures to Environmental Contaminants on the Adult Gut Microbiome.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent organic pollutant exposure contributes to Black/White differences in leukocyte telomere length in the National Health and Nutrition Examination Survey.

Persistent organochlorine pesticides in periprostatic adipose tissue from men with prostate cancer: Ethno-geographic variations, association with disease aggressiveness.

Perfluoroalkyl Substances

Bone mass density following developmental exposures to perfluoroalkyl substances (PFAS): a longitudinal cohort study.

Metals/Metalloids

Non-essential and essential trace element mixtures and kidney function in early pregnancy – A cross-sectional analysis in project viva.

Association between serum folate concentrations and blood lead levels in adolescents: A cross-sectional study.

Relationship of multiple metals mixture and osteoporosis in older Chinese women: An aging and longevity study.

Sex-specific associations of the urinary fourteen-metal mixture with NAFLD and liver fibrosis among US adults: A nationally representative study.

Dietary metal intake and the prevalence of erectile dysfunction in US men: Results from National Health and Nutrition Examination Survey 2001-2004.

Air Pollution

Long-term residential exposure to source-specific particulate matter and incidence of diabetes mellitus – A cohort study in northern Sweden.

Using non-parametric Bayes shrinkage to assess relationships between multiple environmental and social stressors and neonatal size and body composition in the Healthy Start cohort.

Maternal Exposure to Fine Particulate Matter and Its Chemical Components Increasing the Occurrence of Gestational Diabetes Mellitus in Pregnant Japanese Women.

Laboratory Studies

Numerous Chemicals/Mixtures

Influence of furan and lead co-exposure at environmentally relevant concentrations on neurobehavioral performance, redox-regulatory system and apoptotic responses in rats.

Developmental exposure to thyroid disrupting chemical mixtures alters metamorphosis and post-metamorphic thymocyte differentiation.

Evaluation of (Anti)androgenic Activities of Environmental Xenobiotics in Milk Using a Human Liver Cell Line and Androgen Receptor-Based Promoter-Reporter Assay.

BPA/Phenols

Bisphenols A and F, but not S, induce apoptosis in bovine granulosa cells via the intrinsic mitochondrial pathway.

Effects of bisphenol A on human umbilical arteries.

Mechanism of bisphenol S exposure on color sensitivity of zebrafish larvae.

Exposure to bisphenol A induced oxidative stress, cell death and impaired epithelial homeostasis in the adult Drosophila melanogaster midgut.

Protective effects of cyanidin-3-O-glucoside on BPA-induced neurodevelopmental toxicity in zebrafish embryo model.

Biodegradation of high di-(2-Ethylhexyl) phthalate (DEHP) concentration by food waste composting and its toxicity assessment using seed germination test.

Phthalates

Evaluation of the toxicity of di-iso-pentyl-phthalate (DiPeP) using the fish Danio rerio as an experimental model.

Consequences of in vitro benzyl butyl phthalate exposure for blubber gene expression and insulin-induced Akt activation in juvenile grey seals.

Parabens/Triclosan/Antimicrobials

Triclosan exposure induced disturbance of gut microbiota and exaggerated experimental colitis in mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model.

Perfluoroalkyl Substances

Cumulative maternal and neonatal effects of combined exposure to a mixture of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) during pregnancy in the Sprague-Dawley rat.

The vitamin D receptor as a potential target for the toxic effects of per- and polyfluoroalkyl substances (PFASs): An in-silico study.

Assessment of unique behavioral, morphological, and molecular alterations in the comparative developmental toxicity profiles of PFOA, PFHxA, and PFBA using the zebrafish model system.

Molecular and genetic analyses revealed the phytotoxicity of perfluorobutane sulfonate.

Flame Retardants

Tetrabromobisphenol A effects on differentiating mouse embryonic stem cells reveals unexpected impact on immune system.

Bioavailability of non-aromatic brominated flame retardants in rats from dust and oil vehicles.

Parental whole life-cycle exposure to tris (2-chloroethyl) phosphate (TCEP) disrupts embryonic development and thyroid system in zebrafish offspring.

Pesticides

Exposure to the pesticides linuron, dimethomorph and imazalil alters steroid hormone profiles and gene expression in developing rat ovaries.

Tannic acid antagonizes atrazine exposure-induced autophagy and DNA damage crosstalk in grass carp hepatocytes via NO/iNOS/NF-κB signaling pathway to maintain stable immune function.

Developmental deltamethrin: Sex-specific hippocampal effects in Sprague Dawley rats.

Environmental exposure to triazole fungicide causes left-right asymmetry defects and contributes to abnormal heart development in zebrafish embryos by activating PPARγ-coupled Wnt/β-catenin signaling pathway.

Imidacloprid: Comparative toxicity, DNA damage, ROS production and risk assessment for aquatic non-target organisms.

Multi- and transgenerational synergistic effects of glyphosate and chlorpyrifos at environmentally relevant concentrations to the estuarine rotifer Proales similis.

Metals/Metalloids

Toxic effect of heavy metals on ovarian deformities, apoptotic changes, oxidative stress, and steroid hormones in rainbow trout.

Microplastics/Nanomaterials

Effect of size continuum from nanoplastics to microplastics on marine mussel Mytilus edulis: Comparison in vitro/in vivo exposure scenarios.

The significance of trophic transfer of microplastics in the accumulation of plastic additives in fish: An experimental study using brominated flame retardants and UV stabilizers.

Microplastics perturb colonic epithelial homeostasis associated with intestinal overproliferation, exacerbating the severity of colitis.

Tissue-specific accumulation, bioaccumulation, and depuration of liquid crystal monomers (LCMs) in adult zebrafish (Danio rerio).

Air Pollution

Wildfire Variable Toxicity: Identifying Biomass Smoke Exposure Groupings through Transcriptomic Similarity Scoring.

Miscellaneous

Sexually concordant and dimorphic transcriptional responses to maternal trichloroethylene and/or N-acetyl cysteine exposure in Wistar rat placental tissue.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Dynamic variation and inhalation exposure of organophosphates esters and phthalic acid esters in face masks.

Seasonal occurrence and risk assessment of endocrine-disrupting compounds in Tagus estuary biota (NE Atlantic Ocean coast).

BPA/Phenols

Evaluation of the bisphenol released in the saliva after residual adhesive removal in orthodontic patients by using ultrasonic scaling and rotary system: A single-center randomized clinical trial.

Phthalates

Occurrence of phthalate esters and preliminary data on microplastics in fish from the Tyrrhenian sea (Italy) and impact on human health.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Inhalation and dermal absorption as dominant pathways of PCB exposure for residents of contaminated apartment buildings.

Persistent organic pollutants in female humpback whales Megaptera novaeangliae from the gulf of Maine.

Perfluoroalkyl Substances

First Evidence of Prenatal Exposure to Emerging Poly- and Perfluoroalkyl Substances Associated with E-Waste Dismantling: Chemical Structure-Based Placental Transfer and Health Risks.

Adsorption of PFAAs in the Vadose Zone and Implications for Long-Term Groundwater Contamination.

The fate and behavior of perfluorooctanoic acid (PFOA) in constructed wetlands: Insights into potential removal and transformation pathway.

Biota-Sediment Accumulation Factors (BSAFs) for Per- and Polyfluorinated Substances (PFAS).

Critical review on phytoremediation of polyfluoroalkyl substances from environmental matrices: Need for global concern.

Pesticides

Urinary concentrations and determinants of glyphosate and glufosinate in pregnant Canadian participants in the MIREC study.

Challenges with the current methodology for conducting Endangered Species Act risk assessments for pesticides in the United States.

Combined effects of landscape composition and agrochemicals on frog communities amid sugarcane-dominated agroecosystems.

Metals/Metalloids

Chronic dietary exposure to total arsenic, inorganic arsenic and water-soluble organic arsenic species based on results of the first German total diet study.

Evaluation of water arsenic filter treatment in a participatory intervention to reduce arsenic exposure in American Indian communities: The strong heart water study.

Microplastics/Nanomaterials

Sponges as libraries: Increase in microplastics in Cinachyrella alloclada after 36 years.

Pharmaceuticals/Personal Care Products

Do Pharmaceuticals in the Environment Pose a Risk to Wildlife?

Neuroactive pharmaceuticals in estuaries: Occurrence and tissue-specific bioaccumulation in multiple fish species.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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