EDC Science Weekly, Nov. 11 – 17, 2020

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Online symposium: Endocrine Disruptors – Reduce the impact on our health Nov. 19

Webinars:

Environmental reproductive justice: Racial disparities in environmental pollution and chemical exposures Nov. 18

Promoting a Culture of Health through Racial Healing and Transformation Nov. 19

Are fluoropolymers really of low concern for human and environmental health and separate from other PFAS? Dec. 3

Methods/Tools/Screening

DEDuCT 2.0: An updated knowledgebase and an exploration of the current regulations and guidelines from the perspective of endocrine disrupting chemicals.

Bringing Big Data to Bear in Environmental Public Health: Challenges and Recommendations.

Commentaries/Conference Summaries

Ultraprocessed Food: Addictive, Toxic, and Ready for Regulation.

Breaking It Down: Estimating Short-Chain PFAS Half-Lives in a Human Population. [Science Selection in EHP]

Reviews

Numerous EDCs

Putative Involvement of Endocrine Disruptors in the Alzheimer’s disease Via the Insulin-Regulated Aminopeptidase / GLUT4 Pathway.

New frontiers of developmental endocrinology opened by researchers connecting irreversible effects of sex hormones on developing organs.

Pollutants and sperm quality: a systematic review and meta-analysis.

Perfluoroalkyl Substances

PFAS Thermal Destruction at Wastewater Treatment Facilities: A State of the Science Review.

Pesticides

The effect of diazinon on blood glucose homeostasis: a systematic and meta-analysis study.

Update on human exposure to glyphosate, with a complete review of exposure in children.

A comprehensive review on environmental toxicity of azole compounds to fish.

Application of Chiral and Achiral Supercritical Fluid Chromatography in Pesticide Analysis: A Review.

Potentially Toxic Elements

Comprehensive insights into arsenic- and iron-redox genes, their taxonomy and associated environmental drivers deciphered by a meta-analysis.

Microplastics

Gathering at the top? Environmental controls of microplastic uptake and biomagnification in freshwater food webs.

Plastic pollution in aquatic systems in Bangladesh: A review of current knowledge.

Microplastics in the coral reefs and their potential impacts on corals: A mini-review.

A review: Research progress on microplastic pollutants in aquatic environments.

Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature.

Microplastics and nanoplastics in the environment: Macroscopic transport and effects on creatures.

Air Pollution

Systematic Review and Meta-Analysis of Recent High-Quality Studies on Exposure to Particulate Matter and Risk of Lung Cancer.

Exposure to air pollutants and risk of congenital anomalies: A systematic review and metaanalysis.

Miscellaneous

Sex differences in COVID-19: the role of androgens in disease severity and progression.

A review on effective removal of emerging contaminants from aquatic systems: Current trends and scope for further research.

Impact of Parental Exposure on Offspring Health in Humans.

Human Health Studies

Numerous Chemicals

Associations between polyfluoroalkyl substance and organophosphate flame retardant exposures and telomere length in a cohort of women firefighters and office workers in San Francisco.

Thyroid Receptor Antagonism of Chemicals Extracted from Personal Silicone Wristbands within a Papillary Thyroid Cancer Pilot Study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations of PCBS, dioxins and furans with follicle-stimulating hormone and luteinizing hormone in postmenopausal women: National Health and Nutrition Examination Survey 1999-2002.

Perfluoroalkyl Substances

Per- and polyfluoroalkyl substance mixtures and gestational weight gain among mothers in the Health Outcomes and Measures of the Environment study.

Associations between serum isomers of perfluoroalkyl acids and metabolic syndrome in adults: Isomers of C8 Health Project in China.

Associations between apolipoprotein B and selected perfluoroalkyl substances among diabetics and nondiabetics.

Association between exposure to polyfluoroalkyl chemicals and increased fractional exhaled nitric oxide in adults.

Pesticides

Prospective association between organic food consumption and the risk of type 2 diabetes: findings from the NutriNet-Santé cohort study.

Mixture of Organophosphates Chronic Exposure and Pancreatic Dysregulations in Two Different Population Samples.

Association of activities related to pesticide exposure on headache severity and neurodevelopment of school-children in the rural agricultural farmlands of the Western Cape of South Africa.

Potentially Toxic Elements

A Benchmark Dose Analysis for Maternal Pregnancy Urine-Fluoride and IQ in Children.

Clinical biochemical parameters associated with the exposure to multiple environmental metals in residents from Kabwe, Zambia.

Relationship between blood Lead status and anemia in Ugandan children with malaria infection.

Interaction between a Mixture of Heavy Metals (Lead, Mercury, Arsenic, Cadmium, Manganese, Aluminum) and GSTP1, GSTT1, and GSTM1 in Relation to Autism Spectrum Disorder.

Blood Transcriptome Response to Environmental Metal Exposure Reveals Potential Biological Processes Related to Alzheimer’s Disease.

Air Pollution

Prenatal Fine Particulate Matter (PM_2.5) Exposure and Pregnancy Outcomes-Analysis of Term Pregnancies in Poland.

Association between exposure to airborne particulate matter less than 2.5 μm and human fecundity in China.

Pollutant-sex specific differences in respiratory hospitalization and mortality risk attributable to short-term exposure to ambient air pollution.

Incident cardiovascular disease and particulate matter air pollution in South Korea using a population-based and nationwide cohort of 0.2 million adults.

Fine particulate matter constituents and sub-clinical outcomes of cardiovascular diseases: A multi-center study in China.

The Association between Air Pollution and Hospitalization for Patients with Systemic Lupus Erythematosus in Chile: A daily time series analysis.

Air pollution and noncognitive traits among Chinese adolescents.

The association of urinary metabolites of polycyclic aromatic hydrocarbons with obstructive coronary artery disease: A red alert for action.

Air pollutants and risk of death due to COVID-19 in Italy.

Pharmaceuticals/Personal Care Products

Markers of oxidative stress after three days of nanoTiO₂ sunscreen use in humans: a pilot study.

Miscellaneous

Prenatal androgen exposure and children’s gender-typed behavior and toy and playmate preferences.

Laboratory Studies

BPA/Phenols

Evaluation of the effects of low nanomolar bisphenol A-like compounds’ levels on early human embryonic development and lipid metabolism with human embryonic stem cell in vitro differentiation models.

The effect of hormonal levels and oxidative stress on bisphenol A and soy isoflavone reproductive toxicity in murine offspring.

Transgenerational effects on intestinal inflammation status in mice perinatally exposed to bisphenol S.

The chemical environmental pollutants BPA and BPS induce alterations of the proteomic profile of different phenotypes of human breast cancer cells: A proposed interactome.

Developmental neurotoxicity of low concentrations of bisphenol A and S exposure in zebrafish.

Bisphenol AF induces apoptosis via estrogen receptor beta (ERβ) and ROS-ASK1-JNK MAPK pathway in human granulosa cell line KGN.

Phthalates

Diethylhexyl phthalate induces teratogenic effects through oxidative stress response in a chick embryo model.

Protective effects of Lactobacillus plantarum strain P1 against toxicity of the environmental oestrogen di-n-butyl phthalate in rats.

Parabens/Triclosan/Antimicrobials

Long-term exposure to triclosan increases migration and invasion of human breast epithelial cells in vitro.

Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models.

Perfluoroalkyl Substances

Thyroid disrupting effects of perfluoroundecanoic acid and perfluorotridecanoic acid in zebrafish (Danio rerio) and rat pituitary (GH3) cell line.

Perfluorooctanoic acid-induced cellular and subcellular alterations in fish hepatocytes.

Flame Retardants

Hippocampal proteomic analysis reveals the disturbance of synaptogenesis and neurotransmission induced by developmental exposure to organophosphate flame retardant triphenyl phosphate.

Probing the Mechanism of Hepatotoxicity of Hexabromocyclododecanes through Toxicological Network Analysis.

Pesticides

Assessing the combined toxicity of carbamate mixtures as well as organophosphorus mixtures to Caenorhabditis elegans using the locomotion behaviors as endpoints.

Investigation of oxidative stress enzymes and histological alterations in tilapia exposed to chlorpyrifos.

Morpho-Functional Alterations in the Gills of a Seawater Teleost, the Ornate Wrasse (Thalassoma pavo L.), after Short-Term Exposure to Chlorpyrifos.

Lufenuron induces reproductive toxicity and genotoxic effects in pregnant albino rats and their fetuses.

Toxicity of the herbicides diuron, propazine, tebuthiuron, and haloxyfop to the diatom Chaetoceros muelleri.

Acetamiprid-induced Cyto- and Genotoxicity in the AR42J Pancreatic Cell Line.

Simulation of hemo- and biochemical toxicities associated with chronic inhalation exposure to 2,2-DichloroVinyl Dimethyl Phosphate (DDVP) in Wistar rat.

Paraquat exposure over generation affects lifespan and reproduction through mitochondrial disruption in C. elegans.

A mixture of pesticides at environmental concentrations induces oxidative stress and cholinergic effects in the neotropical fish Rhamdia quelen.

Potentially Toxic Elements

Cadmium chloride-induced transgenerational neurotoxicity in zebrafish development.

Cadmium-stimulated invasion of rat liver cells during malignant transformation: Evidence of the involvement of oxidative stress/TET1-sensitive machinery.

Evaluation of transgenerational effects caused by metals as environmental pollutants in Daphnia magna.

Impact of prenatal arsenic exposure on the testes and epididymides of prepubertal rats.

The role of endoplasmic reticulum stress in lead (Pb)-induced mitophagy of HEK293 cells.

Intraspecific variability of responses to combined metal contamination and immune challenge among wild fish populations.

Microplastics/Nanomaterials

Effects of Ocean Acidification and Microplastics on Microflora Community Composition in the Digestive Tract of the Thick Shell Mussel Mytilus coruscus Through 16S RNA Gene Sequencing.

Effects of nanoplastics on energy metabolism in the oriental river prawn (Macrobrachium nipponense).

Proinflammatory properties and lipid disturbance of polystyrene microplastics in the livers of mice with acute colitis.

Environmentally relevant concentrations and sizes of microplastic do not impede marine diatom growth.

Investigate the influence of microplastics weathering on their heavy metals uptake in stormwater.

Response of Coral Reef Dinoflagellates to Nanoplastics under Experimental Conditions Suggests Downregulation of Cellular Metabolism.

Impacts of microplastics on three different juvenile shrimps: Investigating the organism response distinction.

Intestinal mitochondrial unfolded protein response induced by nanoplastic particles in Caenorhabditis elegans.

Polystyrene microplastics alter the intestinal microbiota function and the hepatic metabolism status in marine medaka (Oryzias melastigma).

Mixtures

Influence of multi-walled carbon nanotubes on enantioselective bioaccumulation and oxidative stress toxicity of indoxacarb in zebrafish(Danio rerio).

Alterations in the Gut Microbiota of Zebrafish (Danio rerio) in Response to Water-Soluble Crude Oil Components and Its Mixture With a Chemical Dispersant.

Miscellaneous

Chronic Exposure to Environmental Level Phenanthrene Induces Non-Obesity-Dependent Insulin Resistance in Male Mice. [a PAH]

Monohaloacetonitriles induce cytotoxicity and exhibit different mode of action in endocrine disruption. [disinfection by-products]

Exposure/Environment Studies

BPA/Phenols

Study on the Release Potential of BPA and Steroid Estrogens in the Sediments of Erhai Lake, a Typical Plateau Lake of China.

Occurrence and Fate of Bisphenol A and its Congeners in Two Wastewater Treatment Plants and Receiving Surface Waters from Romania.

The sinking behavior of micro-nano particulate matter for bisphenol analogues in the surface water of an ecological demonstration zone, China.

Phthalates

Biomonitoring of emerging DINCH metabolites in pregnant women in charleston, SC: 2011-2014.

Phthalates and organophosphate esters in surface water, sediments and zooplankton of the NW Mediterranean Sea: Exploring links with microplastic abundance and accumulation in the marine food web.

Parabens/Triclosan/Antimicrobials

Parabens in personal care products and indoor dust from Hanoi, Vietnam: Temporal trends, emission sources, and non-dietary exposure through dust ingestion.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Human biomonitoring results of contaminant and nutrient biomarkers in Old Crow, Yukon, Canada. [POPs and metals]

Wild boar (Sus scrofa) as bioindicator for environmental exposure to organic pollutants.

Atmospheric concentrations and temporal trends of polychlorinated biphenyls and organochlorine pesticides in the Arctic during 2011-2018.

Dioxins and dioxin-like PCBs in the ambient air of the Valencian Region (Spain): Levels, human exposure, and risk assessment.

Perfluoroalkyl Substances

Occurrence and seasonal distribution of legacy and emerging per- and polyfluoroalkyl substances (PFASs) in different environmental compartments from areas around ski resorts in northern China.

Perfluoroalkyl acid (PFAA) profile and concentrations in two co-occurring tit species: distinct differences indicate non-generalizable results across passerines.

A method for detecting perfluorooctanoic acid and perfluorooctane sulfonate in water samples using genetically engineered bacterial biosensor.

Facing the Challenge of Poly- and Perfluoroalkyl Substances in Water: Is Electrochemical Oxidation the Answer?

Flame Retardants

Temporal variability of organophosphate flame retardant metabolites in spot, first morning, and 24-h urine samples among healthy adults.

Can Silicone Passive Samplers be Used for Measuring Exposure of e-Waste Workers to Flame Retardants?

Pesticides

Use of post-registration monitoring data to evaluate the ecotoxicological risks of pesticides to surface waters: a case study with chlorpyrifos in the Iberian Peninsula.

Cascading effects of insecticides and road salt on wetland communities.

Potentially Toxic Elements

Arsenic and lead in the indoor residential settings of different socio-economic status; assessment of human health risk via dust exposure.

Seasonal variations in exposure to methylmercury and its dietary sources among pregnant Inuit women in Nunavik, Canada.

Dietary exposure assessment of methylmercury and polyunsaturated fatty acids in saltwater fish and processed foods among Taiwanese women of child-bearing age and children: A novel core food-matching approach.

Monthly variations in mercury exposure of school children and adults in an industrial area of southwestern China.

Mercury consumption and human health: Linking pollution and social risk perception in the southeastern United States.

Inorganic elements in live vs dead nesting olive ridley marine turtles in the Mexican Pacific: Introducing a new statistical methodology in ecotoxicology.

A synthesis of patterns of environmental mercury inputs, exposure and effects in New York State.

Occupational human exposure to mercury in artisanal small-scale gold mining communities of Colombia.

Integrating active and passive monitoring to assess sublethal effects and mortality from lead poisoning in birds of prey.

An upwelling area as a hot spot for mercury biomonitoring in a climate change scenario: A case study with large demersal fishes from Southeast Atlantic (SE-Brazil).

Microplastics

Microplastics as vectors of the antibiotics azithromycin and clarithromycin: Effects towards freshwater microalgae.

A Relevant Screening of Organic Contaminants Present on Freshwater and Pre-Production Microplastics.

Investigation of microplastics contamination in drinking water of a German city.

Air Pollution

Two communities, one highway and the fight for clean air: the role of political history in shaping community engagement and environmental health research translation.

Air pollution caused by phthalates and cyclic siloxanes in Hanoi, Vietnam: Levels, distribution characteristics, and implications for inhalation exposure.

Impact of Covid-19 lockdown on air quality in the Poland, Eastern Europe.

Pharmaceuticals/Personal Care Products

Veterinary antibiotics and estrogen hormones in manures from concentrated animal feedlots and their potential ecological risks.

Miscellaneous

Integrating environmental justice into applied ecology research: Somebody else’s problem?

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.