EDC Science Weekly, Nov. 1-7, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Science summaries and highlights

Events

Nov. 12 webinar: Plastics Treaty Negotiations: Who has a seat at the table? [CHE-Alaska]

Nov. 13 webinar: The Overturning of Chevron Deference: Impacts on Environmental Health Decision Making [CHE and UCSF’s EaRTH Center]

Nov. 14 webinar: Strengthening the Health Aspects of the Future Plastics Treaty [WHO, HCWH, IPEN, Geneva Environment Network]

Nov. 21 webinar: Introduction to ECHA’s guidance on new CLP hazard classes [ECHA]

Dec. 3 webinar: Fluoride, Neurodevelopment, and Cognition: A National Toxicology Program monograph [EDC Strategies Partnership]

Dec. 9 webinar, save the date: Behind the Scenes at EPA: What’s going wrong? [CHE and UCSF’s EaRTH Center]

April 27-29, 2025 conference: Break the Cycle of Children’s Environmental Health Disparities

May 21 – June 4, 2025 course: Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO) [applications due Jan 10, financial aid is available]

More events

Regulations/Policy

Endocrine-disrupting chemicals – pesticide regulatory issues from the EU perspective

Orchestration within plastics governance – From global to Arctic.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Cumulative Health Risk from Exposure Load (CHREL): Looking at multi-chemical exposures through the lens of biomonitoring guidance values.

Assessing plasmatic transport inhibitors of thyroid hormone in mammals in the Xenopus Eleutheroembryonic Thyroid Assay (XETA).

Statistical Applications of Virtual Control Groups to Nonrodent Animal Toxicity Studies: an Initial Evaluation.

A new approach methodology to identify tumorigenic chemicals using short-term exposures and transcript profiling.

Quantitative read-across structure-property relationship (q-RASPR): a novel approach to estimate the bioaccumulative potential for diverse classes of industrial chemicals in aquatic organisms.

Towards realism in hazard assessment of plastic and rubber leachates – Methodological considerations.

Is there any added value of the second generation in the Extended One-Generation Reproductive Toxicity Study (EOGRTS)? A retrospective analysis of 24 EOGRTS.

Commentaries

Making invisible chemicals used in plastic materials visible.

Why medical products must not be excluded from the Global Plastics Treaty

Gut Check: Microbiota and Obesity in Mice Exposed to Polystyrene Microspheres. [Science Selection in EHP]

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Obesogenic effects of six classes of emerging contaminants.

Protecting our future: environmental hazards and children’s health in the face of environmental threats: a comprehensive overview.

Prenatal exposure to synthetic chemicals in relation to HPA Axis activity: A systematic review of the epidemiological literature.

Environmental pollution and cancer.

Evaluation of organ developmental toxicity of environmental toxicants using zebrafish embryos.

Phthalates

Phthalate exposure and reproductive effects in rodents: a model for approaches on the protective role of natural products.

Parabens/Triclosan/Antimicrobials

A systematic review and meta-analysis of the impact of triclosan exposure on human semen quality.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Environmental fate and transformation mechanisms of chlorinated organic pollutants from the petrochemical industry: Insights for pollution control and remediation.

Pesticides

State of nano pesticides application in smallholder agriculture production systems: Human and environmental exposure risk perspectives.

Metals/Metalloids

Unraveling the role of heavy metals xenobiotics in cancer: a critical review.

Microplastics/Nanomaterials

Micro(nano)plastics: an Emerging Burden for Human Health.

Global soil microplastic assessment in different land-use systems is largely determined by the method of analysis: A meta-analysis.

Microplastic and antibiotics in waters: Interactions and environmental risks.

Recent advances in mechanistic insights into microplastics mitigation strategies via emerging advanced oxidation processes: Legislation, challenges, and future direction.

Microplastics in the environment: A critical overview on its fate, toxicity, implications, management, and bioremediation strategies.

Micro/nano plastics in the urinary system: Pathways, mechanisms, and health risks.

Waste to wealth: Polyhydroxyalkanoates (PHA) production from food waste for a sustainable packaging paradigm.

Production of biodegradable food packaging from mango peel via enzymatic hydrolysis and polyhydroxyalkanoates synthesis: A review on microbial intervention.

Meta-analysis shows that microplastics affect ecosystem services in terrestrial environments.

Miscellaneous

Priorities to inform research on tire particles and their chemical leachates: A collective perspective.

Environmental Exposure Inequities Among Sexual and Gender Minority Populations in the United States: A Scoping Review.

Human Health Studies

Numerous Chemicals/Mixtures

The associations between exposure to mixed environmental endocrine disruptors and sex steroid hormones in men: a comparison of different statistical models.

Elucidation of endogenous and exogenous chemicals in maternal serum using high-resolution mass spectrometry.

Associations of maternal and paternal preconception and maternal pregnancy urinary phthalate biomarker and bisphenol A concentrations with offspring autistic behaviors: The PEACE study.

BPA/Phenols

Exposure to alkylphenols during early pregnancy and the risk of gestational diabetes mellitus: Fetal sex-specific effects.

Phthalates

Associations between pre- and post-natal exposure to phthalate and DINCH metabolites and gut microbiota in one-year old children.

Gestational phthalate exposure and behavioral problems in preschool-aged children with increased likelihood of autism spectrum disorder.

Parabens/Triclosan/Antimicrobials

Trimester-specific exposure to triclocarban during pregnancy: Associations with oxidative stress and size at birth.

PFAS

Mid-Childhood Plasma Concentrations of Per- and Polyfluoroalkyl Substances, Modifiable Lifestyle Factors, and Bone Mineral Density Through Late Adolescence.

Relationship between per-fluoroalkyl and polyfluoroalkyl substance exposure and insulin resistance in nondiabetic adults: Evidence from NHANES 2003-2018.

Association between Serum Per- and polyfluoroalkyl Substances Levels and Metabolic Dysfunction-associated Steatotic Liver Disease.

Flame Retardants

The association between brominated flame retardants exposure with Parkinson’s disease in US adults: a cross-sectional study of the National Health and Nutrition Examination Survey 2009-2016.

Pesticides

Pesticide Exposure and Its Association with Parkinson’s Disease: A Case-Control Analysis.

Exposure to the herbicide 2,4-dichlorophenoxyacetic acid and prostate cancer among U.S. adult men.

Pesticides and prostate cancer incidence and mortality: An environment-wide association study.

Prenatal exposure to neonicotinoid insecticides, fetal endocrine hormones and birth size: Findings from SMBCS.

Metals/Metalloids

Prenatal metal exposures and kidney function in adolescence in Project Viva.

Associations of multiple metals exposure with immunoglobulin levels in pregnant women: Hangzhou Birth Cohort Study.

Association of Chronic Arsenic Exposure with Cellular Immune Profile in MINIMat Adolescents: A Birth Cohort in Bangladesh.

Associations between prenatal exposure to metal mixtures and infant reproductive hormones during mini-puberty.

Association between exposure to arsenic and the risk of cardiovascular disease: Potential role of vascular endothelial injury.

Air Pollution

Prenatal exposure to air pollution during the early and middle stages of pregnancy is associated with adverse neurodevelopmental outcomes at ages 1 to 3 years.

Miscellaneous

Environmental Health Assessment by Local Environmental Justice Experts for Evidence-based Decision-making in an Agricultural Community of Northern California.

Laboratory Studies

Numerous Chemicals/Mixtures

Epigenetic transgenerational inheritance of toxicant exposure-specific non-coding RNA in sperm.

BPA/Phenols

The effects of 17β-trenbolone and bisphenol A on sexual behavior and social dominance via the hypothalamic-pituitary-gonadal axis in male mice.

Cucumeropsis mannii seed oil (CMSO) restores testicular mitochondrial dysfunctions by modulating the activities of dysregulated testicular mitochondrial enzymes in male albino rats exposed to bisphenol A.

Influence of bisphenol A and its analogues on human gut microbiota composition and metabolic activity: Insights from an in vitro model.

Bisphenol S exposure promoted stemness of triple-negative breast cancer cells via regulating Gli1-mediated Sonic hedgehog pathway.

The combined use of biological investigations, bio chromatographic and in silico methods to solve the puzzle of BADGE and its derivative’s toxicity.

Nonylphenol and Cetyl Alcohol Polyethoxylates Disrupt Thyroid Hormone Receptor Signaling to Disrupt Metabolic Health.

Phthalates

Dibutyl phthalate disrupts [Ca²⁺]_i, reactive oxygen species, [pH]_i, protein kinases and mitochondrial activity, impairing sperm function.

Shatavarin-IV rescues the Di (2-ethylhexyl) phthalate (DEHP) induced oxidative stress in rat granulosa cells in vitro.

piRNA array analysis provide insight into the mechanism of DEHP-induced testicular toxicology in pubertal male rats.

Parabens/Triclosan/Antimicrobials

Long-term exposure to triclocarban induces splenic injuries in mice: Insights from spatial metabolomics and lipidomics.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Disruption of canonical AHR-mediated induction of hepatocyte PKM2 expression compromises antioxidant defenses and increases TCDD-induced hepatotoxicity.

PFAS

Analyzing the impact of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) on the reproductive system using network toxicology and molecular docking.

Perfluorooctane sulfonate (PFOS), a novel environmental pollutant, induces liver injury in mice by activating hepatocyte ferroptosis.

Comparative Proteomics Highlights that GenX Exposure Leads to Metabolic Defects and Inflammation in Astrocytes.

Flame Retardants

A comprehensive evaluation of the endocrine-disrupting effects of emerging organophosphate esters.

The effect of tris (1,3-dichloro-2-propyl) phosphate on the early embryonic heart development of Oryzias melastigma.

Exposure to an environmentally representative mixture of polybrominated diphenyl ethers (PBDEs) alters zebrafish neuromuscular development.

Decabromodiphenyl ethane (DBDPE) inhibited the growth and feeding by disrupting the gut and digestive gland homeostasis in octopus Amphioctopus fangsiao (Mollusca: Cephalopoda).

Organotins

Tributyltin Enhances Macrophage Inflammation and Lipolysis, Contributing to Adipose Tissue Dysfunction.

Pesticides

Vitamin E improves oxidative stress, apoptosis, and steroidogenesis impairment in glyphosate-induced mice.

Effects of thiacloprid, a neonicotinoid pesticide, on rat reproductive system: Pregnancy hormone disruption and abortion trends.

Peripubertal exposure to oxyfluorfen, a diphenyl herbicide, delays pubertal development in the male rat by antagonizing androgen receptor activity.

Microplastics/Nanomaterials

Unveiling the Heart’s Hidden Enemy: Dynamic Insights into Polystyrene Nanoplastic-Induced Cardiotoxicity Based on Cardiac Organoid-on-a-Chip.

Negative effects of polyvinyl chloride microplastics and the plasticizer DnOP on earthworms: Co-exposure enhances oxidative stress and immune system damage in earthworms.

Comparison of biofilm-covered microplastics and sand particles as vectors of PCB-153 to Paracentrotus lividus.

Adsorption of neonicotinoid insecticides by mulch film-derived microplastics and their combined toxicity.

Multigenerational effects of combined exposure of triphenyltin and micro/nanoplastics on marine medaka (Oryzias melastigma): From molecular levels to behavioral response.

Polyethylene microplastics affect behavioural, oxidative stress, and molecular responses in the Drosophila model.

Are Biobased Microfibers Less Harmful than Conventional Plastic Microfibers: Evidence from Earthworms.

Combined ecotoxicity of polystyrene microplastics and Di-(2-ethylhexyl) phthalate increase exposure risks to Mytilus coruscus based on the bioaccumulation, oxidative stress, metabolic profiles, and nutritional interferences.

Coexposure to microplastic and Bisphenol A exhacerbates damage to human kidney proximal tubular cells.

Air Pollution

Exposure of RAW264.7 macrophages to exhaust emissions (gases and PAH) and non-exhaust emissions (tire particles) induces additive or synergistic TNF-α production depending on the tire particle size.

Pharmaceuticals/Personal Care Products

Investigation into the Quantitative Structure-Biotoxicity Relationship of Antibiotics and their Estrogenic Receptor Disruption Effects.

Endocrine-Disrupting Effects of Salicylate Preservatives on Neurosteroidogenesis: Targeting 5α-Reductase Type 1.

Miscellaneous

Transgenerational intestinal toxicity of 6-PPD quinone in causing ROS production, enhancement in intestinal permeability and suppression in innate immunity in C. elegans.

Transgenerational response of glucose metabolism in Caenorhabditis elegans exposed to 6-PPD quinone.

Tire rubber-derived contaminant 6PPD had the potential to induce metabolism disorder in early developmental stage of zebrafish.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

PFAS, PCBs, PCDD/Fs, PAHs and extractable organic fluorine in bio-based fertilizers, amended soils and plants: Exposure assessment and temporal trends.

BPA/Phenols

National investigation of bisphenols in the surface soil in China.

Phthalates

Distribution of phthalate esters and their metabolites in peanut plant during the entire growth period and their dietary risk assessment of peanuts in China.

Exploring the use of gull eggs as bioindicators of phthalate esters exposure.

Phthalate ester and cholesterol profiles of blubber samples of the free-ranging Amazon River dolphin (Cetacea: Iniidae: Inia geoffrensis) in the Brazilian Amazon.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Quantification of persistent organic pollutants in breastmilk and estimated infant intake, Norway.

Feeding and biological differences induce wide variation in legacy persistent organic pollutant concentrations among toothed whales and polar bear in the Arctic.

PFAS

A Prospective Analysis of Per- and Polyfluoroalkyl Substances from Early Pregnancy to Delivery in the Atlanta African American Maternal-Child Cohort.

Exposure to and Transplacental Transfer of Per- and Polyfluoroalkyl Substances in a Twin Pregnancy Cohort in Korea.

The trends of per-and polyfluoroalkyl substances (PFAS) in drinking water systems in Maryland United States.

Suspect and non-target screening of per- and polyfluoroalkyl substances (PFAS) and other halogenated substances in electrochemically oxidized landfill leachate and groundwater.

Leachability of per- and poly-fluoroalkyl substances from contaminated concrete.

Flame Retardants

Human Biomonitoring of Serum Polybrominated Diphenyl Ethers by Supported Liquid Extraction and Gas Chromatography Coupled With Tandem Mass Spectrometry.

Dietary and Terrestrial Exposure to Methoxylated Polybrominated Diphenoxybenzene Contaminants in Great Lakes Herring Gulls.

Brominated flame retardant in animal feeds from Poland.

Pesticides

Concentrations of Neonicotinoid insecticides and their metabolites in multiple urine samples collected from pregnant women in Japan.

Metals/Metalloids

Effect of Adopting a Gluten-Free Diet on Exposure to Arsenic and Other Heavy Metals in Children With Celiac Disease: A Prospective Cohort Study.

Assessing the sustainability and safety of polyethylene terephthalate (PET) liners for lead service lines (LSL) upgrades.

Microplastics/Nanomaterials

Emerging investigator series: open dumping and burning: an overlooked source of terrestrial microplastics in underserved communities.

High frequency of plastic ingestion in procellariiform seabirds (albatrosses, petrels and shearwaters) in the Southwest Atlantic Ocean.

Quantification of textile microfibers from laundry wastewater using the Rock-Eval® device: Difference between natural and synthetic microfiber origin.

The Impact of Microplastics on Lake Communities: A Mesocosm Study.

Nature-based solutions to the management of legacy plastic pollution: Filter-feeders as bioremediation tools for coastal microplastics.

Possible hazards from biodegradation of soil plastic mulch: Increases in microplastics and CO₂ emissions.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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