EDC Science Weekly, May 5 – 11, 2021

Post author:HEEDS
Post published:May 11, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Interesting Article, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Today! May 11 Webinar: Suspect Screening, Prioritization, and Confirmation of Environmental Chemicals in Maternal-Newborn Pairs from San Francisco (EDC Strategies Partnership)

May 21 Virtual Town Hall: How Toxic Chemicals are Causing DIsastrous Consequences for Human Reproduction and Other Species (Center for Environmental Health)

Interesting Article of the Week

Confronting Racism in Environmental Health Sciences: Moving the Science Forward for Eliminating Racial Inequities.

Methods/Tools/Screening

Estrogenicity of chemical mixtures revealed by a panel of bioassays.

Exploring Potential Carcinogenic Activity of Per- and Polyfluorinated Alkyl Substances Utilizing High-Throughput Toxicity Screening Data.

Experimental liver models: from cell culture techniques to microfluidic organs-on-chip.

Data analysis strategies for the characterization of chemical contaminant mixtures. Fish as a case study.

SpheraCosmolife: a new tool for the risk assessment of cosmetic products.

Commentaries/Conference Summaries

Microplastics are everywhere – but are they harmful? [News feature in Nature]

Lead and Cadmium as Cardiovascular Risk Factors: The Burden of Proof Has Been Met.

JAHA Spotlight on Air Pollution and Cardiovascular Disease: A Call for Urgent Action. [special issue in J. Amer Heart Assoc, that includes many articles below, plus this additional editorial: Getting Sympathetic About Air Pollution Exposure.

Impact of Air Pollution on Allergic Rhinitis and Asthma: Consensus Statement by Indian Academy of Pediatrics.

Running in polluted air is a two-edged sword – physical exercise in low air pollution areas is cardioprotective but detrimental for the heart in high air pollution areas.

Special Issue “Reclamation of polluted soils for food production and human health: part 1”.

How Family Histories Can Inform Research About Germ Cell Exposures: The Example of Autism.

Reviews

Numerous EDCs

Epigenetic Modifications Associated with Exposure to Endocrine Disrupting Chemicals in Patients with Gestational Diabetes Mellitus. [BPA, phthalates, parabens]

Exposure to obesogenic endocrine disrupting chemicals and obesity among youth of Latino or Hispanic origin in the United States and Latin America: A lifecourse perspective.

Exposure to endocrine-disrupting compounds such as phthalates and bisphenol A is associated with an increased risk for obesity.

Mixtures

Interactions Between Microplastics and Heavy Metals in Aquatic Environments: A Review.

Mechanisms of the synergistic lung tumorigenic effect of arsenic and benzo(a)pyrene combined- exposure.

BPA/Phenols

Toxicity of bisphenol analogues on the reproductive, nervous, and immune systems, and their relationships to gut microbiome and metabolism: insights from a multi-species comparison.

Phthalates

Research progress on the effect of Di-(2-ethylhexyl) phthalate (DEHP) on reproductive health at different periods in life.

The effects of phthalate ester exposure on human health: A review.

Flame Retardants

A meta-analysis of factors influencing concentrations of brominated flame retardants and organophosphate esters in indoor dust.

Occurrence, bioaccumulation, fate, and risk assessment of novel brominated flame retardants (NBFRs) in aquatic environments – A critical review.

Pesticides

A systematic review on the metabolic effects of chlorpyrifos.

Labelling and denominating lung toxicity effects of pesticides.

Bees and pesticides: the research impact and scientometrics relations.

The Power of Drosophila melanogaster for Modeling Neonicotinoid Effects on Pollinators and Identifying Novel Mechanisms.

Potentially Toxic Elements

Impact of dietary mercury intake during pregnancy on the health of neonates and children: a systematic review.

Mechanisms of oxidative stress in Methylmercury-induced neurodevelopmental toxicity.

Plastic additives: challenges in ecotox hazard assessment.

Associations between exposure to heavy metals and the risk of chronic kidney disease: a systematic review and meta-analysis.

Microplastics

Effects of microplastics on the functional traits of aquatic benthic organisms: A global-scale meta-analysis.

Effect of microplastics on aquatic biota: A hormetic perspective.

Air Pollution

Association between outdoor particulate air pollution and the risk of osteoporosis: a systematic review and meta-analysis.

Effects of Ambient Air Pollution on Blood Pressure Among Children and Adolescents: A Systematic Review and Meta-Analysis.

Role of atmospheric particulate matter exposure in COVID-19 and other health risks in human: A review.

Association of COVID-19 transmission with high levels of ambient pollutants: Initiation and impact of the inflammatory response on cardiopulmonary disease.

Pharmaceuticals/Personal Care Products

Trends in environmental and toxicity research on organic ultraviolet filters: A scientometric review.

Miscellaneous

Impact of the exposome on the development and function of pancreatic β-cells.

Why is the Incidence of Type 1 Diabetes Increasing?

Social and environmental risks as contributors to the clinical course of heart failure.

A crucial review on polycyclic aromatic Hydrocarbons – Environmental occurrence and strategies for microbial degradation.

Human Health Studies

Numerous Chemicals

BPA, Parabens, and Phthalates in Relation to Endometrial Cancer Risk: A Case-Control Study Nested in the Multiethnic Cohort.

Prenatal Exposure to Endocrine-Disrupting Chemicals and Subsequent Brain Structure Changes Revealed by Voxel-Based Morphometry and Generalized Q-Sampling MRI.

Perturbation of serum metabolome in relation to type 2 diabetes mellitus and urinary levels of phthalate metabolites and bisphenols.

Interaction of prenatal bisphenols, maternal nutrients, and toxic metal exposures on neurodevelopment of 2-year-olds in the APrON cohort.

Phthalates

Associations between Prenatal Exposure to Phthalates and Timing of Menarche and Growth and Adiposity into Adulthood: A Twenty-Years Birth Cohort Study.

Association between prenatal phthalate exposure and anthropometric measures of newborns in a sample of Iranian population.

The associations of phthalate biomarkers during pregnancy with later glycemia and lipid profiles.

Associations between urinary phthalate metabolite concentrations and markers of liver injury in the US adult population.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations of accumulated selected persistent organic pollutants in adipose tissue with insulin sensitivity and risk of incident type-2 diabetes.

Persistent organic pollutants and the size of ovarian reserve in reproductive-aged women.

Pesticides

Organophosphate pesticides and progression of chronic kidney disease among children: A prospective cohort study.

Different Timing of Prenatal Organophosphate Pesticides Exposure Is Influenced Different Aspects of Infant Developmental Performance.

Prenatal exposure to pyrethroid and organophosphate insecticides and language development at age 20-36 months among children in the Odense Child Cohort.

Potentially Toxic Elements

Effects of Low-dose Mercury Exposure in Newborns on mRNA Expression Profiles.

Multiple metal exposure and obesity: A prospective cohort study of adults living along the Yangtze River, China.

Arsenic Exposure and Melanoma Among US Adults Aged 20 or Older, 2003-2016.

Metals toxicity and its correlation with the gene expression in Alzheimer’s disease.

Air Pollution

Prenatal exposure to ambient fine particulate matter and early childhood neurodevelopment: A population-based birth cohort study.

Effects of using different exposure data to estimate changes in premature mortality attributable to PM_2.5 and O₃ in China.

Effect of Short-Term Exposure to Fine Particulate Matter and Temperature on Acute Myocardial Infarction in Korea.

Short-Term Effects of Particle Size and Constituents on Blood Pressure in Healthy Young Adults in Guangzhou, China

Acute Exposure to Diesel Exhaust Increases Muscle Sympathetic Nerve Activity in Humans. [intervention study]

Long-Term Exposure to Particulate Air Pollution Is Associated With 30-Day Readmissions and Hospital Visits Among Patients With Heart Failure.

Particulate Air Pollution and Risk of Cardiovascular Events Among Adults With a History of Stroke or Acute Myocardial Infarction.

Air Pollution, housing and respirfatory tract Infections in Children: NatIonal birth Cohort study (PICNIC): study protocol.

Joint effects of ethnic enclave residence and ambient volatile organic compounds exposure on risk of gestational diabetes mellitus among Asian/Pacific Islander women in the United States.

Association of short-term exposure to air pollution with depression in patients with sleep-related breathing disorders.

Spatio-temporal associations of air pollutant concentrations, GP respiratory consultations and respiratory inhaler prescriptions: a 5-year study of primary care in the borough of Lambeth, South London.

Climatic modification effects on the association between PM1 and lung cancer incidence in China.

Long-term exposure to particulate matter and residential greenness in relation to androgen and progesterone levels among rural Chinese adults.

Emulating causal dose-response relations between air pollutants and mortality in the Medicare population.

Effects of air pollution on mortality of patients with chronic kidney disease: A large observational cohort study.

The association between short-term exposure to air pollutants and rotavirus infection in Wuhan, China.

Ambient fine particulate matter air pollution and the risk of hospitalization among COVID-19 positive individuals: Cohort study.

The Association between air pollution and COVID-19 related mortality in Santiago, Chile: A daily time series analysis.

COVID-19 and air pollution in Vienna-a time series approach.

Particulate matter concentrations and their association with COVID-19-related mortality in Mexico during June 2020 Saharan dust event.

Impact of the inversion and air pollution on the number of patients with Covid-19 in the metropolitan city of Tehran.

Miscellaneous

Nitrate in Drinking Water during Pregnancy and Spontaneous Preterm Birth: A Retrospective Within-Mother Analysis in California.

The Prevalence of Cancer in Britain Before Industrialization.

Laboratory Studies

BPA/Phenols

Alterations of Kiss 1 receptor, GnRH receptor and nuclear receptors of the hypothalamo-pituitary-ovarian axis following low dose bisphenol-A exposure in Wistar rats.

Effects of high-dose bisphenol A on the mouse oral mucosa: A possible link with oral cancers.

The mechanism of cytotoxicity of 4-nonylphenol in a human hepatic cell line involves ER-stress, apoptosis, and mitochondrial dysfunction.

Human transthyretin binding affinity of halogenated thiophenols and halogenated phenols: An in vitro and in silico study.

Phthalates

Phthalates promote the invasion of hepatocellular carcinoma cells by enhancing the interaction between Pregnane X receptor and E26 transformation specific sequence 1.

Acute Toxicity and DNA Instability Induced by Exposure to Low Doses of Triclosan and Phthalate DEHP, and Their Combinations, in vitro.

Parabens/Triclosan/Antimicrobials

Prenatal exposure to propylparaben at human-relevant doses accelerates ovarian aging in adult mice.

Environmentally relevant concentrations of triclocarban affect morphological traits and melanogenesis in zebrafish larvae.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effects of Low-Dose Gestational TCDD Exposure on Behavior and on Hippocampal Neuron Morphology and Gene Expression in Mice.

Perfluoroalkyl Substances

Multi- and trans-generational disturbances of perfluorobutane sulfonate and perfluorohexane sulfonate on lipid metabolism in Caenorhabditis elegans.

Shift in skin microbiota and immune functions of zebrafish after combined exposure to perfluorobutanesulfonate and probiotic Lactobacillus rhamnosus.

Flame Retardants

Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells.

Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery.

Organotins

Tributyltin perturbs femoral cortical architecture and polar moment of inertia in rat.

Pesticides

Glyphosate exposure attenuates testosterone synthesis via NR1D1 inhibition of StAR expression in mouse Leydig cells.

Eusocial insect declines: Insecticide impairs sperm and feeding glands in bumblebees.

Ameliorative Effects of Boswellic Acid on Fipronil-Induced Toxicity: Antioxidant State, Apoptotic Markers, and Testicular Steroidogenic Expression in Male Rats.

Can the exposure system adopted influence the results of the atrazine toxicity in hepatic tissue of fish?

DNA damage and biochemical responses in estuarine bivalve Donax incarnatus (Gmelin, 1791) exposed to sub-lethal concentrations of an organophosphate pesticide monocrotophos.

L-carnitine extenuates endocrine disruption, inflammatory burst and oxidative stress in carbendazim-challenged male rats via upregulation of testicular StAR and FABP9, and downregulation of P38-MAPK pathways.

Oxidative stress induced by methomyl exposure reduces the quality of early embryo development in mice.

Potentially Toxic Elements

Arsenic exposure in drinking water reduces Lgr5 and secretory cell marker gene expression in mouse intestines.

Microplastics/Nanomaterials

Toxic effects of acute exposure to polystyrene microplastics and nanoplastics on the model insect, silkworm Bombyx mori.

Preliminary study on impacts of polystyrene microplastics on the hematological system and gene expression in bone marrow cells of mice.

Toxicity Assessment of Nano-ZnO Exposure on the Human Intestinal Microbiome, Metabolic Functions, and Resistome Using an In Vitro Colon Simulator.

Air Pollution

The Effects of Chronic Exposure to Ambient Traffic-Related Air Pollution on Alzheimer’s Disease Phenotypes in Wildtype and Genetically Predisposed Male and Female Rats.

Pharmaceuticals/Personal Care Products

Hormonal activity in commonly used Black hair care products: evaluating hormone disruption as a plausible contribution to health disparities.

Transcriptome aberration in mice uterus associated with steroid hormone response and inflammation induced by dioxybenzone and its metabolites.

Endocrine disrupting potential of veterinary drugs by in vitro stably transfected human androgen receptor transcriptional activation assays.

The potential endocrine disruption mechanism of anthelmintic drug niclosamide by activating estrogen receptors and estrogen-related receptors.

Toxicity of synthetic Endocrine Disrupting Compounds on meiofauna: Estradiol benzoate as a case study.

Mixtures

Morphological and transcriptomic alterations in neonatal lamb testes following developmental exposure to low-level environmental chemical mixture.

Exposure/Environment Studies

Phthalates

Exposure estimates of phthalates and DINCH from foods and personal care products in comparison with biomonitoring data in 24-hour urine from the Norwegian EuroMix biomonitoring study.

Parabens/Triclosan/Antimicrobials

Fate processes of Parabens, Triclocarban and Triclosan during wastewater treatment: assessment via field measurements and model simulations.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated biphenyls (PCBs) in the colostrum samples from the Yangtze River Region: Exposure profile and risk assessment.

Levels of Polychlorinated Dibenzo-p-Dioxins/Furans (PCDD/Fs) and Dioxin-Like Polychlorinated Biphenyls (DL-PCBs) in Human Breast Milk in Chile: A Pilot Study.

A Web-Based Database on Exposure to Persistent Organic Pollutants in China.

Persistent pollutants in fresh and abandoned eggs of Common Tern (Sterna hirundo) and Arctic Tern (Sterna paradisaea) in Ireland.

Formation of Environmentally Persistent Free Radicals during Thermochemical Processes and their Correlations with Unintentional Persistent Organic Pollutants.

Selective pressure of biphenyl/polychlorinated biphenyls on the formation of aerobic bacterial associations and their biodegradative potential.

Perfluoroalkyl Substances

Biomonitoring: A tool to assess PFNA body burdens and evaluate the effectiveness of drinking water intervention for communities in New Jersey.

Fate and budget of poly- and perfluoroalkyl substances in three common garden plants after experimental additions with contaminated river water.

Legacy and emerging per- and polyfluoroalkyl substances (PFASs) in Dagang Oilfield: Multimedia distribution and contributions of unknown precursors.

PFAS and their substitutes in groundwater: Occurrence, transformation and remediation.

Distribution, behaviour, bioavailability and remediation of poly- and per-fluoroalkyl substances (PFAS) in solid biowastes and biowaste-treated soil.

Effects of hydrothermal treatments on destruction of per- and polyfluoroalkyl substances in sewage sludge.

Study protocol for a randomised controlled trial examining the effect of blood and plasma donation on serum perfluoroalkyl and polyfluoroalkyl substance (PFAS) levels in firefighters.

Spatial and temporal baseline of perfluorooctanesulfonic acid retained in sediment core samples from Puget Sound, Washington, USA.

Field study on the transportation characteristics of PFASs from water source to tap water.

Per and polyfluoroalkyl substances (PFAS) at high concentrations in neonatal Australian pinnipeds.

Flame Retardants

Uptake and translocation of polybrominated diphenyl ethers in the rhizosphere soil-crop-atmosphere system in e-waste dismantling areas in Taizhou, China.

Polyethylene mesh knitted fabrics mulching the soil to mitigate China’s haze: A potential source of PBDEs.

Pesticides

Urine biomonitoring of glyphosate in children: exposure and risk assessment.

Organophosphorus pesticide exposure biomarkers in a Mexican population.

Impacts of neonicotinoid seed treatments on the wild bee community in agricultural field margins.

Pesticide residues in the pollen and nectar of oilseed rape (Brassica napus L.) and their potential risks to honey bees.

Insecticide fipronil and its transformation products in human blood and urine: Assessment of human exposure in general population of China.

Occurrence and Distribution of Neonicotinoids and Characteristic Metabolites in Paired Urine and Indoor Dust from Young Adults: Implications for Human Exposure.

Mobility and environmental monitoring of pesticides in the atmosphere – a review.

Potentially Toxic Elements

Risk assessment of soil heavy metal contamination at the census tract level in the city of Santa Ana, CA: implications for health and environmental justice.

Contribution of diet and other factors for urinary concentrations of total arsenic and arsenic species: data for US children, adolescents, and adults.

Arsenic Toxicokinetic Modeling and Risk Analysis: Progress, Needs and Applications.

Assessing the risk of coal-burning arsenic-induced liver damage: a population-based study on hair arsenic and cumulative arsenic.

Targeted risk assessment of mercury exposure of recreational fishers: Are nephrops fishers in Norway at risk?

Blood lead level monitoring related to environmental exposure in the general Iranian population: a systematic review and meta-analysis.

Great-tailed Grackles (Quiscalus mexicanus) as Biomonitors of Atmospheric Heavy Metal Pollution in Urban Areas of Monterrey, Mexico.

Microplastics

Do Microplastics Enter Our Food Chain Via Root Vegetables? A Raman Based Spectroscopic Study on Raphanus sativus.

UV filters and UV stabilisers adsorbed in microplastic debris from beach sand.

UV-Irradiation Facilitating Pb Release from Recycled PVC Microplastics.

Air Pollution

Impact of COVID-19 lockdown on NO₂ and PM_2.5 exposure inequalities in London, UK.

On the investigation of COVID-19 lockdown influence on air pollution concentration: regional investigation over eighteen provinces in Iraq.

Impact of Ambient Air Quality Standards revision on the exposure-response of air pollution in Tianjin, China.

Polycyclic aromatic hydrocarbons in airborne particulate matter samples from Hanoi, Vietnam: Particle size distribution, aryl hydrocarbon ligand receptor activity, and implication for cancer risk assessment.

Urinary metabolites of polycyclic aromatic hydrocarbons after short-term fine particulate matter exposure: A randomized crossover trial of air filtration.

Urban Air Pollution Nanoparticles from Los Angeles: Recently Decreased Neurotoxicity.

Polycyclic aromatic compounds (PAHs, oxygenated PAHs, nitrated PAHs, and azaarenes) in air from four climate zones of China: Occurrence, gas/particle partitioning, and health risks.

Has Carbon Emissions Trading Reduced PM_2.5 in China?

Pharmaceuticals/Personal Care Products

Socioeconomic and Racial/Ethnic Differences in Use of Endocrine-Disrupting Chemical-Associated Personal Care Product Categories among Pregnant Women.

Personal care product use among diverse women in California: Taking Stock Study.

Urinary benzophenones and synthetic progestin in Chinese adults and children: concentration, source and exposure.

Non-target analysis of organic waste amended agricultural soils: Characterization of added organic pollution.

Mixtures

A 30-Year Study of Impacts, Recovery, and Development of Critical Effect Sizes for Endocrine Disruption in White Sucker (Catostomus commersonii) Exposed to Bleached-Kraft Pulp Mill Effluent at Jackfish Bay, Ontario, Canada.

Insights into the vertical distribution of the microbiota in steel plant soils with potentially toxic elements and PAHs contamination after 60 years operation: Abundance, structure, co-occurrence network and functionality.

Miscellaneous

A Different Kind of Storm: Natech Events in Houston’s Fenceline Communities.

Identification of chemicals of emerging concern in urine of Flemish adolescents using a new suspect screening workflow for LC-QTOF-MS.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

If you enjoy this newsletter, please feel free to donate here! Thank you!

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.