EDC Science Weekly, May 30 – June 5, 2025

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Comparison of the effects of plastic-free diet, plastic-free diet education and exposure feedback on urinary bisphenol A levels in adolescents.
Parabens, bisphenols, and other environmental phenols exposure from cosmetics use in Korean adolescent girls: Findings from a 2-day intervention study.

Science summaries and highlights

Events

June 9 webinar: Microplastics and Health Webinar Series: Research Priorities, Mitigation Strategies, and Public Communication in the Face of Uncertainties [National Academies]

June 10 conference: Preventing diseases by reducing exposure to harmful chemicals (hybrid) [Health and Environment Alliance (HEAL)]

June 16-17 workshop: Roadmap to phase out animal testing for chemical safety assessments [The European Chemicals Agency (ECHA)]

June 17 webinar: Community engagement for breast cancer prevention [CHE]

June 18 webinar: Defend Our Health: Authors & Friends, feat. Sharon Udasin [Defend Our Health and Island Press]

June 19 webinar: Key areas of regulatory challenge: research needs and opportunities [ECHA]

June 19 conference: Endocrine disruption: Perspectives from the 2024 ICEDA Awardees [Intersectoral Centre for Endocrine Disruptor Analysis (ICEDA)]

June 24 webinar: Environmental health research at EPA: What’s happening at ORD? [EDC Strategies Partnership]

June 25 online conference: TSCA reform- Nine years later [Environmental Law Institute]

July 8 webinar: Communicating about EDCs & Health: Why words matter [CHE]

July 30 – Aug. 1 conference: U.S. Developmental Origins of Health and Disease (DOHaD) Society Annual Meeting

Sept. 15: ECHO symposium: translating science to action [hybrid] [NIH Environmental Influences on Child Health Outcomes (ECHO)]

Sept. 22-23 save the date: Second Annual Scientific Symposium on Plastics and Human Health [NYU Langone Health Center for the Investigation of Environmental Hazards (CIEH)]

More events

Regulations/Policy

Data Requirements for Implementing the “Essential-Use” Concept in Chemical Legislation.

Countdown to 2027 – maximising use of NAMs in food safety assessment: closing the gap for regulatory assessments in Europe.

More EDC policy, FPF’s regulations open for comment, Science’s Trump-Tracker, and links to preserved resources removed from U.S. federal websites

Methods/Tools/Screening

Plastic-Associated Chemicals: Late Lessons from Early Equilibrium Partitioning Science.

Commentaries

Development gone awry: Fetal exposure to bisphenol A and cancer.

Desflurane, Climate Change, and PFAS Pollution: Appropriate Metrics for Science Based Ethical Decision Making.

Rates of Colorectal and Other Cancers Are Rising in Young Adults, Puzzling Researchers [News in JAMA]

Beyond Genes: Human Exposome Project to Tackle External Drivers of Disease [News in JAMA]

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Unveiling the nexus between environmental exposures and testicular damages: revelations from autophagy and oxidative stress imbalance.

MicroRNA expression in response to environmental hazards: Implications for health.

Oxidative Stress, Genetic Factors and Behavioral Responses to Chemical Exposure: Insights into Cancer Development in Zebrafish (Danio Rerio).

Targeting Cardiotoxicity Induced by Environmental Toxins: The Role of Natural Products.

Phthalates

The effect of phthalates on insulin secretion of pancreatic beta cells based on cellular studies, a systematic review.

PFAS

The accumulation of per- and polyfluoroalkyl substances (PFAS) at the air-water interface: A systematic review.

A Critical Review of Populations with Occupational Exposure to Per- and Polyfluoroalkyl Substances: External Exposome, Internal Exposure Levels, and Health Effects.

A review on the latest frontiers in water quality in the era of emerging contaminants: A focus on perfluoroalkyl compounds.

Pesticides

Prenatal pesticide exposure and adverse reproductive outcomes: Epidemiological evidence and mechanistic insights.

Metals/Metalloids

Association between arsenic exposure and intrauterine growth restriction: A systematic review and meta-analysis.

Microplastics/Nanomaterials

The neurotoxic threat of micro- and nanoplastics: evidence from In Vitro and In Vivo models.

Experimental methods for assessing biological effects of microplastics on mouse models: trends, gaps, and future directions.

Microplastics: a global threat to life and living.

Miscellaneous

Tire wear particles in aquatic environments: From biota to ecosystem impacts.

Human Health Studies

BPA/Phthalates

Association between endocrine disrupting chemicals exposure and the risk of all-cause mortality in individuals with diabetes mellitus or its complications: A prospective cohort study.

Urinary bisphenol A and its substitutes exposure increased the risk of renal tubular injury (N-acetyl-β-d-glucosaminidase) in the general Taiwanese population.

Individual and joint effects of exposure to phthalates and the risk of cardiovascular disease in the chronic kidney disease population: NHANES 2005-2018.

Association between serum and red blood cell folate concentrations and urinary phthalate metabolite concentrations in US adults: evidence from a large population-based study.

Associations between urinary phthalate metabolite mixtures, semen quality, and serum reproductive hormone levels in Japanese men seeking fertility treatment.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposure to airborne polychlorinated biphenyls and risk of uterine leiomyomata, endometriosis, and polycystic ovarian syndrome: a register-based Danish cohort study.

Prenatal and postnatal exposure to PCBs and neurodevelopment of preschoolers living in the PCB-contaminated region.

Beyond the Surface: Mapping DDE’s Metabolic Footprint on Adolescent Obesity.

PFAS

Poly- and perfluoroalkyl substances (PFAS) in the first 1000 days reduce linear growth, lean body mass and bone mineral density at age 3 years.

Association between perfluoroalkyl and polyfluoroalkyl substances and adolescents’ sleep disorders: NHANES 2005-2018.

Flame Retardants

Early-life exposure to organophosphate esters and child neurodevelopment in the French national birth cohort.

Associations of urinary organophosphate ester metabolites with bone mineral density in U.S. children and adolescents aged 8-19 years: a cross-sectional study based on NHANES 2011-2018.

Metals/Metalloids

Association of urinary arsenic concentrations with inflammation: overall and by folate intake, body mass index, and gender.

Heavy metals, noradrenaline/adrenaline ratio, and microbiome-associated hormone precursor metabolites: biomarkers for social behaviour, ADHD symptoms, and executive function in children.

Time-varying exposure to element mixtures and children’s cognition at 5 years of age: findings from the New Hampshire Birth Cohort Study.

Association of urinary cadmium and arsenic with gynecological cancers: Results from NHANES 2003-2018.

Prenatal exposure to trace elements impacts mother-infant gut microbiome, metabolome and resistome during the first year of life.

Biological ageing mediates the associations between urinary metals and metabolic dysfunction-associated steatotic liver disease.

Air Pollution

Unraveling the Molecular Links between Fine Particulate Matter Exposure and Early Birth Risks in African American Mothers: A Metabolomics Study in the Atlanta African American Maternal-Child Cohort.

Down-regulation of serum SIRT6 levels is associated with an increased risk of chronic intestinal inflammation in children exposed to airborne particulate matter and polycyclic aromatic hydrocarbons from e-waste.

Effects of PM_2.5 constituents on gestational diabetes mellitus in Chinese pregnant women: The potential modifying role of vitamin B₁₂.

The mediating and moderating effect of BMI in the relationship between air pollution and nonalcoholic fatty liver disease: A prospective cohort study.

Social vulnerability and cancer risk from air toxins in Louisiana: a spatial analysis of environmental health disparities.

Laboratory Studies

BPA/Phenols

Bisphenol A exposure induces polycystic ovarian syndrome phenotype B and reduces fertility in adolescent female rats.

Integrated lipidomics and metabolomics approach to assess sex-dependent effects of acute bisphenol A exposure on hepatic lipid metabolism in zebrafish.

Unravelling immunomodulatory effects of bisphenol A substitutes on human macrophages, T and B lymphocytes using in vitro models.

Pathophysiologically relevant bisphenol S exposure accelerates aging by disrupting brown adipose tissue-regulated energy metabolism.

Elucidating the mechanisms of environmental pollutant BPA inducing neurotoxicity through metabolomics and network toxicology strategy.

Chronic BPAF exposure differentially enhances fat deposition in mice fed normal or high-fat diets via lipid metabolism dysregulation.

Loss of adult visual responses by developmental BPA exposure is correlated with altered estrogenic signaling.

Exploring the toxicity of bisphenol A and its analogue bisphenol S-MPE to Escherichia coli K12 from integrated AutoQSAR and transcriptomics analysis.

Environmentally-relevant doses of bisphenol A and S exposure in utero disrupt germ cell programming across generations resolved by single nucleus multi-omics.

Nonylphenol exposure induces myocardial fibrosis via the RhoA/ROCK1/MLC-signaling pathway.

Phthalates

Subacute dibutyl phthalate exposure impairs hepatic T cells and facilitates hepatitis B progression in mouse liver.

Environmental Levels of Bis(2-ethylhexyl)-tetrabromophthalate (TBPH) Cause Thyroid Toxicity and Early Carcinogenic Signals in Juvenile Fish.

Di-n-butyl and di-iso-pentyl phthalates and their mixture increase oxidative stress and embryo-larval malformations in zebrafish (Danio rerio).

The Inhibition of Prostaglandin Production During Ovulation by Exposure to a Phthalate Mixture is Circumvented by cAMP Analogue Supplementation in a Human Granulosa Cell Model.

PFAS

Perfluorooctane sulfonate exposure disrupts steroid hormone synthesis in rats via the gut-metabolism-testis axis.

Comparative cytotoxicity and toxicological mechanisms of 6:2 Cl-PFAES and PFOS in pancreatic β cells: implications for glucose metabolism disruption.

Perfluorooctane sulfonate (PFOS) promotes transformational transfer of antibiotic resistance genes and cross-resistance between antibiotics and PFOS.

Per- and Polyfluoroalkyl Substances Suppress Macrophage Alternative Activation to Disrupt Hepatic Lipid Metabolism.

Investigation of the pancreatic toxicological effects of oral ingestion of perfluorobutanesulfonic acid (PFBS) in Sprague-Dawley rats.

Integrated PBPK Modelling for PFOA Exposure and Risk Assessment.

Neurodevelopmental effects of exposure to environmentally relevant concentrations of perfluorooctane sulfonic acid (PFOS), perfluorobutanesulfonic acid (PFBS) and 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA) on larval zebrafish: Multi-omics and neuropathology perspective.

Systematic Exploration of Potential Toxicity Targets and Molecular Mechanisms of Emerging Short-Chain PFAS Substitutes: PFBA- and PFBS-Induced Hepatocellular Carcinoma Based on Toxicity Network Analysis, Machine Learning, and Biomimetic Calculations.

HFPO homologues, the novel alternatives to PFOA, impair male reproduction in mice through inducing mitochondrial dysfunction.

Analyzing the potential targets and mechanism of per- and polyfluoroalkyl substances (PFAS) on breast cancer by integrating network toxicology, single-cell sequencing, spatial transcriptomics, and molecular simulation.

Flame Retardants

Development of swimming speed-based biomarker reveals interactive toxicity of TCEP and TCPP in amphibian larvae.

TBBPA-BDBPE induces ferroptosis in trophoblasts through chaperone-mediated autophagy of GPX4.

Phenotypic and Lipidomic Alterations in Lung Cells Induced by Organophosphate Flame Retardants.

Pesticides

Ecotoxicological impacts of fipronil sulfone: Developmental and behavioral disruptions in zebrafish embryos and larvae.

Impact of pubertal imidacloprid exposure on the genital tract of Japanese quail (Coturnix Coturnix japonica): Histomorphometric and ultrastructural study.

Metals/Metalloids

Prenatal arsenic exposure disrupts placental angiogenesis by altering Pdgfb promoter epigenetic modification.

Prenatal arsenic exposure causes cognitive dysfunction in offspring through KDM5-regulated reprogramming of autophagy in developing brain, an effect attenuated by alpha-ketoglutarate.

Integrated analysis of methylomic and transcriptomic profiles in fetal mouse hypothalamus in response to maternal gestational exposure to arsenic.

The effect of arsenic on mitochondrial fatty acid metabolism via inhibition of carnitine palmitoyltransferase 1B and choline kinase beta in C2C12 cells.

Downregulated NT-3 and PI3K/AKT signaling pathway mediates arsenic-induced apoptosis in hippocampal neurons in vivo and in vitro.

Microplastics/Nanomaterials

Untargeted metabolomics and transcriptomics joint analysis of the effects of polystyrene nanoplastics on lipid metabolism in the mouse liver.

Adverse effects of a realistic concentration of human exposure to microplastics on markers of placental barrier permeability in pregnant rats.

The Single and Combined Effects of Decabromodiphenyl Ethane and Mixed Microplastics on Male Mice Reproductive Toxicity.

Network toxicology and bioinformatics analysis reveal the molecular mechanisms of polyethylene terephthalate microplastics in exacerbating diabetic nephropathy.

Polystyrene microplastics induces senescence of osteocytes by activating the cyclooxygenase-2 signaling pathway.

Miscellaneous

Dye intermediates N-phenyl-2-naphthylamine and o-tolidine are novel environmental androgens with reproductive toxicity in male rats.

6PPD and 6PPDQ embryonic exposure induced distinct developmental neurotoxicity in zebrafish.

p-phenoxyphenol impaired male fertility by disrupting the testicular function and local microenvironment.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Parabens, bisphenols, and other environmental phenols exposure from cosmetics use in Korean adolescent girls: Findings from a 2-day intervention study.

Applying Nontargeted Analysis to Explore the Chemical Composition of Dust Collected in Infants’ Homes.

BPA/Phenols

Comparison of the Effects of Plastic-Free Diet, Plastic-Free Diet Education and Exposure Feedback on Urinary Bisphenol: A Levels in Adolescents.

Pollution load of bisphenol a in the effluent of plastic recycling industries in the coastal areas of Southern Caspian Sea.

Trend analysis of environmental concentrations of Bisphenol A in European waters and sediments.

Suspect screening of bisphenol A (BPA) structural analogues and functional alternatives in human milk from Canada and South Africa.

A simulation study on the temperature-dependent release of endocrine-disrupting chemicals from polypropylene and polystyrene containers.

PFAS

Evaluating the environmental occurrence of per- and polyfluoroalkyl substances (PFAS) and potential exposure risk for recreational shellfish harvesters in the Great Bay Estuary, New Hampshire.

Novel PFAS in alligator blood discovered with non-targeted ion mobility spectrometry-mass spectrometry.

Quantifyin g PFAS contamination and environmental risk in municipal solid waste landfill refuse: Implications for landfill reuse.

Per- and polyfluoroalkyl substances in surface water and sediment in Great Lakes tributaries and relations with watershed attributes.

Evaluating per- and polyfluoroalkyl substance (PFAS) prevalence and potential for biological effects in Lake Superior tributaries.

Potential for biological effects of per- and polyfluoroalkyl substances in Great Lakes tributaries and associations with land cover and wastewater effluent.

Target analysis of per- and polyfluoroalkyl substances in surface water: Occurrence, seasonal trends, and risk-based prioritization in the Minjiang River.

Municipal and Industrial Wastewater Treatment Plant Effluent Contributions to Per- and Polyfluoroalkyl Substances in the Potomac River: A Basin-Scale Measuring and Modeling Approach.

Levels of perfluoroalkyl carboxylic acids in recycled plastic pellets: A small input into the plastics cycle.

Particle and per- and polyfluoroalkyl substance (PFAS) concentrations from different types of fire extinguishers.

Variation in dietary preference related the per- and polyfluoroalkyl substance exposure in two sympatric seabird species from the Yellow Sea, China.

Bioaccumulation and distribution of per- and polyfluoroalkyl substances and organophosphate flame retardants in marine organisms from the Vietnamese coast: Links to species traits and environmental exposure.

Flame Retardants

Children’s exposure risk toward brominated flame retardants and organophosphate esters during preschool attendance and potential contamination sources.

Pesticides

Determinants of Pesticide Exposure Among Girls in Rural Costa Rica: A Silicone Wristband Study.

Determinants of urinary pesticide metabolite concentrations in school-aged children from rural Bogotá, Colombia.

[Children’s exposure to pesticides in Brazil: a scoping review]. [in Portuguese]

Measured exposures to glyphosate in applicators and the general population: an updated review of the scientific literature since 2020.

Are brackish water copepods susceptible to neonicotinoid pesticides? An experimental assessment across different salinity levels.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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