EDC Science Weekly, May 26 – June 1, 2023

Post author:HEEDS
Post published:June 1, 2023
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Highlights: Industry cover-ups for pesticides and PFAS (see the Regulations/policy section below); PFAS in pharmaceuticals?

More EDC science highlights

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar June 7: Kids and Chemicals: PFAS Exposure and the Metabolism [CHE-Alaska]

Webinar June 8: The Chemical Footprint of a Plastic Bottle [CHE]

Webinar June 13: CHE Café: Science, Storytelling & A New War on Cancer

More events

Regulations/Policy

Non-disclosure of developmental neurotoxicity studies obstructs the safety assessment of pesticides in the European Union. [see related article in The Guardian]

The Devil they Knew: Chemical Documents Analysis of Industry Influence on PFAS Science [see related blog by PRHE]

More EDC policy. Also see this new webpage from the Food Packaging Forum that lists proposed regulations open for comment.

Methods/Tools/Screening

Development of a data-driven approach to Adverse Outcome Pathway network generation: a case study on the EATS-modalities.

Toxicity Weighting for Human Biomonitoring Mixture Risk Assessment: A Proof of Concept.

Priorities and Challenges in Methodology for Human Health Risk Assessment from Combined Exposure to Multiple Chemicals.

Assessing CaMPARI as new approach methodology for evaluating neurotoxicity.

Screening strategy for 1210 exogenous chemicals in serum by two-dimensional liquid chromatography-mass spectrometry.

More tools and resources

Commentaries

Advances in chemical analysis of micro- and nanoplastics. [intro to a special issue in Analytical and Bioanalytical Chemistry]

Endocrine Disruptors and Child H\ealth: Food Contaminant Monitoring in the European Union.

Editorial: Developmental origin of diseases: a special focus on the parental contribution towards offspring’s adult health. [intro to a special issue in Frontiers in Endocrinology]

Why ideas of ‘planetary boundaries’ must uphold environmental justice.

Is the Environmental Risk of Metformin Underestimated?

Reviews

Numerous Chemicals/Mixtures

Environmental Pollution and the Risk of Developing Metabolic Disorders: Obesity and Diabetes.

Reproductive toxicity of combined effects of endocrine disruptors on human reproduction.

Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution.

Effects of endocrine disrupting compounds on female fertility.

Male Germ Cell Telomeres and Chemical Pollutants.

Human hair as a noninvasive matrix to assess exposure to micro-organic contaminants: State of the art review.

Iodine Deficiency, Maternal Hypothyroxinemia and Endocrine Disrupters Affecting Fetal Brain Development: A Scoping Review.

Viable remediation techniques to cleansing wastewaters comprising endocrine-disrupting compounds.

BPA/Phenols

Potential effects of bisphenol A on diabetes mellitus and its chronic complications: A narrative review.

Estrogenic and non-estrogenic effects of bisphenol A and its action mechanism in the zebrafish model: An overview of the past two decades of work.

Recent Advances in Sources, Migration, Public Health, and Surveillance of Bisphenol A and Its Structural Analogs in Canned Foods.

Phthalates

Hypospadias, cryptorchidism, and breast cancer in children born to New Zealand servicemen who served in Malaya and may have had exposure to dibutyl phthalate: review of a previous study and updated review of international literature.

Perfluoroalkyl Substances

Public Health Evaluation of PFAS Exposures and Breastfeeding: A Systematic Literature Review.

A Review: Per- and Polyfluoroalkyl Substances-Biological Degradation.

Flame Retardants

Occurrence and Health Effects of Hexabromocyclododecane: An Updated Review.

Pesticides

Nanotechnology-based pesticides: Environmental fate and ecotoxicity.

Could pesticide exposure be implicated in the high incidence rates of depression, anxiety and suicide in farmers? A systematic review.

Metals/Metalloids

Systemic impact of heavy metals and their role in cancer development: a review.

Microplastics/Nanomaterials

Adverse health effects and mechanisms of microplastics on female reproductive system: a descriptive review.

Effects of microplastics on the toxicity of co-existing pollutants to fish: A meta-analysis.

A global synthesis of microplastic contamination in wild fish species: Challenges for conservation, implications for sustainability of wild fish stocks and future directions.

Interactions of human drug transporters with chemical additives present in plastics: Potential consequences for toxicokinetics and health.

Microplastic pollution in riverine ecosystems: threats posed on macroinvertebrates.

Microplastics in coastal and oceanic surface waters and their role as carriers of pollutants of emerging concern in marine organisms.

Microplastics and Antibiotic Resistance: The Magnitude of the Problem and the Emerging Role of Hospital Wastewater.

Air Pollution

Air Pollution: A Silent Key Driver of Dementia.

Human Health Studies

Numerous Chemicals/Mixtures

Challenges of studying the dietary exposure to chemical mixtures: Example of the association with mortality risk in the E3N French prospective cohort.

Association between environmental chemical exposure and albumin-to-creatinine ratio is modified by hypertension status in women of reproductive age.

Bisphenol and phthalate exposure during pregnancy and the development of childhood lung function and asthma. The generation R study.

BPA/Phenols

Prenatal bisphenol exposure and intelligence quotient in children at six years of age: A prospective cohort study.

Prenatal Exposure to Bisphenol A: Is There an Association between Bisphenol A in Second Trimester Amniotic Fluid and Fetal Growth?

Phthalates

Association between phthalate exposure and the risk of depressive symptoms in the adult population of the United States.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Association between Organochlorine Pesticides and Vitamin D in Female Subjects.

An Analysis of Reproductive Outcomes for Conceptions of Participants of the Air Force Health Study.

Prenatal exposure to persistent organic pollutants and molar-incisor hypomineralization among 12-year-old children in the French mother-child cohort PELAGIE.

Perfluoroalkyl Substances

Per- and Polyfluoroalkyl Substances (PFAS) Mixture during Pregnancy and Postpartum Weight Retention in the New Hampshire Birth Cohort Study (NHBCS).

Maternal Serum, Cord and Human Milk Levels of Per- and Polyfluoroalkyl Substances (PFAS), Association with Predictors and Effect on Newborn Anthropometry.

Associations between exposure to a mixture of perfluoroalkyl and polyfluoroalkyl substances and age at menarche in adolescent girls utilizing three statistical models.

Association between prenatal or early postnatal exposure to perfluoroalkyl substances and language development in 18 to 36-month-old children from the Odense Child Cohort.

Newborn metabolomic signatures of maternal per- and polyfluoroalkyl substance exposure and reduced length of gestation.

Association between perfluoroalkyl and polyfluoroalkyl substances exposure and fetal overgrowth: A prospective birth cohort study conducted in China.

Association of Early Pregnancy Perfluoroalkyl and Polyfluoroalkyl Substance Exposure With Birth Outcomes.

Association between perfluoroalkyl and polyfluoroalkyl internal exposure and serum α-Klotho levels in middle-old aged participants.

Perfluorooctanoic Acid (PFOA) Exposure and Abnormal Alanine Aminotransferase: Using Clinical Consensus Cutoffs Compared to Statistical Cutoffs for Abnormal Values.

Combined Effects of Multiple Per- and Polyfluoroalkyl Substances Exposure on Allostatic Load Using Bayesian Kernel Machine Regression.

Pesticides

Urinary neonicotinoid insecticides and adiposity measures among 7-year-old children in northern China: A cross-sectional study.

An Exploratory Study of the Metabolite Profiling from Pesticides Exposed Workers.

The determinants of thyroid function among vegetable farmers with primary exposure to chlorpyrifos: A cross-sectional study in Central Java, Indonesia.

Assessing farmer’s exposure to pesticides and the risk for non-communicable diseases: A biomonitoring study.

Metals/Metalloids

Prenatal metal levels and congenital anomalies of the kidney and urinary tract: The Japan Environment and Children’s Study.

Metal Homeostasis and Exposure in Distinct Phenotypic Subtypes of Insulin Resistance among Children with Obesity.

Associations between multiple urinary metals and the risk of hypertension in community-dwelling older adults.

The Relationship of Arsenic Exposure with Hypertension and Wide Pulse Pressure: Preliminary Evidence from Coal-Burning Arsenicosis Population in Southwest China.

Association and Interaction between Heavy Metals and Hyperuricemia in a Taiwanese Population.

Chronic Kidney Disease Induced by Cadmium and Diabetes: A Quantitative Case-Control Study.

Assessment of Cadmium (Cd) and Lead (Pb) Blood Concentration on the Risk of Endometrial Cancer.

Relationship between urinary biomarkers of early kidney damage and exposure to inorganic toxins in a pediatric population of Apizaco, Tlaxcala, Mexico.

Air Pollution

Risk of type 2 diabetes after diagnosed gestational diabetes is enhanced by exposure to PM2.5.

The association between chemical constituents of ambient fine particulate matter and obesity in adults: A large population-based cohort study.

The policy implemented by the government and the protection effect of PM2.5 decreasing on blood pressure in adolescents: From a quasi-experimental study.

Pharmaceuticals/Personal Care Products

Diminished ovarian reserve in adolescent cancer survivors treated with heavy metal chemotherapy.

Miscellaneous

Environmental melamine exposure and adverse kidney outcomes in patients with type 2 diabetes mellitus.

Association of polycyclic aromatic hydrocarbon internal exposure and urinary iodine concentration with thyroid volume in children.

Associations between prenatal exposure to polycyclic aromatic hydrocarbons and thyroid hormones in umbilical cord blood.

Residential proximity to petrol stations and risk of childhood leukemia.

Laboratory Studies

Numerous Chemicals/Mixtures

Multigenerational Effects of a Complex Human-Relevant Exposure during Folliculogenesis and Preimplantation Embryo Development: The FEDEXPO Study.

Loss of Nuclear/DNA Integrity in Mouse Epididymal Spermatozoa after Short-Term Exposure to Low Doses of Dibutyl Phthalate or Bisphenol AF and Its Mitigation by Oral Antioxidant Supplementation.

BPA/Phenols

Bisphenol A interferes with lncRNA Fhadlos2 and RUNX3 association in adolescent mouse ovary.

Bisphenol S Increases Cell Number and Stimulates Migration of Endometrial Epithelial Cells.

Global gene expression analysis reveals novel transcription factors associated with long-term low-level exposure of EA.hy926 human endothelial cells to bisphenol A.

Identification of aquatic ecological risk of bisphenol S in four Asian countries based on the SSD and alternative toxicity data of model species Danio rerio.

Bisphenol A-induced autophagy ameliorates human B cell death through Nrf2-mediated regulation of Atg7 and Beclin1 expression by Syk activation.

Phthalates

Distribution of Micro-Nano PS, DEHP, and/or MEHP in Mice and Nerve Cell Models In Vitro after Exposure to Micro-Nano PS and DEHP.

Mono-(2-ethylhexyl) Phthalate (MEHP)-Induced Telomere Structure and Function Disorder Mediates Cell Cycle Dysregulation and Apoptosis via c-Myc and Its Upstream Transcription Factors in a Mouse Spermatogonia-Derived (GC-1) Cell Line.

Prenatal DEHP Exposure Induces Premature Testicular Aging by Promoting Leydig Cell Senescence through the MAPK Signaling Pathways.

Migration of di(2-ethylhexyl) phthalate, diisononylcyclohexane-1,2-dicarboxylate and di(2-ethylhexyl) terephthalate from transfusion medical devices in labile blood products: A comparative study.

Parabens/Triclosan/Antimicrobials

Rhus tripartite methanolic extract alleviates propylparaben-induced reproductive toxicity via anti-inflammatory, antioxidant, 5-α reductase in male rats.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Connecting suborganismal data to bioenergetic processes: killifish embryos exposed to a dioxin-like compound.

The p,p’-DDE disturbs the M1 function without affecting the M2 phenotype nor unstimulated Bone Marrow-Derived Macrophages from BALB/c mice.

Resveratrol ameliorates ortho- polychlorinated biphenyls’ induced toxicity in ovary cells.

Perfluoroalkyl Substances

Environmental exposure and ecotoxicological properties of a new generation fluorosurfactant (cC6O4): A comparison with selected legacy perfluoroalkyl acids (PFAA).

Perfluorooctane sulfonate and perfluorooctanoic acid inhibit progesterone-responsive capacitation through cAMP/PKA signaling pathway and induce DNA damage in human sperm.

Category-Based Toxicokinetic Evaluations of Data-Poor Per- and Polyfluoroalkyl Substances (PFAS) using Gas Chromatography Coupled with Mass Spectrometry.

Immunotoxicity and Transcriptome Analyses of Zebrafish (Danio rerio) Embryos Exposed to 6:2 FTSA.

Mitochondrial dysfunction in metabolic disorders induced by per- and polyfluoroalkyl substance mixtures in zebrafish larvae.

PFOA exposure induces aberrant glucose and lipid metabolism in the rat liver through the AMPK/mTOR pathway.

Perfluoroalkyl Substances (PFAS) Affect Inflammation in Lung Cells and Tissues.

Per/polyfluoroalkyl substances modulate plasmid transfer of antibiotic resistance genes: A balance between oxidative stress and energy support.

Flame Retardants

Tris(1,3-dichloro-2-propyl) phosphate causes female-biased growth inhibition in zebrafish: Linked with gut microbiota dysbiosis.

Disruption of neurosteroid synthesis and release by tris(2,3-dibromopropyl)isocyanurate in primary mouse cortical astrocytes in vitro.

Pesticides

Ultrastructural Evaluation of Mouse Oocytes Exposed In Vitro to Different Concentrations of the Fungicide Mancozeb.

Immunotoxicity of relevant mixtures of pesticides and metabolites on THP-1 cells

MicroRNA‑30a‑5p regulates cypermethrin-induced apoptosis of Sertoli cells by targeting KLF9 in vitro.

The health risk of acetochlor metabolite CMEPA is associated with lipid accumulation induced liver injury.

Neurotoxic effects of exposure to glyphosate in rat striatum: Effects and mechanisms of action on dopaminergic neurotransmission.

Exposure to the fungicide prothioconazole and its metabolite prothioconazole-desthio induced hepatic metabolism disorder and oxidative stress in mice.

Gut microbiota composition and gene expression changes induced in the Apis cerana exposed to acetamiprid and difenoconazole at environmentally realistic concentrations alone or combined.

Solitary bee behaviour and pollination service delivery is differentially impacted by neonicotinoid and pyrethroid insecticides.

Metals/Metalloids

Long-term Effects of Prenatal Arsenic Exposure from Gestational Day 9 to Birth on Lung, Heart, and Immune Outcomes in the C57BL/6 Mouse Model.

Disturbance of gut microbiota aggravates cadmium-induced neurotoxicity in zebrafish larvae through V-ATPase.

Microplastics/Nanomaterials

Additive effects of microplastics on accumulation and toxicity of cadmium in male zebrafish.

Toxicity and Biodistribution of Fragmented Polypropylene Microplastics in ICR Mice.

Combined exposure to polystyrene nanoplastics and bisphenol A induces hepato- and intestinal-toxicity and disturbs gut microbiota in channel catfish (Ictalurus punctatus).

Combined exposure to microplastics and amitriptyline caused intestinal damage, oxidative stress and gut microbiota dysbiosis in zebrafish (Danio rerio).

Alleviation of neurotoxicity induced by polystyrene nanoplastics by increased exocytosis from neurons.

Dietary polystyrene nanoplastics exposure alters hepatic glycolipid metabolism, triggering inflammatory responses and apoptosis in Monopterus albus.

The internal dose makes the poison: higher internalization of polystyrene particles induce increased perturbation of macrophages.

Polystyrene nanoplastics decrease nutrient accumulation, disturb sex hormones, and inhibit reproductive development in juvenile Macrobrachium nipponense.

Pharmaceuticals/Personal Care Products

Reduced Survival and Disruption of Female Reproductive Output in Two Copepod Species (Acartia clausi and A. tonsa) Exposed to the Model Endocrine Disruptor 17α-Ethinylestradiol.

Miscellaneous

Prenatal exposure to benzo[a]pyrene depletes ovarian reserve and masculinizes embryonic ovarian germ cell transcriptome transgenerationally.

Dietary crude oil exposure during sex differentiation skewed adult sex ratio towards males in the zebrafish.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

The transfer of environmental contaminants (Brominated and Chlorinated dioxins and biphenyls, PBDEs, HBCDDs, PCNs and PFAS) from recycled materials used for bedding to the eggs and tissues of chickens.

Perfluoroalkyl Substances and POPs

Persistent organic pollutants (POPs) and per- and polyfluoroalkyl substances (PFASs) in liver from wild and farmed tilapia (Oreochromis niloticus) from Lake Kariba, Zambia: Levels and geographic trends and considerations in relation to environmental quality standards (EQSs).

Unknown Organofluorine Mixtures in U.S. Adult Serum: Contribution from Pharmaceuticals?

Watershed scale PFAS fate and transport model for source identification and management implications.

PFAS surveillance in abiotic matrices within vital aquatic habitats throughout Florida.

Forever legacies? Profiling historical PFAS contamination and current influence on groundwater used for drinking water.

Community-facing toxicokineticmodels to estimate PFAS serum levels based on life history and drinking water exposures.

Estimation of per- and poly-fluoroalkyl substances mass loads in the Danube River using passive sampling.

Comparison of eco-improvement on constructed wetlands with nano zero valent iron introduction under different levels of PFOA stress: Perspectives on plant, microbe, and PFOA removal.

Flame Retardants

Higher ecological risks and lower bioremediation potentials identified for emerging OPEs than legacy PCBs in the Beibu Gulf, China.

Feed as a source of polybrominated diphenyl ethers (PBDEs).

Pesticides

Anticoagulant rodenticides are associated with increased stress and reduced body condition of avian scavengers in the Pacific Northwest.

Metals/Metalloids

The importance of monitoring endocrine-disrupting chemicals and essential elements in biological samples of fertilizer industry workers.

Microplastics/Nanomaterials

Effects of agricultural land types on microplastic abundance: A nationwide meta-analysis in China.

Miscellaneous

Risk characterization of human exposure to polycyclic aromatic hydrocarbons in vulnerable groups.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.