EDC Science Weekly, May 26 – June 1, 2021

NOTE: This list has gotten TOO long so I am going to start leaving out numerous articles, especially the dozens of weekly articles on air pollution, metals, pesticides, studies of a particular region’s environment, and additional studies that are less focused on endocrine disruption.

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar June 9: DDT Exposure in Grandmothers Linked to Obesity, Earlier Periods in Granddaughters: New Meaning of “Persistence” for an Environmental Chemical Banned 50 Years Ago (EDC Strategies Partnership)

Webinar June 10: 25 Years After Our Stolen Future: What Have We Learned About Endocrine Disruption? (Society of Toxicology of Canada and The Intersectoral Centre for Endocrine Disruptor Analysis (ICEDA))

Webinar June 10: Putting the EU Chemicals Strategy for Sustainability into action: Looking forward (Food Packaging Forum)

Online conference June 15-16: 1st International Endocrine Disruptor Conference on the Island of Ireland (PROTECTED Project)

Regulations/Policy

Derivation of a Human In Vivo Benchmark Dose for Perfluorooctanoic Acid From ToxCast In Vitro Concentration-Response Data Using a Computational Workflow for Probabilistic Quantitative In Vitro to In Vivo Extrapolation.

Reviews

Numerous EDCs

Fish toxicity testing for identification of thyroid disrupting chemicals.

Environmental impact on reproductive health and risk mitigating strategies.

Probiotics as a biological detoxification tool of food chemical contamination: A review.

Parabens

Parabens as chemicals of emerging concern in the environment and humans: A review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

1,1,1-trichloro-2,2-bis (p-chlorophenyl)-ethane (DDT) and 1,1-Dichloro-2,2-bis (p, p’-chlorophenyl) ethylene (DDE) as endocrine disruptors in human and wildlife: a possible implication of mitochondria.

Perfluoroalkyl Substances

To which extent are per-and poly-fluorinated substances associated to metabolic syndrome?

Pesticides

A Review and Update with Perspective of Evidence that the Herbicide Glyphosate (Roundup) is a Cause of Non-Hodgkin Lymphoma.

Trends in science on glyphosate toxicity: a scientometric study.

Potentially Toxic Elements

Effects of heavy metals on reproduction owing to infertility.

Heavy metals and adult neurogenesis.

Microplastics

Micro (nano) plastic pollution: The ecological influence on soil-plant system and human health.

Resolving the effects of environmental micro- and nanoplastics exposure in biota: A knowledge gap analysis.

Microplastics in terrestrial ecosystems: moving beyond the state of the art to minimize the risk of ecological surprise.

Critical review on microplastics in fecal matter: Research progress, analytical methods and future outlook.

Air Pollution

Semen quality as a potential susceptibility indicator to SARS-CoV-2 insults in polluted areas.

Pharmaceuticals/Personal Care Products

Racial/Ethnic Disparities in Pregnancy and Prenatal Exposure to Endocrine-Disrupting Chemicals Commonly Used in Personal Care Products.

Review of aquatic toxicity of pharmaceuticals and personal care products to algae.

Human Health Studies

Numerous Chemicals

Prenatal exposures to mixtures of endocrine disrupting chemicals and children’s weight trajectory up to age 5.5 in the SELMA study.

BPA/Phenols

Effects of prenatal exposure to bisphenols on newborn leucocyte telomere length: a prospective birth cohort study in China.

Hospital-based case control study and animal study on the relationship between nonylphenol exposure and depression.

Phthalates

Prenatal urinary concentrations of phthalate metabolites and behavioral problems in Mexican children: The Programming Research in Obesity, Growth Environment and Social Stress (PROGRESS) study.

Exposure to Di-2-ethylhexyl phthalate (DEHP) and Infertility in Women, NHANES 2013-2016.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Interactions among thyroid hormones and serum lipid levels in association with PCB exposure in the Mohawk Akwesasne population.

BMI modifies the association between dietary intake and serum levels of PCBs.

Serum concentrations of organochlorine pesticides, biomarkers of oxidative stress, and risk of breast cancer.

Pesticides

Early-life farm exposure and ovarian reserve in a U.S. cohort of women.

Pilot study of exposure of the male population to organophosphate and pyrethroid pesticides in a region of high agricultural activity (Córdoba, Argentina).

Residential proximity to plant nurseries and risk of childhood leukemia.

Potentially Toxic Elements

Adipose tissue cadmium concentrations as a potential risk factor for insulin resistance and future type 2 diabetes mellitus in GraMo adult cohort.

Miscellaneous

E-waste polycyclic aromatic hydrocarbon (PAH) exposure leads to child gut-mucosal inflammation and adaptive immune response.

Serum lipids mediate the relationship of multiple polyaromatic hydrocarbons on non-alcoholic fatty liver disease: A population-based study.

Effects of Environmental Crude Oil Pollution on Newborn Birth Outcomes: A Retrospective Cohort Study.

Laboratory Studies

BPA/Phenols

Gonadal sex steroid hormone secretion after exposure of male rats to estrogenic chemicals and their combinations. [BPA, BPS]

Gestational low-dose BPA exposure impacts suprachiasmatic nucleus neurogenesis and circadian activity with transgenerational effects.

Bisphenol A and Bisphenol S Oxidative Effects in Sheep Red Blood Cells: An In Vitro Study.

Unraveling the mechanism of long-term bisphenol S exposure disrupted ovarian lipids metabolism, oocytes maturation, and offspring development of zebrafish.

Protective role of Mas Cotek (Ficus deltoidea) against the toxic effects of bisphenol A on morphology and sex steroid receptor expression in the rat uterus.

Protective effect of alpha-lipoic acid on bisphenol A-induced learning and memory impairment in developing mice: nNOS and keap1/Nrf2 pathway.

Individual and combined effects of BPA, BPS and BPAF on the cardiomyocyte differentiation of embryonic stem cells.

Effects of 2,4-dichlorophenol exposure on zebrafish: Implications for the sex hormone synthesis.

Phthalates

Perinatal exposure to known endocrine disrupters alters ovarian development and systemic steroid hormone profile in rats.

Intermittent fasting ameliorates di-(2-ethylhexyl) phthalate-induced precocious puberty in female rats: A study of the hypothalamic-pituitary-gonadal axis.

Potential effect of fish oil to preserve expression of cell cycle and tight junction regulating genes in colon after di-isononyl phthalate ingestion in albino Wistar rats.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposure to a low concentration of mixed organochlorine pesticides impairs glucose metabolism and mitochondrial function in L6 myotubes and zebrafish.

Perfluoroalkyl Substances

Exploration of the developmental toxicity of TCS and PFOS to zebrafish embryos by whole-genome gene expression analyses.

Flame Retardants

Sex-Specific Disruption of the Prairie Vole Hypothalamus by Developmental Exposure to a Flame Retardant Mixture.

Pesticides

Grandmother’s pesticide exposure revealed bi-generational effects in Daphnia magna.

Host Metabolic Disorders Induced by Alterations in Intestinal Flora under Dietary Pesticide Exposure.

Triazophos and its metabolite diethyl phosphate have different effects on endocrine hormones and gut health in rats.

Sublethal effects of Isoclast™ Active (50% sulfoxaflor water dispersible granules) on larval and adult worker honey bees (Apis mellifera L.).

Persistent proteomic changes in glutamatergic and GABAergic signaling in the amygdala of adolescent rats exposed to chlorpyrifos as juveniles.

Potentially Toxic Elements

Resveratrol attenuates arsenic-induced cognitive deficits via modulation of Estrogen-NMDAR-BDNF signalling pathway in female mouse hippocampus.

Microplastics

An automatic flow-through system for exploration of the human bioaccessibility of endocrine disrupting compounds from microplastics. [BPA, phthalates]

Parental transfer of nanopolystyrene-enhanced tris(1,3-dichloro-2-propyl) phosphate induces transgenerational thyroid disruption in zebrafish.

Chronic and transgenerational effects of polystyrene microplastics at environmentally relevant concentrations on earthworms (Eisenia fetida).

Air Pollution

Diesel exhaust exposure alters the expression of networks implicated in neurodegeneration in zebrafish brains.

Miscellaneous

A systematic approach to metabolic characterization of thyroid-disrupting chemicals and their in vitro biotransformants based on prediction-assisted metabolomic analysis.

Exposure/Environment Studies

BPA/Phenols/Phthalates

Biomonitoring of fast-elimination endocrine disruptors – Results from a 6-month follow up on human volunteers with repeated urine and hair collection. [bisphenols, phthalates, pesticides]

Human biomonitoring reference values and characteristics of Phthalate exposure in the general population of Taiwan: Taiwan Environmental Survey for Toxicants 2013-2016.

Perfluoroalkyl Substances

Assessment of exposure to perfluoroalkyl substances (PFASs) in dogs by fur analysis.

Flame Retardants

COVID-19 face masks: A new source of human and environmental exposure to organophosphate esters.

Pesticides

Pesticide exposure among Latinx child farmworkers in North Carolina.

Potentially Toxic Elements

Diet and erythrocyte metal concentrations in early pregnancy-cross-sectional analysis in Project Viva.

Lead concentrations and isotope ratios in blood, breastmilk and feces: contribution of both lactation and soil/dust exposure to infants in a lead mining area, Kabwe, Zambia.

Pharmaceuticals/Personal Care Products

Occurrence of pharmaceuticals and personal care products in bottled water and assessment of the associated risks.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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