EDC Science Weekly, May 24-30, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: Pesticide exposure and COVID; USDA analysis of PFAS in food packaging; hair products and EDCs in Black women; op-ed: an outdated flammability standard leads to flame retardant exposure in cars.

More science highlights

Events

June 6 webinar: PFAS: federal drinking water standards & opportunities for nursing action [Alliance of Nurses for Healthy Environments (ANHE) Policy & Advocacy Committee]

June 10 webinar: Exploring the impact of endocrine disruptors on human health [International Society of Endocrinology (ISE) and the European Society of Endocrinology (ESE)]

June 10-11 workshop: Complementary and integrative interventions to prevent and mitigate the effects of endocrine-disrupting chemicals [NCCIH]

June 10-12: National PFAS Conference in Ann Arbor, MI

June 12: Endocrine disruptors interactive workshop [In Brussels and online. EndocRine Guideline Optimisation (ERGO)]

June 13-14: EURION final event [In Brussels and online. European Cluster to Improve Identification of Endocrine Disruptors (EURION)]

June 18 webinar: Research needs for protecting human health and the environment – an EU agencies’ perspective [ECHA]

June 23-28: Gordon Research Conference on EDCs in Tuscany, Italy

July 12 and 31: Virtual symposium: Measuring Microplastics register for July 12; register for July 31 [NYU Langone Center for the Investigation of Environmental Hazards (CIEH)]

Aug. 5-8: DOHaD summer course in Portland, OR [OHSU Center for Developmental Health]

Oct. 14-16: 8th Annual meeting of the U.S. DOHaD Society: exploring translational DOHaD science: from cells to communities in Chapel Hill, NC [abstracts due Aug. 1]

More events

Regulations/Policy

Beyond the Tailpipe: An Outdated Flammability Standard Leads to Organohalogen Flame Retardant Exposures inside Cars.

EDC policy and regulations open for comment

Methods/Tools/Screening

Development of a Zebrafish Embryo-Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research.

The application of natural language processing for the extraction of mechanistic information in toxicology.

Machine learning-enhanced molecular network reveals global exposure to hundreds of unknown PFAS.

Accurate Enthalpies of Formation for PFAS from First-Principles: Combining Different Levels of Theory in a Generalized Thermochemical Hierarchy.

Evaluation of the Interaction-Based Hazard Index Formula Using Data on Four Trihalomethanes from U.S. EPA’s Multiple-Purpose Design Study.

Translating nanoEHS data using EPA NaKnowBase and the resource description framework.

Inter- and trans-generational impacts of environmental exposures on the germline resolved at the single-cell level

Status of single-cell RNA sequencing for reproductive toxicology in zebrafish and the transcriptomic trade-off

Unique challenges and best practices for single cell transcriptomic analysis in toxicology

Commentaries

Editorial overview: Navigating complex chemical mixtures in risk assessment

Inhalation of Microplastics-A Toxicological Complexity.

Controversy on health-based guidance values for bisphenol A-the need of criteria for studies that serve as a basis for risk assessment.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Obesogens in Adolescence: Challenging Aspects and Prevention Strategies.

Effects of Hazardous Chemicals on Secondary Sex Ratio: A Comprehensive Review.

Neurotoxicity of Some Environmental Pollutants to Zebrafish. [pesticides and microplastics]

Exploring the intricate relationship between miRNA dysregulation and breast cancer development: insights into the impact of environmental chemicals.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

A systematic review and meta-analysis of environmental contaminant exposure impacts on weight loss and glucose regulation during calorie-restricted diets in preclinical studies: Persistent organic pollutants may impede glycemic control.

PFAS

Impacts of PFOS, PFOA and their alternatives on the gut, intestinal barriers and gut-organ axis.

How Per- and Poly-Fluoroalkyl Substances Affect Gamete Viability and Fertilization Capability: Insights from the Literature.

Flame Retardants

Exploiting Waste towards More Sustainable Flame-Retardant Solutions for Polymers: A Review.

Pesticides

Epigenetic processes involved in response to pesticide exposure in human populations: a systematic review and meta-analysis.

Emerging trends to replace pesticides with nanomaterials: Recent experiences and future perspectives for ecofriendly environment.

Chromatographic Methods for the Determination of Glyphosate in Cereals Together with a Discussion of Its Occurrence, Accumulation, Fate, Degradation, and Regulatory Status.

Is autism a PIN1 deficiency syndrome? A proposed etiological role for glyphosate.

Microbial pesticides – challenges and future perspectives for testing and safety assessment with respect to human health.

Metals/Metalloids

Heavy metal exposure and metabolomics analysis: an emerging frontier in environmental health.

Microplastics/Nanomaterials

A review on micro- and nanoplastics in humans: Implication for their translocation of barriers and potential health effects.

Mind over Microplastics: Exploring Microplastic-Induced Gut Disruption and Gut-Brain-Axis Consequences.

The potential of micro- and nanoplastics to exacerbate the health impacts and global burden of non-communicable diseases.

Potential Effects of Environmental and Occupational Exposure to Microplastics: An Overview of Air Contamination.

Microplastics and Oxidative Stress-Current Problems and Prospects.

Nanoplastics and Neurodegeneration in ALS.

Reproductive toxicity and related mechanisms of micro(nano)plastics in terrestrial mammals: Review of current evidence.

Overview of the environmental risks of microplastics and their controlled degradation from the perspective of free radicals.

Air Pollution

Environmental pollution to kidney disease: an updated review of current knowledge and future directions.

Miscellaneous

Food Plants and Environmental Contamination: An Update.

Human Health Studies

Numerous Chemicals/Mixtures

Prenatal Exposure to Chemical Mixtures and Metabolic Syndrome Risk in Children. [see related Commentary, In Utero Metabolic Disruption-A Preventable Antecedent of Adult Disease?]

Maternal exposure to bisphenols, phthalates, perfluoroalkyl acids, and trace elements and their associations with gestational diabetes mellitus in the APrON cohort.

Association between Prenatal Dietary Toxicants and Infant Neurodevelopment: The Role of Fish.

Insights into the early-life chemical exposome of Nigerian infants and potential correlations with the developing gut microbiome.

Exposure to environmental pollutants selects for xenobiotic-degrading functions in the human gut microbiome.

A Prospective Cohort Study of Persistent Endocrine Disrupting Chemicals and Perceived Stress.

BPA/Phenols

Bisphenol AF exposure synergistically increases the risk for suicidality among early adolescents with child maltreatment: A prospective cohort study.

No Differences in Urine Bisphenol A Concentrations between Subjects Categorized with Normal Cognitive Function and Mild Cognitive Impairment Based on Montreal Cognitive Assessment Scores.

Modulation of Sirtuin 3 by N-Acetylcysteine Preserves Mitochondrial Oxidative Phosphorylation and Restores Bisphenol A-Induced Kidney Damage in High-Fat-Diet-Fed Rats.

Phthalates

Endocrine effect of phthalate metabolites and a butterfly effect of prenatal exposure to androgens on qualitative aspects of female sexual response- an initial survey.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Agent orange exposure and prostate cancer risk in the million veteran program.

Residential proximity to dioxin-emitting facilities and risk of non-Hodgkin lymphoma in the NIH-AARP Diet and Health Study.

PFAS

Temporal Trend of Serum Perfluorooctanoic Acid and Perfluorooctane Sulfonic Acid among U.S. Adults with or without Comorbidities in NHANES 1999-2018.

Immune cell profiles associated with human exposure to perfluorinated compounds (PFAS) suggest changes in Natural Killer, T helper and T cytotoxic cell subpopulations.

Association of Combined PFOA, PFOS, Metals and Allostatic Load on Hepatic Disease Risk.

Association between exposure to per- and polyfluoroalkyl substance and liver injury in American adults.

Flame Retardants

Estimated daily intake and cumulative risk assessment of organophosphate esters and associations with DNA damage among e-waste workers in Hong Kong.

Pesticides

Organophosphate pesticide exposure and risk of SARS-CoV-2 infection

Glyphosate contamination of drinking water and the occurrence of oxidative stress: exposure assessment to rural Brazilian populations.

Metals/Metalloids

Association Between Exposure to Multiple Toxic Metals in Follicular Fluid and the Risk of PCOS Among Infertile Women: The Mediating Effect of Metabolic Markers.

Prenatal arsenic metabolite exposure is associated with increased newborn mitochondrial DNA copy number: evidence from a birth cohort study.

Associations of a toenail metal mixture with attention and memory in the Gulf long-term follow-up (GuLF) study.

Microplastics/Nanomaterials

Prevalence and implications of microplastic contaminants in general human seminal fluid: A Raman spectroscopic study.

Air Pollution

Effect of fine particulate matter exposure on gestational diabetes mellitus risk: a retrospective cohort study.

Air pollution exposure, accelerated biological aging, and increased thyroid dysfunction risk: Evidence from a nationwide prospective study.

PAHs

Urinary polycyclic aromatic hydrocarbon metabolites and hyperlipidemia: NHANES 2007-2016.

Associations of urinary polycyclic aromatic hydrocarbon (PAH) metabolites and their mixture with thyroid hormone concentration during pregnancy in the LIFECODES cohort: A repeated measures study.

Laboratory Studies

BPA/Phenols

Algal toxicity and food chain transport characteristics of three common bisphenols and their mixtures.

A novel bellidifolin intervention mitigates nonalcoholic fatty liver disease-like changes induced by bisphenol F.

Phthalates

SLC7A11 as a therapeutic target to attenuate phthalates-driven testosterone level decline in mice.

Developmental toxicity and mechanism of dibutyl phthalate and alternative diisobutyl phthalate in the early life stages of zebrafish (Danio rerio).

Assessment of biodegradation and toxicity of alternative plasticizer di(2-ethylhexyl) terephthalate: Impacts on microbial biofilms, metabolism, and reactive oxygen species-mediated stress response.

Parabens/Triclosan/Antimicrobials

Toxicology and carcinogenesis study of triclosan administered dermally to B6C3F1/N mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

PCB169 exposure aggravated the development of non-alcoholic fatty liver in high-fat diet-induced male C57BL/6 mice.

PFAS

Identifying novel mechanisms of per- and polyfluoroalkyl substance-induced hepatotoxicity using FRG humanized mice.

Segmentation of Renal Thyroid Follicle Colloid in Common Carp: Insights into Perfluorooctanoic Acid-Induced Morphometric Alterations.

Exposure to a PFOA, PFOS and PFHxS Mixture during Gestation and Lactation Alters the Liver Proteome in Offspring of CD-1 Mice.

Feeding Ration Impacts Larval Pimephales Promelas 7-Day Subchronic Growth Endpoint: Case Study with Perfluorooctanesulfonic Acid.

Mixtures of legacy and replacement perfluorosulphonic acids (PFSAs) demonstrate ratio-, concentration- and endpoint-dependent synergistic interactions in vitro.

Maternal F-53B exposure during pregnancy and lactation affects bone growth and development in male offspring.

Species Difference? Bovine, Trout, and Human Plasma Protein Binding of Per- and Polyfluoroalkyl Substances.

Flame Retardants

Environmentally Relevant Concentrations of Triphenyl Phosphate (TPhP) Impact Development in Zebrafish.

Role of autonomic nervous system in BDE-209 maternal exposure induced immunotoxicity in female offspring.

Pesticides

Glycometabolic disorder induced by chronic exposure to low-concentration imidacloprid in zebrafish.

Parental exposure to Cypermethrin causes intergenerational toxicity in zebrafish offspring.

Unraveling Paraquat-Induced Toxicity on Mouse Neural Stem Cells: Dose-Response Metabolomics Insights and Identification of Sensitive Biomarkers for Risk Assessment.

Aminomethylphosphonic Acid (AMPA), a Glyphosate Metabolite, Decreases Plasma Cholinesterase Activity in Rats.

Intake of imidacloprid in lethal and sublethal doses alters gene expression in Apis mellifera bees.

Metals/Metalloids

Thyroid Under Siege: Unravelling the Toxic Impact of Real-Life Metal Mixture Exposures in Wistar Rats.

Toxicity and speciation of inorganic arsenics and their adverse effects on in vivo endpoints and oxidative stress in the marine medaka Oryzias melastigma.

Microplastics/Nanomaterials

Polystyrene microplastics disturb maternal glucose homeostasis and induce adverse pregnancy outcomes.

Polystyrene nanoplastics induce intestinal and hepatic inflammation through activation of NF-κB/NLRP3 pathways and related gut-liver axis in mice.

Triclosan-loaded aged microplastics exacerbate oxidative stress and neurotoxicity in Xenopus tropicalis tadpoles via increased bioaccumulation.

Inhibitory Impact of Prenatal Exposure to Nano-Polystyrene Particles on the MAP2K6/p38 MAPK Axis Inducing Embryonic Developmental Abnormalities in Mice.

Disruption of early embryonic development in mice by polymethylmethacrylate nanoplastics in an oxidative stress mechanism.

Melatonin counteracts polyethylene microplastics induced adreno-cortical damage in male albino rats.

Comparative Study of the Effects of Different Surface-Coated Silver Nanoparticles on Thyroid Disruption and Bioaccumulation in Zebrafish Early Life.

The size-dependent effects of nanoplastics in mouse primary hepatocytes from cells to molecules.

How do fish consume microplastics? An experimental study on accumulation pattern using Nile tilapia (Oreochromis niloticus).

Pharmaceuticals/Personal Care Products

Effects of environmentally relevant concentrations of florfenicol on the glucose metabolism system, intestinal microbiome, and liver metabolome of zebrafish. [an antibiotic]

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Hair Product Use and Urinary Biomarker Concentrations of Non-Persistent Endocrine Disrupting Chemicals among Reproductive-aged Black Women.

Frequency of personal care product use among reproductive-aged Black individuals and associations with socio-demographic characteristics.

Human Biomonitoring of Environmental Chemicals among Elderly in Wuhan, China: Prioritizing Risks Using EPA’s ToxCast Database.

Microplastics and Endocrine Disruptors in Typical Wastewater Treatment Plants in Megacity Shanghai.

Emerging Contaminants in the Effluent of Wastewater Should Be Regulated: Which and to What Extent?

Occurrence and Prioritization of Human Androgen Receptor Disruptors in Sewage Sludges Across China.

BPA/Phenols

Biomonitoring Study of Urinary Bisphenol A Levels and Impact of Bottle-Feeding Practices Among Infants and Children From North India.

Bisphenol A release from CAD/CAM splint materials.

Prevalence of synthetic phenolic antioxidants in food contact materials from China and their implications for human dietary exposure through take-away food.

Phthalates

Phthalates and other organic chemicals in agricultural soils after use of different types of conventional and biodegradable plastics.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Short- and medium-chain chlorinated paraffins in surface sediment from Lake Ontario.

PFAS

Non-targeted analysis of per- and polyfluorinated substances in consumer food packaging. [USDA]

Linking exposure to per- and polyfluoroalkyl substances (PFAS) in house dust and biomonitoring data in eight impacted communities.

Predicting the dynamics of per- and polyfluoroalkyl substances in coastal regions of Africa: vulnerability index and adverse ecological pathways from remote-sensed variables.

Identification and quantification of novel per- and polyfluoroalkyl substances (PFAS) contamination in a Great Lakes urban-dominated watershed.

Persistence of PFOA Pollution at a PTFE Production Site and Occurrence of Replacement PFASs in English Freshwaters Revealed by Sentinel Species, the Eurasian Otter (Lutra lutra).

Flame Retardants

Organophosphate esters in milk across thirteen countries from 2020 to 2023: Concentrations, sources, temporal trends and ToxPi priority to humans.

Exposure to organophosphate esters among Inuit adults of Nunavik, Canada.

Decabromodifenyl Ether (BDE-209) in Surface Soils from Warsaw and Surrounding Areas: Characterization of Non-Carcinogenic Risk Associated with Oral and Dermal Exposure.

Inventorization and ecological risk assessment of tetrabromobisphenol A and hexabromocyclododecane in sediments from Guangdong coastal area of South China Sea.

Pesticides

Biological Monitoring of Glyphosate Exposure among Knapsack Sprayers in Khon Kaen, Thailand.

Metals/Metalloids

Spatial – temporal mapping of urine cadmium levels in China during 1980 – 2040: Dietary improvements lower exposure amid rising pollution.

Microplastics/Nanomaterials

Identification and Visualization of Polystyrene Microplastics/Nanoplastics in Flavored Yogurt by Raman Imaging.

Determination of Microplastics in Omega-3 Oil Supplements.

Microscopic Raman-based rapid detection of submicron/nano polypropylene plastics in tea and tea beverages.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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