EDC Science Weekly, May 19 – 25, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar May 31: Kids and chemicals: PFAS exposure and metabolism [CHE]

Webinar June 8: The Chemical Footprint of a Plastic Bottle [CHE]

Webinar June 13: CHE Café: Science, Storytelling & A New War on Cancer

For more events, see our new online compilation of upcoming events

Regulations/Policy

Enhancing Regulations to Reduce Exposure to PFAS — Federal Action on “Forever Chemicals”

Application of human biomonitoring data to support policy development, raise awareness and environmental public health protection among countries within the HBM4EU project.

Managing PMT/vPvM substances in consumer products through the concepts of essential-use and functional substitution: a case-study for cosmetics.

Methods/Tools/Screening

Methods

Predicting the ecotoxicity of endocrine disruptive chemicals: Multitasking in silico approaches towards global models.

Advancing Computational Toxicology by Interpretable Machine Learning.

A putative adverse outcome network for neonatal mortality and lower birth weight in rodents: Applicability to per- and polyfluoroalkyl substances and relevance to human health.

Systematic computational toxicity analysis of the ozonolytic degraded compounds of azo dyes: Quantitative structure-activity relationship (QSAR) and adverse outcome pathway (AOP) based approach.

Application of systematic evidence mapping to identify available data on the potential human health hazards of selected market-relevant azo dyes.

Development and initial testing of EcoToxChip, a novel toxicogenomics tool for environmental management and chemical risk assessment.

Commentaries

Obesogens and Obesity: State-of-the-Science and Future Directions Summary from a HEEDS Workshop

Looking beyond Cancer: Glyphosate and Liver, Metabolic Diseases in Youth. [Science Selection in EHP]

Reviews

Numerous Chemicals/Mixtures

Endocrine-disrupting chemicals and autoimmune diseases.

Evaluation of mixture toxicity literature and chemical space: a data centric approach.

Molecular underpinnings of developmental toxicity by the concept of “Signal Toxicity”

Hazardous chemicals in recycled and reusable plastic food packaging

BPA/Phenols

A review on immunomodulatory effects of BPA analogues.

Perfluoroalkyl Substances

Review of the Zebrafish as a Model to Investigate per- and Polyfluoroalkyl Substance Toxicity.

Pesticides

Occurrence and exposure assessment of glyphosate in the environment and its impact on human beings.

Occupational exposure to pesticides and symptoms of depression in agricultural workers. A systematic review.

Microplastics/Nanomaterials

Global research hotspots and trends on microplastics: a bibliometric analysis.

Recent advances on microplastic aging: Identification, mechanism, influence factors, and additives release.

Plastic or plastic-free life: From formation to removal.

Miscellaneous

Hypothesis-driven weight of evidence evaluation indicates styrene lacks endocrine disruption potential.

Human Health Studies

BPA/Phenols

Enhancing de novo ceramide synthesis induced by bisphenol A exposure aggravates metabolic derangement during obesity. [human and animal study]

Parabens/Triclosan/Antimicrobials

Triclosan is associated with breast cancer via oxidative stress and relative telomere length.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Prenatal Organochlorine Pollutant Exposure and Risk of Schizophrenia in a National Birth Cohort.

Perfluoroalkyl Substances

Prenatal Exposure to Perfluoroalkyl Substances and Cognitive and Neurobehavioral Development in Children at 6 Years of Age.

Behavioral outcomes and exposure to perfluoroalkyl substances among children aged 6-13 years: The TEDDY child study.

Associations of prenatal and postnatal exposure to perfluoroalkyl substances with pubertal development and reproductive hormones in females and males: The HOME study.

Impact of exposure to per- and polyfluoroalkyl substances on fecal microbiota composition in mother-infant dyads.

Sex-specific effect of perfluoroalkyl substances exposure on liver and thyroid function biomarkers: A mixture approach.

Prenatal exposures to per- and polyfluoroalkyl substances and epigenetic aging in umbilical cord blood: The healthy start study.

Associations of Pregnancy Per- and Polyfluoroalkyl Substance Concentrations and Uterine Fibroid Changes across Pregnancy: NICHD Fetal Growth Studies – Singletons Cohort.

Combining the targeted and untargeted screening of environmental contaminants reveals associations between PFAS exposure and vitamin D metabolism in human plasma.

Pesticides

Triazine herbicides exposure, natural immunoglobulin M antibodies, and fasting plasma glucose changes: Association and mediation analyses in general Chinese urban adults.

Metals/Metalloids

Why Do People Gain Belly Fat in Rural Areas? A Study of Urinary Metal(loid)s and Abdominal Obesity in China.

Blood metal/metalloid concentration of male subjects undergoing IVF/ICSI treatment outcomes: A prospective cohort study.

Prenatal Lead Exposure is Negatively Associated with the Gut Microbiome in Childhood.

Air Pollution

The association of exposure to air pollution with changes in plasma glucose indices, and incidence of diabetes and prediabetes: A prospective cohort of first-degree relatives of patients with type 2 diabetes.

Miscellaneous

Association of polycyclic aromatic hydrocarbons with osteoarthritis among adults: an analysis of the NHANES 2001-2016.

Volatile Hydrocarbon Exposures and Incident Coronary Heart Disease Events: Up to Ten Years of Follow-up among Deepwater Horizon Oil Spill Workers.

Laboratory Studies

Numerous Chemicals/Mixtures

Developmental exposure to a real-life environmental chemical mixture alters testicular transcription factor expression in neonatal and pre-pubertal rams, with morphological changes persisting into adulthood.

BPA/Phenols

Bisphenol A induced hepatic steatosis by disturbing bile acid metabolism and FXR/TGR5 signaling pathways via remodeling the gut microbiota in CD-1 mice.

Dysfunction of the medial prefrontal cortex contributes to BPA-induced depression- and anxiety-like behavior in mice.

In utero bisphenol A exposure disturbs germ cell cyst breakdown through the PI3k/Akt signaling pathway and BDNF expression.

Prenatal exposure to bisphenol AF induced male offspring reproductive dysfunction by triggering testicular innate and adaptive immune responses.

Toxicity of bisphenol A (BPA) and its derivatives in diverse biological models with the assessment of molecular mechanisms of toxicity.

Environmentally relevant levels of BPA and NOR disturb early skeletal development in zebrafish.

The impacts of exposure to Bisphenol A in the adult female prostate Meriones unguiculatus.

Melatonin inhibited the progression of gastric cancer induced by Bisphenol S via regulating the estrogen receptor 1.

Parabens/Triclosan/Antimicrobials

Environmentally relevant concentrations of triclosan induce lethality and disrupt thyroid hormone activity in zebrafish (Danio rerio).

Perfluoroalkyl Substances

Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish.

Flame Retardants

Neurotoxicity of an emerging organophosphorus flame retardant, resorcinol bis(diphenyl phosphate), in zebrafish larvae.

Pesticides

Maternal pre-conceptional glyphosate exposure impacts the offspring hepatic and ovarian proteome.

Glyphosate potentiates insulin resistance in skeletal muscle through the modulation of IRS-1/PI3K/Akt mediated mechanisms: An in vivo and in silico analysis.

Exposure to fipronil, 2,4-D and vinasse influences macroinvertebrate assemblage structure: An experimental mesocosm approach.

Exposure to Mancozeb results in increased MAPK phosphorylation and locomotor deficits in zebrafish larvae.

Bigger and bolder: Widespread agricultural pollutant 17β-trenbolone increases growth and alters behaviour in tadpoles (Litoria ewingii).

Systematic evaluation of the toxicological effects of deltamethrin exposure in zebrafish larvae.

Herbicide atrazine impairs metabolic plasticity of mixotrophic organisms: Evidence in photochemistry, morphology, and gene expression.

Effects of the neonicotinoid insecticides thiamethoxam and imidacloprid on metamorphosis of the toad Rhinella arenarum at environmentally-relevant concentrations.

Metals/Metalloids

Arsenite exposure disturbs maternal-to-zygote transition by attenuating H3K27ac during mouse preimplantation development.

Microplastics/Nanomaterials

Single-use take-away cups of paper are as toxic to aquatic midge larvae as plastic cups.

Polystyrene microplastics trigger adiposity in mice by remodeling gut microbiota and boosting fatty acid synthesis.

Differently surface-labeled polystyrene nanoplastics at an environmentally relevant concentration induced Crohn’s ileitis-like features via triggering intestinal epithelial cell necroptosis.

Microplastics aggravates rheumatoid arthritis by affecting the proliferation/migration/inflammation of fibroblast-like synovial cells by regulating mitochondrial homeostasis.

TiO₂ nanoparticles combined with polystyrene nanoplastics aggravated reproductive toxicity in female mice via exacerbating intestinal barrier disruption.

Single-cell transcriptomic analysis reveals heterogeneity of the patterns of responsive genes and cell communications in liver cell populations of zebrafish exposed to polystyrene nanoplastics.

Attenuative effect of astilbin on polystyrene microplastics induced testicular damage: Biochemical, spermatological and histopathological-based evidences.

Bioavailability of micro/nanoplastics and their associated polycyclic aromatic hydrocarbons to Daphnia Magna: Role of ingestion and egestion of plastics.

Pharmaceuticals/Personal Care Products

Trace analysis of benzophenone-type UV filters in water and their effects on human estrogen and androgen receptors.

The impact of pharmaceutical pollutants on daphnids – A metabolomic approach.

Miscellaneous

Sex-specific respiratory and systemic endocrine effects of acute acrolein and trichloroethylene inhalation.

Gut Microbiota from Short-Chain Chlorinated Paraffin-Exposed Mice Promotes Astrocyte Activation by Disrupting the Intestinal Tight Junction via Zonulin Upregulation.

Prenatal airborne polycyclic aromatic hydrocarbon exposure, altered regulation of peroxisome proliferator-activated receptor gamma (Ppar)γ, and links with mammary cancer.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Associations between faecal chemical pollutants and hormones in primates inhabiting Kibale National Park, Uganda.

BPA/Phenols

Occurrence, distribution, and ecological risk of bisphenol analogues in marine ecosystem of urbanized coast and estuary.

Phthalates

Residual status and source analysis of phthalate esters in Ulungur Lake, China.

Parabens/Triclosan/Antimicrobials

Occurrence, distribution, and risk assessment of parabens in the surface water of Terengganu River, Malaysia.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

PCDD/F and DL-PCB exposure among residents upwind and downwind of municipal solid waste incinerators and source identification.

Sea spray as a secondary source of chlorinated persistent organic pollutants? – Conclusions from a comparison of seven fresh snowfall events in 2019 and 2021.

Perfluoroalkyl Substances

Impact of precursors and bioaccessibility on childhood PFAS exposure from house dust.

PFAS in municipal landfill leachate: Occurrence, transformation, and sources.

Leaching of select per-/poly-fluoroalkyl substances, pharmaceuticals, and hormones through soils amended with composted biosolids.

Occurrence and tissue distribution of 33 legacy and novel per- and polyfluoroalkyl substances (PFASs) in Baikal seals (Phoca sibirica).

Legacy and Emerging Per- and Polyfluoroalkyl Substances in a Subtropical Marine Food Web: Suspect Screening, Isomer Profile, and Identification of Analytical Interference.

Toxic effects of three perfluorinated or polyfluorinated compounds (PFCs) on two strains of freshwater algae: Implications for ecological risk assessments.

Flame Retardants

Occurrence of hexabromocyclododecanes (HBCDs) and tetrabromobisphenol A (TBBPA) in indoor dust from different microenvironments: levels, profiles, and human exposure.

Spatial distribution, source, and ecological risk of polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecanes (HBCDs) in Jiaozhou Bay, China.

Occurrence and risk assessment of organophosphate esters in global aquatic products.

Microplastics/Nanomaterials

Chemical composition and potential health risks of tire and road wear microplastics from light-duty vehicles in an urban tunnel in China.

Investigation of microplastic ingestion in commercial fish from Surabaya river, Indonesia.

Pharmaceuticals/Personal Care Products

Prioritization of pharmaceuticals and personal care products in the surface waters of Korea: Application of an optimized risk-based methods.

Occurrence of and dermal exposure to benzene, toluene and styrene in sunscreen products marketed in the United States.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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