EDC Science Weekly, May 19 – 25, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Identification and prioritisation for risk assessment of phthalates, structurally similar substances and replacement substances potentially used as plasticisers in materials and articles intended to come into contact with food.

Protocol for the exposure assessment as part of the risk assessment of phthalates, structurally similar substances and replacement substances potentially used as plasticisers in materials and articles intended to come into contact with food [also see Phthalates and other plasticisers: priorities for reassessment from EFSA re these two articles]

Methods/Tools/Screening

Systematic evidence on migrating and extractable food contact chemicals: Most chemicals detected in food contact materials are not listed for use.

Quantitative analyses of misclassification rates in the hazard classification of environmental chemicals: Evaluation of procedures for deriving predicted no-effect concentrations in the Chemical Substance Control Law in Japan.

Human iPSC-derived hepatocytes in 2D and 3D suspension culture for cryopreservation and in vitro toxicity studies.

Diagnostic Fragmentation Pathways for Identification of Phthalate Metabolites in Nontargeted Analysis Studies.

Commentaries

Incorporating the Gut Microbiome in the Risk Assessment of Xenobiotics and Identifying Beneficial Components for One Health.

Reviews

Numerous Chemicals/Mixtures

Endocrine disrupting chemicals: effects on pituitary, thyroid and adrenal glands.

Endocrine-disrupting chemicals and the risk of gestational diabetes mellitus: a systematic review and meta-analysis.

Registered human trials addressing environmental and occupational toxicant exposures: scoping review of immunological markers and protective strategies.

Recent advances in immunotoxicity and its impact on human health: causative agents, effects and existing treatments.

BPA/Phenols

Bisphenol A in the environment and recent advances in biodegradation by fungi.

Perfluoroalkyl Substances

Dermal uptake: An important pathway of human exposure to perfluoroalkyl substances?

PFAS use in electronic products and exposure risks during handling and processing of e-waste: A review.

Pesticides

Systematic literature review of the epidemiology of glyphosate and neurological outcomes.

Temephos, an organophosphate larvicide for residential use: a review of its toxicity.

Potentially Toxic Elements

Associations of cadmium exposure with risk of metabolic syndrome and its individual components: a meta-analysis.

Microplastics

Microplastics May Be a Significant Cause of Male Infertility.

Interactions of microplastics with organic, inorganic and bio-pollutants and the ecotoxicological effects on terrestrial and aquatic organisms.

Biodegradable Microplastics: A Review on the Interaction with Pollutants and Influence to Organisms.

Microplastic properties and their interaction with hydrophobic organic contaminants: a review.

Air Pollution

Prenatal exposure to air pollution and the risk of eczema in childhood: a systematic review and meta-analysis.

Miscellaneous

Tattoo inks are toxicological risks to human health: A systematic review of its ingredients, fate inside skin, toxicity due to polycyclic aromatic hydrocarbons, primary aromatic amines, metals, and overview of regulatory frameworks.

Human Health Studies

Numerous Chemicals/Mixtures

The association of co-exposure to polycyclic aromatic hydrocarbon and phthalates with blood cell-based inflammatory biomarkers in children: A panel study.

BPA/Phenols

Plastic bottle feeding produces changes in biochemical parameters in human infants – A pilot study.

Plasma concentration of Bisphenol A and leptin in patients with meningioma and glioma: A pilot study.

Phthalates

Associations of prenatal phthalate exposure with neurobehavioral outcomes in 4.5- and 7.5-month-old infants.

The mediating role of plasma microRNAs in the association of phthalates exposure with arterial stiffness: A panel study.

Phthalate exposure and DNA oxidative damage in young people of takeaway food lovers.

Parabens/Triclosan/Antimicrobials

Association between parabens concentrations in human amniotic fluid and the offspring birth size: A Sub-study of the Persian birth cohort.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organochlorine pesticide exposures, metabolic enzyme genetic polymorphisms and semen quality parameters among men attending an infertility clinic.

Exposure to p,p´-DDE during early pregnancy, anthropometry, and gestational age at birth, in a flower-growing region of Mexico.

Perfluoroalkyl Substances

Higher free thyroxine associated with PFAS exposure in first trimester. The Odense Child Cohort.

Associations between the concentrations of α-klotho and selected perfluoroalkyl substances in the presence of eGFR based kidney function and albuminuria: Data for US adults aged 40-79 years.

Evaluated serum perfluoroalkyl acids and their relationships with the incidence of rheumatoid arthritis in the general population in Hangzhou, China.

Flame Retardants

Association of prenatal exposure to polybrominated diphenyl ethers at low levels with adiposity measures in children up to 6 years.

Pesticides

Synthetic Pyrethroids Exposure and Embryological Outcomes: A Cohort Study in Women from Fertility Clinic.

Pesticide residue intake from fruit and vegetable consumption and risk of laparoscopically-confirmed endometriosis.

Investigation of Relationships Between the Geospatial Distribution of Cancer Incidence and Estimated Pesticide Use in the U.S. West.

Potentially Toxic Elements

Differential fat accumulation in early adulthood according to adolescent-BMI and heavy metal exposure.

In-utero co-exposure to toxic metals and micronutrients on childhood risk of overweight or obesity: new insight on micronutrients counteracting toxic metals.

Burden of Coronary Heart Disease and Cancer from Dietary Exposure to Inorganic Arsenic in Adults in China, 2016.

Interaction of biomass fuels use and metals exposure on hypertension: A prospective cohort study in rural areas along the Yangtze River, China

Exposure to several polychlorinated biphenyls (PCBs) is associated with chronic kidney disease among general adults: Korean National Environmental Health Survey (KoNEHS) 2015-2017.

Environmental metal exposure, seminal plasma metabolome and semen quality: Evidence from Chinese reproductive-aged men.

Air Pollution

Time-varying association between fetal death and gestational exposure to ambient fine particles: a nationwide epidemiological study of 49 million fetuses in the contiguous US from 1989 to 2004.

Miscellaneous

Associations of benzotriazoles and benzothiazoles with estrogens and androgens among pregnant women: A cohort study with repeated measurements.

Laboratory Studies

Numerous Chemicals/Mixtures

High Content Imaging Analyses of the Effects of Bisphenols and Organophosphate Esters on TM4 Mouse Sertoli Cells.

BPA/Phenols

Bisphenol analogues induced metabolic effects through eliciting intestinal cell heterogeneous response.

Oxysterols profiles in zebrafish (Danio rerio) embryos exposed to bisphenol A.

Bisphenol a exposure decreases learning ability through the suppression of mitochondrial oxidative phosphorylation in the hippocampus of male mice.

In utero bisphenol AF exposure causes fetal Leydig cell dysfunction and induces multinucleated gonocytes by generating oxidative stress and reducing the SIRT1/PGC1α signals.

Transgenerational effects of parental bisphenol S exposure on zebrafish (Danio rerio) reproduction.

Maternal perinatal exposure to bisphenol S induces an estrogenic like effect in glucose homeostasis in male offspring.

Bisphenol A exposure induces metastatic aggression in low metastatic MCF-7 cells via PGC-1α mediated mitochondrial biogenesis and epithelial-mesenchymal plasticity.

Covalent Protein Modification: An Unignorable Factor for Bisphenol A-Induced Hepatotoxicity.

Low concentrations of bisphenol A promote the activation of the mitochondrial apoptotic pathway on Beta-TC-6 cells via the generation of intracellular reactive oxygen species and mitochondrial superoxide.

Phthalates

Development of di(2-ethylhexyl) phthalate-containing thioglycolic acid immobilized chitosan mucoadhesive gel as an alternative hormone therapy for menopausal syndrome.

Preconception exposure to dibutyl phthalate (DBP) impairs spermatogenesis by activating NF-κB/COX-2/RANKL signaling in Sertoli cells.

Dimethyl phthalate induces blood immunotoxicity through oxidative damage and caspase-dependent apoptosis.

Mono-n-butyl phthalate regulates nuclear factor erythroid 2-related factor 2 and nuclear factor kappa B pathway in an ovalbumin-induced asthma mouse model.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Insights into toxicity of polychlorinated naphthalenes to multiple human endocrine receptors: Mechanism and health risk analysis.

Perfluoroalkyl Substances

Induction of aggression and anxiety-like responses by perfluorooctanoic acid is accompanied by modulation of cholinergic- and purinergic signaling-related parameters in adult zebrafish.

Perfluorinated Iodine Alkanes Promoted Neural Differentiation of mESCs by Targeting miRNA-34a-5p in Notch-Hes Signaling.

Flame Retardants

Toxic effects of polystyrene nanoplastics and polybrominated diphenyl ethers to zebrafish (Danio rerio).

Neurotoxicity of Tris (1,3-dichloroisopropyl) phosphate in Caenorhabditis elegans.

Pesticides

Maternal cypermethrin exposure during perinatal period dysregulates gonadal steroidogenesis, gametogenesis and sperm epigenome in F1 rat offspring.

The Cardiotoxic Effect of Roundup® is not Induced by Glyphosate: A Non-specific Blockade of Human Ca_V1.2 Channels.

Investigation on the interaction of pyrethroid pesticides to estrogen receptor alpha through computational and experimental methods.

Metabolomic analysis of honey bee (Apis mellifera L.) response to glyphosate exposure.

Differentiating metabolomic responses of amphibians to multiple stressors.

Cypermethrin induces apoptosis of Sertoli cells through the endoplasmic reticulum pathway.

Pesticides Inhibit Retinoic Acid Catabolism in PLHC-1 and ZFL Fish Hepatic Cell Lines.

Potentially Toxic Elements

Differential toxicity of potentially toxic elements to human gut microbes.

An integrated biomarker approach: Non-monotonic responses to cadmium exposure in the suckermouth catfish Hypostomus plecostomus.

Sodium Arsenite does not Affect Prostate Carcinogenesis in a Chemically-Hormonally-Induced Rat Model.

Melatonin improves arsenic-induced hypertension through the inactivation of the Sirt1/autophagy pathway in rat.

Cabbage (Brassica oleracea) mitigates lead (II) acetate-induced testicular dysfunction in Wistar rats via up-regulation of Bcl-2 protein expression, pituitary-testicular hormonal axis and down-regulation of oxido-inflammatory reactions.

Microplastics

Polystyrene microplastic exposure induces insulin resistance in mice via dysbacteriosis and pro-inflammation.

Chronic exposure to polyvinyl chloride microplastics induces liver injury and gut microbiota dysbiosis based on the integration of liver transcriptome profiles and full-length 16S rRNA sequencing data.

Oxidative stress mediated by the TLR4/NOX2 signalling axis is involved in polystyrene microplastic-induced uterine fibrosis in mice.

Distinct accumulation of nanoplastics in human intestinal organoids.

Evaluation of potential toxicity of polyethylene microplastics on human derived cell lines.

Bisphenol A and microplastics weaken the antimicrobial ability of blood clams by disrupting humoral immune responses and suppressing hemocyte chemotactic activity.

Di-(2-ethylhexyl) phthalate exacerbated the toxicity of polystyrene nanoplastics through histological damage and intestinal microbiota dysbiosis in freshwater Micropterus salmoides.

Air Pollution

Integrated analysis of an in vivo model of intra-nasal exposure to instilled air pollutants reveals cell-type specific responses in the placenta.

Miscellaneous

Are “liquid plastics” a new environmental threat? The case of polyvinyl alcohol.

Toxicological evaluation of brominated vegetable oil in Sprague Dawley rats.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Occurrence and seasonal variation of several endocrine disruptor compounds (pesticides, bisphenols, musks and UV-filters) in water and sediments from the estuaries of Tagus and Douro Rivers (NE Atlantic Ocean coast).

From data to reliable conclusions: Identification and comparison of persistent micropollutants and transformation products in 37 wastewater samples by non-target screening prioritization.

Phthalates

Exposure to phthalate esters in Japanese females in Kyoto, Japan from 1993 to 2016: Temporal trends and associated health risks.

National-scale urinary phthalate metabolites in the general urban residents involving 26 provincial capital cities in China and the influencing factors as well as non-carcinogenic risks.

Phthalate esters (PAEs) concentration pattern reflects dietary habitats (δ¹³C) in blood of Mediterranean loggerhead turtles (Caretta caretta).

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposure levels of PCDD/Fs and PCBs in human blood and the transplacental transfer characteristics in cord blood of newborns near the industrialized area.

Health risk assessment of polychlorinated biphenyls (PCBs) in baby clothes. A preliminary study.

Perfluoroalkyl Substances

Emerging and Legacy Per- and Polyfluoroalkyl Substances in an Elderly Population in Jinan, China: The Exposure Level, Short-Term Variation, and Intake Assessment.

Nontargeted Identification and Temporal Trends of Per- and Polyfluoroalkyl Substances in a Fluorochemical Industrial Zone and Adjacent Taihu Lake.

Perfluoroalkyl and polyfluoroalkyl substances (PFASs) in groundwater: current understandings and challenges to overcome.

Efficient workflow for suspect screening analysis to characterize novel and legacy per- and polyfluoroalkyl substances (PFAS) in biosolids.

Flame Retardants

Determination and environmental risk assessment of organophosphorus flame retardants in sediments of the South China Sea.

Contaminant occurrence, spatiotemporal variation, and ecological risk of organophosphorus flame retardants (OPFRs) in Hangzhou Bay and east China sea ecosystem.

Polybrominated diphenyl ethers (PBDEs) in Indian wastewater treatment plant: Occurrence, mass flow and removal.

Pesticides

Predicting environmental concentrations and the potential risk of Plant Protection Products (PPP) on non-target soil organisms accounting for regional and landscape ecological variability in european soils.

Pesticides in surface freshwater: a critical review.

Potentially Toxic Elements

Results of the BfR MEAL Study: In Germany, mercury is mostly contained in fish and seafood while cadmium, lead, and nickel are present in a broad spectrum of foods.

Microplastics

Microplastic and oil pollution in oceans: Interactions and environmental impacts.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, HEEDS, a program of Environmental Health Sciences.

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