A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.
Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies
Events
Webinar May 27: “Taking Charge of Pregnancy” (UCSF EaRTH Center)
Webinar May 27: Computational Toxicology and Exposure Communities of Practice: Introduction to Systematic Review (EPA)
Info gathering session May 27: Anticipatory Research for EPA’s Research and Development Enterprise to Inform Future Environmental Protection: The Road Ahead (EPA/ORD)
Webinar June 9: DDT Exposure in Grandmothers Linked to Obesity, Earlier Periods in Granddaughters: New Meaning of “Persistence” for an Environmental Chemical Banned 50 Years Ago (EDC Strategies Partnership)
Webinar June 10: 25 Years After Our Stolen Future: What Have We Learned About Endocrine Disruption? (Society of Toxicology of Canada and The Intersectoral Centre for Endocrine Disruptor Analysis (ICEDA))
Webinar June 10: Putting the EU Chemicals Strategy for Sustainability into action: Looking forward (Food Packaging Forum)
Online conference June 15-16: 1st International Endocrine Disruptor Conference on the Island of Ireland (PROTECTED Project)
Regulations/Policy
S5(R3) Detection of Reproductive and Developmental Toxicity for Human Pharmaceuticals [Guidance Document by the FDA]
Gaining acceptance in next generation PBK modelling approaches for regulatory assessments – An OECD international effort.
Methods/Tools/Screening
Towards a comprehensive characterisation of the human internal chemical exposome: Challenges and perspectives.
Microplastic Spectral Classification Needs an Open Source Community: Open Specy to the Rescue!
Telomere Length and Arsenic: Improving Animal Models of Toxicity by Choosing Mice With Shorter Telomeres.
The Threshold of Toxicological Concern (TTC) is a pragmatic tool for the safety assessment: Case studies of cosmetic ingredients with low consumer exposure.
Novel perspectives of environmental proteomics.
Structure-based QSAR Models to Predict Repeat Dose Toxicity Points of Departure.
Assessment of the predictive capacity of a physiologically based kinetic model using a read-across approach.
Commentaries
Confronting Environmental Racism. [editorial in EHP, update of a special issue and new policies for authors and reviewers]
Environmental health equity: moving toward a solution-oriented research agenda. [intro to a special issue in the Journal of Exposure Science & Environmental Epidemiology]
Ecological Risk Assessment of Per- and Polyfluorinated Alkyl Substances: Foreword. [special series in Integrated Environmental Assessment and Management]
Introduction to the 51st Annual A&WMA Critical Review: PFOA and Cancer.
In the Name of Racial Justice: Why Bioethics Should Care about Environmental Toxins.
Reviews
Phthalates
Placental outcomes of phthalate exposure.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
Polychlorinated Diphenyl Sulfides: An Emerging Class of Persistent, Bioaccumulative and Toxic Substances (PBTs) in the Environment.
Perfluoroalkyl Substances
A pathway level analysis of PFAS exposure and risk of gestational diabetes mellitus.
A review of the occurrence, transformation, and removal of poly- and perfluoroalkyl substances (PFAS) in wastewater treatment plants.
Pesticides
Association between pesticide exposure and colorectal cancer risk and incidence: A systematic review.
Potentially Toxic Elements
Global soil pollution by toxic elements: Current status and future perspectives on the risk assessment and remediation strategies – A review.
Hazardous metal additives in plastics and their environmental impacts.
A critical review on the interactions of microplastics with heavy metals: Mechanism and their combined effect on organisms and humans.
Microplastics
Microplastics as a vehicle of exposure to chemical contamination in freshwater systems: Current research status and way forward.
Microplastics and plankton: Knowledge from laboratory and field studies to distinguish contamination from pollution.
Microplastic pollution in African countries’ water systems: a review on findings, applied methods, characteristics, impacts, and managements.
Microplastics in the environment: Occurrence, perils, and eradication.
Effects of pristine microplastics and nanoplastics on soil invertebrates: A systematic review and meta-analysis of available data.
Questioning the suitability of available microplastics models for risk assessment – A critical review.
Air Pollution
Ambient Air Pollution: Health Hazards to Children.
Emerging role of air pollution and meteorological parameters in COVID-19.
Exposure to outdoor air pollution at different periods and the risk of leukemia: a meta-analysis.
Wildfire exposure during pregnancy and the risk of adverse birth outcomes: A systematic review.
Pharmaceuticals/Personal Care Products
Ecotoxicological effects, environmental fate and risks of pharmaceutical and personal care products in the water environment: A review.
Miscellaneous
Nontraditional Risk Factors for Obesity in Modern Society. [includes EDCs]
Human Health Studies
Numerous Chemicals
Risk of Breast Cancer and pre-diagnostic urinary excretion of bisphenol A, triclosan, and parabens: the Multiethnic Cohort Study.
Hokkaido birth cohort study on environment and children’s health: cohort profile 2021. [plus findings so far]
BPA/Phenols
Associations between urinary concentrations of bisphenol A and sperm DNA fragmentation in young men.
DNA methylation at GRIN2B partially mediates the association between prenatal bisphenol F exposure and cognitive functions in 7-year-old children in the SELMA study.
Phthalates
Urinary phthalate metabolite concentrations and serum hormone levels in pre- and perimenopausal women from the Midlife Women’s Health Study.
Evaluation of reproductive hormones in Egyptian workers occupationally exposed to di-2-ethylhexyl phthalate (DEHP): a cross-sectional study.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
Association of persistent organic pollutants with sensorimotor neuropathy in participants with and without diabetes or prediabetes: Results from the population-based KORA FF4 study.
Perfluoroalkyl Substances
Impact of the increasing concentrations of selected perfluoroalkyl acids on the observed concentrations of red blood cell folate among US adults aged ≥20 years.
Flame Retardants
Prenatal exposure to organophosphate esters and neonatal thyroid-stimulating hormone levels: A birth cohort study in Wuhan, China.
Pesticides
Prenatal Exposure to Glyphosate and Its Environmental Degradate, Aminomethylphosphonic Acid (AMPA), and Preterm Birth: A Nested Case-Control Study in the PROTECT Cohort (Puerto Rico). [see accompanying commentary, Glyphosate Exposure during Pregnancy and Preterm Birth (More Research Is Needed).]
Potentially Toxic Elements
Cadmium tissue level in women diagnosed with breast cancer – A case control study.
Associations between blood cadmium and endocrine features related to PCOS-phenotypes in healthy women of reproductive age: a prospective cohort study.
A prospective study of maternal 25-hydroxyvitamin D (25OHD) in the first trimester of pregnancy and second trimester heavy metal levels.
Exposure to atmospheric metals using moss bioindicators and neonatal health outcomes in Portland, Oregon.
Impact of environmental mercury exposure on the blood cells oxidative status of fishermen living around Mundaú lagoon in Maceió – Alagoas (AL), Brazil.
Evaluation of environmental effects of heavy metals on biochemical profile and oxidative stress among children at brick kiln sites.
Effect of heavy metals on ventricular repolarization and depolarization in the Metropolitan Manila Development Authority (MMDA) traffic enforcers’ health study.
Association of vitamins, minerals, and lead with Lipoprotein(a) in a cross-sectional cohort of US adults.
Air Pollution
L-arginine supplementation to mitigate cardiovascular effects of walking outside in the context of traffic-related air pollution in participants with elevated blood pressure: A randomized, double-blind, placebo-controlled trial.
Placental gene networks at the interface between maternal PM2.5 exposure early in gestation and reduced infant birthweight.
Susceptibility of patients with chronic obstructive pulmonary disease to heart rate difference associated with the short-term exposure to metals in ambient fine particles: A panel study in Beijing, China.
Mortality attributable to fine particulate matter in Asia, 2000-2015: a cross-sectional cause-of-death analysis.
Long-Term Ambient Air Pollution Exposures and Circulating and Stimulated Inflammatory Mediators in a Cohort of Midlife Adults.
The joint association of physical activity and fine particulate matter exposure with incident dementia in elderly Hong Kong residents.
Prenatal Ambient Ultrafine Particle Exposure and Childhood Asthma in the Northeastern United States.
Risk for preeclampsia following exposure to PM2.5 during pregnancy.
Multiple environmental exposures along daily mobility paths and depressive symptoms: A smartphone-based tracking study.
The effects of an air quality alert program on premature mortality: A difference-in-differences evaluation in the region of Paris.
Breast cancer risk in relation to ambient concentrations of nitrogen dioxide and particulate matter: results of a population-based case-control study corrected for potential selection bias (the CECILE study).
Effects of short- and long-term exposure to atmospheric pollution on COVID-19 risk and fatality: analysis of the first epidemic wave in Northern Italy.
Effect of meteorological factors and Air Quality Index on the COVID-19 epidemiological characteristics: an ecological study among 210 countries.
Miscellaneous
Neurotoxicant exposures and rates of Chronic Multisymptom Illness and Kansas Gulf War illness criteria in gulf war deployed women veterans.
Laboratory Studies
BPA/Phenols
Bisphenol-A alters hematopoiesis through EGFR/ERK signaling to induce myeloblastic condition in zebrafish model.
Chronic exposure to Bisphenol A resulted in alterations of reproductive functions via immune defense, oxidative damage and disruption DNA/histone methylation in male rare minnow Gobiocypris rarus.
Low doses of BPF-induced hypertrophy in cardiomyocytes derived from human embryonic stem cells via disrupting the mitochondrial fission upon the interaction between ERβ and calcineurin A-DRP1 signaling pathway.
Bisphenol analogs AF, S and F: effects on functional characteristics of porcine granulosa cells.
Effects of Bisphenol A and Bisphenol S Exposure at Low Doses on the Metabolome of Adolescent Male Sprague-Dawley Rats.
Phthalates
Prenatal exposure to di-n-butyl phthalate induces erectile dysfunction in male adult rats.
Stereological analysis and transcriptome profiling of testicular injury induced by di-(2-ethylhexyl) phthalate in prepubertal rats.
Peritubular macrophages are recruited to the testis of peri-pubertal rats after mono-(2-ethylhexyl) phthalate exposure and is associated with increases in the numbers of spermatogonia.
Parabens/Triclosan/Antimicrobials
Metabolic fate of environmental chemical triclocarban in colon tissues: roles of gut microbiota involved.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
Developmental and lifelong dioxin exposure induces measurable changes in cardiac structure and function in adulthood.
Effects of endocrine-disrupting chemicals on hypothalamic oxytocin and vasopressin systems. (PCBs)
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced suppression of immunity in THP-1-derived macrophages and the possible mechanisms.
Perfluoroalkyl Substances
Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome.
Behavior Effects of Structurally Diverse Per- and Polyfluoroalkyl Substances in Zebrafish.
Metabolic profiling in human SH-SY5Y neuronal cells exposed to perfluorooctanoic acid (PFOA).
Flame Retardants
New insights into the mechanism of hepatocyte apoptosis induced by typical organophosphate ester: An integrated in vitro and in silico approach.
Toxic effects of Decabromodiphenyl ether (BDE-209) on thyroid of broiler chicks by transcriptome profile analysis.
2,2’4,4′-Tetrabromodiphenyl Ether (PBDE-47) Modulates the Intracellular miRNA Profile, sEV Biogenesis and Their miRNA Cargo Exacerbating the LPS-Induced Pro-Inflammatory Response in THP-1 Macrophages.
Pesticides
Developmental toxicity of procymidone to larval zebrafish based on physiological and transcriptomic analysis.
How does sublethal permethrin effect non-target aquatic organisms?
Tebuconazole induces liver injury coupled with ROS-mediated hepatic metabolism disorder.
Organophosphorus pesticide quinalphos (Ekalux 25 E.C.) reduces sperm functional competence and decreases the fertilisation potential in Swiss albino mice.
Integrated non-targeted lipidomics and metabolomics analyses for fluctuations of neonicotinoids imidacloprid and acetamiprid on Neuro-2a cells.
Multi-generational exposure to fipronil, 2,4-D, and their mixtures in Chironomus sancticaroli: Biochemical, individual, and population endpoints.
Comparative Evaluation of the Cytotoxicity of Glyphosate-Based Herbicides and Glycine in L929 and Caco2 Cells.
Potentially Toxic Elements
Real-time in vitro monitoring of the subcellular toxicity of inorganic Hg and methylmercury in zebrafish cells.
Metal pollutants have additive negative effects on honey bee cognition.
Sex-Specific Effects of Prenatal and Early Life Inorganic and Methylated Arsenic Exposure on Atherosclerotic Plaque Development and Composition in Adult ApoE-/- Mice.
Mercury immunotoxicity in the brown watersnake (Nerodia taxispilota): An in vitro study.
Evaluation of toxic effects induced by arsenic trioxide or/and antimony on autophagy and apoptosis in testis of adult mice.
Lead nitrate and cadmium chloride induced hepatotoxicity and nephrotoxicity: Protective effects of sesamol on biochemical indices and pathological changes.
Cadmium Impairs Autophagy Leading to Apoptosis by Ca2+-Dependent Activation of JNK Signaling Pathway in Neuronal Cells.
Tissue-Specific Expression of Genes Involved in Cellular Transportation in Common Carp (Cyprinus carpio) Exposed to Cadmium.
Protective effects of caffeic acid phenethyl ester on cadmium-induced testicular injury: A crucial role of antioxidant enzymes in male mice infertility.
Microplastics/Nanomaterials
Transgenerational effects on development following microplastic exposure in Drosophila melanogaster.
Systematic toxicity evaluation of polystyrene nanoplastics on mice and molecular mechanism investigation about their internalization into Caco-2 cells.
Effects induced by polyethylene microplastics oral exposure on colon mucin release, inflammation, gut microflora composition and metabolism in mice.
Dose-dependent hepatic toxicity and oxidative stress on exposure to nano and bulk selenium in mice.
Polystyrene microplastics induce an immunometabolic active state in macrophages.
Effects of microplastics (MPs) and tributyltin (TBT) alone and in combination on bile acids and gut microbiota crosstalk in mice.
Air Pollution
Label-free detection of uptake, accumulation, and translocation of diesel exhaust particles in ex vivo perfused human placenta.
Pharmaceuticals/Personal Care Products
Toxicological Study on Chiral Fluoxetine Exposure to Adult Zebrafish (Danio rerio): Enantioselective and Sexual Mechanism on Disruption of the Brain Serotonergic System. [anti-depressants]
Toxic effects of octocrylene on zebrafish larvae and liver cell line (ZFL). [UV filter]
Miscellaneous
Lethal, behavioral, growth and developmental toxicities of alkyl-PAHs and non-alkyl PAHs to early-life stage of brine shrimp, Artemia parthenogenetica.
Transcriptome responses in polar cod (Boreogadus saida) liver slice culture exposed to benzo[a]pyrene and ethynylestradiol: Insights into anti-estrogenic effects.
Exposure/Environment Studies
BPA/Phenols
Drivers of owning more BPA.
Urinary biomonitoring of occupational exposures to Bisphenol A Diglycidyl Ether (BADGE) – based epoxy resins among construction painters in metal structure coating.
Investigation of endocrine disruptor pollutants and their metabolites along the Romanian Black Sea Coast: occurrence, distribution and risk assessment. [bisphenols and UV filters]
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
High Levels of Legacy and Emerging Contaminants in Killer Whales (Orcinus orca) from Norway, 2015 to 2017. [flame retardants, PFAS, PCBs, mercury]
Exposure and risk assessment of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (dl-PCBs) for primiparous mothers and breastfed infants in Penang, Malaysia.
Global footprints of organochlorine pesticides: a pan-global survey.
Extreme Exposure Levels of PCDD/Fs Inhaled from Biomass Burning Activity for Cooking in Typical Rural Households.
Ecological risk assessment and long-term environmental pollution caused by obsolete undisposed organochlorine pesticides.
Perfluoroalkyl Substances
Unsaturated PFOS and Other PFASs in Human Serum and Drinking Water from an AFFF-Impacted Community.
Per- and polyfluoroalkyl substances (PFASs) in the soil-plant system: Sorption, root uptake, and translocation.
Quantification of Biodriven Transfer of Per- and Polyfluoroalkyl Substances from the Aquatic to the Terrestrial Environment via Emergent Insects.
Planktonic microbial responses to perfluorinated compound (PFC) pollution: Integrating PFC distributions with community coalescence and metabolism.
Cross-Flow Treatment of PFAS in Water: Materials Challenges and Potential Solutions.
Distribution and fate of per- and polyfluoroalkyl substances (PFAS) in wastewater treatment facilities.
Flame Retardants
Bioaccumulation of different congeners of Poly-Brominated Diphenyl Ethers (PBDEs) in muscle tissue of males and females of Clupea harengus from the North Sea.
Long-term trends of airborne halogenated flame retardants (HFRs) by means of tree leaf and shoot analyses.
Seasonal concentration variation and potential influencing factors of organophosphorus flame retardants in a wastewater treatment plant.
Equatorial Atlantic pelagic predators reveal low content of PBDEs in contrast to MeO-BDEs: An analysis of brominated diphenyl ethers in blue shark and yellowfin tuna.
Pesticides
International regulatory situation of pesticides authorized for use in Brazil: potential for damage to health and environmental impacts.
Personal exposure assessment of pesticides in residents: the association between hand wipes and urinary biomarkers.
Oviposition Response of Monarch Butterfly (Lepidoptera: Nymphalidae) to Imidacloprid-Treated Milkweed.
Glyphosate-based herbicide exposure affects diatom community development in natural biofilms.
Glyphosate use in urban landscape soils: Fate, distribution, and potential human and environmental health risks.
Potentially Toxic Elements
Heavy metal analysis of drinking water supply, wastewater management, and human health risk assessment across secondary schools in Badagry coastal community, Lagos State, Nigeria.
Risk Factors and Hazards in the Household Environment for Elevated Blood Lead Levels in Urban Preschool Children of Vellore: A Case-Control Approach in the MAL-ED Birth Cohort.
Methylmercury Measurements in Dried Blood Spots from Electronic Waste Workers Sampled from Agbogbloshie, Ghana.
Potential risks from the accumulation of heavy metals in canola plants.
Metal Bioaccumulation in the Gill, Liver, and Muscle of Bluefish (Pomatomus saltatrix) From the Northeastern Mediterranean and Human Health Risk Assessment Associated with Their Seasonal Consumption.
Heavy metals in processed seafood products from Turkey: risk assessment for the consumers.
Dietary exposure to potentially toxic elements through sushi consumption in Catalonia, Spain.
Lethal impacts of selenium counterbalance the potential reduction in mercury bioaccumulation for freshwater organisms.
Microplastics
In situ effects of a microplastic mixture on the community structure of benthic macroinvertebrates in a freshwater pond.
A Maze in Plastic Wastes: Autonomous Motile Photocatalytic Microrobots against Microplastics.
Migration of (non-) intentionally added substances and microplastics from microwavable plastic food containers.
Air Pollution
Air pollution impacts of COVID-19-related containment measures.
Improvement in air quality and its impact on land surface temperature in major urban areas across India during the first lockdown of the pandemic.
Mixtures
Identifying Chemicals and Mixtures of Potential Biological Concern Detected in Passive Samplers from Great Lakes Tributaries Using High-throughput Data and Biological Pathways.
Framework for Non-targeted Investigation of Contaminants Released by Wildfires into Stormwater Runoff: Case Study in the Northern San Francisco Bay Area.
Miscellaneous
Characterizing azobenzene disperse dyes in commercial mixtures and children’s polyester clothing.
A review of 17α-ethynylestradiol (EE2) in surface water across 32 countries: Sources, concentrations, and potential estrogenic effects.
From landfills to landscapes – nature based solutions for water management taking into account legacy contamination.
Characterization of unsubstituted and methylated polycyclic aromatic hydrocarbons in settled dust: Combination of instrumental analysis and in vitro reporter gene assays and implications for cancer risk assessment.
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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.
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