EDC Science Weekly, May 12 – 18, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar May 19: Obesogens and the Obesity Pandemic: A focus on prevention (EDC Strategies Partnership)

Regulations/Policy

Environmental and human health at risk – Scenarios to achieve the Farm to Fork 50% pesticide reduction goals.

Evaluating the EU’s Efforts to Improve Resilience to Health and Environmental Risks Associated with Pesticide Use by Analyzing the National Action Plans of EU Member States from 2009 to 2019.

Methods/Tools/Screening

Thyroid-like hormone signalling in invertebrates and its potential role in initial screening of thyroid hormone system disrupting chemicals.

In Vitro Assays to Identify Metabolism-Disrupting Chemicals with Diabetogenic Activity in a Human Pancreatic β-Cell Model.

Diisopropylfluorophosphate (DFP) volatizes and cross-contaminates wells in a common 96-well plate format used in zebrafish larvae toxicology studies.

Identifying Protein Features and Pathways Responsible for Toxicity Using Machine Learning and Tox21: Implications for Predictive Toxicology.

A microengineered biomimetic model of the placental barrier to study environmental exposures during pregnancy.

A High-Throughput Toxicity Screen of 42 Per- and Polyfluoroalkyl Substances (PFAS) and Functional Assessment of Migration and Gene Expression in Human Placental Trophoblast Cells.

Commentaries/Conference Summaries

Invited Perspective: The Promise of Fit-for-Purpose Systematic Evidence Maps for Supporting Regulatory Health Assessment. [re article, Systematic Evidence Map for Over One Hundred and Fifty Per- and Polyfluoroalkyl Substances (PFAS).]

Editorial: Endocrine Disruption in Light of Dohad: The Challenges of Contaminants of Emerging Concern in Food and Water.

The EU chemicals strategy for sustainability: an opportunity to develop new approaches for hazard and risk assessment. [letter]

Emerging Contaminants: Fluorinated Alternatives to Existing PFAS. [intro to special issue on this topic]

Hemispheres of Influence: Bridging the Disconnect between Environmental Neurotoxicology and Clinical Practice. [Focus in EHP]

Skin Protection Dilemma: Testing Detects Benzene in Some Sun Care Products. [Science Selection in EHP]

Invited Perspective: Causal Implications of Gene by Environment Studies Applied to Gulf War Illness. re article, Evaluation of a Gene-Environment Interaction of PON1 and Low-Level Nerve Agent Exposure with Gulf War Illness: A Prevalence Case-Control Study Drawn from the U.S. Military Health Survey’s National Population Sample.

Reviews

Numerous Chemicals/Mixtures

‘Omics in environmental epidemiological studies of chemical exposures: A systematic evidence map.

Environmental Exposure to Non-Persistent Endocrine Disrupting Chemicals and Endometriosis: A Systematic Review.

Epigenetic Inheritance: Intergenerational Effects of Pesticides and Other Endocrine Disruptors on Cancer Development.

BPA/Phenols

Increased gut serotonin production in response to bisphenol A structural analogues may contribute to their obesogenic effects.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The toxicological profile of polychlorinated naphthalenes (PCNs).

Perfluoroalkyl Substances

Effects of exposure to per- and polyfluoroalkyl substances on vaccine antibodies: A systematic review and meta-analysis based on epidemiological studies.

Pesticides

Organophosphorus Pesticides as Modulating Substances of Inflammation through the Cholinergic Pathway.

Toxic Effects of Glyphosate on the Nervous System: A Systematic Review.

What can the Allium cepa test say about pesticide safety? A review.

Advancement and New Trends in Analysis of Pesticide Residues in Food: A Comprehensive Review.

Potentially Toxic Elements

Phytochemicals in the Management of Arsenic Toxicity.

Arsenic exposures and prostate cancer risk: A multilevel meta-analysis.

Air Pollution

Association between ambient air pollution exposure during pregnancy and gestational diabetes mellitus: a meta-analysis of cohort studies.

Exposure to air pollution and risk of ovarian cancer: a review.

Long-term exposure to traffic-related air pollution and selected health outcomes: A systematic review and meta-analysis.

Prenatal exposure to ambient air pollution and adverse birth outcomes: An umbrella review of 36 systematic reviews and meta-analyses.

Miscellaneous

Particle Safety Assessment in Additive Manufacturing: From Exposure Risks to Advanced Toxicology Testing.

Human Health Studies

Numerous Chemicals/Mixtures

Maternal occupational exposure to chemicals and child cognitive function.

The Labin Region, an ecologically vulnerable geographical area in Croatia: Mortality characteristics in an area polluted by industrial over a 40-year period.

BPA/Phenols

BPA and BPS increase oxidative stress inducing a decrease in physical fitness and dyslipidemia in young adults.

Parabens/Triclosan/Antimicrobials

Risk of thyroid cancer and benign nodules associated with exposure to parabens among Chinese adults in Wuhan, China.

Association between triclosan exposure and obesity measures among 7-year-old children in northern China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Evaluation of the persistent organic pollutants association with type 2 diabetes: A prospective study from Karachi, Pakistan.

Exposure to DDT and DDE and functional neuroimaging in adolescents from the CHAMACOS cohort.

Perfluoroalkyl Substances

Influence of Perfluoroalkyl Substances on Occurrence of Coronavirus Disease 2019.

The Association between Multiple Per- and Polyfluoroalkyl Substances’ Serum Levels and Allostatic Load.

Flame Retardants

Polybrominated diphenyl ethers in early pregnancy and preterm birth: Findings from the NICHD Fetal Growth Studies.

Potentially Toxic Elements

Arsenic in Drinking Water and Incidences of Leukemia and Lymphoma: Implication for Its Dural Effects in Carcinogenicity.

Exposure to metal mixtures and hypertensive disorders of pregnancy: A nested case-control study in China.

Air Pollution

Long-term exposure to wildfires and cancer incidence in Canada: a population-based observational cohort study.

Laboratory Studies

Numerous Chemicals/Mixtures

Effects of Toxicants on Blood-Brain Barrier Function in Resilient Versus Non-resilient Mice.

The Molecular Quality and Mitochondrial Activity of Porcine Cumulus-Oocyte Complexes Are Affected by Their Exposure to Three Endocrine-Active Compounds under 3D In Vitro Maturation Conditions.

In vitro testicular toxicity of environmentally relevant endocrine-disrupting chemicals: 2D vs. 3D models of prepubertal Leydig TM3 cells.

BPA/Phenols

Effect of BPA on CYP450s expression, and nicotine modulation, in fetal rat brain.

Genetic Background in the Rat Impacts Metabolic Outcomes of Post-wean BPF Exposure.

Comparing the Effects of Bisphenol A, C, and F on Bovine Theca Cells In Vitro.

Generality and diversity on the kinetics, toxicity and DFT studies of sulfate radical-induced transformation of BPA and its analogues.

Bisphenol S induces Agrp expression through GPER1 activation and alters transcription factor expression in immortalized hypothalamic neurons: A mechanism distinct from BPA-induced upregulation.

Dietary Zinc Deficiency Increases Bisphenol A Toxicity in Diabetic Rat: Studies on the Testicular and Epididymal Pathophysiology.

Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats.

A study on bisphenol S induced nephrotoxicity and assessment of altered downstream kidney metabolites using gas chromatography-mass spectrometry based metabolomics.

Astaxanthin improves the development of the follicles and oocytes through alleviating oxidative stress induced by BPA in cultured follicles.

Phthalates

Di-(2-ethylhexyl) phthalate substitutes accelerate human adipogenesis through PPARγ activation and cause oxidative stress and impaired metabolic homeostasis in mature adipocytes.

Maternal exposure to di-2-ethylhexyl phthalate (DEHP) depresses lactation capacity in mice.

Effect of di-ethylhexyl phthalate (DEHP) on androgen related proteins in JEG-3 placental cells.

Parabens/Triclosan/Antimicrobials

Pre-implantation triclosan exposure alters uterine receptivity through affecting tight junction protein†.

Antimicrobial Triclosan (TCS) Increases Production of Interleukin 1 beta (IL-1β) in Human Immune Cells.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Type 2 Diabetes Induced by Changes in Proteomic Profiling of Zebrafish Chronically Exposed to a Mixture of Organochlorine Pesticides at Low Concentrations.

Generative Deep Learning of the Single Cell Dose Response of 2,3,7,8 Tetrachlorodibenzo-p-dioxin in Mouse Liver.

Impact of Prenatal and Postnatal Exposure to Endocrine Disrupter DDT on Adrenal Medulla Function.

Toxic Effects on Thyroid Gland of Male Adult Lizards (Podarcis Siculus) in Contact with PolyChlorinated Biphenyls (PCBs)-Contaminated Soil.

Characterizing the transcriptional signature regulated by the AHR ligands TCDD and kynurenine in colon cancer cells.

Perfluoroalkyl Substances

Perfluorooctanoic acid–induced lipid metabolism disorder in SD rat liver and its effect on the expression of fatty acid metabolism–related proteins.

Impact of a hexafluoropropylene oxide trimer acid (HFPO-TA) exposure on impairing the gut microbiota in mice.

Select Per- and Polyfluoroalkyl Substances (PFAS) Induce Resistance to Carboplatin in Ovarian Cancer Cell Lines.

Flame Retardants

2,2′,4,4′-Tetrabromodiphenyl Ether (PBDE 47) Selectively Stimulates Proatherogenic PPARγ Signatures in Human THP-1 Macrophages to Contribute to Foam Cell Formation.

Thyroid Supplementation Reverses the Abnormal Social and Oxytocin Phenotype Produced by Developmental Exposure to PBDEs in a Sex-Dependent Manner.

Computational Insight into Biotransformation Profiles of Organophosphorus Flame Retardants to Their Diester Metabolites by Cytochrome P450.

Exposure to the Brominated Flame Retardant Hexabromocyclododecane Results in Systemic Changes in Polyunsaturated Fatty Acid Metabolism Within Phospholipids of Mice.

Organotins

Effects of Dibutyltin Exposures on Translation Regulatory Factors eIF4E, eIF4B, and S6 in Human Immune Cells.

Pesticides

Biochemical and body condition markers in Rhinella icterica tadpoles exposed to atrazine, glyphosate, and quinclorac based herbicides in ecologically relevant concentrations.

Zebrafish Larvae Rapidly Recover from Locomotor Effects and Neuromuscular Alterations Induced by Cholinergic Insecticides.

Developing a Prenatal Acute Exposure and Medical Countermeasure Evaluation Model for Organophosphate Compounds in a Genetically Modified Mouse.

Biochemical and osmoregulatory responses of the African clawed frog experimentally exposed to salt and pesticide.

Effects of chronic exposure to the fungicide vinclozolin on gut microbiota community in an aquatic turtle.

In Vitro Assessment and Toxicological Prioritization of Pesticide Mixtures at Concentrations Derived from Real Exposure in Occupational Scenarios.

Genotoxicity, oxidative stress and transcriptomic effects of Nitenpyram on human bone marrow mesenchymal stem cells.

The Impact of Early Life Exposure to Glyphosate.

Glyphosate increases anxiety-like behavior and threat response to novel neutral stimuli.

The Effect of Atrazine on Fear Behaviors in Rats.

Environmental Neurotoxic Pesticide Exposure Induces Gut Inflammation and Enteric Neuronal Degeneration by Impairing Enteric Glial Mitochondrial Function in Pesticide Models of Parkinson’s Disease: Potential Relevance to Gut-Brain Axis Inflammation in Parkinson’s Disease Pathogenesis.

Potentially Toxic Elements

Low-Level Lead Exposure During Development Differentially Affects Neurobehavioral responses in Male and Female Mouse Offspring: A Longitudinal Study.

Potential benefits of egg white hydrolysate in the prevention of Hg-induced dysfunction in adipose tissue.

Preclinical In Vitro Model to Assess the Changes in Permeability and Cytotoxicity of Polarized Intestinal Epithelial Cells during Exposure Mimicking Oral or Intravenous Routes: An Example of Arsenite Exposure.

A novel chronic in vivo oral cadmium exposure-washout mouse model for studying cadmium toxicity and complex diabetogenic effects.

Sex Differences in Antioxidant Gene Expression in response to Chronic Arsenic Exposure.

Microplastics

Long-term effects of lithium and lithium-microplastic mixtures on the model species Daphnia magna: Toxicological interactions and implications to ‘One Health’.

Influence of microplastics on the bioconcentration of organic contaminants in fish: Is the “Trojan horse” effect a matter of concern?

Concurrent water- and foodborne exposure to microplastics leads to differential microplastic ingestion and neurotoxic effects in zebrafish.

Nanoplastics are bioaccumulated in fish liver and muscle and cause DNA damage after a chronic exposure.

Impacts of conventional and biodegradable microplastics on juvenile Lates calcarifer: Bioaccumulation, antioxidant response, microbiome, and proteome alteration.

The first plastic produced, but the latest studied in microplastics research: The assessment of leaching, ecotoxicity and bioadhesion of Bakelite microplastics.

Uterine Microvascular Dysfunction After Plastic Particle Inhalation.

Polystyrene microplastics up-regulates liver glutamine and glutamate synthesis and promotes autophagy-dependent ferroptosis and apoptosis in the cerebellum through the liver-brain axis.

Nanoplastic effects on human vascular endothelial cells: A comparison of primary cells (HUVEC) and immortalized cells (hy926) after exposure to polystyrene nanoplastics.

Combined toxicity of polystyrene microplastics and ammonium perfluorooctanoate to Daphnia magna: Mediation of intestinal blockage.

Miscellaneous

mRNA-miRNA sequencing reveals mechanisms of 2,2′-dipyridyl disulfide-induced thyroid disruption in Japanese flounder (Paralichthys olivaceus).

IPPD-induced growth inhibition and its mechanism in zebrafish.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Assessing Marine Endocrine-Disrupting Chemicals in the Critically Endangered California Condor: Implications for Reintroduction to Coastal Environments.

BPA/Phenols

Novel hyphenation of DGT in-situ passive sampling with YES assay to ascertain the potency of emerging endocrine disruptors in water systems in New Zealand.

Influence of Temperature on the Quantity of Bisphenol A in Bottled Drinking Water.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

A retrospective study on dioxins and dioxin-like polychlorinated biphenyls in milk and dairy products from the Latium region (Italy) over a 7-year study period (2011-2017).

Perfluoroalkyl Substances

Comprehensive screening of polar emerging organic contaminants including PFASs and evaluation of the trophic transfer behavior in a freshwater food web.

Perfluoroalkyl substances in hen eggs from different types of husbandry.

Occurrence of per- and polyfluoroalkyl substances (PFAS) in municipal solid waste landfill leachates from western China.

Perfluoroalkyl Substances (PFASs) in Rivers and Drinking Waters from Qingdao, China.

Per- and polyfluoroalkyl substances (PFASs) in groundwater from a contaminated site in the North China Plain: Occurrence, source apportionment, and health risk assessment.

Flame Retardants

Occurrence, distribution and risk assessment of organophosphate esters (OPEs) in water sources from Northeast to Southeast China.

Trophic transfer of methylmercury and brominated flame retardants in adjacent riparian and aquatic food webs: ¹³C indicates biotransport of contaminants through food webs.

Pesticides

Excretion time courses of lambda-cyhalothrin metabolites in the urine of strawberry farmworkers and effect of coexposure with captan.

Pesticide residues on children’s hands, home indoor surfaces, and drinking water among conventional and organic farmers in Thailand.

Potentially Toxic Elements

Contamination of breast milk with lead, mercury, arsenic, and cadmium in Iran: a systematic review and meta-analysis.

Exposure variability and determining factors of urinary metals for schoolchildren in Taiwan.

Dental amalgam: the history and legacy you perhaps never knew?

Updated trends for atmospheric mercury in the Arctic: 1995-2018.

Microplastics

Why is inhalation the most discriminative route of microplastics exposure?

Microplastic accumulation in the gastrointestinal tracts of nestling and adult migratory birds.

Tobacco as a Source of Microplastics. Tobacco and Environment: World No Tobacco Day 2022.

Are we ignoring the role of urban forests in intercepting atmospheric microplastics?

Occurrence of Microplastics in Tap and Bottled Water: Current Knowledge.

Pharmaceuticals/Personal Care Products

Personal Care and Household Cleaning Product Use among Pregnant Women and New Mothers during the COVID-19 Pandemic.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS.

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