EDC Science Weekly, Mar. 8-14, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: Effects of behavioral, clinical, and policy interventions in reducing exposure to bisphenols and phthalates; migration of chemicals from “sustainable” food contact materials.

More science highlights

Events

Mar. 19 webinar: Obesogens: A unifying theory for the global rise in obesity [EDC Strategies Partnership]

Mar. 22: HEEDS EDC- North Carolina annual meeting [free and open to anyone]

Mar. 25: U.S. Research Community stakeholder call on the future plastic pollution instrument [U.S. Dept. of State; not open to media]

Mar. 26 webinar: EDC Free Asia: Regulatory policies and frameworks addressing environmental and human exposure to EDCs [IPEN]

Apr. 3 webinar: A Global Plastics Treaty That Protects Endocrine Health [Endocrine Society EDC Special Interest Group]

Apr. 5: NIEHS Biomedical Career Symposium [EPA campus in Research Triangle Park, NC]

June 10-12: National PFAS Conference in Ann Arbor MI

June 23-28: Gordon Research Conference on EDCs June, in Tuscany Italy

More events

Regulations/Policy

Effects of Behavioral, Clinical, and Policy Interventions in Reducing Human Exposure to Bisphenols and Phthalates: A Scoping Review. and see related, Invited Perspective: Why Systematic Reviews, Scoping Reviews, and Evidence-to-Decision Frameworks Are Critical for Transparent, Consistent, Equitable, and Science-Based Decision-Making in Environmental Health.

The new normal chemical landscape: the future of risk assessment toward optimum consumer safety.

Regulatory Science Perspective on the Analysis of Microplastics and Nanoplastics in Human Food.

Using emerging science to inform risk characterizations for wildlife within current regulatory frameworks.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Informing methods for detecting and quantifying microplastics through the lens of a global intercalibration exercise: An editorial overview of the Special Issue and beyond. [intro to a special issue in Chemosphere]

Review of the Terminology, Approaches, and Formulations Used in the Guidelines on Quantitative Risk Assessment of Chemical Hazards in Food.

Screening

Endocrine disrupting potential of total and bioaccessible extracts of dust from seven different types of indoor environment.

Identification of endocrine-disrupting chemicals targeting key DCM-associated genes via bioinformatics and machine learning.

Assessing developmental neurotoxicity of emerging environmental chemicals using multiple in vitro models: A comparative analysis.

Novel Estrogen Receptor Dimerization BRET-Based Biosensors for Screening Estrogenic Endocrine-Disrupting Chemicals.

Use of All-Male cyp17a1-Deficient Zebrafish (Danio rerio) for Evaluation of Environmental Estrogens.

Commentaries

Here, There, and Everywhere: Forever Chemicals and Leggings [in Medscape]

Commentary: Causal relationship between particulate matter 2.5 and diabetes: two sample Mendelian randomization.

Editorial: Recent advances in bioremediation of emerging contaminants and endocrine disruptors. [intro to a research topic in Frontiers in Microbiology]

Twenty-eight years of GM Food and feed without harm: why not accept them?

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

The human health effects of unconventional oil and gas development (UOGD): A scoping review of epidemiologic studies.

Redox mechanisms of environmental toxicants on male reproductive function.

Southeast Asia’s environmental challenges: emergence of new contaminants and advancements in testing methods.

Phthalates

Phthalates and uterine disorders.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The Aryl Hydrocarbon Receptor Interacting Protein in cancer and immunity: Beyond a chaperone protein for the dioxin receptor.

PFAS

Involvement of per- and polyfluoroalkyl compounds in tumor development.

Exploring the Potential Link between PFAS Exposure and Endometrial Cancer: A Review of Environmental and Sociodemographic Factors.

Toward the development of a molecular toolkit for the microbial remediation of per-and polyfluoroalkyl substances.

Flame Retardants

Relationship between flame retardants and respiratory health- A systematic review and meta-analysis of observational studies.

Pesticides

Toxicity of glyphosate to animals: A meta-analytical approach.

Non-acute exposure of neonicotinoids, health risk assessment, and evidence integration: a systematic review.

Multi-omics and gut microbiome: Unveiling the pathogenic mechanisms of early-life pesticide exposure.

Pesticides exposure and compromised fitness in wild birds: Focusing on the reproductive endocrine disruption.

Meta-analytical review of antioxidant mechanisms responses in animals exposed to herbicide 2,4-D herbicide.

Metals/Metalloids

The effects of heavy metal exposure on brain and gut microbiota: A systematic review of animal studies.

Glycemic Changes Related to Arsenic Exposure: An Overview of Animal and Human Studies.

Microplastics/Nanomaterials

The potential impact of nano- and microplastics on human health: Understanding human health risks.

Beyond the cradle – Amidst microplastics and the ongoing peril during pregnancy and neonatal stages: A holistic review.

Assessing the inconsistency of microplastic measurements in foods and beverages.

Air Pollution

Airborne Exposure to Pollutants and Mental Health: A Review with Implications for United States Veterans.

Miscellaneous

Where the rubber meets the road: Emerging environmental impacts of Tire Wear particles and their chemical cocktails.

Human Health Studies

Numerous Chemicals/Mixtures

First Insight into Fetal Exposure to Legacy and Emerging Plasticizers Revealed by Infant Hair and Meconium: Occurrence, Biotransformation, and Accumulation.

Co-exposure to phthalates and polycyclic aromatic hydrocarbons and the risk of gestational hypertension in Chinese women.

Co-exposure to 55 endocrine-disrupting chemicals linking diminished sperm quality: Mixture effect, and the role of seminal plasma docosapentaenoic acid.

BPA/Phthalates

Relationship of bisphenol A substitutes bisphenol F and bisphenol S with adiponectin/leptin ratio among children from the environment and development of children cohort.

Prenatal exposure to environmental toxins and comprehensive dental findings in a population cohort of children.

Phthalate biomarkers composition in relation to fatty liver: evidence from epidemiologic and in vivo studies.

Associations of Bisphenols Exposure and Hyperuricemia Based on Human Investigation and Animal Experiments.

PFAS

Effect modification by maternal vitamin D status in the association between prenatal exposure to per- and polyfluoroalkyl substances and neurodevelopment in 2-year-old children.

Relative risks of childhood developmental vulnerabilities in three Australian communities with exposure to per- and polyfluoroalkyl substances: data linkage study.

Flame Retardants

Prenatal exposure to polybrominated diphenyl ethers and inattention/hyperactivity symptoms in mid to late adolescents.

Prenatal exposure to a mixture of organophosphate flame retardants and infant neurodevelopment: A prospective cohort study in Shandong, China.

Pesticides

Organophosphorus pesticide exposure from house dust and parent-reported child behavior in Latino children from an orchard community.

Glyphosate exposure, muscular health and functional limitations in middle-aged and older adults.

Evaluation of paraoxonase I and hemoglobin levels in farmers and agricultural workers in relation to organophosphorus and carbamate levels in their blood and urine samples: A cross sectional study.

Associations between pesticide exposure with biomarkers of stroke risk factors in farmers.

Urinary glyphosate levels and association with mortality in the 2013-16 National Health and Nutrition Examination Survey.

Metals/Metalloids

In utero arsenic exposure and early childhood motor development in the New Hampshire Birth Cohort Study.

Associations of environmental cadmium exposure with kidney damage: Exploring mediating DNA methylation sites in Chinese adults.

Reduced burden of Arsenic-Related cancers after water mitigation in Taiwan.

Evidence of reduced gestational age in response to in utero arsenic exposure and implications for aging trajectories of the newborn.

Investigating the Influence of Heavy Metals and Environmental Factors on Metabolic Syndrome Risk Based on Nutrient Intake: Machine Learning Analysis of Data from the Eighth Korea National Health and Nutrition Examination Survey (KNHANES).

Miscellaneous

Evaluating the impact of polycyclic aromatic hydrocarbon bioaccumulation in adipose tissue of obese women.

Laboratory Studies

Numerous Chemicals/Mixtures

Embryonic exposures to cadmium and PAHs cause long-term and interacting neurobehavioral effects in zebrafish.

Combined effects of binary mixtures of 17β-estradiol and testosterone in western mosquitofish (Gambusia affinis) after full life-cycle exposure.

BPA/Phenols

Bisphenol-A Abrogates Proliferation and Differentiation of C2C12 Mouse Myoblasts via Downregulation of Phospho-P65 NF-κB Signaling Pathway.

Evaluation of the toxic potential of Bisphenol-A glycidylmethacrylate (BisGMA) on the third instar larvae of transgenic Drosophila.

The Effects of Short- and Long-Term Ingestion of Plastic Toxin Bisphenol A on Gastrointestinal Transit Time in Rats.

Bisphenol A promotes cell death in healthy respiratory system cells through inhibition of cell proliferation and induction of G2/M cell cycle arrest.

Bisphenol A: Unveiling Its Role in Glioma Progression and Tumor Growth.

Phthalates

Di-n-butyl phthalate promotes the neural differentiation of mouse embryonic stem cells through neurogenic differentiation 1.

Mechanisms of imbalanced testicular homeostasis in infancy due to aberrant histone acetylation in undifferentiated spermatogonia under different concentrations of Di(2-ethylhexyl) phthalate (DEHP) exposure.

Disruption of gonocyte development following neonatal exposure to di (2-ethylhexyl) phthalate.

Diethylhexyl phthalate exposure amplifies oxidant and inflammatory response in fetal hyperglycemia model predisposing insulin resistance in zebrafish embryos.

In silico investigation of the role of miRNAs in a possible developmental origin of prostate cancer in F1 and F2 offspring of mothers exposed to a phthalate mixture.

Prenatal Exposure to Environmentally Relevant Low Dosage Dibutyl Phthalate Reduces Placental Efficiency in CD-1 Mice.

PFAS

Perfluorooctanoic acid induces cardiac dysfunction in human induced pluripotent stem cell-derived cardiomyocytes.

Per- and polyfluoroalkyl substances inhibit human and rat 17β-hydroxysteroid dehydrogenase 1: Quantitative structure-activity relationship and molecular docking analysis.

Visualization of PFOA accumulation and its effects on phospholipid in zebrafish liver by MALDI Imaging.

Transcriptomics-Based Points of Departure for Daphnia magna Exposed to 18 Per- and Polyfluoroalkyl Substances.

Time-course transcriptome analysis discloses PFDMO2OA (C8 HFPO-TA)-induced developmental malformations and cardiovascular toxicities in zebrafish.

Investigating mouse hepatic lipidome dysregulation following exposure to emerging per- and polyfluoroalkyl substances (PFAS).

Comparative hepatotoxicity of novel lithium bis(trifluoromethanesulfonyl)imide (LiTFSI, ie. HQ-115) and legacy Perfluorooctanoic acid (PFOA) in male mice: Insights into epigenetic mechanisms and pathway-specific responses.

Single-cell RNA sequencing reveals the heterogeneity of hepatic non-parenchymal cell responses to chronic PFO5DoDA exposure in male mice.

Flame Retardants

BDE-99 stimulates generation of aberrant brown/beige adipocytes.

Environmentally Relevant Concentrations of Tetrabromobisphenol A Exposure Impends Neurovascular Formation through Perturbing Mitochondrial Metabolism in Zebrafish Embryos and Human Primary Endothelial Cells.

Pesticides

Environmental Evaluation on Toxicity, Toxic Mechanism, and Hydrolysis Behavior of Potential Acethydrazide Fungicide Candidates.

Behavioral and biochemical consequences after chronic exposition to the herbicide atrazine in tadpoles.

Maternal exposure to deltamethrin during pregnancy and lactation impairs neurodevelopment of male offspring.

Impact of glyphosate-based herbicide exposure through maternal milk on offspring’s antioxidant status, neurodevelopment, and behavior.

Both acute glyphosate and the aminomethylphosphonic acid intoxication decreased the acetylcholinesterase activity in rat hippocampus, prefrontal cortex and gastrocnemius muscle.

Pesticide-induced alterations in zebrafish (Danio rerio) behavior, histology, DNA damage and mRNA expression: An integrated approach.

Transgenerational effects of triazole fungicides on gene expression and egg compounds in non-exposed offspring: A case study using Red-Legged Partridges (Alectoris rufa).

Assessing the toxicity of pesticides exposure on hepatic miRNA-target gene alterations in rat liver tissues via molecular and integrated network bioinformatics analysis.

Persistent diazinon induced neurotoxicity: The effect on inhibitory avoidance memory performance, amyloid precursor proteins, and TNF-α levels in the prefrontal cortex of rats.

Imidacloprid disrupts larval molting regulation and nutrient energy metabolism, causing developmental delay in honey bee Apis mellifera.

Metals/Metalloids

Effects of dietary arsenic exposure on liver metabolism in mice.

‘Environmental standard limit concentration’ arsenic exposure is associated with anxiety, depression, and autism-like changes in early-life stage zebrafish.

A dynamic model of inorganic arsenic-induced carcinogenesis reveals an epigenetic mechanism for epithelial-mesenchymal plasticity.

Microplastics/Nanomaterials

Polystyrene microplastics induce anxiety via HRAS derived PERK-NF-κB pathway.

Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage.

The adverse effects of developmental exposure to polystyrene nanoparticles on cognitive function in weaning rats and the protective role of trihydroxy phenolacetone.

TDCPP and TiO₂ NPs aggregates synergistically induce SH-SY5Y cell neurotoxicity by excessive mitochondrial fission and mitophagy inhibition.

Polystyrene microplastics promote intestinal colonization of Aeromonas veronii through inducing intestinal microbiota dysbiosis.

Polystyrene Nano- and Microplastic Particles Induce an Inflammatory Gene Expression Profile in Rat Neural Stem Cell-Derived Astrocytes In Vitro.

Polystyrene microplastics impair the functions of cultured mouse Leydig (TM3) and Sertoli (TM4) cells by inducing mitochondrial-endoplasmic reticulum damage.

Polystyrene nanoplastics and cadmium co-exposure aggravated cardiomyocyte damage in mice by regulating PANoptosis pathway.

Air Pollution

Altered metabolome and microbiome associated with compromised intestinal barrier induced hepatic lipid metabolic disorder in mice after subacute and subchronic ozone exposure.

Miscellaneous

Effects of the plastic additive 2,4-di-tert-butylphenol on intestinal microbiota of zebrafish.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Studies of Potential Migration of Hazardous Chemicals from Sustainable Food Contact Materials.

Endocrine disrupting chemicals in Italian drinking water systems: Insights from a three-year investigation combining chemical and effect-based tools.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Short- and medium-chain chlorinated paraffins in breast milk in Shanghai, China: Occurrence, characteristics, and risk assessment.

Contamination of aquatic ecosystems by persistent organic pollutants (POPs) originating from landfills in Canada and the United States: A rapid scoping review.

Biomagnification of persistent organic pollutants (POPs) in detritivorous, phytophagous, and predatory invertebrates: How POPs enter terrestrial food web?

Flame Retardants

Contamination levels, influencing factors, and risk assessment of polybrominated diphenyl ethers in house dust of northern Serbia.

Pesticides

PBPK modeling to support risk assessment of pyrethroid exposure in French pregnant women.

Microplastics/Nanomaterials

Plasticizing Pregnancy: Microplastics Identified in Expectant Mothers’ Feces.

Atlas and source of the microplastics of male reproductive system in human and mice.

Intravenous hypertonic fluids as a source of human microplastic exposure.

Temporal evolution of plastic additive contents over the last decades in two major European rivers (Rhone and Rhine) from sediment cores analyses.

Characteristics of microplastics in the atmosphere of Anyang City.

Microplastics in the Water Column of the Rhine River Near Basel: 22 Months of Sampling.

Miscellaneous

Spatiotemporal variation of 6PPD and 6PPDQ in dust and soil from e-waste recycling areas.

Non-targeted screening and photolysis transformation of tire-related compounds in roadway runoff.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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