EDC Science Weekly, Mar. 7-13, 2025

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

A global estimate of multiecosystem photosynthesis losses under microplastic pollution.

Plastics in the food system.

Science summaries and highlights

Events

Mar. 14-15: Lou Guillette Jr. Symposium, in person at the University of Florida in Gainesville AND via zoom! [Healthy Environment and Endocrine Disruptor Strategies (HEEDS)]

Mar. 20 webinar: Microplastics and Health Webinar Series: Webinar 2 – Distribution of Microplastics in the Environment and Human Exposure Pathways [National Academies]

Mar. 26 webinar: Impacts of Fracking in North & South America: Resources in English & Spanish [Collaborative for Health and Environment (CHE)]

Mar. 26 webinar: Impact of pesticides on human health [Health and Environment Alliance (HEAL)]

Apr. 15 webinar: Children’s Health: Assessing impacts of the exposome [EDC Strategies Partnership]

Apr. 15-16: Iowa PFAS Conference, in person in Iowa City [Iowa College of Engineering]

Apr. 24 webinar: Childhood cancer and the environment: Prevention opportunities [CHE-Alaska]

Apr. 25: HEEDS EDC-North Carolina group 5th Annual Meeting, in person in Raleigh [HEEDS]

Apr. 27-29 conference: Break the Cycle of Children’s Environmental Health Disparities

May 10-13: EDC sessions at European endocrinology society meeting [European Society for Pediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE)]

June 16-17 workshop: Roadmap to phase out animal testing for chemical safety assessments [The European Chemicals Agency (ECHA)]

July 30 – Aug. 1 conference: U.S. Developmental Origins of Health and Disease (DOHaD) Society Annual Meeting.

More events

Regulations/Policy

Invited Perspective: Toward Making Environmental Epidemiology Research More Impactful in Policy-Relevant Risk Assessments.

Accelerating adoption of new approach methodologies in regulatory decision making: an industry perspective.

Regulatory Frameworks and State-of-the-Art Decontamination Technologies for Recycled Polystyrene for Food Contact Applications.

More EDC policy and regulations open for comment and links to preserved resources removed from U.S. federal websites

Methods/Tools/Screening

A small-scale data driven and graph neural network based toxicity prediction method of compounds.

Derivation of a health-based guidance value for bisphenol A via the weight of evidence approach.

Using transcriptomics data and Adverse Outcome Pathway networks to explore endocrine disrupting properties of Cadmium and PCB-126.

Evaluation of in vivo fish and amphibian endocrine test guideline assays: current status and future needs.

Mechanisms of developmental neurotoxicity mediated by perturbed thyroid hormone homeostasis in the brain: an adverse outcome pathway network.

Evaluation of estrogenic and anti-estrogenic activity of endocrine disruptors using breast cancer spheroids: a comparative study of T47D and MCF7 cell lines in 2D and 3D models.

Leveraging AlphaFold Models to Predict Androgenic Effects of Endocrine-Disrupting Chemicals Through Zebrafish Androgen Receptor Analysis.

Why Was My Manuscript Rejected without Review? Focus on Public Health and Environmental Exposures, Ecotoxicology, and Micro/Nanoplastics.

News item: Food Packaging Forum updates database on migrating food contact materials

Commentaries

A perspective from U.S. Environmental Protection Agency (EPA) scientists: how your epidemiologic analyses can inform the human health risk assessment process.

Key developments in fluorinated heterocycles. [re fluorinated pharmaceuticals]

Emerging concerns associated with e-waste exposure

Time to count plastics in climate action.

Are microplastics bad for your health? More rigorous science is needed.

Plastics: Here, There, and Everywhere – Implications for Gastrointestinal Health and Disease.

Invited Perspective: Should You Scrap Your Plastic Cutting Board?

Invited Perspective: Prenatal and childhood exposure to fluoride and cognitive development: findings from the longitudinal MINIMat cohort in rural Bangladesh.

The promise and pitfalls of “Make America Healthy Again”.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Effects of endocrine disrupting chemicals on adrenal function.

Examining the Impact of Environmental Non-Persistent Compounds: Phthalates, BPA, and Benzophenone on Endometriosis.

The links between soil and water pollution and cardiovascular disease.

Environmental ototoxicants: an update.

Immunotoxicity of thyroid hormone system disrupting compounds in fish.

BPA/Phenols

Bisphenol A exposure and neurodevelopmental disorders and problems in children under 12 years of age: A systematic review and meta-analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Agent Orange and head and neck cancer: A systematic review and meta-analysis.

PFAS

Exposure to Per- and Polyfluoroalkyl Substances and the Risk of Prostate and Ovarian Cancer: An Epidemiologic Meta-Analysis.

Per- and polyfluoroalkyl substances and type 2 diabetes among older adults: Synthesizing cross-sectional population study and meta-analysis.

Per- and poly-fluoroalkyl substances as forever chemicals in drinking water: Unraveling the nexus with obesity and endocrine disruption – A mini review.

Biotransforming the “Forever Chemicals”: Trends and Insights from Microbiological Studies on PFAS.

Pesticides

Scarcity of pesticide data in New Zealand with a focus on neonicotinoids: A review.

Re-Evaluating the Use of Glyphosate-based Herbicides: Implications on Fertility.

Microplastics/Nanomaterials

Plastics matter in the food system.

Nanoplastics as Gene and Epigenetic Modulators of Endocrine Functions: A Perspective.

The infiltration of microplastics in human systems: Gastrointestinal accumulation and pathogenic impacts.

Microplastic aging and adsorption in the atmosphere, and their associated impacts on various spheres of the earth: A review.

Biological Effects of Micro-/Nano-Plastics in Macrophages.

Human Health Studies

Numerous Chemicals/Mixtures

Phosphate Flame Retardants and Plasticizers and Their Association with Reproductive and Steroid Hormone Levels among Peripubertal-Aged Children: The Hokkaido Birth Cohort Study.

Chemical exposure in females of childbearing age associated with sex hormones: Evidence from an untargeted exposomic approach.

BPA/Phenols

Perinatal Bisphenol Exposure and Small-for-Gestational-Age Neonates: The Evolving Effect of Replacements Then and Now.

Phthalates

Associations between prenatal phthalate exposure and newborn telomere length: Effect modification by infant sex.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Prenatal exposure to organochlorine pesticides and polychlorinated biphenyls and risk of testicular germ cell cancer later in life.

PFAS

Transplacental transfer efficiency of perfluoroalkyl substances (PFAS) after long-term exposure to highly contaminated drinking water: a study in the Ronneby Mother-Child Cohort.

Prenatal PFAS exposures and cardiometabolic health in middle childhood in the Maternal-Infant Research on Environmental Chemicals-ENDO (MIREC-ENDO) cohort.

Prenatal per- and polyfluoroalkyl substances and blood pressure trajectories in the New Hampshire Birth Cohort Study.

Association of prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances with fetal growth trajectories.

Early-pregnancy per- and polyfluoroalkyl substances and maternal post-pregnancy weight trajectory.

Metals/Metalloids

Prenatal placental metal accumulation and its association with child attention deficit/hyperactivity disorder and autism spectrum disorder symptom at 3 years of age: The role of psychosocial-environmental support in infancy.

Impact of cord blood cadmium concentration on neonatal secondary sex ratio: The Japan Environment and Children’s Study.

A prospective ultrasound study of whole blood metals and incidence of uterine leiomyomata.

Association between heavy metal exposure and asthma in adults: Data from the Korean National Health and Nutrition Examination Survey 2008-2013.

Circulating MicroRNAs in Association with Urinary Arsenic: A Community-Based Multi-Center Study in China.

Interactive and joint effects of toxic metals and oxidative balance score on the risk of mortality in adults with NAFLD.

Laboratory Studies

BPA/Phenols

Bisphenols exposure at environmentally relevant dose promoted ovarian cancer progression and modulated tumor microenvironment through β-catenin/SPP1 axis.

Paternal bisphenol A exposure alters craniofacial cartilage development in rare minnow (Gobiocypris rarus) descendants.

Neuroprotective effects of gastrodin against bisphenol A induced-ADHD-like symptoms in rats.

Phthalates

DAPK3 is Essential for DBP-Induced Autophagy of Mouse Leydig Cells.

Di-(2-ethylhexyl)-phthalate disrupts mouse placental growth by regulating the cell cycle of mouse placental trophoblasts through the Trim38-p53 signaling axis.

Rhythm- and sex-dependent lipid accumulation in Drosophila melanogaster by phthalates.

Down-regulation of TET2 inhibits testosterone synthesis in offspring mice exposed to DBP during pregnancy through LH/cAMP/PKA/StAR signaling mediated by LHR.

Parabens/Triclosan/Antimicrobials

Triclosan exacerbates atopic dermatitis in mouse models via thymic stromal lymphopoietin.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effects of combined stressors to TCDD and high temperature on HSP/CYPs signaling in the zebrafish embryos/larvae.

PFAS

Integrated computational analysis of molecular mechanisms underlying perfluorooctane sulfonic acid induced thyroid toxicity.

In vitro approaches to investigate the effect of chemicals on antibody production: the case study of PFASs.

Effects of Chemical Speciation on Chronic Thyroid Toxicity of Representative Perfluoroalkyl Acids.

Exposure to PFOS, PFBS, PFOA and PFBA impairs cell cycle progression in bovine brain (Bos taurus) endothelial cells.

Preconception exposure to perfluorooctanesulfonic acid (PFOS) and perfluorobutanesulfonic acid (PFBS) impaired reproduction via insulin/insulin-like growth factor signaling pathway without effects on the second generation in Caenorhabditis elegans.

Photodynamic priming overcomes platinum resistance from short-term exposure to select perfluoroalkyl substances in endometrial cancer cell lines.

Single-cell transcriptomics reveals the cellular dynamics of hexafluoropropylene oxide dimer acid in exerting mouse male reproductive toxicity.

Metabolic characterizations of PFOS-induced disruptions in early embryonic development.

Perfluorooctane Sulfonate (PFOS) and Related Compounds Induce Nuclear Receptor 4A1 (NR4A1)-Dependent Carcinogenesis.

Flame Retardants

Decabromodiphenyl ethane exposure-mediated mitochondrial dysfunction drives oxeiptosis in placental trophoblasts and induces fetal growth restriction.

Organotins

Systematic transcriptome-wide analysis and validation of tributyltin-induced differential changes in the liver with sex-specific effects.

Pesticides

Integrated gut microbiota and serum metabolomics reveal glyphosate-induced hepatic injury in mice.

Sublethal pesticide exposure decreases mating and disrupts chemical signaling in a beneficial pollinator.

Acute and chronic pesticide exposure trigger fundamentally different molecular responses in bumble bee brains.

Metals/Metalloids

Profiling of Environmental Mixtures Containing Metals for Their Toxicity Pathways and Mechanism of Action.

Microplastics/Nanomaterials

Multi-omics association pattern between gut microbiota and host metabolism of a filter-feeding fish in situ exposed to microplastics.

Toxic interactions between fluoxetine and microplastics in zebrafish embryonic development.

Blastocyst exposure to plastic during mice in vitro fertilization impacts placental development.

The endoplasmic reticulum-mitochondrial crosstalk involved in nanoplastics and di(2-ethylhexyl) phthalate co-exposure induced the damage to mouse mammary epithelial cells.

Exposure to polystyrene microplastics with different functional groups: Implications for blood pressure and heart.

Artificial plasticenta: how polystyrene nanoplastics affect in-vitro cultured human trophoblast cells.

Mixture Effects of Polystyrene Microplastics on the Gut Microbiota in C57BL/6 Mice.

Immune response to polystyrene microplastics: Regulation of inflammatory response via the ROS-driven NF-κB pathway in zebrafish (Danio rerio).

Sex-specific effects of aged polystyrene microplastics on hepatic AMPK pathway activation and lipid droplet accumulation in MAFLD mice.

Maternal exposure to polystyrene nanoplastics induces sex-specific kidney injury in offspring.

Co-Exposure to Polystyrene Microplastics and Bisphenol A Contributes to the Formation of Liver Fibrosis in Mice through Inhibition of the BMAL1/E-Cad Signaling Pathway.

Air Pollution

Integrative multi-omics analysis of metabolic dysregulation induced by occupational benzene exposure in mice.

Miscellaneous

Sublethal 6PPD-quinone exposure impairs swimming performance and aerobic metabolism in juvenile lake trout (Salvelinus namaycush).

Identification of cell-surface receptors associated with 6-PPD quinone-induced reproductive toxicity in Caenorhabditis elegans after long-term and low-dose exposure: A primordial response including sword effect and shield effect.

Effects of long-term exposure to tire wear particle leachate on life-cycle chronic toxicity and potential toxic mechanisms in the marine copepod Tigriopus japonicus.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Occurrence, Removal, and Ecological and Human Health Risk Assessment of 18 Endocrine Disrupting Compounds in Wastewater Treatment Plants in Nanjing, China.

Multi-target analysis of synthetic phenolic compounds in human blood.

BPA/Phenols

Occurrence, ecological risk and estrogenic effect of 19 bisphenol analogues in the surface water used for drinking water in Shanghai, China.

Phthalates

Phthalates in diapers: Assessment of dermal exposure of babies and environmental phthalate release.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposures to polycyclic aromatic hydrocarbons among adults and children: Contributions from multiple pathways and sources.

Concentrations of persistent organic pollutants in long-finned pilot whales (Globicephala melas) sampled in a mass stranding event (MSE) on the Irish coast.

PFAS

Degree of food processing and serum poly- and perfluoroalkyl substance concentrations in the US National Health and Nutrition Examination Survey, 2003-2018.

Differences in serum concentrations of per-and polyfluoroalkyl substances by occupation among firefighters, other first responders, healthcare workers, and other essential workers in Arizona, 2020-2023.

Unique per- and polyfluoroalkyl substances (PFAS) source suggested by a Lake Trout (Salvelinus namaycush) PFAS profile in a temperate lake.

Flame Retardants

Flame retardant contamination and ecological risk analysis in estuarine and marine sediments around an industrial port.

Pesticides

Reduced Honeybee Pollen Foraging under Neonicotinoid Exposure: Exploring Reproducible Individual and Colony Level Effects in the Field Using AI and Simulation.

Chronic exposure to tebuconazole impairs offspring growth and survival in farmland birds: an experiment in captive house sparrows.

Microplastics/Nanomaterials

A global estimate of multiecosystem photosynthesis losses under microplastic pollution.

Microplastics in agricultural soils following sewage sludge applications: Evidence from a 25-year study.

Influence of different food matrices on the abundance, characterization, migration kinetics and hazards of microplastics released from plastic packaging (PP and PET).

Seabirds in crisis: Plastic ingestion induces proteomic signatures of multiorgan failure and neurodegeneration.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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