EDC Science Weekly, Mar. 31 – Apr. 6, 2023 – HEEDS

EDC Science Weekly, Mar. 31 – Apr. 6, 2023

Post author:HEEDS
Post published:April 6, 2023
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Highlights: Chemical hair straighteners linked to lower fecundability; so much on plastics of all sizes that I couldn’t include it all

Contents: Events, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar April 13: Long-term Health Effects of Childhood Glyphosate Exposure (EDC Strategies Partnership)

For more events, see the March edition of HEEDS News

Methods/Tools/Screening

Methods

Integrating -omics approaches into population-based studies of endocrine disrupting chemicals: A scoping review.

ReadEDTest: A tool to assess the readiness of in vitro test methods under development for identifying endocrine disruptors

Quantitative structure activity relationship studies of androgen receptor binding affinity of endocrine disruptor chemicals with index of ideality of correlation, their molecular docking, molecular dynamics and ADME studies.

Methodology for Effect-Based Identification of Bioconcentratable Endocrine Disrupting Chemicals (EDCs) in Water: Establishment, Validation, and Application.

Tools

qHTSWaterfall: 3-dimensional visualization software for quantitative high-throughput screening (qHTS) data.

The Hazard index at thirty-seven: New science new insights

Screening

Predictive liver lipid biomarker signature of Acetyl-coenzyme A carboxylase inhibitor related developmental toxicity in non-pregnant female Han Wistar rats – lipidomics biomarker discovery and validation.

Commentaries

Editorial: Advances in removal of toxic substances from wastewater [intro to a special issue in Frontiers in Environmental Science]

The Supreme Court Is Harming Public Health and the Environment

The impact of the endocrine-disrupting chemicals on the glucose-6-phosphate dehydrogenase enzyme activity.

The universe of fluorinated polymers and polymeric substances and potential environmental impacts and concerns.

Reviews

Numerous Chemicals/Mixtures

Does the environment affect menopause? A review of the effects of endocrine disrupting chemicals on menopause.

Systematic review of physiologically based kinetic lactation models for transfer of xenobiotic compounds to milk.

Regulatory roles of extracellular vesicles in adverse pregnancy outcomes exposed with environmental toxicants.

Ecological adaptation of earthworms for coping with plant polyphenols, heavy metals, and microplastics in the soil: A review.

BPA/Phenols

Bisphenols in water: Occurrence, effects, and mitigation strategies.

Pesticides

Suicide and suicidality in people exposed to pesticides: A systematic review and meta-analysis.

Nanopesticides in comparison with agrochemicals: Outlook and future prospects for sustainable agriculture.

Meta-analysis of metal nanoparticles degrading pesticides: what parameters are relevant?

Metals/Metalloids

Exposure to essential and non-essential trace elements and risks of congenital heart defects: A narrative review.

Microplastics/Nanomaterials/Plastics

Plastic pollution and fungal, protozoan, and helminth pathogens – A neglected environmental and public health issue?

The detrimental effects of micro-and nano-plastics on digestive system: An overview of oxidative stress-related adverse outcome pathway.

An update on the biological effects of quantum dots: From environmental fate to risk assessment based on multiple biological models.

Air Pollution

The effect of ambient ozone exposure on three types of diabetes: a meta-analysis.

Ambient air pollution and clinical dementia: systematic review and meta-analysis.

Human Health Studies

Numerous Chemicals/Mixtures

The association between endocrine disrupting chemicals and MAFLD: Evidence from NHANES survey. [arsenic, phthalates, PFAS]

BPA/Phenols

Relation of urinary bisphenol concentration and diabetes or prediabetes in French adults: A cross-sectional study.

Phthalates

Urinary phthalate metabolites and small non-coding RNAs from seminal plasma extracellular vesicles among men undergoing infertility treatment.

Secondary oxidized di-2-ethylhexyl phthalate metabolites may be associated with progression from isolated premature thelarche to central precocious or early puberty.

Urinary Phthalate Metabolites and Slow Walking Speed in the Korean Elderly Environmental Panel II Study.

Parabens/Triclosan/Antimicrobials

Exposure to endocrine disrupters and cardiometabolic health effects in preschool children: Urinary parabens are associated with wider retinal venular vessels.

Cell cycle, apoptosis, cell differentiation, and lipid metabolism gene expression in endometriotic tissue and exposure to parabens and benzophenones.

Perfluoroalkyl Substances

The role of exposure to per- and polyfluoroalkyl substances in racial/ethnic disparities in hypertension: Results from the study of Women’s health across the nation.

Associations of perfluoroalkyl substances (PFAS) with lipid and lipoprotein profiles.

Flame Retardants

Associations of urinary organophosphate esters metabolites with asthma and lung function in adolescents.

Pesticides

Maternal and Paternal Household Pesticide Exposure During Pregnancy and Risk of Childhood Acute Lymphoblastic Leukemia.

Metals/Metalloids

Arsenic metabolism, diabetes prevalence, and insulin resistance among Mexican Americans: A mendelian randomization approach

Urinary levels of potentially toxic elements (PTEs) in female beauticians and their association with urinary biomarkers of oxidative stress/inflammation and kidney injury.

Association Between Estimated Geocoded Residential Maternal Exposure to Lithium in Drinking Water and Risk for Autism Spectrum Disorder in Offspring in Denmark [see related, Lithium in Drinking Water-A Novel Environmental Risk Factor for Autism Spectrum Disorder?]

The concentrations of essential/toxic elements in serum of COVID-19 patients are not directly related to the severity of the disease.

Cross-sectional association between systemic metal concentrations and immune markers in patients with total joint arthroplasty.

Relationship of blood heavy metals and osteoporosis among the middle-aged and elderly adults: A secondary analysis from NHANES 2013 to 2014 and 2017 to 2018.

Association of multi-metals with the risk of hypertension and the interaction with obesity: A cross-sectional study in China.

National analysis of urinary cadmium concentration and kidney stone: Evidence from NHANES (2011-2020).

Air Pollution

Association between long-term air pollution exposure and development of diabetes among community-dwelling adults: Modification of the associations by dietary nutrients.

Association of smoking and dietary polycyclic aromatic hydrocarbon exposure on the prevalence of metabolic syndrome in Korean adults.

Residential green space improves cognitive performances in primary schoolchildren independent of traffic-related air pollution exposure.

Parental occupational exposure to chemicals and risk of breast cancer in female offspring.

Long-Term Exposure to Air Pollution and COVID-19 Vaccine Antibody Response in a General Population Cohort (COVICAT Study, Catalonia).

Pharmaceuticals/Personal Care Products

Use of chemical hair straighteners and fecundability in a North American preconception cohort.

Miscellaneous

Polycyclic aromatic hydrocarbon (PAH) exposure during pregnancy and child anthropometry from birth to 10 years of age: Sex-specific evidence from a cohort study in rural Bangladesh.

Laboratory Studies

Numerous Chemicals/Mixtures

Metabolomic analysis of the inhibitory effect of phthalates and bisphenol A on the antioxidant activity of vitamin D in human samples using liquid chromatography-mass spectrometry.

Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study. [metals and bpa/phthalates mixtures]

Impacts of co-exposure to zearalenone and trifloxystrobin on the enzymatic activity and gene expression in zebrafish.

BPA/Phenols

The fate of bisphenol A, bisphenol S, and their respective glucuronide metabolites in ovarian cells.

In vivo and in silico assessments of estrogenic potencies of bisphenol A and its analogs in zebrafish (Danio rerio): Validity of in silico approaches to predict in vivo effects.

BPS-induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT-1/Nrf2/NFĸB and IR/PI3K/pAkt/GLUT-4 expressions in adult golden hamster.

Bisphenol A prevents MCF-7 breast cell apoptosis via the inhibition of progesterone receptor transactivation.

Granulosa cells undergo BPA-induced apoptosis in a miR-21-independent manner.

Proarrhythmic toxicity of low dose bisphenol A and its analogs in human iPSC-derived cardiomyocytes and human cardiac organoids through delay of cardiac repolarization.

Exposure to bisphenol A or its phenolic analogs during early life induces different types of anxiety-like behaviors after maturity in male mice.

Acute/chronic exposure to bisphenol A induced immunotoxicity in zebrafish and its potential association with pancreatic cancer risk.

Phthalates

Human relevant exposure to di-n-butyl phthalate tampers with the ovarian insulin-like growth factor 1 system and disrupts folliculogenesis in young adult mice.

Ferroptosis participates in dibutyl phthalate-aggravated allergic asthma in ovalbumin-sensitized mice.

New insight into phytometabolism and phytotoxicity mechanism of widespread plasticizer di (2-ethylhexyl) phthalate in rice plants.

Parabens/Triclosan/Antimicrobials

New insight into molecular mechanism of P450-Catalyzed metabolism of emerging contaminants and its consequence for human health: A case study of preservative methylparaben.

Perfluoroalkyl Substances

Cannabidiol Alleviates Perfluorooctanesulfonic Acid-Induced Cardiomyocyte Apoptosis by Maintaining Mitochondrial Dynamic Balance and Energy Metabolic Homeostasis.

Probing the Interactions of Perfluorocarboxylic Acids of Various Chain Lengths with Human Serum Albumin: Calorimetric and Spectroscopic Investigations.

Poly- and Perfluoroalkyl Substances Induce Immunotoxicity via the TLR Pathway in Zebrafish: Links to Carbon Chain Length.

A study on the effectiveness of sodium selenite in treating cadmium and perfluoro octane sulfonic (PFOS) poisoned zebrafish (Danio rerio).

Flame Retardants

Exploring the underlying molecular mechanism of tri(1,3-dichloropropyl) phosphate-induced neurodevelopmental toxicity via thyroid hormone disruption in zebrafish by multi-omics analysis.

Glucoregulatory disruption in male mice offspring induced by maternal transfer of endocrine disrupting brominated flame retardants in DE-71.

Pesticides

Untargeted metabolomics reveals the preventive effect of quercetin on nephrotoxicity induced by four organophosphorus pesticide mixtures.

The Effect of sub-chronic Linuron Exposure on Thyroid, Liver, and Kidney Function in Male Wistar Rats.

Comparative toxicological evaluations of novel forms nano-pesticides in liver and lung of albino rats.

Mixture effects of co-formulants and two plant protection products in a liver cell line.

Behavioral effects induced by the oral administration of acetamiprid in male mice during the postnatal lactation period or adulthood.

Transfluthrin- and prallethrin-based insecticides elicit specific enzymatic antioxidant responses in different tissue of zebrafish.

Toxicity mechanism of peri-implantation pesticide beta-cypermethrin exposure on endometrial remodeling in early pregnant mice.

In vitro interaction of the pesticides flupyradifurone, bupirimate and its metabolite ethirimol with the ATP-binding cassette transporter G2 (ABCG2).

Chronic diflubenzuron exposure causes reproductive toxic effects in female marine medaka (Oryzias melastigma).

Exposure to dithiocarbamate fungicide Ziram results in hepatic and renal toxicity in Long Evan rats.

Effects of prenatal pesticide exposure on the fetal brain and placenta transcriptomes in a rodent model.

Accelerated abdominal lipid depletion from pesticide treatment alters honey bee pollen foraging strategy, but not onset, in worker honey bees.

Oral exposure to thiacloprid-based pesticide (Calypso SC480) causes physical poisoning symptoms and impairs the cognitive abilities of bumble bees.

Metals/Metalloids

Alpha-ketoglutarate alleviates cadmium-induced inflammation by inhibiting the HIF1A-TNFAIP3 pathway in hepatocytes.

Mechanism of Learning and Memory Impairment in Rats Exposed to Arsenic and/or Fluoride Based on Microbiome and Metabolome.

Embryonic mercury exposure in zebrafish: Alteration of metabolites and gene expression, related to visual and behavioral impairments.

Attenuating effects of selenium and zinc against hexavalent chromium-induced oxidative stress, hormonal instability, and placenta damage in preimplanted rats.

Microplastics/Nanomaterials

Effects of microplastics and lead exposure on gut oxidative stress and intestinal inflammation in common carp (Cyprinus carpio L.).

Toxicity of polystyrene nanoplastics to human embryonic kidney cells and human liver cells: Effect of particle size and Pb²⁺ enrichment.

Brassinosteroids alleviate nanoplastic toxicity in edible plants by activating antioxidant defense systems and suppressing nanoplastic uptake.

Air Pollution

Multidimensional Analysis of Lung Lymph Nodes in a Mouse Model of Allergic Lung Inflammation following PM2.5 and Indeno[1,2,3-cd]pyrene Exposure [see related
Invited Perspective: Environmental Chemical-Sensing AHR Remains an Enigmatic Key Player in Toxicology]

Pharmaceuticals/Personal Care Products

A study to assess the health effects of an anticancer drug (cyclophosphamide) in zebrafish (Danio rerio): eco-toxicity of emerging contaminants.

Comparison of developmental toxicity of benzophenone-3 and its metabolite benzophenone-8 in zebrafish.

Miscellaneous

Investigating Endocrine Disrupting Impacts of Nine Disinfection Byproducts on Human and Zebrafish Estrogen Receptor Alpha.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Temporal trends and predictors of phthalate, phthalate replacement, and phenol biomarkers in the LIFECODES Fetal Growth Study.

Trends of legacy and emerging organic contaminants in a sediment core from Cienfuegos Bay, Cuba, from 1990 to 2015.

Phthalates

Risk assessment of phthalate metabolites accumulated in fish to the Indo-Pacific humpback dolphins from their largest habitat.

Riverine inputs, spatiotemporal variations, and potential sources of phthalate esters transported into the Bohai Sea from an urban river in northern China.

Perfluoroalkyl Substances

Predictors of serum- per- and polyfluoroalkyl substance (PFAS) concentrations among infants in Guinea-Bissau, West Africa.

Perfluoroalkyl substances in Baltic fish – the risk to consumers.

Spatial and temporal variability of per- and polyfluoroalkyl substances (PFAS) in environmental media of a small pond: Toward an improved understanding of PFAS bioaccumulation in fish.

Effects of perfluoroalkyl substances on the operational efficiency, microbial communities, and key metabolic pathways of constructed rapid infiltration system with coke as filler layer.

Flame Retardants

Organophosphate flame retardants and plastics in soil from an abandoned e-waste recycling site: significant ecological risks derived from plastic debris.

Co-occurrence and distribution of organophosphate tri- and di-esters in dust and hand wipes from an e-waste dismantling plant in central China.

Emission and environmental distribution of decabromodiphenyl ethane (DBDPE) in China from 2006 to 2026: Retrospection, forecasting, and implications for assessment and management.

Pesticides

Ecotoxicity of pesticide formulations and their mixtures: the case of potato crops in Costa Rica.

Risk assessment of human exposure to airborne pesticides in rural greenhouses.

Development of a mechanistic model for analyzing avian reproduction data for pesticide risk assessment.

Chemical monitoring and risk assessment of 56 pesticides in the Ave River and adjoining Atlantic coastline (Iberian Peninsula, Portugal).

Probabilistic risk assessment of endocrine disrupting pesticides in Iran.

Elevated 2,4-Dichlorophenoxyacetic acid (2,4-D) herbicide concentrations in the household dust of farmers with recent occupational use.

Metals/Metalloids

Mercury Bioaccumulation and Cortisol Interact to Influence Endocrine and Immune Biomarkers in a Free-Ranging Marine Mammal.

An approach to assess potential environmental mercury release, food web bioaccumulation, and human dietary methylmercury uptake from decommissioning offshore oil and gas infrastructure.

Low-cost informational intervention reduced drinking water arsenic exposure in Bangladesh.

Does elevated CO₂ enhance the arsenic uptake by rice? Yes or maybe: Evidences from FACE experiments.

Heavy metal contamination in pristine environments: lessons from the Juan Fernandez fur seal (Arctocephalus philippii philippii).

Patterns of contamination and burden of lead and arsenic in rooftop harvested rainwater collected in Arizona environmental justice communities.

Microplastics/Nanomaterials/Plastics

First record of plastic ingestion by a freshwater stingray.

Co-occurrence of macroplastics, microplastics, and legacy and emerging plasticisers in UK soils.

Air Pollution

Ecotoxicity of PM10 emissions generated during controlled burning of waste PET

Miscellaneous

Dietary Exposure and Health Risk of the Emerging Contaminant Fluorinated Liquid-Crystal Monomers.

Enhanced Formation of 6PPD-Q during the Aging of Tire Wear Particles in Anaerobic Flooded Soils: The Role of Iron Reduction and Environmentally Persistent Free Radicals.

Melamine in Iranian foodstuffs: A systematic review, meta-analysis, and health risk assessment of infant formula.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.