EDC Science Weekly, Mar. 31 – Apr. 6 – HEEDS

EDC Science Weekly, Mar. 31 – Apr. 6

Post author:HEEDS
Post published:April 6, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar April 14: Urgency of Addressing Forever Chemicals: The Scientific Basis for Managing PFAS as a Chemical Class (CHE Alaska)

Webinar April 20: Do chemicals in plastic consumer products contribute to obesity? (EDC Strategies Partnership)

Methods/Tools/Screening

Using alternative test methods to predict endocrine disruption and reproductive adverse outcomes: do we have enough knowledge?

Setting the European environment and health research agenda -under-researched areas and solution-oriented research.

Assessing Safety without Animal Testing: The Road Ahead.

The use of categorical regression in evidence integration.

Structure-to-process design framework for developing safer pesticides.

The role of alternative toxicological trials in drug discovery programs: The case of Caenorhabditis elegans and other methods.

What is required to combine human biomonitoring and health surveys?

Development and Application of an Open Tool for Sharing and Analyzing Integrated Clinical and Environmental Exposures Data: Asthma Use Case.

Reviews

Numerous Chemicals/Mixtures

Jerry Heindl of HEEDS coordinated the writing of these three reviews– the full text will be available open access shortly:

They are part of a Special Edition on Impact of Endocrine Disrupting Chemicals on Health and Disease in Biomedical Pharmacology. See the introductory editorial, Impact of Endocrine Disrupting Chemicals on Health and Disease.

Exploring the causes of semen quality changes post-bariatric surgery: a focus on endocrine-disrupting chemicals.

Role of environmental toxicants in the development of hypertensive and cardiovascular diseases.

Phthalates

Exposure to phthalates from personal care products: Urinary levels and predictors of exposure.

Perfluoroalkyl Substances

Assessment of the Emerging Threat Posed by Perfluoroalkyl and Polyfluoroalkyl Substances to Male Reproduction in Humans.

Potentially Toxic Elements

Correlation between as, Cd, Hg, Pb and Sn concentration in human milk and breastfeeding mothers’ food consumption: a systematic review and infants’ health risk assessment.

Heavy Metal and Metalloid – Induced Reproductive Toxicity.

Heavy metals and neurodevelopment of children in low and middle-income countries: A systematic review.

E-WASTE threatens health: The scientific solution adopts the one health strategy.

Metabolic characteristics related to the hazardous effects of environmental arsenic on humans: A metabolomic review.

Mechanistic understanding of the toxic effects of arsenic and warfare arsenicals on human health and environment.

Challenges of fluoride pollution in environment: Mechanisms and pathological significance of toxicity – A review.

Effects of rare earth elements (REE) on terrestrial organisms: current status and future directions.

Microplastics

Do poly(lactic acid) microplastics instigate a threat? A perception for their dynamic towards environmental pollution and toxicity.

Pharmaceuticals/Personal Care Products

Adverse effects of prenatal dexamethasone exposure on fetal development.

Miscellaneous

Impact of benzo[a]pyrene with other pollutants induce the molecular alternation in the biological system: Existence, detection, and remediation methods.

Human Health Studies

Phthalates

Exposure to phthalates in early pregnancy and the risk of fetal growth restriction: a nested case-control study in a Zhuang Chinese population.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Association of Organochlorine Pesticides With Genetic Markers of Endoplasmic Reticulum Stress in Type 2 Diabetes Mellitus: A Case-Control Study Among the North-Indian Population.

Serum multiple organochlorine pesticides in relation to testosterone concentrations among Chinese men from an infertility clinic.

Perfluoroalkyl Substances

Perfluorooctanoate and perfluorooctane sulfonate in umbilical cord blood and child cognitive development: Hamamatsu Birth Cohort for Mothers and Children (HBC Study).

Chlorinated Polyfluorinated Ether Sulfonates and Thyroid Hormone Levels in Adults: Isomers of C8 Health Project in China.

Association between serum per- and polyfluoroalkyl substances and thrombograms in young and middle-aged Taiwanese populations.

Pesticides

Association of Glyphosate Exposure with Blood DNA Methylation in a Cross-Sectional Study of Postmenopausal Women.

Association between exposure to organophosphorus pesticides and the risk of diabetes among US Adults: Cross-sectional findings from the National Health and Nutrition Examination Survey.

Exploratory analysis of the associations between neonicotinoids and measures of adiposity among US Adults: NHANES 2015-2016.

[Prenatal pyrethroid pesticides exposure and neurodevelopment of 2-year-old children: a birth cohort study]. [Chinese]

Potentially Toxic Elements

A case-control study on the relationship between urine trace element levels and autism spectrum disorder among Iranian children.

Effects of prenatal exposure to arsenic on neonatal birth size in Wujiang, China.

Correlation of Lead Poisoning and Intelligence Status of School Children in a Southern Nigerian Urban City.

Laboratory Studies

Numerous Chemicals/Mixtures

Historical exposure to chemicals reduces tolerance to novel chemical stress in Daphnia (waterflea). (PFOS, atrazine, arsenic, and the drugs diclofenac and trimethoprim)

Long-term co-exposure DBP and BaP causes imbalance in liver macrophages polarization via activation of Notch signaling regulated by miR-34a-5p in rats.

BPA/Phenols

Effects of mammalian target of rapamycin and aryl hydrocarbon receptor-mediating autophagy signaling on the balance of Th17/Treg cells during perinatal bisphenol A exposure in female offspring mice.

A single-cell atlas of bisphenol A (BPA)-induced testicular injury in mice.

Impact of chronic exposure of rats to bisphenol A from perinatal period to adulthood on intraprostatic levels of 5α-reductase isozymes, aromatase, and genes implicated in prostate cancer development.

BPA disrupted the testis testosterone levels by interfering ER enrichments within StAR 5′ flanking region in rare minnow Gobiocypris rarus.

Phthalates

Maternal exposure to bis(2-ethylhexyl) phthalate during the thyroid hormone-dependent stage induces persistent emotional and cognitive impairment in middle-aged offspring mice.

Dibutyl phthalate-induced oxidative stress and apoptosis in swine testis cells and therapy of naringenin via PTEN/PI3K/AKT signaling pathway.

Effects of Lycium barbarum glycopeptide on renal and testicular injury induced by di(2-ethylhexyl) phthalate.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Dioxin-like polychlorinated biphenyl 126 (PCB126) disrupts gut microbiota-host metabolic dysfunction in mice via aryl hydrocarbon receptor activation.

Perfluoroalkyl Substances

Icariin attenuates perfluorooctane sulfonate-induced testicular toxicity by alleviating Sertoli cell injury and downregulating the p38MAPK/MMP9 pathway.

Cellular Interactions and Fatty Acid Transporter CD36-Mediated Uptake of Per- and Polyfluorinated Alkyl Substances (PFAS).

Perfluorooctanoic acid (PFOA) as a stimulator of estrogen receptor-negative breast cancer MDA-MB-231 cell aggressiveness: Evidence for involvement of fatty acid 2-hydroxylase (FA2H) in the stimulated cell migration.

Maternal Sodium p-Perfluorous Nonenoxybenzene Sulfonate Exposure Disturbed Lipid Metabolism and Induced an Imbalance in Tyrosine Metabolism in the F1 Generation of Mice.

[Effect of perfluorooctanoic acid on lipid accumulation in rat liver cells BRL-3A and its possible mechanism]. [Chinese]

Flame Retardants

Potential obesogenic effects of TBBPA and its alternatives TBBPS and TCBPA revealed by metabolic perturbations in human hepatoma cells.

Alkyl organophosphate flame retardants (OPFRs) induce lung inflammation and aggravate OVA-simulated asthmatic response via the NF-кB signaling pathway.

Dissolved organic matter heightens the toxicity of tetrabromobisphenol A to aquatic organisms.

Pesticides

Repeated exposure to chlorpyrifos is associated with a dose-dependent chronic neurobehavioral deficit in adult rats.

Single and joint toxicity assessment of acetamiprid and thiamethoxam neonicotinoids pesticides on biochemical indices and antioxidant enzyme activities of a freshwater fish Catla catla.

Dietary Exposure to Bifenthrin and Fipronil Impacts Swimming Performance in Juvenile Chinook Salmon (Oncorhynchus tshawytscha).

Transcriptome analysis reveals sex-specific alterations in gonads of green mussel exposed to organophosphorus insecticide triazophos.

The heart as a target for deltamethrin toxicity: Inhibition of Nrf2/HO-1 pathway induces oxidative stress and results in inflammation and apoptosis.

Age-related tolerance to paraquat-induced parkinsonism in Drosophila melanogaster.

Potentially Toxic Elements

Minocycline reverses developmental arsenic exposure-induced microglia activation and functional alteration in BALB/c mice.

Low dose of arsenic exacerbates toxicity to mice and IPEC-J2 cells exposed with deoxynivalenol: Aryl hydrocarbon receptor and autophagy might be novel therapeutic targets.

Arsenic Exposure Impairs Intestinal Stromal Cells.

Developmental arsenic exposure impairs cognition, directly targets DNMT3A, and reduces DNA methylation.

Effects of cadmium exposure on thyroid gland and endochondral ossification in Rana zhenhaiensis.

Sub-chronic cadmium and lead compound exposure induces reproductive toxicity and development of testicular germ cell neoplasia in situ in murine model: Attenuative effects of resveratrol.

Microplastics

Effects of Polyester Fibers and Car Tire Particles on Freshwater Invertebrates.

Microplastics impact the accumulation of metals in earthworms by changing the gut bacterial communities.

Effects of microplastics on the accumulation and neurotoxicity of methylmercury in zebrafish larvae.

Pharmaceuticals/Personal Care Products

Chronic toxicity of diclofenac, carbamazepine and their mixture to Daphnia magna: a comparative two-generational study.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Correlates of non-persistent endocrine disrupting chemical mixtures among reproductive-aged Black women in Detroit, Michigan.

Priority Organic Pollutants and Endocrine-Disrupting Compounds in Arctic Marine Sediments (Svalbard Islands, Norway).

Mercury, legacy and emerging POPs, and endocrine-behavioural linkages: Implications of Arctic change in a diving seabird.

The world-wide waste web.

BPA/Phenols

Exposure to Bisphenolic Analogues in the Sixth Total Diet Study – China, 2016-2019.

Effects of Tooth Brushing and MouthWashing on Leaching Bisphenol A Levels From an Orthodontic Adhesive: An In Vitro Study.

Phthalates

Determinants of phthalate exposures in pregnant women in New York City.

Exposure characteristics of phthalate metabolites among the Zunyi cohort of pregnant women in Southwest China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Spatial-temporal distribution, cancer risk, and disease burden attributed to the dietary dioxins exposure of Chinese residents.

Live in same region, respond differently: Canine and human response to pollutants in placental accumulation.

Perfluoroalkyl Substances

Perfluorinated alkyl substances in Canadian human milk as part of the Maternal-Infant Research on Environmental Chemicals (MIREC) study.

Understanding Public Perceptions of Per- and Polyfluoroalkyl Substances: Infodemiology Study of Social Media.

Exposure to Emerging and Legacy Polyfluoroalkyl Substances in the Sixth Total Diet Study – China, 2016-2019.

PFAS in drinking water and serum of the people of a southeast Alaska community: A pilot study.

The Air that we Breathe: Neutral and volatile PFAS in Indoor Air.

Potential disruption of thyroid hormones by perfluoroalkyl acids in an Arctic seabird during reproduction.

Per- and polyfluoroalkyl substances (PFASs) in the blood of police and Beagle dogs from Harbin, China: Concentrations and associations with hematological parameters.

Spatiotemporal distribution of perfluoroalkyl acid in Chinese eggs.

Occurrence of PFASs and its effect on soil bacteria at a fire-training area using PFOS-restricted aqueous film-forming foams.

Assessment of per- and polyfluoroalkyl substances (PFAS) in the Indian River Lagoon and Atlantic coast of Brevard County, FL reveals distinct spatial clusters.

Flame Retardants

A nationwide survey of 20 legacy brominated flame retardants in indoor dust from China: continuing occurrence, national distribution, and implication for human exposure.

Potentially Toxic Elements

Exposure to Lead and Cadmium in the Sixth Total Diet Study – China, 2016-2019.

Mercury biomonitoring in German adults using volumetric absorptive microsampling.

Microplastics

Discovery and quantification of plastic particle pollution in human blood. [the first study finding microplastics in humans]

Global transportation of plastics and microplastics: A critical review of pathways and influences.

Air Pollution

Projections of future wildfires impacts on air pollutants and air toxics in a changing climate over the western United States.

Miscellaneous

Exposure to Chlorinated Paraffins in the Sixth Total Diet Study – China, 2016‒2019.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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EHN EHN

Lou Guillette Jr. Memorial Symposium
by Sarah Howard on December 16, 2024 at 3:52 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on December 16, 2024 at 3:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Webinar: EDC exposure and gonadal function: consequences and interventions
by Sarah Howard on December 16, 2024 at 3:36 pm
This two part webinar series is sponsored by the Endocrine Society's Special Interest Group (SIG) on endocrine disrupting chemicals (EDCs). The first webinar is scheduled for Jan. 30, 2025, and the second for Feb. 13.

EHN EHN

The plastics crisis: A neuropsychiatric problem hidden in plain sight
by EHN Curators on December 18, 2024 at 7:47 pm
The impact of plastics on health is an area of increasing concern.
Scientists lay out new framework to identify toxics contributing to metabolic disorders
by Katherine McMahon,Sarah Howard on December 17, 2024 at 10:00 am
A new consensus statement published in Nature Reviews Endocrinology proposes a set of 12 characteristics that can be used to identify metabolic-disrupting agents - chemicals, pharmaceuticals, and environmental hazards that increase the risk of metabolic disorders like diabetes and obesity. “This approach will enable a more comprehensive mechanistic understanding of how environmental chemicals and other agents disrupt metabolism and cause adverse outcomes.”
2024 Lou Guillette Jr Outstanding Young Investigator Award Winner: Dr. Chris Kassotis
by Sarah Howard on December 16, 2024 at 4:00 pm
Chris Kassotis, Ph.D., is the 2024 winner of the Lou Guillette, Jr. Outstanding Young Investigator Award, sponsored by Healthy Environment and Endocrine Disruptor Strategies (HEEDS). The award, in honor of scientist and mentor Lou Guillette, Jr., is given to an early-career scientist working in some aspect of endocrine disruptor research. The Kassotis lab focuses on understanding endocrine disrupting chemicals (EDCs) and mixtures, and their potential impacts on human and animal health, with a particular focus on metabolic health. He takes on critical public health issues, such as the health effects of chemicals found in fracking fluids and in artificial turf.

EHN EHN

Pesticide industry fights state efforts to regulate PFAS in farming
by EHN Curators on December 19, 2024 at 11:21 am
Pesticide trade groups are using lobbyists and grassroots networks to delay state laws aimed at curbing PFAS contamination in food and water, citing economic concerns. Lisa Held reports for Civil Eats.
Safe drinking water law marks 50 years, but challenges persist
by EHN Curators on December 19, 2024 at 11:19 am
Fifty years after the Safe Drinking Water Act became law, millions still lack reliable access to clean water, particularly in marginalized communities and small towns. Brett Walton reports for Circle of Blue.
RFK Jr. plans to eliminate fluoride in water, but states hold the power
by EHN Curators on December 18, 2024 at 11:47 am
President-elect Donald Trump's health appointee, Robert F. Kennedy Jr., aims to end fluoride in drinking water nationwide, but many states maintain mandates that the federal government cannot override. Hannah Recht reports for The Washington Post.