EDC Science Weekly, Mar. 3 – 9, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Methods/Tools/Screening

Integrating Selection and Risk Assessment of Chemical Mixtures: A Novel Approach Applied to a Breast Milk Survey.

Automated Network Assembly of Mechanistic Literature for Informed Evidence Identification to Support Cancer Risk Assessment.

In silico predictions of the human pharmacokinetics/toxicokinetics of 65 chemicals from various classes using conformal prediction methodology.

Comprehensive LC-MS/MS method combined with tandem hybrid hydrolysis for multiple exposure assessment of multiclass environmental pollutants.

Predicting molecular initiating events using chemical target annotations and gene expression.

Impact of COVID-19 pandemic on research and careers of early career researchers: a DOHaD perspective.

Commentaries/Conference Summaries

New Directions in Environmental Justice Research at the U.S. Environmental Protection Agency: Incorporating Recognitional and Capabilities Justice Through Health Impact Assessments.

The One-Two-Three Punch: Exposure, Susceptibility, and Disease Burden among U.S. Populations of Color. [Science Selection in EHP]

Editorial: Toxicity Mechanisms, Exposure, Toxicokinetic and Risk Assessment Aspects of Metals, Toxic for Animals and Humans.

Editorial: Reflections of the QSAR2021 meeting.

Translational Neurotoxicology – The 17^th biennial meeting of the International Neurotoxicology Association.

Assessing chemical carcinogenicity: hazard identification, classification, and risk assessment. Insight from a Toxicology Forum state-of-the-science workshop.

Reviews

Numerous Chemicals/Mixtures

Role-Playing Between Environmental Pollutants and Human Gut Microbiota: A Complex Bidirectional Interaction.

Impact of endocrine disrupting chemicals on neurodevelopment: the need for better testing strategies for endocrine disruption-induced developmental neurotoxicity.

Early-Life Environment Influence on Late-Onset Alzheimer’s Disease.

Frontiers in quantifying wildlife behavioural responses to chemical pollution.

[The effect of Endocrine disrupting chemicals on myocardial fibrosis and related mechanism]. [in Chinese]

BPA/Phenols

Critical review of the toxicity mechanisms of bisphenol F in zebrafish (Danio rerio): Knowledge gaps and future directions.

Phthalates

Exposure to phthalates and female reproductive health: a literature review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Climate change influence on the levels and trends of persistent organic pollutants (POPs) and chemicals of emerging Arctic concern (CEACs) in the Arctic physical environment – a review.

Perfluoroalkyl Substances

Human exposure pathways to poly- and perfluoroalkyl substances (PFAS) from indoor media: A systematic review.

Pesticides

‘Inert’ ingredients are understudied, potentially dangerous to bees and deserve more research attention.

Potentially Toxic Elements

Systemic review of genetic and epigenetic factors underlying differential toxicity to environmental lead (Pb) exposure.

A scoping review of infant and children health effects associated with cadmium exposure.

The association between environmental cadmium exposure, blood pressure, and hypertension: a systematic review and meta-analysis.

Air Pollution

Exposure to Outdoor Particulate Matter Air Pollution and Risk of Gastrointestinal Cancers in Adults: A Systematic Review and Meta-Analysis of Epidemiologic Evidence.

Probiotics, prebiotics, and synbiotics to prevent or combat air pollution consequences: The gut-lung axis.

Miscellaneous

“I Can’t Breathe”: Examining the Legacy of American Racism on Determinants of Health and the Ongoing Pursuit of Environmental Justice.

Harmony between Man and His Environment: Reviewing the Trump Administration’s Changes to the National Environmental Policy Act in the Context of Environmental Racism.

Prospecting carbon-based nanomaterials for the treatment and degradation of endocrine-disrupting pollutants.

Human Health Studies

Numerous Chemicals/Mixtures

Associations between the Maternal Exposome and Metabolome during Pregnancy.

Phthalates

Association between mixed exposure of phthalates and cognitive function among the U.S. elderly from NHANES 2011-2014: Three statistical models.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organochlorine pesticides, oxidative stress biomarkers, and leukemia: a case-control study.

Perfluoroalkyl Substances

The influences of perfluoroalkyl substances on the rheumatoid arthritis clinic.

Pesticides

Urinary organophosphate metabolite concentrations and birth sizes among women conceiving through in vitro fertilization in Shanghai, China.

[Relationship between pesticide exposure and lipid metabolism in population]. [Chinese]

Potentially Toxic Elements

Blood metals and vitamin D status in a pregnancy cohort: A bidirectional biomarker analysis.

Relationships Between Urinary Metals and Diabetes Traits Among Mexican Americans in Starr County, Texas, USA.

Effect of occupational exposure to lead on serum levels of lipid profile and liver enzymes: An occupational cohort study.

Effects of heavy metals in acute ischemic stroke patients: A cross-sectional study.

Associations of multiple metals with lung function in welders by four statistical models.

Miscellaneous

Exposure to oil pollution and maternal outcomes: The Niger Delta prospective cohort study.

Cancer risk associated with soil distribution of polycyclic aromatic hydrocarbons within three environmental justice neighborhoods in Houston, Texas.

Association of Deepwater Horizon Oil Spill Response and Cleanup Work With Risk of Developing Hypertension.

Laboratory Studies

Numerous Chemicals/Mixtures

Non-destructive biomarkers can reveal effects of the association of microplastics and pharmaceuticals or personal care products.

Metabolic Consequences of Developmental Exposure to Polystyrene Nanoplastics, the Flame Retardant BDE-47 and Their Combination in Zebrafish.

BPA/Phenols

Transgenerational effects of bisphenol A on zebrafish reproductive tissues and sperm motility.

Gestational Bisphenol A Exposure Impacts Embryonic Hypothalamic Microglia Numbers, Ramification, and Phagocytic Cups.

Effect of nonylphenol on the colonic mucosa in rats and intervention with zinc-selenium green tea (Camellia sinensis).

Combined reverse osmosis and UV/H₂O₂ treatment of aqueous solutions of bisphenol A and 17α-ethinylestradiol: assessment of estrogenic activity.

Phthalates

The possible thyroid disruptive effect of di-(2-ethyl hexyl) phthalate and the potential protective role of selenium and curcumin nanoparticles: a toxicological and histological study.

Autism spectrum disorder-like behavior induced in rat offspring by perinatal exposure to di-(2-ethylhexyl) phthalate.

Parabens/Triclosan/Antimicrobials

Oxysterols Profile in Zebrafish Embryos Exposed to Triclocarban and Propylparaben-A Preliminary Study.

Tris(1,3-dichloro-2-propyl) phosphate disrupts the trajectory of cytosine methylation within developing zebrafish embryos.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Placenta and fetal brain share a neurodevelopmental disorder DNA methylation profile in a mouse model of prenatal PCB exposure.

α-Tocopherol Prevents Sperm Apoptosis and Necrosis in Rats Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin.

Perfluoroalkyl Substances

The toxicity of perfluorodecanoic acid is mainly manifested as a deflected immune function.

A high-throughput assay for screening the abilities of per- and polyfluoroalkyl substances in inducing plasma kallikrein-like activity.

Perfluorooctane sulfonates induces neurobehavioral changes and increases dopamine neurotransmitter levels in zebrafish larvae.

Graphene oxide chronic exposure enhanced perfluorooctane sulfonate mediated toxicity through oxidative stress generation in freshwater clam Corbicula fluminea.

Impact of Firefighting Aqueous Film-Forming Foams on Human Cell Proliferation and Cellular Mortality.

Flame Retardants

Effects of long-term exposure to TDCPP in zebrafish (Danio rerio) – Alternations of hormone balance and gene transcriptions along hypothalamus-pituitary axes.

2,2′,4,4′-Tetrabromodiphenyl ether disrupts spermatogenesis in mice by interfering with the ER-Nrf1-Tfam-mitochondria pathway.

Comprehensive evaluation of the toxicity of the flame retardant (decabromodiphenyl ether) in a bioindicator fish (Gambusia affinis).

Pesticides

In the screening of alternative insecticides to control Aedes aegytpti larvae 2-methylanthraquinone showed no genotoxicity and low toxicity to zebrafish (Danio rerio).

Hexaconazole exposure ravages biosynthesis pathway of steroid hormones: revealed by molecular dynamics and interaction.

Use of computational toxicology tools to predict in vivo endpoints associated with Mode of Action and the endocannabinoid system: A case study with chlorpyrifos, chlorpyrifos-oxon and ^Δ9Tetrahydrocannabinol.

Genotoxicity of Glyphosate on Cultured Human Lymphocytes.

In vivo mutagenic effects and oxidative stress parameters evaluation of cypermethrin and benzoate of emamectin and their mixtures in female mice.

Potentially Toxic Elements

Molecular pathways dysregulated by Pb²⁺ exposure prompts pancreatic beta-cell dysfunction.

Letrozole protects against cadmium-induced inhibition of spermatogenesis via LHCGR and Hsd3b6 to activate testosterone synthesis in mice.

Comparative analysis unveils the cadmium-induced reproductive toxicity on the testes of Pardosa pseudoannulata.

Honey bees cannot sense harmful concentrations of metal pollutants in food.

[Relationships between lead-induced learning and memory impairments and gut microbiota disturbance in mice]. [Chinese]

Microplastics

Polystyrene microplastics affect learning and memory in mice by inducing oxidative stress and decreasing the level of acetylcholine.

Pharmaceuticals/Personal Care Products

Acetaminophen (APAP, paracetamol) interferes with the first trimester human fetal ovary development in an ex vivo model

Miscellaneous

Dose makes poison: Insights into the neurotoxicity of perinatal and juvenile exposure to environmental doses of 16 priority-controlled PAHs.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Diet quality and exposure to endocrine-disrupting chemicals among US adults.

Feathers as an integrated measure of organohalogen contamination, its dietary sources and corticosterone in nestlings of a terrestrial bird of prey, the northern Goshawk (Accipiter gentilis).

Effects of an action-guided intervention on optimistic bias and protective behaviors regarding endocrine disruptors in young women.

Phthalates

Identification of profiles and determinants of maternal pregnancy urinary biomarkers of phthalates and replacements in the Illinois Kids Development Study.

Phthalates bioconcentration in the soft corals: Inter- and intra- species differences and ecological aspects.

Perfluoroalkyl Substances

Natural biofilm as a potential integrative sample for evaluating the contamination and impacts of PFAS on aquatic ecosystems.

Perfluoroalkyl substances in marine food webs from South China Sea: Trophic transfer and human exposure implication.

Perfluoroalkyl substances (PFAS) in freshwater fish from urban lakes in Hanoi, Vietnam: concentrations, tissue distribution, and implication for risk assessment.

Flame Retardants

Characterization of organophosphate esters (OPEs) and polyfluoralkyl substances (PFASs) in settled dust in specific workplaces.

Organophosphate esters and their diester metabolites in infant formulas and baby supplementary foods collected in Beijing, China: Occurrence and the implications for infant exposure.

A natural environmental chamber study on the emissions and fate of organophosphate esters in the indoor environment.

Pesticides

Oxidative, biochemical and histopathological alterations in fishes from pesticide contaminated river Ganga, India.

Potentially Toxic Elements

Wild shrimp have an order of magnitude higher arsenic concentrations than farmed shrimp from Brazil illustrating the need for a regulation based on inorganic arsenic.

Microplastics

Using a non-invasive technique to identify suspected microplastics in grey seals (Halichoerus grypus) living in the western North Sea.

Ranking of potential hazards from microplastics polymers in the marine environment.

Long-term exposure of a free-living freshwater micro- and meiobenthos community to microplastic mixtures in microcosms.

Pharmaceuticals/Personal Care Products

Pharmaceuticals and personal care products in water streams: Occurrence, detection, and removal by electrochemical advanced oxidation processes.

Miscellaneous

Measurement of Polycyclic Aromatic Hydrocarbons in Baby Food Samples in Tehran, Iran With Magnetic-Solid-Phase-Extraction and Gas-Chromatography/Mass-Spectrometry Method: A Health Risk Assessment.

Occurrence, distribution, sources, and bioaccumulation of polycyclic aromatic hydrocarbons (PAHs) in multi environmental media in estuaries and the coast of the Beibu Gulf, China: a health risk assessment through seafood consumption.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

If you enjoy this newsletter, please feel free to donate here! Thank you!