EDC Science Weekly, Mar. 24 – 30, 2022 – HEEDS

EDC Science Weekly, Mar. 24 – 30, 2022

Post author:HEEDS
Post published:March 30, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar March 30: Reversing the Plastics Crisis Through a Human Rights Approach (CHE Alaska)

Webinar March 31: Environmental justice voices now: Disasters, cultural fire practices, and building community capacity (Agents of Change in Environmental Justice)

Webinar April 14: Urgency of Addressing Forever Chemicals: The Scientific Basis for Managing PFAS as a Chemical Class with Carol Kwiatkowski, Ph.D. (CHE Alaska)

Webinar April 20: Do chemicals in plastic consumer products contribute to obesity? (EDC Strategies Partnership)

Methods/Tools/Screening

Latent Variables Capture Pathway-Level Points of Departure in High-Throughput Toxicogenomic Data.

Prediction of the Neurotoxic Potential of Chemicals Based on Modelling of Molecular Initiating Events Upstream of the Adverse Outcome Pathways of (Developmental) Neurotoxicity.

Zebrafish larvae acute toxicity test: A promising alternative to the fish acute toxicity test.

Screening of ToxCast Chemicals Responsible for Human Adverse Outcomes with Exposure to Ambient Air.

Advanced human developmental toxicity and teratogenicity assessment using human organoid models.

Commentaries

Invited Perspective: Integrating Data Reveals Benefits of Remediation for Children’s Exposure to Hazardous Substances. re Estimating the Effects of Soil Remediation on Children’s Blood Lead near a Former Lead Smelter in Omaha, Nebraska, USA.

Widening the Lens on PFASs: Direct Human Exposure to Perfluoroalkyl Acid Precursors (pre-PFAAs). [Feature article]

The Road to Achieving the European Commission’s Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies.

Impact of Cumulative Environmental and Dietary Xenobiotics on Human Microbiota: Risk Assessment for One Health.

General Challenges and Recommendations for the Water Quality Criteria of Endocrine Disrupting Chemicals (EDCs).

Toward Assessing Absolute Environmental Sustainability of Chemical Pollution.

Targeting the Macrophage: Immune Cells May Be the Key to Phthalate-Induced Liver Toxicity. [Science Selection in EHP]

Environmental risk of pharmaceuticals: Let us look at the whole package. [letter]

Reviews

Numerous Chemicals/Mixtures

Endocrine Disruptors and Obesity: an Overview.

Endocrine-disrupting chemicals and breast cancer: Disparities in exposure and importance of research inclusivity. [PFAS and parabens]

Pediatric Exposures to Neurotoxicants: A Review of Magnetic Resonance Imaging and Spectroscopy Findings.

BPA/Phenols

The toxic effects of endocrine disrupting chemicals (EDCs) on gut microbiota: Bisphenol A (BPA). A review.

Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study.

Flame Retardants

Declining semen quality and polybrominated diphenyl ethers (PBDEs): Review of the literature to support the derivation of a reference dose for a mixture risk assessment.

Pesticides

Human exposure to neonicotinoids and the associated health risks: A review.

Neonicotinoids: mechanisms of systemic toxicity based on oxidative stress-mitochondrial damage.

Potentially Toxic Elements

Cadmium and breast cancer – current state and research gaps in the underlying mechanisms.

The impact of mercury contamination on human health in the Arctic: A state of the science review.

Exposure to Metal Mixtures in Association with Cardiovascular Risk Factors and Outcomes: A Scoping Review.

Microplastics

A review of interactions of microplastics and typical pollutants from toxicokinetics and toxicodynamics perspective.

The Intestinal Barrier-Shielding the Body from Nano- and Microparticles in Our Diet.

Human Health Studies

Phthalates

Urine Phthalate Levels and Liver Function in US Adolescents: Analyses of NHANES 2007-2016.

Biomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort.

Prenatal exposure to phthalates and peripheral blood and buccal epithelial DNA methylation in infants: An epigenome-wide association study.

Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns.

Risk of Abdominal Obesity Associated with Phthalate Exposure of Nurses.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Maternal serum persistent organic pollutant exposure and offspring diagnosed ADHD in a national birth cohort.

Perfluoroalkyl Substances

Per- and polyfluoroalkyl substances (PFAS) and male reproductive function in young adulthood; a cross-sectional study.

Associations between prenatal exposure to perfluoroalkyl substances, hypomethylation of MEST imprinted gene and birth outcomes.

Per- and perfluoroalkyl substances alternatives, mixtures and liver function in adults: A community-based population study in China.

Pesticides

Assessing Dietary Pesticide Intake and Potential Health Effects: The Application of Global Metabolomics Analysis.

Occupational exposures to pesticides and other chemicals: a New Zealand motor neuron disease case-control study.

Potentially Toxic Elements

Effects of multi-metal exposure on the risk of diabetes mellitus among people aged 40-75 years in rural areas in southwest China.

Total Reflection X-ray Fluorescence Analysis of Plasma Elements in Autistic Children from India.

Maternal exposure to cadmium during pregnancy is associated with changes in DNA methylation that are persistent at 9 years of age.

Maternal Blood Levels of Toxic and Essential Elements and Birth Outcomes in Argentina: The EMASAR Study.

Association between Heavy Metal Exposure and Dyslipidemia among Korean Adults: From the Korean National Environmental Health Survey, 2015-2017.

Association of maternal heavy metal exposure during pregnancy with isolated cleft lip and palate in offspring: Japan Environment and Children’s Study (JECS) cohort study.

Arsenic in private well water and birth outcomes in the United States.

Miscellaneous

The socioeconomic landscape of the exposome during pregnancy.

Laboratory Studies

Numerous Chemicals/Mixtures

Prenatal Exposure to an EDC Mixture, NeuroMix: Effects on Brain, Behavior, and Stress Responsiveness in Rats.

Drosophila ecdysone receptor activity-based ex vivo assay to assess the endocrine disruption potential of environmental chemicals.

BPA/Phenols

Sex-specific changes in oxidative stress parameters and longevity produced by Bisphenol F and S compared to Bisphenol A in Drosophila melanogaster.

Neurotoxic effects of synthetic phenolic antioxidants on dopaminergic, serotoninergic, and GABAergic signaling in larval zebrafish (Danio rerio).

Waves of follicle development, growth and degeneration in adult ovary of zebrafish (Danio rerio) on chronic exposure to environmental estrogens in laboratory.

A single-cell atlas of bisphenol A (BPA)-induced testicular injury in mice.

Evaluating the Effects of BPA and TBBPA Exposure on Pregnancy Loss and Maternal-Fetal Immune Cells in Mice.

Exposure to low-dose bisphenol A induces spleen damage in a murine model: Potentially through oxidative stress?

Early-life exposure to bisphenol A induces dysregulation of lipid homeostasis by the upregulation of SCD1 in male mice.

Evaluation of BPA effects on autophagy in Neuro-2a cells.

Bisphenol A exposure triggers the malignant transformation of prostatic hyperplasia in beagle dogs via cfa-miR-204/KRAS axis.

Hepatic metabolism of chlorinated derivatives of bisphenol A (Cl_xBPA) and interspecies differences between rats and humans.

Maternal exposure to bisphenol S induces neuropeptide signaling dysfunction and oxidative stress in the brain, and abnormal social behaviors in zebrafish (Danio rerio) offspring.

Phthalates

Mono(2-ethylhexyl) phthalate modulates lipid accumulation and reproductive signaling in Daphnia magna.

Mono-2-ethylhexyl Phthalate Promotes Migration and Invasion by Regulating the Epithelial-Mesenchymal Transition in SH-SY5Y Cells.

Microplastics: A major source of phthalate esters in aquatic environments.

Parabens/Triclosan/Antimicrobials

Activation of retinoic acid-related orphan receptor γ(t) by parabens and benzophenone UV-filters.

Chronic exposure to propylparaben at the humanly relevant dose triggers ovarian aging in adult mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The Disposition of Polychlorinated Biphenyls (PCBs) Differs Between Germ-free and Conventional Mice.

Evaluation of Early Biomarkers of Atherosclerosis Associated with Polychlorinated Biphenyl Exposure: An in Vitro and in Vivo Study.

Acute exposure to environmentally relevant levels of DDT alters muscle mitochondrial function in vivo in rats but not in vitro in L6 myotubes: A pilot study.

Perfluoroalkyl Substances

Replacement per- and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes.

[Effect of perfluorooctanoic acid on lipid accumulation in rat liver cells BRL-3A and its possible mechanism]. [in Chinese]

Flame Retardants

Pathways involved in the human vascular Tetrabromobisphenol A response: calcium and potassium channels and nitric oxide donors.

Pesticides

Maternal exposure to glyphosate-based herbicide promotes changes in the muscle structure of C57BL/6 mice offspring.

Chronic Perigestational Exposure to Chlorpyrifos Induces Perturbations in Gut Bacteria and Glucose and Lipid Markers in Female Rats and Their Offspring.

Evaluation of parental and transgenerational effects of clotrimazole in Daphnia magna – A multi-parametric approach.

Imidacloprid Induces Histopathological Damages in the Midgut, Ovary, and Spermathecal Stored Spermatozoa of Queens After Chronic Colony Exposure.

Toxicity of the Pesticides Imidacloprid, Difenoconazole and Glyphosate Alone and in Binary and Ternary Mixtures to Winter Honey Bees: Effects on Survival and Antioxidative Defenses.

Thiacloprid-induced hepatotoxicity in zebrafish: Activation of the extrinsic and intrinsic apoptosis pathways regulated by p53 signaling pathway.

Potentially Toxic Elements

Potentiation of methylmercury toxicity by combined metal exposure: In vitro and in vivo models of a restricted metal exposome.

Cadmium disrupts mouse embryonic stem cell differentiation into ovarian granulosa cells through epigenetic mechanisms.

Diabetogenic and Obesogenic Effects of Cadmium in Db/Db Mice and Rats at a Clinically Relevant Level of Exposure.

Enhanced Uptake of Arsenic Induces Increased Toxicity with Cadmium at Non-Toxic Concentrations on Caenorhabditis elegans.

Microplastics/Nanomaterials

Detecting Micro- and Nanoplastics Released from Food Packaging: Challenges and Analytical Strategies.

Charge-specific adverse effects of polystyrene nanoplastics on zebrafish (Danio rerio) development and behavior.

Toxicity evaluation of the combination of emerging pollutants with polyethylene microplastics in zebrafish: Perspective study of genotoxicity, mutagenicity, and redox unbalance.

Screening of the Toxicity of Polystyrene Nano- and Microplastics Alone and in Combination with Benzo(a)pyrene in Brine Shrimp Larvae and Zebrafish Embryos.

Differentiation in the expression of toxic effects of polyethylene-microplastics on two freshwater fish species: Size matters.

Combined effect of diazepam and polystyrene microplastics on the social behavior of medaka (Oryzias latipes).

Silver nanoparticles modify hypothalamic-pituitary-interrenal axis and block cortisol response to an acute stress in zebrafish, Danio rerio.

Double-Sided Nano-ZnO: Superior Antibacterial Properties and Induced Hepatotoxicity in Zebrafish Embryos.

Multi-omics reveals that Bifidobacterium breve M-16V may alleviate the immune dysregulation caused by nanopolystyrene.

Human airway organoids and microplastic fibers: A new exposure model for emerging contaminants.

Pharmaceuticals/Personal Care Products

Synthetic estrogen bioaccumulates and changes the behavior and biochemical biomarkers in adult zebrafish.

Miscellaneous

HIF-1alpha/VEGF pathway mediates 1,3,6,8-tetrabromo-9 H-carbazole-induced angiogenesis: a potential vascular toxicity of an emerging contaminant.

Pentachlorophenol has significant adverse effects on hematopoietic and immune system development in zebrafish (Danio rerio).

Transient Post-Natal Exposure to Xenoestrogens Induces Long-Term Alterations in Cardiac Calcium Signaling.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Exposure to Endocrine Disrupting Chemicals in Canada: Population-Based Estimates of Disease Burden and Economic Costs.

Influencing Factors of Behavior for Reducing Exposure to Endocrine Disrupting Chemicals and Demand for Related Education.

Biomonitoring bisphenols, parabens, and benzophenones in breast milk from a human milk bank in Southern Spain.

BPA/Phenols

Rethinking electrochemical oxidation of bisphenol A in chloride medium: Formation of toxic chlorinated oligomers.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Application of a pharmacokinetic model in characterizing sources of polychlorinated biphenyl exposure and determining threshold daily intakes for adverse health effects in infants and toddlers.

Differential Bioaccumulation Patterns of α, β-Hexachlorobenzene and Dicofol in Adipose Tissue from the GraMo Cohort (Southern Spain).

Persistent organic pollutants in water resources: Fate, occurrence, characterization and risk analysis.

Perfluoroalkyl Substances

Healthy eating index and diet diversity score as determinants of serum perfluoroalkyl acid (PFAA) concentrations in a national survey of Swedish adolescents.

Per- and poly-fluoroalkyl substances (PFAS) in river discharge: Modeling loads upstream and downstream of a PFAS manufacturing plant in the Cape Fear watershed, North Carolina.

Interactions between dissolved organic matter and perfluoroalkyl acids in natural rivers and lakes: A case study of the northwest of Taihu Lake Basin, China.

Translocation, bioaccumulation, and distribution of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in plants.

Perfluoroalkyl Substances (PFASs) in the Canadian Freshwater Environment.

Flame Retardants

The environmental fate of biomass associated polybrominated diphenyl ethers.

Pesticides

Are native bees in Brazil at risk from the exposure to the neonicotinoid imidacloprid?

An Alternative Strategy for Screening and Confirmation of 330 Pesticides in Ground- and Surface Water Using Liquid Chromatography Tandem Mass Spectrometry.

Potentially Toxic Elements

The groundwater arsenic contamination in the Bengal Basin-A review in brief.

Microplastics

A review of microplastic fibres: generation, transport, and vectors for metal(loid)s in terrestrial environments.

Investigation of microplastic pollution in Arctic fjord water: a case study of Rijpfjorden, Northern Svalbard.

Air Pollution

Air Pollution in American Indian Versus Non-American Indian Communities, 2000-2018.

Tripling of western US particulate pollution from wildfires in a warming climate.

Air (ine)quality in the European Union.

Pharmaceuticals/Personal Care Products

Wastewater surveillance for 168 pharmaceuticals and metabolites in a WWTP: Occurrence, temporal variations and feasibility of metabolic biomarkers for intake estimation.

Occurrence and fate of pharmaceuticals, personal care products (PPCPs) and pesticides in African water systems: A need for timely intervention.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.