EDC Science Weekly, Mar. 21-27, 2025

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Risk of longer-term endocrine conditions in the Deepwater Horizon Oil Spill Coast Guard cohort study – five years of follow-up.
Periods of susceptibility for phthalate exposure and preterm birth: a pooled analysis of 16 US cohorts.
Improving methodologies for cumulative risk assessment: health Risks from VOCs in fenceline communities in Pennsylvania.

Science summaries and highlights

Events

Mar. 27 webinar (today!): It All Adds Up: Toxic Chemicals and the Future of Women’s Health [Center for Environmental Health]

Apr. 15 webinar: Children’s Health: Assessing impacts of the exposome [EDC Strategies Partnership]

Apr. 15-16: Iowa PFAS Conference, in person in Iowa City [Iowa College of Engineering]

Apr. 24 webinar: Childhood cancer and the environment: Prevention opportunities [CHE-Alaska]

CANCELLED: Apr. 25: HEEDS EDC-North Carolina group 5th Annual Meeting [HEEDS]

Apr. 27-29 conference: Break the Cycle of Children’s Environmental Health Disparities

May 10-13: EDC sessions at European endocrinology society meeting [European Society for Pediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE)]

June 16-17 workshop: Roadmap to phase out animal testing for chemical safety assessments [The European Chemicals Agency (ECHA)]

July 30 – Aug. 1 conference: U.S. Developmental Origins of Health and Disease (DOHaD) Society Annual Meeting

More events

Regulations/Policy

Ethical principles for regulatory risk decision-making.

New approach methodologies: EU regulatory horizons.

Trump officials will screen NIH funding opportunities [News item in Science; also see their Trump-Tracker]

More EDC policy, regulations open for comment and links to preserved resources removed from U.S. federal websites

Methods/Tools/Screening

Improving Methodologies for Cumulative Risk Assessment: A Case Study of Noncarcinogenic Health Risks from Volatile Organic Compounds in Fenceline Communities in Southeastern Pennsylvania.

Validation of an Estrogen Receptor Dimerization(α-α/α-β/β-β) BRET-Based Biosensors for Screening Estrogenic Endocrine-Disrupting Chemicals.

Amphibian studies to investigate the endocrine disrupting properties of chemicals through the thyroid modality: a comparison of their statistical power.

FluoroMatch IM: An Interactive Software for PFAS Analysis by Ion Mobility Spectrometry.

Commentaries

Expression of concern: Detection of microplastics in human saphenous vein tissue using μFTIR: A pilot study.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

The impact of endocrine disrupting chemicals on adrenal corticosteroids – a systematic review of epidemiological studies.

Neurobehavioral effects of low dose exposure to chemical mixtures: a review.

Environmental Pollutants, Occupational Exposures, and Liver Disease.

Environmental contamination and male reproductive health: (ir) reversible effects in child- and adulthood.

Immunotoxicological disruption of pregnancy as a new research area in immunotoxicology.

BPA/Phenols

Mechanisms of bisphenol A and its analogs as endocrine disruptors via nuclear receptors and related signaling pathways.

Parabens/Triclosan/Antimicrobials

Parabens exposure and its impact on diabesity: a review.

PFAS

New fluorine-free low surface energy surfactants and surfaces.

Advances in PFAS electrochemical reduction: Mechanisms, materials, and future perspectives.

Pesticides

Green Revolution to Clinical Burden: Connecting the Dots between Pesticide Consumption and Cancer Incidents in India

Metals/Metalloids

Metal Dyshomeostasis as a Driver of Gut Pathology in Autism Spectrum Disorders.

Heavy Metal-Gut Microbiota Interactions: Probiotics Modulation and Biosensors Detection.

Microplastics/Nanomaterials

Microplastics and nanoplastics: emerging threats to cardiovascular health – a comprehensive review.

Microplastics and Impaired Male Reproductive Health – Exploring Biological Pathways of Harm: A Narrative Review.

Interactions between microplastics and microbiota in a One Health perspective.

Micro- and Nano-Plastic-Induced Adverse Health Effects on Lungs and Kidneys Linked to Oxidative Stress and Inflammation.

Exploring Environmental Behaviors and Health Impacts of Biodegradable Microplastics.

Microplastics and chemical additives from disposable face masks: Environmental, human health and behavioural impacts.

Microplastics in the marine environment: Challenges and the shift towards sustainable plastics and plasticizers.

Plastics of the Future? Interdisciplinary Review on Biobased and Biodegradable Polymers: Progress in Chemistry, Societal Views, and Environmental Implications.

Human Health Studies

Numerous Chemicals/Mixtures

Prenatal exposure to synthetic phenols assessed in multiple urine samples and dysregulation of steroid hormone homeostasis in two European cohorts.

Risk of longer-term endocrine and metabolic conditions in the Deepwater Horizon Oil Spill Coast Guard cohort study – five years of follow-up.

First Evidence in the Association of Phenolic Endocrine-Disrupting Chemicals with Secondary Non-Alcoholic Fatty Liver Disease: A Case-Control Study in South China.

Associations of endocrine-disrupting chemicals mixtures with serum lipid and glucose metabolism among overweight/obese and normal-weight children: A panel study.

Community-based insights into the connection between endocrine-disrupting chemicals and depressive symptoms.

BPA/Bisphenols

Higher bisphenol analogues exposure levels in e-waste workers and their associations with DNA oxidative damage in Hong Kong.

Phthalates

Periods of susceptibility for associations between phthalate exposure and preterm birth: Results from a pooled analysis of 16 US cohorts.

Does healthy lifestyle attenuate the associations of phthalates with depression? A cross-sectional study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Prenatal exposure to persistent organic pollutants and emotional and behavioral outcomes from early childhood to adolescence: Rhea Cohort Study in Crete, Greece.

Ethnic and Sex Differences in the Association Between Organochlorine Exposure and Cognitive Function in Late Life.

Impact of dioxins and polychlorinated biphenyls on kidney parameters: The modulatory role of vitamin D.

Association between combined exposure to organochlorine pesticides and history of uterine fibroids in NHANES: findings from four statistical models.

PFAS

Assessment of per- and polyfluoroalkyl substances (PFAS) exposure and associations with oxidative stress biomarkers among pregnant women from the PROTECT cohort.

Association and binding interaction between per- and polyfluoroalkyl substances and maternal thyroid hormones: A case study based on a prospective birth cohort in Wuxi, China.

Prenatal Concentrations of Perfluoroalkyl Substances and Maternal Beta Cell Function at 7 to 9 Years of Follow-Up.

Branched perfluorohexanesulfonic acid (PFHxS) and perfluoroheptanoic acid (PFHpA): ‘Safer’ per- and polyfluoroalkyl substances (PFASs) alternatives for their effects on gut microbiota and metabolic function in children.

Association between exposure to perfluoroalkyl substances (PFASs) and risk of hyperemesis gravidarum.

Per- and polyfluoroalkyl substances exposures are associated with non-alcoholic fatty liver disease, particularly fibrosis.

Transfer patterns of human blood to follicular fluid of per- and polyfluoroalkyl substances with distinct molecular structures and physico-chemical properties.

Associations between in utero exposure of per- and polyfluoroalkyl substances (PFAS) mixture and anthropometry measures at birth.

Fetal exposure to perfluoroalkyl substances (PFAS) in drinking water and congenital malformations: A nation-wide register-based study on PFAS in drinking water.

Flame Retardants

An assessment of organophosphate ester mixtures and the placental transcriptome.

Association between exposure to organophosphate esters and cognitive function in older adults in the United States: NHANES 2011-2014.

Association of joint exposure to multiple brominated flame retardants with kidney impairment risk among adult population: Evidence from non-pooled samples of NHANES.

Pesticides

Associations of individual and mixtures of organophosphate pesticides with the risk of osteoporosis in adult population.

Metals/Metalloids

Association of Arsenic and Nickel with Markers of Insulin Resistance and Beta Cell Dysfunction: A Case-Control Study in Indo Gangetic Plain.

Association Between Multiple Plasma Toxic Metal and Metalloid Exposures and Hypertension in Elderly Chinese Adults.

Microplastics/Nanomaterials

Urinary Metabolomics of Plastic Manufacturing Workers: A Pilot Study.

Air Pollution

Pregnancy as a Susceptible Period to Ambient Air Pollution Exposure on the Maternal Postpartum Metabolome.

Air pollution exposure and incidence of cardiometabolic diseases: Exploring the modifying role of dietary antioxidant intake in adults.

Miscellaneous

Mycoestrogen Exposure During Pregnancy: Impact of the ABCG2 Q141K Variant on Birth and Placental Outcomes.

Laboratory Studies

Numerous Chemicals/Mixtures

In Vitro Hazard Characterization of Contaminants Migrating from Recycled Paper Food Contact Materials

BPA/Phenols

Bisphenol-S exposure of zebrafish unveils the hidden risks of bisphenol paradigm with growth, developmental, and behavioral impacts similar to bisphenol-A.

Prenatal bisphenol A exposure causes sperm quality and functional defects via Leydig cell impairment and meiosis arrest in mice offspring.

Mitigating bisphenol-induced neurotoxicity: exploring the therapeutic potential of diosmin in zebrafish larvae.

Low lipid levels caused by bisphenol S exposure trigger neuroinflammation and apoptosis in the brain of zebrafish.

Silymarin attenuates post-weaning bisphenol A-induced renal injury by suppressing ferroptosis and amyloidosis through Kim-1/Nrf2/HO-1 signaling modulation in male Wistar rats.

Identification of key genes linking bisphenols exposure and breast cancer.

Phthalates

Persistent effects of early-life exposure to dibutyl phthalate on zebrafish: Immune system dysfunction via HPA axis.

Diethyl-hexyl-cyclohexane (Eco-DEHCH) is a safer phthalate alternative that does not elicit neuroendocrine disrupting effects.

Evaluation of a hypothesized Sertoli cell-based adverse outcome pathway for effects of diisononyl phthalate on the developing testis.

Mechanisms and targeted prevention of hepatic osteodystrophy caused by a low concentration of di-(2-ethylhexyl)-phthalate.

Clinical evaluation of red cell concentrates in non-DEHP plasticized containers compared with standard DEHP plasticized containers: A quasi-randomized observational multicentre study.

PFAS

Exposure to Sodium p-Perfluorous Nonenoxybenzenesulfonate Induces Renal Fibrosis in Mice by Disrupting Lysine Metabolism.

Perfluorooctane sulfonate induced ferritinophagy via detyrosinated alpha tubulin-TRIM21-HERC2-regulated NCOA4 degradation in hepatocytes.

Multigeneration responses of Daphnia magna to short-chain per- and polyfluorinated substances (PFAS).

Identification of new PFAS for severe interference with thyroid hormone transport: A combined in vitro/silico approach.

Phosphate-enabled mechanochemical PFAS destruction for fluoride reuse and related Recovery of fluoride from ‘forever chemicals’ could lead to circular economy for fluorine

Flame Retardants

Mechanistic Analysis of Decabromodiphenyl Ether-Induced Neurotoxicity in Humans Using Network Toxicology and Molecular Docking.

Differential developmental effects and its potential mechanism of long-term exposure to TBBPA in two generations of marine medaka (Oryzias melastigma) during early life stages.

Pesticides

Glyphosate-based herbicide as a potential risk factor for breast cancer.

Diazinon induces testicular dysfunction and testicular cell damage through increased reactive oxygen species production in mouse.

Fluxapyroxad induces chronic colonic inflammation via inhibiting intestinal aryl hydrocarbon receptors in mice.

Impact of long-term deltamethrin exposure on Alzheimer’s-related neurodegeneration in rats.

Developmental toxicity of formulated insecticide mixture containing imidacloprid and beta-cyfluthrin in fish: Insights using zebrafish.

Investigation of the mechanisms of liver injury induced by emamectin benzoate exposure at environmental concentrations in zebrafish: A multi-omics approach to explore the role of the gut-liver axis.

Metals/Metalloids

Metformin Mitigates the Impact of Arsenic Exposure on the Maternal and Offspring Reproductive System of Female Mice.

Arsenic and vanadium co-exposure induced cerebellar neurotoxicity: aggravates apoptosis, inflammation, oxidative stress, and locomotor deficits in juvenile BALB/c mice.

Can quercetin reduce arsenic induced toxicity in mouse BALB/c 3T3 fibroblast cells? A study involving in vitro, molecular docking, and ADME predictions.

Microplastics/Nanomaterials

Polystyrene microplastics induce nephrotoxicity through DDIT4-mediated autophagy and apoptosis.

Exposure to Di(2-Ethylhexyl) Phthalate Increases the Internalization of Polystyrene Microplastics by Human Hepatocellular Carcinoma Cells and Leads to Cell Damage.

Pharmaceuticals/Personal Care Products

Decidual Disrupting Effects of Low-Dose Benzophenone-Type UV Filters in Human Endometrial Stromal Cells via ER/PR/FOXO1 Signaling.

In Vitro Exposure to the Endocrine-Disrupting Chemical Climbazole Impairs Human Sperm Motility, Hormonal Signalling, and Mitochondrial Activity.

Miscellaneous

Inhalation exposure to tire rubber particle-sourced pollutant 6PPD-quinone involving basolateral amygdala impairment in male ICR mice.

Prenatal exposure to phenanthrene impairs spermatogenesis and fertility by elevating apoptosis, altering gene expression, and disrupting steroidogenesis in adult male mice across two generations.

The accumulation of Microcystin-LR in the gonads of Pelophylax nigromaculatus during the reproductive periods induces reproductive endocrine disorders in their offspring.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Organophosphorus Flame Retardant, Phthalate, and Alternative Plasticizer Contamination in Novel Plant-Based Food: A Food Safety Investigation.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Mother-Child Exposure to Polychlorinated Biphenyls and Organochlorine Pesticides in the Northern Finland Cohort (NUGEN).

PFAS

Associations between self-reported consumption of foods and serum PFAS concentrations in a sample of pregnant women in the United States.

Serum concentrations of per- and polyfluoroalkyl substances (PFAS) among men from the Danish fire services and Armed Forces.

Leaching profile of per- and polyfluoroalkyl substances from selected e-waste components and potential exposure pathways from discarded components.

Emission of Perfluoroalkyl Acids and Perfluoroalkyl Ether Carboxylic Acids to the Atmosphere from a Fluorochemical Industrial Park in China.

Per- and poly-fluoroalkyl substances (PFAS) contamination of surface waters by historic landfills via groundwater plumes: ecosystem exposure and downstream mass loading.

Digging deep: microbial PFAS-degradation in landfill sediments.

Pesticides

Determination of skin-insect repellent icaridin and DEET in human urine using solid-phase extraction and liquid chromatography with tandem mass spectrometry and its application to a sample of Japanese adults.

Metals/Metalloids

Prevalence of Exposure to Environmental Metal Mixtures Among Pregnant Women in the United States National Health and Nutrition Examination Survey (NHANES) 1999-2018.

Microplastics/Nanomaterials

A global assessment of microplastic abundance and characteristics on marine turtle nesting beaches.

Dynamic material flow analysis of microplastics lost from artificial turfs: A case study from Norway.

Plastic contamination in fish digestive tracts in Amazonian rivers during a period of extreme low water.

Pharmaceuticals/Personal Care Products

Assessing the exposure to the UV filter DHHB in urine samples from the German Environmental Specimen Bank (2000-2021): Evaluating the impact of a potential impurity of di-n-hexyl phthalate in DHHB.

Miscellaneous

Polycyclic aromatic hydrocarbon (PAH) exposure among European adults: Evidence from the HBM4EU aligned studies.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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