EDC Science Weekly, Mar. 17 – 23, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Highlights this week: Microplastics found in human testis and semen; Prenatal exposure to chemicals alter telomere length in children; Newly available documents expose how Monsanto influenced governmental regulations; Diabetes in people living near a PCB plant; Neonics found in human infants; Are pets good indicators of PFAS exposure?

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar March 23: Making the Invisible Visible: The PFAS Project Lab (CHE-Alaska)

Apr. 11: Intersectoral Centre for Endocrine Disruptor Analysis (ICEDA) Awards Conference

Webinar April 13: Long-term Health Effects of Childhood Glyphosate Exposure (EDC Strategies Partnership)

Regulations/Policy

“Ashamed to Put My Name to It”: Monsanto, Industrial Bio-Test Laboratories, and the Use of Fraudulent Science, 1969-1985.

To tax or to ban? A discrete choice experiment to elicit public preferences for phasing out glyphosate use in agriculture.

Important role of the government in reducing pesticide use and risk sustainably in Thailand: Current situation and recommendations.

From EFSA:

Methods/Tools/Screening

Quantification and stability assessment of urinary phenolic and acidic biomarkers of non-persistent chemicals using the SPE-GC/MS/MS method.

Application of a developed triple-classification machine learning model for carcinogenic prediction of hazardous organic chemicals to the US, EU, and WHO based on Chinese database.

Comparing “causal” and “traditional” approaches in the association of long-term exposure to ambient air pollution on mortality: How sensitive are the results?

Considering developmental neurotoxicity in vitro data for human health risk assessment using physiologically-based kinetic modeling: deltamethrin case study.

Quantitation of Total PFAS Including Trifluoroacetic Acid with Fluorine Nuclear Magnetic Resonance Spectroscopy.

Reduced Transcriptome Analysis of Zebrafish Embryos Prioritizes Environmental Compounds with Adverse Cardiovascular Activities.

Commentaries

Addressing chemical pollution in biodiversity research.

Political deafness may impede transition to biological control.

Low-dose chemical stimulation and pest resistance threaten global crop production.

Reviews

Numerous Chemicals/Mixtures

Early Environment and Telomeres: a Long-Term Toxic Relationship.

Epigenotoxicity: a danger to the future life.

The impact of air pollution and endocrine disruptors on reproduction and assisted reproduction.

Protective effects of Korean Red Ginseng against toxicity of endocrine-disrupting chemicals.

Occupational Exposure to Physical and Chemical Risk Factors: A Systematic Review of Reproductive Pathophysiological Effects in Women and Men.

Perfluoroalkyl Substances

A review of cardiovascular effects and underlying mechanisms of legacy and emerging per- and polyfluoroalkyl substances (PFAS).

Systematic Evidence Mapping of Potential Exposure Pathways for Per- and Polyfluoroalkyl Substances Based on Measured Occurrence in Multiple Media.

Molecularly imprinted polymers for per- and polyfluoroalkyl substances enrichment and detection.

Pesticides

Pesticides as a risk factor for cognitive impairment: Natural substances are expected to become alternative measures to prevent and improve cognitive impairment.

Metals/Metalloids

Association Between Non-alcoholic Fatty Liver Disease and Heavy Metal Exposure: a Systematic Review.

A review on arsenic in the environment: contamination, mobility, sources, and exposure.

Microplastics/Nanomaterials

Environmentally sustainable implementations of two-dimensional nanomaterials.

Overview of microplastic pollution and its influence on the health of organisms.

Micro- and nanoplastic toxicity: A review on size, type, source, and test-organism implications.

Beyond ingestion: Adhesion of microplastics to aquatic organisms.

Air Pollution

Health effects of air pollutant mixtures (volatile organic compounds, particulate matter, sulfur and nitrogen oxides) – a review of the literature.

Ambient air pollution and gestational diabetes mellitus: An updated systematic review and meta-analysis.

Pharmaceuticals/Personal Care Products

Safety of benzophenone-type UV filters: A mini review focusing on carcinogenicity, reproductive and developmental toxicity.

Review of warming and acidification effects to the ecotoxicity of pharmaceuticals on aquatic organisms in the era of climate change.

Emerging challenges of the impacts of pharmaceuticals on aquatic ecosystems: A diatom perspective.

Miscellaneous

Trichloroethylene: An Invisible Cause of Parkinson’s Disease?

Human Health Studies

Numerous Chemicals/Mixtures

Environmental exposures are important risk factors for advanced liver fibrosis in African American adults.

BPA/Phenols

Associations between exposure to a mixture of phenols and sex steroid hormones among pre- and postmenopausal women: evidence from NHANES 2015-2016.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Nutritional Modulation of Associations between Prenatal Exposure to Persistent Organic Pollutants and Childhood Obesity: A Prospective Cohort Study. [see related: Invited Perspective: Can Eating a Healthy Diet during Pregnancy Attenuate the Obesogenic Effects of Persistent Organic Pollutants?]

Polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, pesticides, and diabetes in the Anniston Community Health Survey follow-up (ACHS II).

Individual and mixtures of polychlorinated biphenyls and organochlorine pesticides exposure in relation to metabolic syndrome among Chinese adults.

Association of bone mineral density with trichlorophenol: a population-based study.

Perfluoroalkyl Substances

Associations of per- and polyfluoroalkyl substances and alternatives with reproductive hormones in women of childbearing age.

Flame Retardants

Sex-specific effects of prenatal organophosphate ester (OPE) metabolite mixtures and adverse infant birth outcomes in the maternal and developmental risks from environmental and social stressors (MADRES) pregnancy cohort.

Metals/Metalloids

Arsenic causing gallbladder cancer disease in Bihar.

Associations of urinary and blood cadmium concentrations with all-cause mortality in US adults with chronic kidney disease: a prospective cohort study.

Human exposure to dust and heavy metals in industrial regions and its relationship with the prevalence of multiple sclerosis disease.

Association between Serum Iron, Blood Lead, Cadmium, Mercury, Selenium, Manganese and Low Cognitive Performance in Old Adults from National Health and Nutrition Examination Survey (NHANES): A Cross-Sectional Study.

Placental levels of essential and non-essential trace element in relation to neonatal weight in Northwestern Spain: application of generalized additive models.

Air Pollution

Maternal 25(OH)D attenuates the relationship between ambient air pollution during pregnancy and fetal hyperinsulinism.

Associations among Historical Neighborhood Disinvestment, Hazardous Air Pollutants, and Current Adult Asthma Prevalence.

Associations of outdoor fine particulate air pollution and cardiovascular disease: Results from the Prospective Urban and Rural Epidemiology Study in China (PURE-China).

Effects of short-term PM_2.5 exposure on blood lipids among 197,957 people in eastern China.

Long-term exposure to PM_2.5 and O₃ with cardiometabolic multimorbidity: Evidence among Chinese elderly population from 462 cities.

Miscellaneous

Polycyclic aromatic hydrocarbons exposure and plasma lncRNA signature: A profile and functional analysis.

Laboratory Studies

Numerous Chemicals/Mixtures

Interacted toxic mechanisms of ochratoxin A and tricyclazole on the zebrafish (Danio rerio).

In silico assessment of mixture toxicity mechanisms involved in the pathogenesis of thyroid diseases: the combination of toxic metal(oid)s and decabrominated diphenyl ether.

Combined toxicity of 3,5,6-trichloro-2-pyridinol and 2-(bromomethyl)naphthalene in the early stages of zebrafish (Danio rerio) embryos: Abnormal heart development at lower concentrations via differential expression of heart forming-related genes.

BPA/Phenols

Increased levels of IL-17 and autoantibodies following Bisphenol A exposure were associated with activation of PI3K/AKT/mTOR pathway and abnormal autophagy in MRL/lpr mice.

Exposure to Bisphenol A induces abnormal fetal heart development by promoting ferroptosis.

Bisphenol F induced hyperglycemia via activation of oxidative stress-responsive miR-200 family in the pancreas.

Bisphenols, but not phthalate esters, modulate gene expression in activated human MAIT cells in vitro.

Toxic effects of bisphenol AF on the embryonic development of marine medaka (Oryzias melastigma).

Importance of relative binding of bisphenol A and bisphenol S to plasma proteins for predicting their in vivo potencies.

Phthalates

Long-Term Exposure to Di(2- Ethylhexyl) Phthalate, Diisononyl Phthalate, and a Mixture of Phthalates Alters Estrous Cyclicity and/or Impairs Gestational Index and Birth Rate in Mice.

Parabens/Triclosan/Antimicrobials

Immunotoxicity induced by triclocarban exposure in zebrafish triggering the risk of pancreatic cancer.

Flame Retardants

Triphenyl phosphate-induced macrophages dysfunction by activation TLR4-mediated ERK/NF-κB pathway.

Organotins

Biochemical mechanisms of tributyltin chloride-induced cell toxicity in Sertoli cells.

Pesticides

Effect of probiotics on glucose levels and weight gain in mice exposed to low doses of malathion.

TDP-43 is a potential marker of dopaminergic neuronal damage caused by atrazine exposure.

Dithianon exposure induces dopaminergic neurotoxicity in Caenorhabditis elegans.

Neuroprotective Effect of Vitamin D on Behavioral and Oxidative Parameters of Male and Female Adult Wistar Rats Exposed to Mancozeb (manganese/zinc ethylene bis-dithiocarbamate).

Therapeutic effect of gossypetin against paraquat-induced testicular damage in male rats: a histological and biochemical study.

Enantioselective activity and toxicity of chiral acaricide cyflumetofen toward target and non-target organisms.

Enantioselectivity effects of energy metabolism in honeybees (Apis mellifera) by triticonazole.

Atrazine exposure can dysregulate the immune system and increase the susceptibility against pathogens in honeybees in a dose-dependent manner.

Toxic temperatures: Bee behaviours exhibit divergent pesticide toxicity relationships with warming.

Neonicotinoid effects on tropical bees: Imidacloprid impairs innate appetitive responsiveness, learning and memory in the stingless bee Melipona quadrifasciata.

Exposure to flupyradifurone affect health of biocontrol parasitoid Binodoxys communis (Hymenoptera: Braconidae) via disrupting detoxification metabolism and lipid synthesis.

Metals/Metalloids

Arsenic and iron bioavailability in Caco-2 cells: The influence of their co-existence and concentration.

Arsenic induces the global hypophosphorylation of insulin receptor substrate proteins in differentiated human neuroblastoma SH-SY5Y cells.

Early-life cadmium exposure elevates susceptibility to allergic asthma in ovalbumin-sensitized and challenged mice.

Multigenerational exposure of cadmium trans-generationally impairs locomotive and chemotactic behaviors in Caenorhabditis elegans.

Microplastics/Nanomaterials

Maternal Effect of Polyethylene Microplastic Fragments Containing Benzophenone-3 in Different Ages and Broods of Daphnia Magna.

Combined effect of polystyrene microplastics and cadmium on rat blood-testis barrier integrity and sperm quality.

Toxic effects of microplastic (Polyethylene) on fish: Accumulation, hematological parameters and antioxidant responses in Korean Bullhead, Pseudobagrus fulvidraco.

Polystyrene microplastics induce myocardial inflammation and cell death via the TLR4/NF-κB pathway in carp.

Nanoplastics potentiate mercury toxicity in a marine copepod under multigenerational exposure.

Exposure to nanoplastics induces mitochondrial impairment and cytomembrane destruction in Leydig cells.

Isolation and characterization of microplastics from skin care products; interactions with albumin proteins and in-vivo toxicity studies on Artemia salina.

Air Pollution

Fine particulate matter (PM_2.5)-induced pulmonary oxidative stress contributes to increases in glucose intolerance and insulin resistance in a mouse model of circadian dyssynchrony.

Pharmaceuticals/Personal Care Products

The generation of environmentally persistent free radicals on photoaged microbeads from cosmetics enhances the toxicity via oxidative stress.

Miscellaneous

Benzo[b]naphtho[d]thiophenes and naphthylbenzo[b]thiophenes: Their aryl hydrocarbon receptor-mediated activities and environmental presence.

A new strategy to alleviate the obesity induced by endocrine disruptors-A unique lysine metabolic pathway of nanoselenium Siraitia grosvenorii to repair gut microbiota and resist obesity.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Occurrence and risk evaluation of endocrine-disrupting chemicals in wastewater and surface water of Lahore, Pakistan.

BPA/Phenols

Food Thermal Labels are a Source of Dietary Exposure to Bisphenol S and Other Color Developers.

Phthalates

Relationship between shellfish consumption and urinary phthalate metabolites: Korean National Environmental Health Survey (KoNEHS) cycle 3 (2015-2017).

Parabens/Triclosan/Antimicrobials

Human nails as a valuable noninvasive alternative for estimating exposure to parabens.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Using plasma vitellogenin in loggerhead sea turtles to assess reproductive maturation and estrogen-like contaminant exposure.

Perfluoroalkyl Substances

Non-targeted analysis for the screening and semi-quantitative estimates of per-and polyfluoroalkyl substances in water samples from South Florida environments.

Per- and polyfluoroalkyl substances: using comparative medicine to understand exposure and adverse health outcomes in people and their pets.

PFAS levels in fish species in the Po River (Italy): New generation PFAS, fish ecological traits and parasitism in the foreground.

Application of nano-LC – nano-ESI – Orbitrap-MS for trace determination of four priority PFAS in food products considering recently established tolerable weekly intake (TWI) limits.

Variations of the Level, Profile, and Distribution of PFAS around POSF Manufacturing Facilities in China: An Overlooked Source of PFCA.

Flame Retardants

Investigating the associations between organophosphate flame retardants (OPFRs) and fine particles in paired indoor and outdoor air: A probabilistic prediction model for deriving OPFRs in indoor environments.

Bioaccumulation and metabolism of polybrominated diphenyl ethers (PBDEs) in coenobitid hermit crabs from marine litter-polluted beaches in remote islands.

Pesticides

Infantile Internal and External Exposure to Neonicotinoid Insecticides: A Comparison of Levels across Various Sources.

Pesticide residues in nectar and pollen of melon crops: Risk to pollinators and effects of a specific pesticide mixture on Bombus terrestris (Hymenoptera: Apidae) micro-colonies.

Pesticides bioassays using neotropical aquatic species: Trends during the last twenty years and future challenges in Argentina.

Metals/Metalloids

Association between dental amalgam restoration and urine mercury concentrations among young women in Korea: a cross-sectional study.

Developing and Implementing In-Person and Virtual SoilSHOPs in Atlanta, Georgia, as a Community-Engaged Approach to Screen and Prevent Soil Lead Exposure.

Microplastics/Nanomaterials

Is the petrochemical industry an overlooked critical source of environmental microplastics?

Detection and characterization of microplastics in the human testis and semen.

Presence of different microplastics promotes greenhouse gas emissions and alters the microbial community composition of farmland soil.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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