EDC Science Weekly, Mar. 17 – 23, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Mar. 30: Reversing the Plastics Crisis Through a Human Rights Approach

Webinar Mar. 31: Environmental justice voices now: Disasters, cultural fire practices, and building community capacity

Webinar Apr. 20: Do chemicals in plastic consumer products contribute to obesity?

Regulations/Policy

Regulatory Testing for Endocrine Disruptors; Need for Validated Methods and Integrated Approaches.

Rethinking chronic toxicity and carcinogenicity assessment for agrochemicals project (ReCAAP): A reporting framework to support a weight of evidence safety assessment without long-term rodent bioassays.

Methods/Tools/Screening

Evidenced-Based Approaches to Support the Development of Endocrine-Mediated Adverse Outcome Pathways: Challenges and Opportunities.

The AOP-DB RDF: Applying FAIR Principles to the Semantic Integration of AOP Data Using the Research Description Framework.

Merging the exposome into an integrated framework for “omics” sciences.

From Causal Networks to Adverse Outcome Pathways: A Developmental Neurotoxicity Case Study.

Beyond AOPs: A Mechanistic Evaluation of NAMs in DART Testing.

Accounting for Artifacts in High-Throughput Toxicity Assays.

Cell-Based Assays to Identify ERR and ERR/PGC Modulators.

An approach for mixture testing and prioritization based on common kinetic groups.

The Future of 3D Brain Cultures in Developmental Neurotoxicity Testing.

Optimization of Human Neural Progenitor Cells for an Imaging-Based High-Throughput Phenotypic Profiling Assay for Developmental Neurotoxicity Screening.

Machine Learning Applications for Chemical Fingerprinting and Environmental Source Tracking Using Non-target Chemical Data.

Micro and Nanoplastics Identification: Classic Methods and Innovative Detection Techniques.

Commentaries

Time to Break the “Lock-In” Impediments to Chemicals Management.

Navigating a Two-Way Street: Metal Toxicity and the Human Gut Microbiome. [Focus in EHP]

Reviews

Numerous Chemicals/Mixtures

Beyond the behavioural phenotype: Uncovering mechanistic foundations in aquatic eco-neurotoxicology.

BPA/Phenols

BPS and BPF are as Carcinogenic as BPA and are Not Viable Alternatives for its Replacement.

In utero exposure to bisphenols and asthma, wheeze, and lung function in school-age children: a prospective meta-analysis of 8 European birth cohorts.

Phthalates

Plasticizers: negative impacts on the thyroid hormone system.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Sex-specific Associations Between Type 2 Diabetes Incidence and Exposure to Dioxin and Dioxin-like Pollutants: A Meta-analysis.

Pesticides

Cellular and Molecular Events Leading to Paraquat-Induced Apoptosis: Mechanistic Insights into Parkinson’s Disease Pathophysiology.

Advances and future prospects of pyrethroids: Toxicity and microbial degradation.

Potentially Toxic Elements

Environmental exposure of the general population to cadmium as a risk factor of the damage to the nervous system – a critical review of current data.

Mercury and Mercury-Containing Preparations: History of Use, Clinical Applications, Pharmacology, Toxicology, and Pharmacokinetics in Traditional Chinese Medicine.

Microplastics/Nanomaterials

Micro(nano)plastics pollution and human health: A carcinogenesis concern for humans.

Current Insights into Potential Effects of Micro-Nanoplastics on Human Health by in-vitro Tests.

Spatiotemporal Small Non-coding RNAs Expressed in the Germline as an Early Biomarker of Testicular Toxicity and Transgenerational Effects Caused by Prenatal Exposure to Nanosized Particles.

Pro-inflammatory effects of silver nanoparticles in the intestine.

Status and prospects of atmospheric microplastics: A review of methods, occurrence, composition, source and health risks.

Microplastics in the environment: Recent developments in characteristic, occurrence, identification and ecological risk.

Pharmaceuticals/Personal Care Products

Using Experimental Models to Decipher the Effects of Acetaminophen and NSAIDs on Reproductive Development and Health.

Miscellaneous

Omics approaches in bioremediation of environmental contaminants: An integrated approach for environmental safety and sustainability.

Human Health Studies

Numerous Chemicals/Mixtures

Assessment of Pediatric Cancer and Its Relationship to Environmental Contaminants: An Ecological Study in Idaho. [metals, pesticides]

Association between environmental toxic metals, arsenic and polycyclic aromatic hydrocarbons and chronic obstructive pulmonary disease in the US adult population.

BPA/Phenols

Race-specific associations of urinary phenols and parabens with adipokines in midlife women: The Study of Women’s Health Across the Nation (SWAN).

Serum vitamin D level mitigates fractional exhaled nitric oxide linked to bisphenol-A in school-aged children.

Phthalates

Lag associations of gestational phthalate exposure with maternal serum vitamin D levels: Repeated measure analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations between persistent organic pollutants and type 1 diabetes in youth.

Perfluoroalkyl Substances

Perfluoroalkyl Substances and Incident Natural Menopause in Midlife Women: The Mediating Role of Sex Hormones.

Perfluoroalkyl substances influence DNA methylation in school-age children highly exposed through drinking water contaminated from firefighting foam: a cohort study in Ronneby, Sweden.

Global Exposure to Per- and Polyfluoroalkyl Substances and Associated Burden of Low Birthweight.

Per-/polyfluoroalkyl substance concentrations in human serum and their associations with immune markers of rheumatoid arthritis.

Pesticides

Exposure to non-persistent pesticides, BDNF, and behavioral function in adolescent males: Exploring a novel effect biomarker approach.

Prenatal and postnatal exposure to pesticides and school-age children’s cognitive ability in rural Bogotá, Colombia.

The study of human serum metabolome on the health effects of glyphosate and early warning of potential damage.

Potentially Toxic Elements

Domain-specific effects of prenatal fluoride exposure on child IQ at 4, 5, and 6-12 years in the ELEMENT cohort.

Associations of total urinary arsenic with total cholesterol and high-density lipoprotein among 12-17-year-old participants from the 2009-2016 NHANES cycles: A cross-sectional study.

Birth Size Outcomes in Relation to Maternal Blood Levels of Some Essential and Toxic Elements.

Analysis of Whole Blood and Urine Trace Elements in Children with Autism Spectrum Disorders and Autistic Behaviors.

Effect of occupational cadmium exposure on the thyroid gland and associated inflammatory markers among workers of the electroplating industry.

Air Pollution

Association between ambient air pollution and blood sex hormones levels in men.

Effect of air pollution on age at menarche in polish females, born 1993-1998.

Laboratory Studies

Numerous Chemicals/Mixtures

Effects of Individual and Co-exposure of Copper Oxide Nanoparticles and Copper Sulphate on Nile Tilapia Oreochromis niloticus: Nanoparticles Enhance Pesticide Biochemical Toxicity.

Combined toxicity of chlorpyrifos, abamectin, imidacloprid, and acetamiprid on earthworms (Eisenia fetida).

Chlorpyrifos and dichlorvos in combined exposure reveals antagonistic interaction to the freshwater fish Mrigal, Cirrhinus mrigala.

Comparison of Modes of Action Between Fish, Cell and Mitochondrial Toxicity Based on Toxicity Correlation, Excess Toxicity and QSAR for Class-based Compounds.

BPA/Phenols

Bisphenol A impairs macrophages through inhibiting autophagy via AMPK/mTOR signaling pathway and inducing apoptosis.

Parabens/Triclosan/Antimicrobials

The rapid transformation of triclosan in the liver reduces its effectiveness as inhibitor of hepatic energy metabolism.

Flame Retardants

Evaluation of the influences of low dose polybrominated diphenyl ethers exposure on human early retinal development.

Effects of life cycle exposure to dietary 2,2′, 4,4′-tetrabromodiphenyl ether (BDE-47) on medaka fish (Oryzias latipes).

Pesticides

Network Pharmacology Combined with Metabolomics Approach to Investigate the Toxicity Mechanism of Paclobutrazol.

Enantioselective toxic effects of mefentrifluconazole in the early life stage of zebrafish (Danio rerio).

Endocrine, immune and renal toxicity in male largemouth bass after chronic exposure to glyphosate and Rodeo®.

Protective effects of 5-aminolevulinic acid against toxicity induced by alpha-cypermethrin to the liver-gut-microbiota axis in zebrafish.

circRNA-based biomarker candidates for acute cypermethrin and chlorpyrifos toxication in the brain of Zebrafish (Danio rerio).

Neurobehavioral Toxicity Induced by Carbendazim in Rats and the Role of iNOS, Cox-2, and NF-κB Signalling Pathway.

Potentially Toxic Elements

New insights into arsenic, lead, and iron neurotoxicity: Activation of MAPK signaling pathway and oxidative stress.

Cadmium acute exposure induces metabolic and transcriptomic perturbations in human mature adipocytes.

Genome-wide alteration of histone methylation profiles associated with cognitive changes in response to developmental arsenic exposure in mice.

Neuroprotective effects of carvacrol against cadmium-induced neurotoxicity in rats: role of oxidative stress, inflammation and apoptosis.

Candidate master microRNA regulator of arsenic-induced pancreatic beta cell impairment revealed by multi-omics analysis.

Lentinan alleviates arsenic-induced hepatotoxicity in mice via downregulation of OX40/IL-17A and activation of Nrf2 signaling.

Microplastics

The role of nanoplastics on the toxicity of the herbicide phenmedipham, using Danio rerio embryos as model organisms.

Polystyrene microplastics increase Pb bioaccumulation and health damage in the Chinese mitten crab Eriocheir sinensis.

Differential cascading cellular and subcellular toxicity induced by two sizes of nanoplastics.

Polystyrene nanoplastics penetrate across the blood-brain barrier and induce activation of microglia in the brain of mice.

Two types of microplastics (polystyrene-HBCD and car tire abrasion) affect oxidative stress-related biomarkers in earthworm Eisenia andrei in a time-dependent manner.

Air Pollution

Impact of airborne total suspended particles (TSP) and fine particulate matter (PM_2.5 )-induced developmental toxicity in zebrafish (Danio rerio) embryos.

Pharmaceuticals/Personal Care Products

Enantioselective toxic effects of mefentrifluconazole in the early life stage of zebrafish (Danio rerio).

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Exposure profiles and predictors of a cocktail of environmental chemicals in Chinese men of reproductive age.

Targeted screening of 11 bisphenols and 7 plasticizers in food composites from Canada and South Africa.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Pilot study on the concentrations of organochlorine compounds and potentially toxic elements in pregnant women and local food items from the Finnish Lapland.

A time-trend guided non-target screening study of organic contaminants in Baltic Sea harbor porpoise (1988-2019), guillemot (1986-2019), and white-tailed sea eagle (1965-2017) using gas chromatography-high-resolution mass spectrometry.

Temporal Trends of Organochlorine- and Perfluorinated Contaminants in a Terrestrial Raptor in Northern Europe over 34 Years (1986-2019).

Source and Distribution of Emerging and Legacy Persistent Organic Pollutants in the Basins of the Eastern Indian Ocean.

Perfluoroalkyl Substances

Implications of PFAS definitions using fluorinated pharmaceuticals.

Effective coordination, collaboration, communication, and partnering are needed to close the gaps for occupational PFAS exposure.

Municipal solid waste incineration (MSWI) ash co-disposal: Influence on per- and polyfluoroalkyl substances (PFAS) concentration in landfill leachate.

Bioaccumulation of per- and polyfluoroalkyl substance in fish from an urban river: Occurrence, patterns and investigation of potential ecological drivers.

Formation and fate of perfluoroalkyl acids (PFAAs) in a laboratory-scale urban wastewater system.

Flame Retardants

Legacy and emerging flame retardants in sharks from the Western North Atlantic Ocean.

Pesticides

Exposure patterns, chemical structural signatures, and health risks of pesticides in breast milk: A multicenter study in China.

A risk ranking of pesticides in Irish drinking water considering chronic health effects.

Deriving freshwater guideline values for neonicotinoid insecticides: Implications for water quality guidelines and ecological risk assessment.

A novel multi-criteria framework for optimizing ecotoxicological effects and human health risks of neonicotinoid insecticides: Characterization, assessment and regulation strategies.

Potentially Toxic Elements

Environmental exposures to lead, cadmium, and mercury and pterygium in Korean adults.

A risk assessment review of mercury exposure in Arctic marine and terrestrial mammals.

Microplastics

Presence of microplastics in commercial canned tuna.

Microplastic contamination in seafood from Dongshan Bay in southeastern China and its health risk implication for human consumption.

Accumulation of microplastics in greenhouse soil after long-term plastic film mulching in Beijing, China.

Underwater hidden microplastic hotspots: Historical ocean dumping sites.

Air Pollution

Decade-long trends in chemical component properties of PM_2.5 in Beijing, China (2011-2020).

Pharmaceuticals/Personal Care Products

Identification of Triazine UV Filters as an Emerging Class of Abundant, Ubiquitous Pollutants in Indoor Dust and Air from South China: Call for More Concerns on Their Occurrence and Human Exposure.

Miscellaneous

Insights into the hepatotoxicity of pyrene and 1-chloropyrene using an integrated approach of metabolomics and transcriptomics.

Tire wear particle emissions: Measurement data where are you?

New Evidence of Rubber-Derived Quinones in Water, Air, and Soil.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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