EDC Science Weekly, Mar. 17 – 23, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events,Regulations, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Mar. 30 webinar: Environmental chemical exposures and mechanisms underlying human placental dysfunction and disease (UCSF EaRTH Center)

Mar. 31 webinar: Plastics, Endocrine Disrupting Chemicals and Health: Findings of a New Joint Report of the Endocrine Society and International Pollutants Elimination Network (IPEN) (CHE-Alaska)

Apr. 15 webinar: Putting the EU Chemicals Strategy for Sustainability into action: Addressing EDCs and mixtures (Food Packaging Forum)

Apr. 29 webinar: The coming population implosion: chemicals, declining fertility and the polycrisis (OMEGA)

June 15-16 online conference: 1st International Endocrine Disruptor Conference on the Island of Ireland (PROTECTED)

Regulations

The science behind the ban: the outstanding impact of ecotoxicological research on the regulation of neonicotinoids.

Methods/Tools/Screening

Suspect Screening, Prioritization, and Confirmation of Environmental Chemicals in Maternal-Newborn Pairs from San Francisco. [also see accompanying blog, PRHE Finds Evidence of 55 New Chemicals in People]

Using the US EPA CompTox Chemicals Dashboard to interpret targeted and non-targeted GC-MS analyses from human breath and other biological media.

Stem cells of aquatic invertebrates as an advanced tool for assessing ecotoxicological impacts.

Metabolomics in chemical risk analysis – A review.

Considerations for Toxicity Experiments and Risk Assessments with PFAS Mixtures.

Commentaries

Introduction to the Series on “Current Knowledge in Marine Microplastics-Pollution Down to the Nanoscale”. [intro to a series of papers in The Biological Bulletin]

Mixture prioritization and testing: the importance of toxicokinetics.

Microplastics in Seafood: How Much Are People Eating? [Science Selection in EHP]

Potential toxicity of metal trace elements from food in children.

Reviews

Numerous EDCs

Environmental Exposure during Pregnancy: Influence on Prenatal Development and Early Life: A Comprehensive Review.

A profile and review of findings from the Early Markers for Autism study: unique contributions from a population-based case-control study in California.

Endocrine-disrupting chemicals and behaviour: A high risk to take? [BPA and phthalates]

Mixtures

Combined toxicity of endocrine-disrupting chemicals: A review.

Perfluoroalkyl Substances

Epigenetic changes by per- and polyfluoroalkyl substances (PFAS).

Pesticides

Effect of pyrethroid pesticides on the testis of male rats: A meta-analysis.

Gut microbiota-mediated pesticide toxicity in humans: Methodological issues and challenges in the risk assessment of pesticides.

Maternal pesticide exposure and its relation to childhood cancer: an umbrella review of meta-analyses.

Potentially Toxic Elements

Developmental toxicity of cadmium in infants and children: a review.

Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium) – induced hepatotoxicity – A review

Dose-response meta-analysis of arsenic exposure in drinking water and hypertension.

Pb Toxicity on Gut Physiology and Microbiota.

Microplastics/Nanomaterials

The current status of studies of human exposure assessment of microplastics and their health effects: a rapid systematic review.

Ecotoxicological and physiological risks of microplastics on fish and their possible mitigation measures.

Airborne Microplastics: A Review on the Occurrence, Migration and Risks to Humans.

Are microplastic particles a hotspot for the spread and the persistence of antibiotic resistance in aquatic systems?

Sampling, pre-treatment, and identification methods of microplastics in sewage sludge and their effects in agricultural soils: a review.

A comprehensive review on assessment of plastic debris in aquatic environment and its prevalence in fishes and other aquatic animals in India.

Nano and microplastic interactions with freshwater biota – Current knowledge, challenges and future solutions.

Environmental risk of nanomaterials and nanoparticles and EPR technique as an effective tool to study them-a review.

Towards safe and sustainable innovation in nanotechnology: State-of-play for smart nanomaterials.

Air Pollution

Publication trends in research on particulate matter and health impact over a 10-year period: 2009-2018.

Early life exposure to air pollution impacts neuronal and glial cell function leading to impaired neurodevelopment.

Pharmaceuticals/Personal Care Products

Investigating the exposure and impacts of chemical UV-filters in coral reef ecosystems: Review and research gap prioritisation.

Miscellaneous

A Crab Is Not a Fish: Unique Aspects of the Crustacean Endocrine System and Considerations for Endocrine Toxicology.

Role of germ-free animal models in understanding interactions of gut microbiota to host and environmental health: A special reference to zebrafish.

Human Health Studies

Numerous Chemicals

Maternal occupational exposure to endocrine-disrupting chemicals during pregnancy and semen parameters in adulthood: results of a nationwide cross-sectional study among Swiss conscripts.

Time and spatial trends of operated cryptorchidism in France and environmental hypotheses: a nationwide study from 2002 to 2014.

Altered functional activations of prefrontal brain areas during emotional processing of fear in Inuit adolescents exposed to environmental contaminants.

Mixtures

Chemical Mixture Exposures During Pregnancy and Cognitive Abilities in School-Aged Children.

Phthalates

Associations of gestational phthalate exposure and non-nutritive suck among infants from the Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) birth cohort study.

Mediation effects of thyroid function in the associations between phthalate exposure and glucose metabolism in adults.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Dietary exposure to polychlorinated biphenyls (PCB) and risk of Non-Hodgkin’s Lymphoma: evidence from the French E3N prospective cohort.

The Stage at Presentation and Oncologic Outcomes for Agent Orange Exposed and Non-Exposed United States Veterans Diagnosed With Prostate Cancer.

Longitudinal changes in telomere length in PCB-exposed individuals: interaction with CMV infection.

Perfluoroalkyl Substances

Plasma Concentrations of Per- and Polyfluoroalkyl Substances and Body Composition from Mid-childhood to Early Adolescence.

Environmental exposure to per- and polyfluoroalkyl substances mixture and male reproductive hormones.

Pesticides

Associations of acetylcholinesterase inhibition between pesticide spray seasons with depression and anxiety symptoms in adolescents, and the role of sex and adrenal hormones on gender moderation.

Potentially Toxic Elements

Urinary total arsenic and arsenic methylation capacity in pregnancy and gestational diabetes mellitus: A case-control study.

Delta-Aminolevulinic Acid Dehydratase, Low Blood Lead Levels, Social Factors, and Intellectual Function in an Afro-Brazilian Children Community.

In Utero Exposure to Mercury Is Associated With Increased Susceptibility to Liver Injury and Inflammation in Childhood.

Exposure to Cadmium, Lead, and Tobacco Smoke and the 10-Year Cumulative Incidence of Olfactory Impairment: The Beaver Dam Offspring Study.

Serum cardiovascular-related metabolites disturbance exposed to different heavy metal exposure scenarios.

Association of arsenic-induced cardiovascular disease susceptibility with genetic polymorphisms.

Bayesian Benchmark Dose Analysis for Inorganic Arsenic in Drinking Water Associated With Bladder and Lung Cancer Using Epidemiological Data.

Association between prenatal dietary methyl mercury exposure and developmental outcomes on acquisition of articulatory-phonologic skills in children in the Republic of Seychelles.

Principles of studying low-level neurotoxic exposures in children: using the Seychelles Child Development Study of methyl mercury as a prototype.

Association between serum arsenic and oral cancer risk: A case-control study in southeast China.

Air Pollution

Ambient BTEX exposure and mid-pregnancy inflammatory biomarkers in pregnant African American women.

Association between ambient air pollution and high-risk pregnancy: A 2015-2018 national population-based cohort study in Korea.

Effect of short-term exposure to particulate air pollution on heart rate variability in normal-weight and obese adults.

Association of exposure to ambient air pollution with ovarian reserve among women in Shanxi province of north China.

The effects of age on DNA fragmentation, the condensation of chromatin and conventional semen parameters in healthy nonsmoking men exposed to traffic air pollution.

Emergency hospital admissions for cardiovascular diseases attributed to air pollution in Tehran during 2016-2019.

Long-term exposure to air pollutants enhanced associations of obesity with blood pressure and hypertension.

A global association between Covid-19 cases and airborne particulate matter at regional level.

Association between prenatal air pollution exposure and risk of hypospadias in offspring: a systematic review and meta-analysis of observational studies.

Local Contrasts in Concentration of Ambient Particulate Air Pollution (PM2.5) and Incidence of Alzheimer’s Disease and Dementia: Results from the Betula Cohort in Northern Sweden.

Miscellaneous

Polycyclic aromatic hydrocarbons residues and the carcinogenic risk assessment to pregnant women in Nantong, China using QuEChERS method and HPLC- A pilot case study.

Laboratory Studies

BPA/Phenols

Effects of two Bisphenol A replacement compounds, 1,7-bis (4-hydroxyphenylthio)-3,5-dioxaheptane and Bisphenol AF, on development and mRNA expression in chicken embryos.

Phthalates

Bioaccumulation and health risk assessment of phthalate esters in cultured low trophic level fish feded with food waste-based diets.

Curcumin decreases dibutyl phthalate-induced renal dysfunction in Kunming mice via inhibiting oxidative stress and apoptosis.

In vitro evaluation of cytotoxic effects of di (2-ethylhexyl) phthalate (DEHP) produced by Bacillus velezensis strain RP137 isolated from Persian Gulf.

Exposure to phthalates DEHP and DINP May lead to oxidative damage and lipidomic disruptions in mouse kidney.

Parabens/Triclosan/Antimicrobials

Exposure to propylparaben during pregnancy and lactation induces long-term alterations to the mammary gland in mice.

Triclosan affects the expression of nitric oxide synthases (NOSs), peroxisome proliferator-activated receptor gamma (PPARγ), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) in mouse neocortical neurons in vitro.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Expression of estrogen-, progesterone-, and androgen-responsive genes in MCF-7 and MDA-MB-231 cells treated with o,p’-DDT, p,p’-DDT, or endosulfan.

2,3,7,8-Tetrachlorodibenzo-p-dioxin exposure disrupts development of the visceral and ocular vasculature.

Disposition of PCB 11 in Mice Following Acute Oral Exposure.

Perfluoroalkyl Substances

Development of a Gestational and Lactational Physiologically Based Pharmacokinetic (PBPK) Model for Perfluorooctane Sulfonate (PFOS) in Rats and Humans and Its Implications in the Derivation of Health-Based Toxicity Values.

Effect of Perfluorooctanesulfonic acid (PFOS) on immune cell development and function in mice.

N-acetyl cysteine co-treatment abates perfluorooctanoic acid-induced reproductive toxicity in male rats.

Perfluorooctanoic acid-induced immunotoxicity via NF-kappa B pathway in zebrafish (Danio rerio) kidney.

Hydrolysis of FTOH precursors, a simple method to account for some of the unknown PFAS.

The new PFAS C6O4 and its effects on marine invertebrates: First evidence of transcriptional and microbiota changes in the Manila clam Ruditapes philippinarum.

Pesticides

NMR-Based Metabolomics Approach to Explore Brain Metabolic Changes Induced by Prenatal Exposure to Autism-Inducing Chemicals.

Exposure to sublethal concentrations of the glyphosate-based herbicide Faena® increases sensitivity in the progeny of the American cladoceran Daphnia exilis (Herrick, 1895).

Varying modalities of perinatal exposure to a pesticide cocktail elicit neurological adaptations in mice and zebrafish.

Toxic effects of atrazine on immune function in BALB/c mice.

In Silico Analysis to Identify Molecular Targets for Chemicals of Concern: The Case Study of Flocoumafen, an Anticoagulant Pesticide.

Perinatal exposure to low doses of glyphosate-based herbicide combined with a high-fat diet in adulthood causes changes in the jejunums of mice.

Larval oral exposure to thiacloprid: Dose-response toxicity testing in solitary bees, Osmia spp. (Hymenoptera: Megachilidae).

Toxicity and risk assessment of six widely used pesticides on embryo-larval development of the Pacific oyster, Crassostrea gigas.

Sublethal agrochemical exposures can alter honey bees’ and Neotropical stingless bees’ color preferences, respiration rates, and locomotory responses.

The insecticide permethrin induces transgenerational behavioral changes linked to transcriptomic and epigenetic alterations in zebrafish (Danio rerio).

Route of exposure influences pesticide body burden and the hepatic metabolome in post-metamorphic leopard frogs.

Early Toxic Effects in a Central American Native Fish (Parachromis dovii) Exposed to Chlorpyrifos and Difenoconazole.

Potentially Toxic Elements

Ameliorative effect of L-carnitine on chronic lead-induced reproductive toxicity in male rats.

Ameliorative effect of ZnO-NPs against bioaggregation and systemic toxicity of lead oxide in some organs of albino rats.

Ecotoxicity Risk of Low-Dose Methylmercury Exposure to Caenorhabditis elegans: Multigenerational Toxicity and Population Discrepancy.

Microplastics

Effect of surfactants on the transport of polyethylene and polypropylene microplastics in porous media.

Chronic feeding exposure to virgin and spiked microplastics disrupts essential biological functions in teleost fish.

Submicro- and nanoplastics: How much can be expected in water bodies?

Microplastics alter digestive enzyme activities in the marine bivalve, Mytilus galloprovincialis.

Fecal microbiota transplantation attenuates nano-plastics induced toxicity in Caenorhabditis elegans.

Air Pollution

PM2.5 inducing myocardial fibrosis mediated by Ang II/ERK1/2/TGF-β₁ signaling pathway in mice model.

Pharmaceuticals/Personal Care Products

Dangerous connections: biochemical and behavioral traits in Daphnia magna and Daphnia longispina exposed to ecologically relevant amounts of paracetamol.

Mixtures

Influence of the co-exposure of microplastics and tetrabromobisphenol A on human gut: Simulation in vitro with human cell Caco-2 and gut microbiota.

Effects of microplastics and glyphosate on growth rate, morphological plasticity, photosynthesis, and oxidative stress in the aquatic species Salvinia cucullata.

Developmental and Histopathological Changes in the Gonads of Female Japanese Medaka Following Exposure to Water from the Yellow River, China.

Miscellaneous

Endocrine disrupting potency and toxicity of novel sophorolipid quaternary ammonium salts.

Comparing the effects of unconventional and conventional crude oil exposures on zebrafish and their progeny using behavioral and genetic markers.

Exposure/Environment Studies

BPA/Phenols

Lifetime dietary exposure to bisphenol A in the general population and during pregnancy: Foetal exposure and health risk assessment.

Bisphenol A Exposure On Exclusively Breastfed Infants In Lactating Women: An Observational Cross-Sectional Study.

Phthalates

Characteristics of dust-phase phthalates in dormitory, classroom, and home and non-dietary exposure in Beijing, China.

Indoor phthalate exposure and contributions to total intake among pregnant women in the SELMA study.

Seasonal Occurrences and Risk Assessment of Phthalate Esters in Sediment, Water and Biota of Two Sub-Saharan Rivers.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Spatial trends and human health risks of organochlorinated pesticides from bovine milk; a case study from a developing country, Pakistan.

Pilot study on long-term simulation of PCB-153 human body burden in the Tibetan Plateau.

Persistent Organic Pollutants Burden, Trophic Magnification and Risk in a Pelagic Food Web from Coastal NW Mediterranean Sea.

Perfluoroalkyl Substances

PFOS dominates PFAS composition in ambient fine particulate matter (PM_2.5) collected across North Carolina nearly 20 years after the end of its US production.

Per- and polyfluoroalkyl substances (PFASs) in Swedish household dust and exposure of pet cats.

Characteristic distribution patterns of perfluoroalkyl substances in soils according to land-use types.

Characterization of an AFFF impacted freshwater environment using total fluorine, extractable organofluorine and suspect per- and polyfluoroalkyl substance screening analysis.

Influence of perfluoroalkyl acids and other parameters on circulating thyroid hormones and immune-related microRNA expression in free-ranging nestling peregrine falcons.

Occurrence and fate of legacy and novel per- and polyfluoroalkyl substances (PFASs) in freshwater after an industrial fire of unknown chemical stockpiles.

Sediment quality assessment framework for per- and polyfluoroalkyl substances: results from a preparatory study and regulatory implications

The impact of precursors on aquatic exposure assessment for PFAS: Insights from bioaccumulation modeling.

Fate and transport of per- and polyfluoroalkyl substances (PFASs) in the vadose zone

Strategic Resources for Assessing PFAS Ecological Risks at AFFF Sites.

Flame Retardants

Update of the risk assessment of hexabromocyclododecanes (HBCDDs) in food.

Long-Term Field Study on Fate, Transformation, and Vertical Transport of Tetrabromobisphenol A in Soil-Plant Systems.

Pesticides

Chronic exposure to glyphosate in Florida manatee.

Pesticides residues and metabolites in honeybees: A Greek overview exploring Varroa and Nosema potential synergies.

Three-bestseller pesticides in Brazil: Freshwater concentrations and potential environmental risks.

Cocktails of pesticide residues in conventional and organic farming systems in Europe – Legacy of the past and turning point for the future.

Assessing Agrochemical Risk to Mated Honey Bee Queens.

Peer review of the pesticide risk assessment of the active substance phosmet.

Potentially Toxic Elements

Blood Lead Levels in U.S. Children Ages 1-11 Years, 1976-2016.

interesting to compare to:

Blood lead levels of Chinese children from 1991 to 2020: Based on Monte Carlo simulation.

The level of exposure affects the arsenic urinary methylation profile of a population of children.

Heavy metal content of rice meals sold in a Nigerian market population with a high prevalence of hypertension.

Machine Learning Models of Arsenic in Private Wells Throughout the Conterminous United States As a Tool for Exposure Assessment in Human Health Studies.

Concentrations and stable isotopes of mercury in sharks of the Galapagos Marine Reserve: Human health concerns and feeding patterns.

Avian feathers as a biomonitoring tool to assess heavy metal pollution in a wildlife and bird sanctuary from a tropical coastal ecosystem.

Examining historical mercury sources in the Saint Louis River estuary: How legacy contamination influences biological mercury levels in Great Lakes coastal regions.

Microplastics

Lifetime Accumulation of Microplastic in Children and Adults.

Microplastics Originating from Polymer Blends: An Emerging Threat?

Polystyrene microplastic contamination versus microplankton abundances in two lagoons of the Florida Keys.

Dispersal and transport of microplastics in river sediments.

Microplastic contamination in the Skipjack Tuna (Euthynnus affinis) collected from Southern Coast of Java, Indonesia.

Miscellaneous

Highly elevated levels, infant dietary exposure and health risks of medium-chain chlorinated paraffins in breast milk from China: Comparison with short-chain chlorinated paraffins.

Trends in urinary metabolites of polycyclic aromatic hydrocarbons (PAHs) in the non-smoking U.S. population, NHANES 2001-2014.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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