EDC Science Weekly, Mar. 14-20, 2025

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Mitigating the environmental effects of healthcare: the role of the endocrinologist
PFAS in a Canadian population: piloting a novel method to reduce serum-PFAS
Prenatal residential proximity to endocrine disrupting agricultural pesticides and menstrual cycle characteristics among Latina adolescents in California

Science summaries and highlights

Events

Mar. 24 webinar: The Tea on Chemicals of Concern: What’s Hiding in Our Products? [Clean Water Action]

Mar. 26 webinar: Impacts of Fracking in North & South America: Resources in English & Spanish [Collaborative for Health and Environment (CHE)]

Mar. 26 webinar: Impact of pesticides on human health [Health and Environment Alliance (HEAL)]

Mar. 27 webinar: It All Adds Up: Toxic Chemicals and the Future of Women’s Health [Center for Environmental Health]

Apr. 3 summit: A Health Crisis in Plain Sight: How plastics poison our air, food, & bodies, in person in Wash. DC [Moms Clean Air Force]

Apr. 15 webinar: Children’s Health: Assessing impacts of the exposome [EDC Strategies Partnership]

Apr. 15-16: Iowa PFAS Conference, in person in Iowa City [Iowa College of Engineering]

Apr. 24 webinar: Childhood cancer and the environment: Prevention opportunities [CHE-Alaska]

Apr. 25 [tentative date]: HEEDS EDC-North Carolina group 5th Annual Meeting, in person in Raleigh NC [HEEDS]

Apr. 27-29 conference: Break the Cycle of Children’s Environmental Health Disparities

May 10-13: EDC sessions at European endocrinology society meeting [European Society for Pediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE)]

June 16-17 workshop: Roadmap to phase out animal testing for chemical safety assessments [The European Chemicals Agency (ECHA)]

July 30 – Aug. 1 conference: U.S. Developmental Origins of Health and Disease (DOHaD) Society Annual Meeting

More events

Regulations/Policy

Trump’s Environmental Protection Agency moves to gut environmental protections. [News item in BMJ]

A systematic review/meta-analysis of xenobiotics in apple products highlights lack of compliance with European Food Safety Authority Regulation.

Environmental consequences of interacting effects of changes in stratospheric ozone, ultraviolet radiation, and climate: UNEP Environmental Effects Assessment Panel, Update 2024. [includes TFA/PFAS, plastics, etc.]

Editorials in JAMA:

US Science in Peril

The Value of Academic Health Research
Reaffirming the JAMA Network Commitment to the Health of Patients and the Public

More EDC policy and regulations open for comment and links to preserved resources removed from U.S. federal websites

Methods/Tools/Screening

Chemical risk assessment in food animals via physiologically based pharmacokinetic modeling – Part II: Environmental pollutants on animal and human health assessments.

In vivo verification of fish keratocyte explant culture for use as innate immunotoxicity screening assay: 2,4-Dicholorphenoxyacetic acid effects in fathead minnow (Pimephales promelas) keratocyte cell sheet migration.

Implementing AOPs use for pesticide neurotoxicity assessment

The Xenopus Eleutheroembryo Thyroid Assay (XETA), a New Approach Methodology (NAM) for the regulatory assessment of thyroid activity of chemicals.

Derivation of the oral reference dose (RfD) for bisphenol S and bisphenol F based on epidemiological and experimental studies.

Accelerating Animal Replacement: How Universities Can Lead – Results of a One-Day Expert Workshop in Zurich, Switzerland.

Evaluation of the endocrine disrupting potential of Di-isononyl phthalate. [by ExxonMobil]

Commentaries

Comment on “Exposure to Per- and Polyfluoroalkyl Substances and Mortality in U.S. Adults: A Population-Based Cohort Study” and Response to “Comment on ‘Exposure to Per- and Polyfluoroalkyl Substances and Mortality in U.S. Adults: A Population-Based Cohort Study'” led to a voluntary retraction of the paper.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Assessment of Environmental Risk Factors for Gestational Diabetes Mellitus: A Ten-Year Systematic Review and Meta-Analysis.

Modifiable risk factors associated with the risk of developing Parkinson’s disease: a critical review.

Mitigating the environmental effects of healthcare: the role of the endocrinologist.

Ameliorative and protective effects of coenzyme Q10 against natural and chemical toxicity: a narrative review.

Plasticizer sources and concentrations in indoor environments in Europe: A systematic review of existing data.

A systematic review of how endocrine-disrupting contaminants are sampled in environmental compartments: wildlife impacts are overshadowed by environmental surveillance.

The interplay between antimicrobial resistance, heavy metal pollution, and the role of microplastics.

PFAS

Maternal perfluoroalkyl and polyfluoroalkyl substances (PFAS) exposure and preeclampsia: a systematic review and meta-analysis.

Per- and Polyfluoroalkyl Substances (PFAS) in Consumer Products: An Overview of the Occurrence, Migration, and Exposure Assessment.

Review on the sources, distribution and treatment of per- and polyfluoroalkyl substances in global groundwater.

The wheel of time: The environmental dance of aged micro- and nanoplastics and their biological resonance.

[«PFAS», pollutants in the spotlight]. [in French]

Pesticides

Neonicotinoid insecticide sulfoxaflor in the environment: a critical review of environmental fate, degradation mechanism, and toxic effects.

A scoping review to determine if adverse human health effects are associated with use of pyrethroids for mosquito control.

Metals/Metalloids

Arsenic and metabolic diseases: New insights from mesenchymal stem cells.

Microplastics/Nanomaterials

Unseen toxins: Exploring the human health consequences of micro and nanoplastics.

Nanoplastics as Gene and Epigenetic Modulators of Endocrine Functions: A Perspective.

Unveiling the effects of micro and nano plastics in embryonic development.

Fate of microplastics and emerging contaminants: Mechanisms of interactions, bioaccumulation and combined toxicity to aquatic organisms.

Ecological and Health Risk Mediated by Micro(nano)plastics Aging Process: Perspectives and Challenges.

Plastic Pollution and One Health Crisis: A Burning Issue in Environmental Medicine.

Tire-based microplastics: Composition, detection, and impacts of advanced oxidation processes in drinking water treatment.

Air Pollution

Annual Research Review: Exposure to environmental chemicals and psychosocial stress and the development of children’s learning difficulties.

Human Health Studies

Numerous Chemicals/Mixtures

Assessing Environmental Justice in Mexico: How Polluting Industries and Healthcare Disparities Impact Congenital Heart Defects.

Neuromotor effects of early-life exposure to a mixture of endocrine disruptors in Belgian preschool children.

Association between endocrine disrupting chemicals exposure and diabetic kidney disease in adults: A national cross-sectional NHANES study.

Investigating the impact of endocrine-disrupting compounds on antepartum mental health at the Nexus of genetic insights and maternal-fetal outcomes: A prospective study.

BPA/Phthalates

Racial/ethnic disparities in the association of environmental exposure to phthalates and bisphenols mixtures with diabetes mellitus: NHANES 2013-2016.

The role of lifestyle in the impact of constant phthalate exposure on overweight and obesity: A longitudinal cohort study in China.

Association of maternal prenatal phthalate exposure and genetic polymorphisms of metabolic enzyme genes with spontaneous preterm birth: a nested case-control study in China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Pentachlorophenol exposure, plasma metabolomic markers, and gestational diabetes mellitus: Association and potential mediation analyses.

Diet, Polycyclic Aromatic Hydrocarbons, and Oxidative Stress Biomarkers in Pregnancy: a Los Angeles Pregnancy Cohort.

PFAS

Prenatal PFAS exposure associates with DXA assessed markers of adiposity in 7-year-old children from the Odense Child Cohort.

Per- and poly-fluoroalkyl substances (PFAS) in circulation in a Canadian population: their association with serum-liver enzyme biomarkers and piloting a novel method to reduce serum-PFAS.

Paternal and Maternal Exposures to Per- and Polyfluoroalkyl Substances and Child Behavioral Difficulties: A Parental Comparison Study.

Flame Retardants

Associations between exposure to brominated flame retardants and hyperlipidemia risk in U.S. Adults.

Pesticides

Effects of daily exposure to pyrethroid pesticides during infancy on children neurodevelopment at age four: a prospective study in rural Yunnan, China.

Prenatal residential proximity to endocrine disrupting agricultural pesticides and menstrual cycle characteristics among Latina adolescents in California.

Investigating the relationship between pesticide exposure, GSTM1 and GSTT1 polymorphisms, and oxidative stress biomarkers in affected farmers.

Metals/Metalloids

Distinct Clusters of Testosterone Levels, Symptoms, and Serum Trace Elements in Young Men: A Cross-Sectional Analysis.

Miscellaneous

Association between lipid accumulation product index and the prevalence of cardiovascular diseases induced by 2-hydroxyfluorene: A cross-sectional study from the NHANES (2005-2016).

Laboratory Studies

Numerous Chemicals/Mixtures

Glyphosate combined with TBBPA exposure decreased quality and flavor of common carp (Cyprinus carpio) involved inhibiting muscle growth and collagen synthesis.

BPA/Phenols

Caenorhabditis elegans as a Model to Assess the Potential Risk to Human Health Associated with the Use of Bisphenol A and Its Substitutes.

Mechanisms of toxicity caused by bisphenol analogs in human in vitro cell models.

Bisphenol S Promotes Clear Cell Renal Cell Carcinoma Progression by Modulating the WNT5A-Dependent EMT Pathway.

Melatonin Improves Lactational Bisphenol S Induced Pre-Pubertal and Pubertal Testicular Impairments in Offspring.

Bisphenol AF induces cell cycle arrest and apoptosis in TM3 Leydig cells via the p53 signaling pathway.

Exposure of Bisphenols (BPA, BPB and BPC) in HepG2 Cells Results in Lysosomal Dysfunction and Lipid Accumulation.

Phthalates

Morin hydrate treatment minimizes Di(2-ethylhexyl) phthalate-induced uterine fibrosis, oxidative stress, and apoptosis in mice.

Link between gut damage and neurotoxicity with gender differences in zebrafish: Dibutyl phthalate-driven microbiota dysbiosis as a possible major cause.

Maternal di(2-ethylhexyl) phthalate exposure increases the risk of congenital heart disease in mice offspring.

Peritubular Myoid Cells of the Testis Produce Monocyte Chemotactic Protein 1 Upon Direct Exposure to Mono-(2-Ethylhexyl) Phthalate Through the IL-1 Signaling Pathway.

Hepatoprotective effect of royal jelly on dibutyl phthalate-induced liver injury in rats.

The anti-inflammatory effect of the amniotic PPARγ pathways is not dysregulated by the alternative plasticizer DINCH and its metabolite MINCH in human fetal membranes.

Parabens/Triclosan/Antimicrobials

Efficient evaluation of osteotoxicity and mechanisms of endocrine disrupting chemicals using network toxicology and molecular docking approaches: triclosan as a model compound.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Medium-Chain Chlorinated Paraffins Induced Reproductive Toxicity in Female Rats by Interfering with Oocyte Meiosis and Triggering DNA Damage.

Characterization of the marine medaka AHRs and the comparison with those of Japanese medaka in response to dioxin and additional AHR ligands.

PFAS

Extracellular Vesicle (EV) Mechanisms of Toxicity for Per and Polyfluoroalkyl Substances: Comparing Transcriptomic Points of Departure Across Global Versus EV Regulatory Gene Sets.

Perfluorobutanesulfonate Interfering with the Intestinal Remodeling During Lithobates catesbeiana Metamorphosis via the Hypothalamic-Pituitary-Thyroid Axis.

Impact of PFOS Exposure on Murine Fetal Hematopoietic Stem Cells, Associated with Intrauterine Metabolic Perturbation.

Perfluorooctanoic acid and perfluorooctane sulfonate inhibit in vitro osteogenesis: possible role of connexin 43-mediated gap-junctional intercellular communication.

Toxicokinetic and liver proteomic study of the Chinese rare minnow (Gobiocypris rarus) exposed to F-53B.

Flame Retardants

Maternal Exposure to Environmentally Relevant Concentrations of Tris(2,4-di-tert-butylphenyl) Phosphate-Induced Developmental Toxicity in Zebrafish Offspring via Disrupting foxO1/ripor2 Signaling.

Metabolomic and molecular analysis reveals multiple pathways of TBBPA-induced developmental toxicity in zebrafish embryos.

Tetrabromobisphenol S (TBBPS) exposure induced the testicular aging through NLRP3-mediated inflammatory signaling pathway in vitro and in vivo.

Pesticides

Transport mechanisms of pesticide mixtures impairing intestinal barrier function in mice.

Neuroprotective and antioxidant effects of Urtica dioica extract against chlorpyrifos-induced toxicity: an in vivo study.

Chlorpyrifos Induces Apoptosis in Macrophages by Activating Both Intrinsic and Extrinsic Apoptotic Pathways.

Metals/Metalloids

Prenatal arsenic exposure alters EZH2/H3K27me3 to induce RKIP/NF-kB/ERK1/2-mediated early-onset kidney disease in mouse offspring.

Ethanolic extract of Cnidoscolus aconitifolius leaves alleviates insulin resistance by modulating oxidative stress and inflammation in albino rats exposed to heavy metal mixture.

Mechanism of arsenic-induced liver injury in rats revealed by metabolomics and ionomics based approach.

Mechanism of arsenic regulation of mitochondrial damage and autophagy induced synaptic damage through SIRT1 and protective effect of melatonin.

Impact of fluoride on thyroid function and histopathology in cyprinus carpio: Implications for aquatic ecosystems.

Microplastics/Nanomaterials

Gestational exposure to polystyrene microplastics incurred placental damage in mice: Insights into metabolic and gene expression disorders.

Gestational exposure to nanoplastics disrupts fetal development by promoting the placental aging via ferroptosis of syncytiotrophoblast.

Multiomics analysis revealed the effects of polystyrene nanoplastics at different environmentally relevant concentrations on intestinal homeostasis.

Synergistic human health risks of microplastics and co-contaminants: A quantitative risk assessment in water.

Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinflammation in a food-borne polystyrene microplastic exposed mouse model.

Exposure to polystyrene nanoplastics impairs sperm metabolism and pre-implantation embryo development in mice.

Gut microbiota participates in polystyrene microplastics-induced defective implantation through impairing uterine receptivity.

Dissection of the potential mechanism of polystyrene microplastic exposure on cardiomyocytes.Investigating the impact of endocrine-disrupting compounds on antepartum mental health at the Nexus of genetic insights and maternal-fetal outcomes: A prospective study.

Miscellaneous

Comparative effects of 6PPD and 6PPD-Quinone at environmentally relevant concentrations on hepatotoxicity, glucolipid metabolism and ferroptotic response in adult zebrafish.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Environmental justice implications of hydraulic fracturing: A spatio-temporal analysis in texas.

BPA/Phenols

Bisphenol A Biomonitoring after Sealant Placement: A Prospective Cohort Study in Schoolchildren.

Bisphenol compounds in female underwear manufactured in China and their potential risks to women’s health.

PFAS

Estimating historical PFAS exposures in Ronneby, Sweden using biobanked dried blood spots from newborns.

Unraveling the Exposure Spectrum of PFAS in Fluorochemical Occupational Workers: Structural Diversity, Temporal Trends, and Risk Prioritization.

Ten years of PFOS and PFOA human biomonitoring in Italy: Exposure levels and determinants of exposure.

Target and Suspect Screening Reveal PFAS Exceeding European Union Guideline in Various Water Sources South of Lyon, France.

Flame Retardants

High levels of flame retardants in vehicle dust indicate ongoing use of brominated and organophosphate flame retardants in vehicle interiors.

Pesticides

Quantifying the influence of climate change on pesticide risks in drinking water.

Microplastics/Nanomaterials

The aging and pollution behavior of microplastics in tap water supply system subjected to residual chlorine exposure.

Microplastics in wastewater and the role of local wastewater treatment stations in controlling microplastic pollution: a case study from Vietnam.

Pharmaceuticals/Personal Care Products

An integrated analysis of the use and potential risks of pharmaceutical drugs in hospital wastewater: Consumption and occurrence by suspect screening analysis, and antibiotic resistance.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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