EDC Science Weekly, Mar. 10 – 16, 2023 – HEEDS

EDC Science Weekly, Mar. 10 – 16, 2023

Post author:HEEDS
Post published:March 16, 2023
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Mar. 22 webinar: The Ohio Train Derailment: Impacts and Emerging Lessons (EDC Strategies Partnership)

Apr. 11: Intersectoral Centre for Endocrine Disruptor Analysis (ICEDA) Awards Conference

Apr. 13 webinar: Long-term Health Effects of Childhood Glyphosate Exposure (EDC Strategies Partnership)

Regulations/Policy

EU need to protect its environment from toxic per- and polyfluoroalkyl substances.

Per- and polyfluoroalkyl substances (PFAS) registered under REACH-What can we learn from the submitted data and how important will mobility be in PFAS hazard assessment?

Positive outcomes from U.S. lead regulations, continued challenges, and lessons learned for regulating emerging contaminants.

Methods/Tools/Screening

Methods

HExpPredict: In Vivo Exposure Prediction of Human Blood Exposome Using a Random Forest Model and Its Application in Chemical Risk Prioritization. [see related Invited Perspective: Examining Chemicals in Food as a Priority for Toxicity Testing.]

Common laboratory reagents: Are they a double-edged sword in microplastics research?

Practical considerations for specifying a super learner.

Applying a next generation risk assessment framework for skin sensitisation to inconsistent new approach methodology information.

Emerging Metabolic Profiles of Sulfonamide Antibiotics by Cytochromes P450: A Computational-Experimental Synergy Study on Emerging Pollutants.

Tools

ToxicR: A computational platform in R for computational toxicology and dose-response analyses.

The development and application of a novel hazard scoring tool for assessing impacts of cosmetic ingredients on aquatic ecosystems: a case study of rinse-off cosmetics.

Screening

In vitro and in silico assessment of endocrine disrupting effects of food contaminants through pregnane X receptor.

Galaxolide and Irgacure 369 are novel environmental androgens.

Reversibility of thyroid hormone system-disrupting effects on eye and thyroid follicle development in zebrafish (Danio rerio) embryos.

Reviews

Numerous Chemicals/Mixtures

Environmental Toxicants and the Developing Brain.

The Threat Posed by Environmental Contaminants on Neurodevelopment: What Can We Learn from Neural Stem Cells?

Toxicomethylomics revisited: A state-of-the-science review about DNA methylation modifications in blood cells from workers exposed to toxic agents.

Adverse health effects of emerging contaminants on inflammatory bowel disease.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated Diphenyl Ethers in the Environment: A Review and Future Perspectives.

Polychlorinated biphenyls and the risk of endometriosis: Systematic review and Meta-Analysis.

Perfluoroalkyl Substances

Sources, occurrence and toxic effects of emerging per- and polyfluoroalkyl substances (PFAS).

Current per- and polyfluoroalkyl substance (PFAS) research points to a growing threat in animals.

Pesticides

Gut microbiota: a non-target victim of pesticide-induced toxicity.

Metals/Metalloids

Global Human Threat: The Potential Synergism between Mercury Intoxication and COVID-19.

Systematic Review and Meta-analysis of Environmental Toxic Metal Contaminants and the Risk of Ischemic Stroke.

Microplastics/Nanomaterials

Source, occurrence, distribution, fate, and implications of microplastic pollutants in freshwater on environment: A critical review and way forward.

Atmospheric microplastics: exposure, toxicity, and detrimental health effects.

Human Health Studies

Phthalates

A cross sectional pilot study to assess the role of phthalates on respiratory morbidity among patients with chronic obstructive pulmonary disease.

Racial differences in the associations of urinary phthalate metabolites with depression risk.

Parabens/Triclosan/Antimicrobials

Presence of Parabens in Different Children Biological Matrices and Its Relationship with Body Mass Index.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposure to Persistent Organic Pollutants in Danish pregnant women: hormone levels and fetal growth indices.

Perfluoroalkyl Substances

Birth Outcomes in Relation to Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Stress in the Environmental Influences on Child Health Outcomes (ECHO) Program.

Mediating effect of endocrine hormones on association between per- and polyfluoroalkyl substances exposure and birth size: Findings from sheyang mini birth cohort study.

A New Interpretation of Relative Importance on an Analysis of Per and Polyfluorinated Alkyl Substances (PFAS) Exposures on Bone Mineral Density.

[Correlation analysis between prenatal exposure of per-/polyfluoroalkyl compounds and neonatal outcome]. [Chinese]

Pesticides

Exposure to non-persistent pesticides and sexual maturation of Spanish adolescent males.

The association between blood, urine, respiratory, neurobehavioral parameters and occupational exposure to organophosphorus pesticides: a cross-sectional study among formulators.

Metals/Metalloids

Association between mercury exposure and lung function in young adults: A prospective cohort study in Shandong, China.

The burden of mild intellectual disability attributed to prenatal exposure to methylmercury in China, 2017.

Air Pollution

Cognitive Development and Prenatal Air Pollution Exposure in the CHAMACOS Cohort.

Association of Combined Exposure to Ambient Air Pollutants, Genetic Risk, and Incident Rheumatoid Arthritis: A Prospective Cohort Study in the UK Biobank. [see related Invited Perspective: Air Pollutants, Genetics, and the Mucosal Paradigm for Rheumatoid Arthritis Risk.]

Using Parametric g-Computation to Estimate the Effect of Long-Term Exposure to Air Pollution on Mortality Risk and Simulate the Benefits of Hypothetical Policies: The Canadian Community Health Survey Cohort (2005 to 2015). [see related Invited Perspective: The Potential of Potential Outcomes in Air Pollution Epidemiology.]

KCNQ1 rs2237892 polymorphism modify the association between short-term ambient particulate matter exposure and fasting blood glucose: A family-based study.

Critical windows of exposure to air pollution and gestational diabetes: assessing effect modification by maternal pre-existing conditions and environmental factors.

Pharmaceuticals/Personal Care Products

Serum metabolomic profile of hair dye use.

Laboratory Studies

Numerous Chemicals/Mixtures

A mixture of 13 pesticides, contaminants, and food additives below individual NOAELs produces histopathological and organ weight changes in rats.

Evaluation of biochemical, hematological, and genotoxic parameters in mice exposed to individual and combined ethoprophos and cadmium.

Effects of Single and Combined Ciprofloxacin and Lead Treatments on Zebrafish Behavior, Oxidative Stress, and Elements Content.

Combined exposure to titanium dioxide and tetracycline induces neurotoxicity in zebrafish.

BPA/Phenols

Low Dose of BPA Induces Liver Injury through Oxidative Stress, Inflammation and Apoptosis in Long-Evans Lactating Rats and Its Perinatal Effect on Female PND6 Offspring.

ROS mediated pyroptosis-M1 polarization crosstalk participates in inflammation of chicken liver induced by bisphenol a and selenium deficiency.

Evaluation of the bisphenol A-induced vascular toxicity on human umbilical artery.

Bisphenol A disruption promotes mammary tumor microenvironment via phenotypic cell polarization and inflammatory response.

Therapeutic potential of vitamin D against bisphenol A-induced spleen injury in Swiss albino mice.

Bisphenol C induces developmental defects in liver and intestine through mTOR signaling in zebrafish (Danio rerio).

Modulation of Osteogenic Gene Expression by Human Osteoblasts Cultured in the Presence of Bisphenols BPF, BPS, or BPAF.

Phthalates

Changes in testicular histomorphometry and ultrastructure of Leydig cells in adult male Japanese quail exposed to di (n-butyl) phthalate (DBP) during the prepubertal period.

Effects of Preconception Exposure to Phthalates on Mouse Sperm Capacitation Parameters.

Persistent immunosuppressive effects of dibutyl phthalate exposure in adult male mice.

Exposure to diisononyl phthalate deteriorates the quality of porcine oocytes by inducing the apoptosis.

Biologically relevant reductions in fetal testosterone and Insl3 induced by in utero exposure to high levels of di-isononyl phthalate (DINP) in male rats.

Parabens/Triclosan/Antimicrobials

Emerging contaminant triclosan incites endocrine disruption, reproductive impairments and oxidative stress in the commercially important carp, Catla (Labeo catla): An insight through molecular, histopathological and bioinformatic approach.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Comparative in vitro and in silico study on the estrogenic effects of 2,2-bis(4-chlorophenyl)ethanol, 4,4′-dichlorobenzophenone and DDT analogs.

Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver.

Perfluoroalkyl Substances

Accurate prediction by AlphaFold2 for ligand binding in a reductive dehalogenase and implications for PFAS (per- and polyfluoroalkyl substance) biodegradation.

Flame Retardants

Binding of Tetrabromobisphenol A and S to Human Serum Albumin Is Weakened by Coexisting Nanoplastics and Environmental Kosmotropes.

BDE-47 Induces Immunotoxicity in RAW264.7 Macrophages through the Reactive Oxygen Species-Mediated Mitochondrial Apoptotic Pathway.

Reprotoxic Effect of Tris(2,3-Dibromopropyl) Isocyanurate (TBC) on Spermatogenic Cells In Vitro.

Organotins

Simulated gastric hydrolysis and developmental toxicity of dimethyltin bis(2-ethylhexylthioglycolate) in rats.

Pesticides

Chlorpropham, a carbamate ester herbicide, has an endocrine-disrupting potential by inhibiting the homodimerization of human androgen receptor.

Diflovidazin damages the hematopoietic stem cells to zebrafish embryos via the TLR4/ NF-κB/ p53 pathway.

Glyphosate-induced autophagy inhibition results in hepatic steatosis via mediating epigenetic reprogramming of PPARα in roosters.

Assessment of Genetic Damage Induced via Glyphosate and Three Commercial Formulations with Adjuvants in Human Blood Cells.

β-triketone herbicide exposure cause tyrosine and fat accumulation in Caenorhabditis elegans.

Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish.

Parental Preconception and Pre-Hatch Exposure to a Developmental Insult Alters Offspring’s Gene Expression and Epigenetic Regulations: An Avian Model. [chlorpyrifos]

Metals/Metalloids

Effects of four hormones on the mitigation of ovarian damage in tilapia (Oreochromis niloticus) after copper and cadmium exposure.

Lead exposure induced developmental nephrotoxicity in Japanese quail (Coturnix japonica) via oxidative stress-based PI3K/AKT pathway inhibition and NF-κB pathway activation.

Intermittent Lead Exposure Induces Behavioral and Cardiovascular Alterations Associated with Neuroinflammation.

Cognitive outcomes caused by low-level lead, cadmium, and mercury mixture exposure at distinct phases of brain development.

Cadmium exposure during puberty damages testicular development and spermatogenesis via ferroptosis caused by intracellular iron overload and oxidative stress in mice.

Apitoxin alleviates methyl mercury-induced peripheral neurotoxicity in male rats by regulating dorsal root ganglia neuronal degeneration and oxidative stress.

Microplastics/Nanomaterials

Polystyrene microplastics enhance the microcystin-LR-induced gonadal damage and reproductive endocrine disruption in zebrafish.

Di(2-ethylhexyl) phthalate and microplastics cause necroptosis and apoptosis in hepatocytes of mice by inducing oxidative stress.

Nanoplastics pose a greater effect than microplastics in enhancing mercury toxicity to marine copepods.

Hazard assessment of different-sized polystyrene nanoplastics in hematopoietic human cell lines.

Activation of FGF signal in germline mediates transgenerational toxicity of polystyrene nanoparticles at predicted environmental concentrations in Caenorhabditis elegans.

Nanoplastics causes extensive congenital malformations during embryonic development by passively targeting neural crest cells.

Miscellaneous

Effects of common plastic products heat exposure on cognition: Mediated by gut microbiota.

Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Causes Abnormal Locomotion Behaviors and Neurodegeneration in Caenorhabditis elegans.

Vinyl Chloride Enhances High Fat Diet-Induced Proteome Alterations in the Mouse Pancreas Related to Metabolic Dysfunction.

Potential oestrogenic effects (following the OECD test guideline 440) and thyroid dysfunction induced by pure cyanotoxins (microcystin-LR, cylindrospermopsin) in rats.

Levonorgestrel causes feminization and dose-dependent masculinization in medaka fish (Oryzias latipes): Endocrine-disruption activity and its correlation with sex reversal.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Target analysis and suspect screening of UV filters, parabens and other chemicals used in personal care products in human cord blood: Prenatal exposure by mother-fetus transfer.

Incidence of Potentially Toxic Elements and Perfluoroalkyl Substances Present in Canned Anchovies and Their Impact on Food Safety.

Water quality of The Gambia River: A prospective drinking water supply.

Phthalates

Occurrence of Phthalate Esters in Coffee and Risk Assessment.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Transfer and toxicokinetic modeling of non-dioxin-like polychlorinated biphenyls (ndl-PCBs) into accidentally exposed dairy cattle and their calves – a case report.

Historical production and release inventory of PCDD/Fs in China and projections upon policy options by 2025.

Dioxin-like POPs in national samples from global monitoring plan projects (2017-2019).

Perfluoroalkyl Substances

Perfluorooctanoic Acid (PFOA) Incorporated into Iron Particles Promoted the Formation of Disinfection Byproducts under Drinking Water Conditions.

Determination of Poly- and Perfluoroalkylated Substances in Food: How Consistent Are Results across Laboratories?

Evaluating Neutral PFAS for Potential Dermal Absorption from the Gas Phase.

Emerging poly- and perfluoroalkyl substances in water and sediment from Qiantang River-Hangzhou Bay.

Confirming sulfluramid (EtFOSA) application as a precursor of perfluorooctanesulfonic acid (PFOS) in Brazilian agricultural soils.

[Pollution Characteristics and Health Risk Assessment of Per- and Polyfluoroalkyl Substances and Emerging Alternatives in Road Dust, Shijiazhuang].

Pesticides

Determination of pesticide residues in the serum of flower farm workers: A growing occupational hazards in low income countries.

Pesticide Exposure of Residents Living in Wine Regions: Protocol and First Results of the Pestiprev Study.

Imidacloprid exposure is detectable in over one third of wild bird samples from diverse Texas ecoregions.

Monitoring residues of pesticides in food in Brazil: A multiscale analysis of the main contaminants, dietary cancer risk estimative and mechanisms associated.

Metals/Metalloids

Periconceptional diet quality and its relation to blood heavy metal concentrations among pregnant women: The Japan environment and Children’s study.

Residential Proximity to Metal-Containing Superfund Sites and Their Potential as a Source of Disparities in Metal Exposure among U.S. Women.

Sex differences in cadmium and lead concentrations in different biological matrices in athletes. Relationship with iron status.

Stress and reproductive hormones in hair associated with contaminant metal(loid)s of European brown bear (Ursus arctos).

Do foraging ecology and contaminants interactively predict parenting hormone levels in common eider?

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.