EDC Science Weekly, Mar. 10-16, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Mar. 22: More chemicals, fewer words: Exposure to chemical mixtures during pregnancy alters brain development (EDC Strategies Partnership)

Webinar Mar. 30: Reversing the Plastics Crisis Through a Human Rights Approach (CHE-Alaska)

Webinar Apr. 20: Do chemicals in plastic consumer products contribute to obesity? (EDC Strategies Partnership)

Regulations/Policy

One planet: one health. A call to support the initiative on a global science-policy body on chemicals and waste.

Nanocarriers as Active Ingredients Enhancers in the Cosmetic Industry-The European and North America Regulation Challenges.

Can Current Regulations Account for Intentionally Produced Nanoplastics?

Methods/Tools/Screening

An applied environmental justice framework for exposure science.

Statistical Methods for Assessing the Explained Variation of a Health Outcome by a Mixture of Exposures.

Application of Transgenic Zebrafish Models for Studying the Effects of Estrogenic Endocrine Disrupting Chemicals on Embryonic Brain Development.

The ECOTOXicology Knowledgebase: A Curated Database of Ecologically Relevant Toxicity Tests to Support Environmental Research and Risk Assessment.

Use of Chicken Embryo Model in Toxicity Studies of Endocrine-Disrupting Chemicals and Nanoparticles.

Multi-omics strategies for investigating the microbiome in toxicology research.

Commentaries

Planet Contamination with Chemical Compounds. [intro to a special issue in Molecules]

Reviews

Numerous Chemicals/Mixtures

The Association between ADHD and Environmental Chemicals-A Scoping Review.

Environmental Toxicants and Preterm Birth: A Bibliometric Analysis of Research Trends and Output.

Epigenetic Transgenerational Modifications Induced by Xenobiotic Exposure in Zebrafish.

BPA/Phenols

Does Bisphenol A Confer Risk of Neurodevelopmental Disorders? What We Have Learned from Developmental Neurotoxicity Studies in Animal Models.

Actions of Bisphenol A on Different Feto-Maternal Compartments Contributing to Preterm Birth.

Phthalates

Behavioral Effects of Exposure to Phthalates in Female Rodents: Evidence for Endocrine Disruption?

Perfluoroalkyl Substances

An Epidemiologic Review of Menstrual Blood Loss as an Excretion Route for Per- and Polyfluoroalkyl Substances

Pesticides

Time for Re-Evaluating the Human Carcinogenicity of Ethylenedithiocarbamate Fungicides? A Systematic Review.

Potentially Toxic Elements

Toxicological Impact of Rare Earth Elements (REEs) on the Reproduction and Development of Aquatic Organisms Using Sea Urchins as Biological Models.

Interactions and toxicity of non-essential heavy metals (Cd, Pb and Hg): lessons from Drosophila melanogaster.

As and F− cooccurrence in drinking water: critical review of the international scenario, physicochemical behavior, removal technologies, health effects, and future trends

Arsenic in drinking water and kidney cancer: a systematic review.

Air Pollution

Is ambient air pollution a risk factor for Parkinson’s disease? A meta-analysis of epidemiological evidence.

Pharmaceuticals/Personal Care Products

Levels and effects of antidepressant drugs to aquatic organisms.

Physiological Roles of Serotonin in Bivalves: Possible Interference by Environmental Chemicals Resulting in Neuroendocrine Disruption.

Miscellaneous

Estrogen Receptors Mediated Negative Effects of Estrogens and Xenoestrogens in Teleost Fishes-Review.

Human Health Studies

Phthalates

Midlife Urinary Phthalate Metabolite Concentrations and Prior Uterine Fibroid Diagnosis.

Perfluoroalkyl Substances

Gestational Perfluoroalkyl Substance Exposure and DNA Methylation at Birth and 12 Years of Age: A Longitudinal Epigenome-Wide Association Study.

Per- and Polyfluoroalkyl Substances and Risk of Myocardial Infarction and Stroke: A Nested Case-Control Study in Sweden.

Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Child Growth Trajectories in the First Two Years.

The relationship between multiple perfluoroalkyl substances and cardiorespiratory fitness in male adolescents

Pesticides

Prenatal exposure to pesticide residues in the diet in association with child autism-related traits: Results from the EARLI study.

Effects of prenatal exposure to pyrethroid pesticides on neurodevelopment of 1-year- old children: A birth cohort study in China.

Potentially Toxic Elements

Relationships of multiple metals exposure, global DNA methylation, and urothelial carcinoma in central Taiwan.

Elevated serum periostin levels among arsenic-exposed individuals and their associations with the features of asthma.

Exposure to multiple toxic metals and the risk of early embryonic arrest among women undergoing assisted reproductive techniques.

Low-level exposure to lead, cadmium and mercury, and histopathological findings in kidney biopsies

Air Pollution

Association of Airborne Toxins with Geographic Clustering of Cutaneous T Cell Lymphoma in Louisiana.

Laboratory Studies

Numerous Chemicals/Mixtures

In Vitro Hepatotoxic and Neurotoxic Effects of Titanium and Cerium Dioxide Nanoparticles, Arsenic and Mercury Co-Exposure.

Diethylhexyl Phthalate and Bisphenol A Promote Vincristine and Tamoxifen Resistance in Vitro.

BPA/Phenols

Bisphenol A replacement chemicals, BPF and BPS, induce protumorigenic changes in human mammary gland organoid morphology and proteome.

The Endocrine Disruptor Compound Bisphenol-A (BPA) Regulates the Intra-Tumoral Immune Microenvironment and Increases Lung Metastasis in an Experimental Model of Breast Cancer.

Effects of BPZ and BPC on Oxidative Stress of Zebrafish under Different pH Conditions.

Bisphenol chemicals disturb intestinal homeostasis via Notch/Wnt signaling and induce mucosal barrier dysregulation and inflammation.

Perinatal Combinational Exposure to Bisphenol A and a High-Fat Diet Contributes to Transgenerational Dysregulation of Cardiovascular and Metabolic Systems in Mice.

Nursing Exposure to Bisphenols as a Cause of Male Idiopathic Infertility.

Phthalates

Maternal DBP exposure promotes synaptic formation in offspring by activating astrocytes via the AKT/NF-κB/IL-6/JAK2/STAT3 signaling pathway.

Food contact materials as possible endocrine disruptors for PPARs: a consensus scoring analysis.

Single substance and mixture toxicity of dibutyl-phthalate and sodium dodecyl sulphate to marine zooplankton.

Parabens/Triclosan/Antimicrobials

Triclosan (TCS) affects the level of DNA methylation in the human oral squamous cell carcinoma (SCC-15) cell line in a nontoxic concentration.

Perfluoroalkyl Substances

Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish.

Effect of waterborne exposure to perfluorooctanoic acid on nephron and renal hemopoietic tissue of common carp Cyprinus carpio.

Flame Retardants

Thyroid Hormone Disruption by Organophosphate Esters Is Mediated by Nuclear/Membrane Thyroid Hormone Receptors: In Vitro, In Vivo, and In Silico Studies.

The adverse outcome pathway (AOP) of estrogen interference effect induced by triphenyl phosphate (TPP): Integrated multi-omics and molecular dynamics approaches.

Decabromodiphenyl ether induces ROS-mediated intestinal toxicity through the Keap1-Nrf2 pathway

Toxicity evaluation of decabromodiphenyl ethane (DBDPE) to Pleurotus ostreatus: Oxidative stress, morphology and transcriptomics.

Pesticides

Paraquat modulates immunological function in bone marrow-derived macrophages.

Lycopene ameliorates atrazine-induced pyroptosis in spleen by suppressing the Ox-mtDNA/Nlrp3 inflammasome pathway.

Long-Term Changes in Ovarian Follicles of Gilts Exposed Neonatally to Methoxychlor: Effects on Oocyte-Derived Factors, Anti-Müllerian Hormone, Follicle-Stimulating Hormone, and Cognate Receptors.

Metabolomic and Transcript Analysis Revealed a Sex-Specific Effect of Glyphosate in Zebrafish Liver.

Elucidation of the neurological effects of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) using two-photon microscopy in vivo imaging.

Dinitroaniline herbicide pendimethalin affects development and induces biochemical and histological alterations in zebrafish early-life stages.

Mild chronic exposure to pesticides alters physiological markers of honey bee health without perturbing the core gut microbiota.

Study on endocrine disruption effect of paclobutrazol and uniconazole on the thyroid of male and female rats based on lipidomics.

Potentially Toxic Elements

Exposure to low-dose cadmium induces testicular ferroptosis.

The Influence of Interaction between Cadmium with 17β-Estradiol, 2-Methoxyestradiol and 16α-Hydroxyestrone on Viability and p-Glycoprotein in Ovarian Cancer Cell Line.

Integrated transcriptomics and proteomics provide new insights into the cadmium-induced ovarian toxicity on Pardosa pseudoannulata.

Methylmercury Induces Mitochondria- and Endoplasmic Reticulum Stress-Dependent Pancreatic β-Cell Apoptosis via an Oxidative Stress-Mediated JNK Signaling Pathway.

Microplastics

Quantification of differential tissue biomarker responses to microplastic ingestion and plasticizer bioaccumulation in aquaculture reared sea bream Sparus aurata.

Pharmaceuticals/Personal Care Products

Antibiotic Chlortetracycline Causes Transgenerational Immunosuppression via NF-κB.

Miscellaneous

Effects of polycyclic aromatic hydrocarbons on the proliferation and differentiation of placental cells.

Exposure/Environment Studies

BPA/Phthalates/Parabens

Determination of bisphenols and parabens in cow urine distillate from India: implication of human exposure and risk assessment.

Levels of phthalates and bisphenol in toys from Brazilian markets: Migration rate into children’s saliva and daily exposure.

Exposure of preschool-aged children to highly-concerned bisphenol analogues in Nanjing, East China.

Thermal paper as a potential source of bisphenol A for humans and the environment: migration and ecotoxicological impact

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Trace-level analysis of polychlorinated biphenyls, organochlorine pesticides and polycyclic aromatic hydrocarbons in human plasma or serum by dispersive liquid-liquid microextraction and gas chromatography-tandem mass spectrometry.

Quantitative analysis and contamination profiles of PCBs, OCPs, and PAHs in black-tailed gull eggs in the Republic of Korea.

Bacterial communities of the Black Sea exhibit activity against persistent organic pollutants in the water column and sediments.

Management of polychlorinated biphenyls stockpiles and contaminated sites in Africa: A review of 34 countries.

Perfluoroalkyl Substances

Environmental Health Literacy as Knowing, Feeling, and Believing: Analyzing Linkages between Race, Ethnicity, and Socioeconomic Status and Willingness to Engage in Protective Behaviors against Health Threats.

Effects of perfluoroalkyl substances on soil respiration and enzymatic activity: differences in carbon chain-length dependence.

First report of perfluoroalkyl acids (PFAAs) in the Indus Drainage System: Occurrence, source and environmental risk.

Perfluoroalkyl acids in sediment and water surrounding historical fire training areas at Barksdale Air Force Base

Flame Retardants

Human Exposure to Chlorinated Organophosphate Ester Flame Retardants and Plasticizers in an Industrial Area of Shenzhen, China.

Historical record of legacy and alternative halogenated flame retardants in dated sediment from a highly industrialized saltwater lake in Korea.

Pesticides

Assessment of ameliorative effects of organic dietary interventions on neonicotinoid exposure rates in a Japanese population

Honey Bee (Apis mellifera) Exposure to Pesticide Residues in Nectar and Pollen in Urban and Suburban Environments from Four Regions of the United States.

Neonicotinoids exposure assessment in Africanized honey bees (Apis mellifera L.) by using an environmentally-friendly sample preparation technique followed by UPLC-MS/MS.

Potentially Toxic Elements

Mercury Contamination: A Growing Threat to Riverine and Urban Communities in the Brazilian Amazon.

Removal of Toxic and Essential Nutrient Elements from Commercial Rice Brands Using Different Washing and Cooking Practices: Human Health Risk Assessment.

Microplastics

Spatio-vertical distribution of riverine microplastics: Impact of the textile industry.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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