EDC Science Weekly, Mar. 10 – 16, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Today, Mar. 16: MLEEaD Center event: TSCA @5 Years: Opportunities to Act with Foresight: Is the Toxic Substances Control Act (TSCA) Protecting Health and Promoting Environmental Justice? 5 Years After Lautenberg Amendments

Mar. 22: NIH-EPA webinar: Fostering Community Engaged Research in Environmental Health Disparities

Mar. 31 CHE Alaska webinar: Plastics, Endocrine Disrupting Chemicals and Health: Findings of a New Joint Report of the Endocrine Society and International Pollutants Elimination Network (IPEN)

Regulations/Policy

Phthalates Should Be Regulated as a Class to Protect the Brains of Our Children. [this should be available open access next week]

Co-benefits of carbon and pollution control policies on air quality and health till 2030 in China.

Methods/Tools/Screening

Defining and Intervening on Cumulative Environmental Neurodevelopmental Risks: Introducing a Complex Systems Approach.

Distinct genetic regions are associated with differential population susceptibility to chemical exposures.

GGL-Tox: Geometric Graph Learning for Toxicity Prediction.

Commentaries/Conference Summaries

Introduction to special issue endothelial cells in toxicology: Current status and future perspectives.

Yale School of Public Health Symposium: An overview of the challenges and opportunities associated with per- and polyfluoroalkyl substances (PFAS).

Reviews

Numerous EDCs

Environmental Estrogens and Their Biological Effects through GPER Mediated Signal Pathways.

Breast cancer and occupational exposures: an integrative review of the literature.

Experimental Approaches for Characterizing the Endocrine-Disrupting Effects of Environmental Chemicals in Fish.

BPA/Phenols/Phthalates

Plasticizers and Cardiovascular Health: Role of Adipose Tissue Dysfunction.

Pesticides

Pesticide risk assessment in honeybees: Toward the use of behavioral and reproductive performances as assessment endpoints.

Meta-analysis and experimental validation identified atrazine as a toxicant in the male reproductive system.

Potentially Toxic Elements

Arsenic exposure from groundwater: environmental contamination, human health effects, and sustainable solutions.

Biomarkers of effect as determined in human biomonitoring studies on hexavalent chromium and cadmium in the period 2008-2020.

Air Pollution

Ambient air pollution and stillbirth: An updated systematic review and meta-analysis of epidemiological studies.

Ambient fine particulate matter of diameter ≤ 2.5 μm and risk of hemorrhagic stroke: a systemic review and meta-analysis of cohort studies.

Association between gestational exposure and risk of congenital heart disease: A systematic review and meta-analysis.

Human Health Studies

Numerous Chemicals

Exposure to Phenols, Phthalates, and Parabens and Development of Metabolic Syndrome Among Mexican Women in Midlife.

Neurodevelopmental exposome: the effect of in utero co-exposure to heavy metals and phthalates on child neurodevelopment.

BPA/Phenols

Prenatal exposure to bisphenol A and autistic- and ADHD-related symptoms in children aged 2 and5 years from the Odense Child Cohort.

Prenatal exposure to bisphenol analogues and digit ratio in children at ages 4 and 6 years: A birth cohort study.

Phthalates

Associations of prenatal exposure to phthalates with measures of cognition in 7.5-month-old infants.

Early life exposure to phthalates and the development of childhood asthma among Canadian children.

Parabens/Triclosan/Antimicrobials

Prenatal exposure to butyl paraben is associated with fat percentage in 7-year old boys.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents.

Pesticides

Prospective association between dietary pesticide exposure profiles and postmenopausal breast-cancer risk in the NutriNet-Santé cohort.

Potentially Toxic Elements

Low-level lead exposure promotes hepatic gluconeogenesis and contributes to the elevation of fasting glucose level.

Association between cumulative childhood blood lead exposure and hepatic steatosis in young Mexican adults.

Effects of long-term high-level lead exposure on the immune function of workers.

Aggregated cumulative county arsenic in drinking water and associations with bladder, colorectal, and kidney cancers, accounting for population served.

Renal impairment assessment on adults living nearby a landfill: Early kidney dysfunction biomarkers linked to the environmental exposure to heavy metals.

Air Pollution

Multi-dimensional community characteristics in linking particulate matter pollution and cause-specific mortality: 72 communities of South Korea.

Association between short-term exposure to fine particulate pollution and outpatient visits for ulcerative colitis in Beijing, China: A time-series study.

Maternal exposure to PM_2.5 during pregnancy and asthma risk in early childhood: consideration of phases of fetal lung development.

Effect of exposure to fine particulate matter during pregnancy and infancy on paediatric allergic rhinitis.

The association of prenatal exposure to particulate matter with infant growth: A birth cohort study in Beijing, China.

Long-term exposure to ambient PM_2.5 increase obesity risk in Chinese adults: A cross-sectional study based on a nationwide survey in China.

Interaction of Sirtuin 1 (SIRT1) candidate longevity gene and particulate matter (PM2.5) on all-cause mortality: a longitudinal cohort study in China.

Association between air pollution and COVID-19 infection: evidence from data at national and municipal levels.

Laboratory Studies

BPA/Phenols

Bisphenol A: A potential Toll-like receptor 4/myeloid differentiation factor 2 complex agonist.

Epigenetic effects of Bisphenol A on granulosa cells of mouse follicles during in vitro culture: An experimental study.

Physiological Responses of the Goldfish (Carassius auratus) During Subacute Exposure to Organic Pollutants. [BPA, naphthalene, butachlor]

OctylPhenol (OP) Alone and in Combination with NonylPhenol (NP) Alters the Structure and the Function of Thyroid Gland of the Lizard Podarcis siculus.

Phthalates

Diethylhexyl phthalate (DEHP) regulates the proliferation and chemosensitivity of esophageal squamous cell carcinoma cells via regulation of PTEN.

Parabens/Triclosan/Antimicrobials

Continuous Dermal Exposure to Triclocarban Perturbs the Homeostasis of Liver-Gut Axis in Mice: Insights from Metabolic Interactions and Microbiome Shifts.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Toxicity studies of hexachlorobenzene administered by gavage to female Sprague Dawley (Hsd:Sprague Dawley SD) rats.

Prolonged low-dose dioxin exposure impairs metabolic adaptability to high-fat diet feeding in female but not male mice.

Identification of viable TCDD access pathways to human AhR PAS-B ligand binding domain.

Maternal exposure to a human based mixture of persistent organic pollutants (POPs) affect gene expression related to brain function in mice offspring hippocampus.

Perfluoroalkyl Substances

Perfluorooctane sulfonate continual exposure impairs glucose-stimulated insulin secretion via SIRT1-induced upregulation of UCP2 expression.

Airway exposure to perfluorooctanoate exacerbates airway hyperresponsiveness and downregulates glucocorticoid receptor expression in asthmatic mice.

Organotins

Maternal exposure to tributyltin during early gestation increases adverse pregnancy outcomes by impairing placental development.

Pesticides

2,4-Dichlorophenoxyacetic acid induced hepatic and renal toxicological perturbations in rat model: Attenuation by selenium supplementation.

Pendimethalin induces apoptosis in testicular cells via hampering ER-mitochondrial function and autophagy.

Neurotoxicity of chlorpyrifos and chlorpyrifos-oxon to Daphnia magna.

Bixafen causes cardiac toxicity in zebrafish (Danio rerio) embryos.

The genetic basis of susceptibility to low-dose paraquat and variation between the sexes in D. melanogaster.

Synthetic pyrethroids common metabolite 3-phenoxybenzoic acid induces caspase-3 and Bcl-2 mediated apoptosis in human hepatocyte cells.

Analysis of the biochemical and histopathological impact of a mild dose of commercial malathion on Channa punctatus (Bloch) fish.

Potentially Toxic Elements

Metals in microplastics: determining which are additive, adsorbed, and bioavailable.

Alpha-Lipoic Acid Attenuates Cadmium- and Lead-Induced Neurotoxicity by Inhibiting Both Endoplasmic-Reticulum Stress and Activation of Fas/FasL and Mitochondrial Apoptotic Pathways in Rat Cerebral Cortex.

Effects of maternal exposure to arsenic on social behavior and related gene expression in F2 male mice.

Maternal Lead Exposure Impairs Offspring Learning and Memory via Decreased GLUT4 Membrane Translocation.

Transgenerational epigenetic sex determination: Environment experienced by female fish affects offspring sex ratio. [cadmium, temperature]

Microplastics/Nanomaterials

Exploring the Composition and Functions of Plastic Microbiome Using Whole-Genome Sequencing.

Microplastics intake and excretion: Resilience of the intestinal microbiota but residual growth inhibition in common carp.

Transcriptome sequencing and metabolite analysis reveal the toxic effects of nanoplastics on tilapia after exposure to polystyrene.

Prediction of organic compounds adsorbed by polyethylene and chlorinated polyethylene microplastics in freshwater using QSAR.

Chemical conjugation of FITC to track silica nanoparticles in vivo and in vitro: An emerging method to assess the reproductive toxicity of industrial nanomaterials.

Mutational signatures associated with exposure to carcinogenic microplastic compounds bisphenol A and styrene oxide.

Exposure of Human Lung Cells to Polystyrene Microplastics Significantly Retards Cell Proliferation and Triggers Morphological Changes.

Accumulation, transformation and subcellular distribution of arsenite associated with five carbon nanomaterials in freshwater zebrafish specific-tissues.

Pharmaceuticals/Personal Care Products

Effects of Low Concentration Benzophenone-3 Exposure on the Sex Ratio and Offspring Development of Zebrafish (Danio rerio).

Embryotoxicity of Five Cytostatics in Fathead Minnow (Pimephales promelas) Larvae.

Mixtures

Synergistic effect of polystyrene nanoplastics and contaminants on the promotion of insulin fibrillation.

Acute toxicity and biomarker responses in Gammarus locusta amphipods exposed to copper, cadmium, and the organochlorine insecticide dieldrin.

Miscellaneous

Maternal Transfer of 2-Ethylhexyl Diphenyl Phosphate Leads to Developmental Toxicity Possibly by Blocking the Retinoic Acid Receptor and Retinoic X Receptor in Japanese Medaka (Oryzias latipes).

Responses of juvenile fathead minnow (Pimephales promelas) gut microbiome to a chronic dietary exposure of benzo[a]pyrene.

Exposure/Environment Studies

BPA/Phenols

Occurrence of bisphenol A in the milk chain: A monitoring model for risk assessment at a dairy company.

Phthalates

Contamination and human health risks of phthalate esters in vegetable and crop soils from the Huang-Huai-Hai region of China.

Parabens/Triclosan/Antimicrobials

Exposure to Parabens Through The Use of Personal Care Products Among Iranian Men.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Risk-Benefit Modeling to Guide Health Research in Collaboration with Great Lakes Fish Consuming Native American Communities.

Do dissipation and transformation of γ-HCH and p,p’-DDT in soil respond to a proxy for climate change? Insights from a field study on the eastern Tibetan Plateau.

Organochlorine pesticides in honeybee, pollen and honey in Bursa, Turkey.

Perfluoroalkyl Substances

Dietary patterns and PFAS plasma concentrations in childhood: Project Viva, USA.

The fate of poly- and perfluoroalkyl substances in a marine food web influenced by land-based sources in the Norwegian Arctic.

Flame Retardants

Patterns and Trends of Polybrominated Diphenyl Ethers in Bald Eagle Nestlings in Minnesota and Wisconsin, USA.

Insights into the Occurrence, Fate, and Impacts of Halogenated Flame Retardants in Municipal Wastewater Treatment Plants.

Ingested plastics in northern fulmars (Fulmarus glacialis): A pathway for polybrominated diphenyl ether (PBDE) exposure?

Pesticides

Hair versus urine for the biomonitoring of pesticide exposure: Results from a pilot cohort study on pregnant women.

Pyrethroid Exposure Reduces Growth and Development of Monarch Butterfly (Lepidoptera: Nymphalidae) Caterpillars.

Social disruption: Sublethal pesticides in pollen lead to Apis mellifera queen events and brood loss.

Inclusion of Pesticide Transformation Products Is Key to Estimating Pesticide Exposures and Effects in Small U.S. Streams.

Organophosphate poisoning of Hyacinth Macaws in the Southern Pantanal, Brazil.

Potentially Toxic Elements

Cadmium, total mercury, and lead in blood and associations with diet, sociodemographic factors, and smoking in Swedish adolescents.

Impacts on aquatic biota from salinization and metalloid contamination by gold mine tailings in sub-Arctic lakes.

Microplastics/Nanomaterials

Impact of the marine litter pollution on the Mediterranean biodiversity: A risk assessment study with focus on the marine protected areas.

A semi-quantitative risk ranking of potential human exposure to engineered nanoparticles (ENPs) in Europe.

Air Pollution

Plastic Additives in Ambient Fine Particulate Matter in the Pearl River Delta, China: High-Throughput Characterization and Health Implications.

Seasonal variation and affecting factors of organophosphate esters in particulate matter in air: a comparison between measured data and model predictions.

Analysis of the effect of COVID-19 on air pollution: perspective of the Spanish case.

Pharmaceuticals/Personal Care Products

Ecotoxicological risk assessment of contaminants of emerging concern identified by “suspect screening” from urban wastewater treatment plant effluents at a territorial scale. [pharmaceuticals and pesticides]

An Evaluation of the FDA Adverse Event Reporting System and the Potential for Reporting Bias.

Mixtures

Exposure Load: Using biomonitoring data to quantify multi-chemical exposure burden in a population.

Synergistic, antagonistic, and additive effects of heavy metals (copper and cadmium) and polycyclic aromatic hydrocarbons (PAHs) under binary and tertiary combinations in key habitat-forming kelp species of Chile.

Miscellaneous

Polycyclic aromatic hydrocarbons in sediments and fish species from the White Nile, East Africa: Bioaccumulation potential, source apportionment, ecological and health risk assessment.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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