EDC Science Weekly, Mar. 1-7, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: Health Effects of Fossil Fuel-Derived Endocrine Disruptors; Microplastics and Nanoplastics in Atheromas and Cardiovascular Events; Air pollution linked to more than 700 health conditions; Plastic Food Packaging from Five Countries Contains Endocrine- and Metabolism-Disrupting Chemicals.

More science highlights

Events

Mar. 14: PlastChem: State-of-the-science on plastic chemicals [Report launch by the PlastChem project]

Mar. 11-14: 10th Copenhagen Workshop on Endocrine Disruptors – COW2024.

Mar. 19 webinar: Obesogens: A unifying theory for the global rise in obesity [EDC Strategies Partnership]

Mar. 22: HEEDS EDC- North Carolina annual meeting [free and open to anyone]

Apr. 5: NIEHS Biomedical Career Symposium [EPA campus in Research Triangle Park, NC]

June 10-12: National PFAS Conference in Ann Arbor MI

June 23-28: Gordon Research Conference on EDCs June, in Tuscany Italy

More events

Regulations/Policy

Exploring long-term global environmental impacts of chlorinated paraffins (CPs) in waste: Implications for the Stockholm and Basel Conventions and the global plastic treaty.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Quantifying Multipollutant Health Impacts Using the Environmental Benefits Mapping and Analysis Program-Community Edition (BenMAP-CE): A Case Study in Atlanta, Georgia. [see related Invited Perspective: Advancing Cumulative Approaches in Regulatory Decision Making.]

Prediction of the Interactions of a Large Number of Per- and Poly-Fluoroalkyl Substances with Ten Nuclear Receptors.

DTox: A deep neural network-based in visio lens for large scale toxicogenomics data.

Identification of estrogen receptor agonists among hydroxylated polychlorinated biphenyls using classification-based quantitative structure-activity relationship models.

Novel biosensor for high-throughput detection of progesterone receptor-interacting endocrine disruptors.

Evaluating scientific confidence in the concordance of in vitro and in vivo protective points of departure.

Fast and sustainable planar yeast-based bioassay for endocrine disruptors in complex mixtures: Start of cell cultivation to result within one day.

Chemical reactivity theory to analyze possible toxicity of microplastics: Polyethylene and polyester as examples.

Chemical-induced liver cancer: an adverse outcome pathway perspective.

Commentaries

Plastics, Fossil Carbon, and the Heart and Landmark study links microplastics to serious health problems re Microplastics and Nanoplastics in Atheromas and Cardiovascular Events.

Indoor Air Sources of Outdoor Air Pollution: Health Consequences, Policy, and Recommendations: An Official American Thoracic Society Workshop Report.

Trafficking in Disease: More Evidence for Air Pollution-Parkinson’s Association.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Health Effects of Fossil Fuel-Derived Endocrine Disruptors.

Cardiovascular disrupting effects of bisphenols, phthalates, and parabens related to endothelial dysfunction: review of toxicological and pharmacological mechanisms.

Occurrence, bioaccumulation, fate, and risk assessment of emerging pollutants in aquatic environments: A review.

PFAS

The effect of PFAS exposure on glucolipid metabolism in children and adolescents: a meta-analysis.

A comparative review of the toxicity mechanisms of perfluorohexanoic acid (PFHxA) and perfluorohexanesulphonic acid (PFHxS) in fish.

Pesticides

A systematic evidence map and bibliometric analysis of the behavioural impacts of pesticide exposure on zebrafish.

From field to table: Ensuring food safety by reducing pesticide residues in food.

A review of organophosphonates, their natural and anthropogenic sources, environmental fate and impact on microbial greenhouse gases emissions – Identifying knowledge gaps. [including glyphosate]

Metals/Metalloids

A comprehensive review of human health risks of arsenic and fluoride contamination of groundwater in the South Asia region.

Microplastics/Nanomaterials

Hazards of microplastics exposure to liver function in fishes: A systematic review and meta-analysis.

Effects of microplastics on soil microorganisms and microbial functions in nutrients and carbon cycling – A review.

Miscellaneous

Bioprospecting photosynthetic microorganisms for the removal of endocrine disruptor compounds.

The fascinating theory of fetal programming of adult diseases: A review of the fundamentals of the Barker hypothesis.

Human Health Studies

Numerous Chemicals/Mixtures

Prenatal exposure to mixtures of per- and polyfluoroalkyl substances and organochlorines affects cognition in adolescence independent of postnatal exposure.

Trimester-specific effect of maternal co-exposure to organophosphate esters and phthalates on preschooler cognitive development: The moderating role of gestational vitamin D status.

Endocrine disrupting chemical mixture exposure and risk of papillary thyroid cancer in U.S. military personnel: A nested case-control study.

Organic Pollutant Exposure and CKD: A Chronic Renal Insufficiency Cohort Pilot Study.

BPA/Phenols

Bisphenol A exposure affects specific gut taxa and drives microbiota dynamics in childhood obesity.

PFAS

Associations between serum per- and polyfluoroalkyl substances as mixtures and lipid levels: A cross-sectional study in Jinan.

Flame Retardants

The association between brominated flame retardants exposure with bone mineral density in US adults: A cross-sectional study of the national health and nutrition examination survey (NHANES) 2005-2014.

Pesticides

Neonicotinoid insecticides and metabolites levels in neonatal first urine from southern China: Exploring links to preterm birth.

Evaluation of multiple organophosphate insecticide exposure in relation to altered thyroid hormones in NHANES 2007-2008 adult population.

Analysis of the association between urinary glyphosate exposure and fatty liver index: a study for US adults.

Associations between maternal serum neonicotinoid pesticide exposure during pregnancy and newborn telomere length: Effect modification by sampling season.

Metals/Metalloids

Combined exposure to multiple metals on abdominal aortic calcification: results from the NHANES study.

Association between blood heavy metal exposure levels and risk of metabolic dysfunction associated fatty liver disease in adults: 2015-2020 NHANES large cross-sectional study.

Association Between Multiple Heavy Metal Exposures and Cholesterol Levels in Residents Living Near a Smelter Plant in Korea.

Microplastics/Nanomaterials

Microplastics and Nanoplastics in Atheromas and Cardiovascular Events. [see related commentaries above]

Air Pollution

Increasing Racial and Ethnic Disparities in Ambient Air Pollution-Attributable Morbidity and Mortality in the United States. [see related Invited Perspective: Increasing Disparities in Air Pollution Health Burdens in the United States-A Concerning Trend for PM2.5 and a Path Forward.]

Air pollution and human health: a phenome-wide association study.

The role of lifestyle in the association between long-term ambient air pollution exposure and cardiovascular disease: a national cohort study in China.

Pharmaceuticals/Personal Care Products

An Update on Prenatal Diethylstilbestrol Exposure and High-Grade Squamous Intraepithelial Lesions of the Lower Genital Tract.

Laboratory Studies

Numerous Chemicals/Mixtures

Plastic Food Packaging from Five Countries Contains Endocrine- and Metabolism-Disrupting Chemicals.

PPARγ antagonists induce aromatase transcription in adipose tissue cultures.

The combined neurotoxicity of DBP and nano-TiO₂ in embryonic zebrafish (Danio rerio) revealed by oxidative activity, neuro-development genes expression and metabolomics changes.

BPA/Phenols

Deciphering the mechanisms and interactions of the endocrine disruptor bisphenol A and its analogs with the androgen receptor.

Mitigating bisphenol A-induced apoptosis in KGN cells: the therapeutic role of 1,25-dihydroxyvitamin D₃ through upregulation of PGC-1α expression and inhibition of the mitochondrial cytochrome c pathway.

The Protective Effects of Syringic Acid on Bisphenol A-Induced Neurotoxicity Possibly Through AMPK/PGC-1α/Fndc5 and CREB/BDNF Signaling Pathways.

Single and combined exposures to bisphenol A and benzophenone-3 during early mouse pregnancy have differential effects on fetal and placental development.

Melatonin alleviates oxidative stress damage in mouse testes induced by bisphenol A.

Phthalates

Long-term di-(2-ethylhexyl) phthalate exposure reduces sorafenib treatment efficacy by enhancing mesenchymal transition in hepatocellular carcinoma.

Rice straw-derived chitosan-enhanced plasticizers as biologically and environmentally friendly alternatives for sustainable materials.

Ameliorative effects of zinc and vitamin E against phthalates-induced reproductive toxicity in male rats.

Hepatotoxic effects of chronic exposure to environmentally relevant concentrations of Di-(2-ethylhexyl) phthalate (DEHP) on crucian carp: Insights from multi-omics analyses.

Parabens/Triclosan/Antimicrobials

A study on the subchronic toxicity of triclocarban to the early-life development of oryzias melastigma and focused on the analysis of osmoregulatory regulation mechanisms.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Metabolic disturbance of short- and medium-chain chlorinated paraffins to zebrafish larva.

Effects of environmentally relevant concentration of short-chain chlorinated paraffins on BV2 microglia activation and lipid metabolism, implicating altered neurogenesis.

2,3,7,8-Tetrachlorodibenzo-p-dioxin and kynurenine induce Parkin expression in neuroblastoma cells through different signaling pathways mediated by the aryl hydrocarbon receptor.

PFAS

Lactational exposure to perfluorooctane sulfonate remains a potential risk in brain function of middle-aged male mice.

Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes.

Comparing the effects of developmental exposure to alpha lipoic acid (ALA) and perfluorooctanesulfonic acid (PFOS) in zebrafish (Danio rerio).

Angiotoxic effects of chlorinated polyfluorinated ether sulfonate, a novel perfluorooctane sulfonate substitute, in vivo and in vitro.

PFAS promotes disinfection byproduct formation through triggering particle-bound organic matter release in drinking water pipes.

Flame Retardants

Lipid Metabolic Disorders Induced by Organophosphate Esters in Silver Carp from the Middle Reaches of the Yangtze River.

Bis(2-ethylhexyl)-tetrabromophthalate Poses a Higher Exposure Risk and Induces Gender-Specific Metabolic Disruptions in Zebrafish Liver.

Pesticides

Effect of beta-cypermethrin on the reproductive capacity of female mice in advanced age.

Hexaconazole induces developmental toxicities via apoptosis, inflammation, and alterations of Akt and MAPK signaling cascades.

Strobilurin fungicide increases the susceptibility of amphibian larvae to trematode infections.

Predicting the in vivo developmental toxicity of fenarimol from in vitro toxicity data using PBTK modelling-facilitated reverse dosimetry approach.

Thiacloprid impairs reproductive functions of male Wistar rats.

Influence of chlorpyrifos and endosulfan and their metabolites on the virulence of Helicobacter pylori.

Metals/Metalloids

Environmental arsenic pollution induced liver oxidative stress injury by regulating miR-155 through inhibition of AUF1.

Gut microbiota deficiency aggravates arsenic-induced toxicity by affecting bioaccumulation and biotransformation in C57BL/6J mice.

Sustained effects of developmental exposure to inorganic arsenic on hepatic gsto2 expression and mating success in zebrafish.

Combined effects of copper and cadmium exposure on ovarian function and structure in Nile Tilapia (Oreochromis niloticus).

Microplastics/Nanomaterials

Comparing the effects and mechanisms of exposure to polystyrene nanoplastics with different functional groups on the male reproductive system.

Microplastics role in cell migration and distribution during cancer cell division.

The toxicity of polystyrene micro- and nano-plastics on rare minnow (Gobiocypris rarus) varies with the particle size and concentration.

The size-dependence and reversibility of polystyrene nanoplastics-induced lipid accumulation in mice: Possible roles of lysosomes.

Combined effect of polystyrene nanoplastic and di-n-butyl phthalate on testicular health of male Swiss albino mice: analysis of sperm-related parameters and potential toxic effects.

Chlorella alleviates the intestinal damage of tilapia caused by microplastics.

Leaching kinetics and bioaccumulation potential of additive-derived organophosphate esters in microplastics.

Polystyrene microplastic-induced endoplasmic reticulum stress contributes to growth plate endochondral ossification disorder in young rat.

Oral subacute polypropylene microplastics administration effect on potential immunotoxicity in ICR mice.

Ototoxicity of polystyrene nanoplastics in mice, HEI-OC1 cells and zebrafish.

Effects of primary leachates of conventional and alternative plastics in Cyprinodon variegatus fish larvae: Endocrine disruption and toxicological responses.

Nanoplastics causes heart aging/myocardial cell senescence through the Ca²⁺/mtDNA/cGAS-STING signaling cascade.

Miscellaneous

Long-term exposure to 6-PPD quinone at environmentally relevant concentrations causes neurotoxicity by affecting dopaminergic, serotonergic, glutamatergic, and GABAergic neuronal systems in Caenorhabditis elegans.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Assessment of occurrence, partitioning and ecological risk for 144 steroid hormones in Taihu Lake using UPLC-MS/MS with machine learning model.

Phthalates

Associations of concentrations of eight urinary phthalate metabolites with the frequency of use of common adult consumer and personal-care products.

PFAS

Dynamic spatiotemporal changes of per- and polyfluoroalkyl substances (PFAS) in soil and eggs from private gardens at different distances from a fluorochemical plant.

Fate of perfluoroalkyl and polyfluoroalkyl substances (PFAS) through two full-scale wastewater sludge incinerators.

Unveiling per- and polyfluoroalkyl substance contamination in Chinese paper products and assessing their exposure risk.

Assessment of legacy and emerging PFAS in the Oder River: Occurrence, distribution, and sources.

Pesticides

Exposure and risk assessment for agricultural workers during chlorothalonil and flubendiamide treatments in pepper fields.

Pesticides compromise health: a comparison between lizards collected within and outside an agricultural area.

Effects of climate change and mixtures of pesticides on the Amazonian fish Colossoma macropomum.

Fertilisation of agricultural soils with municipal biosolids: Glyphosate and aminomethylphosphonic acid inputs to Québec field crop soils.

Usefulness of oxidative stress biomarkers in native species for the biomonitoring of pesticide pollution in a shallow lake of the Austral Pampas, Argentina.

Microplastics/Nanomaterials

Baking releases microplastics from polyethylene terephthalate bakeware as detected by optical photothermal infrared and quantum cascade laser infrared.

Environmental risks of breakdown nanoplastics from synthetic football fields.

Hidden threats in the plastisphere: Carbapenemase-producing Enterobacterales colonizing microplastics in river water.

Assessing the impact of banning the single-use plastic carrier bags: a case study for Kenyan marine environment looking at macro, meso, and microplastics.

Microplastic abundance in sludge-treated fields: Variance and estimated half-life.

Sea surface microplastics in the Galapagos: Grab samples reveal high concentrations of particles <200 μm in size.

Chemical analysis of marine microdebris pollution in macroalgae from the coastal areas of Argentina.

Mussels (Mytilus spp.) in Svalbard contain microplastic particles in tissues: Implications for monitoring.

Occurrence of microplastics in fish gastrointestinal tracts belongs to different feeding habits from the Bangladesh coast of the Bay of Bengal.

Standardization of monitoring data reassesses spatial distribution of aquatic microplastics concentrations worldwide.

Air Pollution

Global trade-driven transfer of atmospheric polycyclic aromatic hydrocarbon emissions and associated human inhalation exposure risk.

Pharmaceuticals/Personal Care Products

An assessment and characterization of pharmaceuticals and personal care products (PPCPs) within the Great Lakes Basin: Mussel Watch Program (2013-2018).

Miscellaneous

A nation-wide study for the occurrence of PPD antioxidants and 6PPD-quinone in road dusts of China.

Comprehensive approach to national tire wear emissions: Challenges and implications.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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