EDC Science Weekly, June 7-13, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: 6:2 Cl-PFESA, a proposed “safe” alternative for PFOS, diminishes the effectiveness of a chemotherapy drug in the treatment of pancreatic cancer.

More science highlights

Events

June 18 webinar: Research needs for protecting human health and the environment – an EU agencies’ perspective [ECHA]

June 25 webinar: Micro- and Nanoplastics and Public Health: EU research findings [EDC Strategies Partnership]

July 2 webinar: Mapping Environmental Injustice: Disparities in chemical exposures and neurodevelopmental outcomes [CHE-Alaska]

July 12 and 31: Virtual symposium: Measuring Microplastics register for July 12; register for July 31 [NYU Langone Center for the Investigation of Environmental Hazards (CIEH)]

July 24 webinar: 3M’s decades-long cover-up of the “forever chemicals” in your blood [Beyond Plastics]

Sept. 23-24: Plastics and Human Health Symposium [NYU Center for the Investigation of Environmental Hazards (CIEH), save the date]

Oct. 14-16: 8th Annual meeting of the U.S. DOHaD Society: exploring translational DOHaD science: from cells to communities in Chapel Hill, NC [abstracts due Aug. 1]

More events

Regulations/Policy

Changes in PM_2.5-related diabetes risk under the implementation of the clean air act in Shanghai.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Preface to the Special Issue of Food and Chemical Toxicology on “New approach methodologies and machine learning in food safety and chemical risk assessment: Development of reproducible, open-source, and user-friendly tools for exposure, toxicokinetic, and toxicity assessments in the 21st century”. [see the special issue]

Screening 800 putative endocrine disrupting chemicals in a representative mammal, bird, and fish using a neurochemical cell-free testing platform.

Utility of Life Stage-Specific Chemical Risk Assessments Based on New Approach Methodologies (NAMs).

Strategies for Considering Environmental Justice in the Early-Stage Development of Circular Economy Technologies.

A zebrafish-based acoustic motor response (AMR) assay to evaluate chemical-induced developmental neurotoxicity.

Screening structure and predicting toxicity of pesticide adjuvants using molecular dynamics simulation and machine learning for minimizing environmental impacts.

Next Generation Risk Assessment for Occupational Chemical Safety – a Real World Example with Sodium-2-hydroxyethane sulfonate.

Using artificial intelligence to rapidly identify microplastics pollution and predict microplastics environmental behaviors.

Technology acceptance of the PFAS Guide among European companies.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

The association between endocrine disrupting chemicals and nonalcoholic fatty liver disease: A systematic review and meta-analysis.

Protective effects of Panax ginseng as a medical food against chemical toxic agents: molecular and cellular mechanisms.

BPA/Phenols

Bisphenol A and its analogues: from their occurrence in foodstuffs marketed in Europe to improved monitoring strategies-a review of published literature from 2018 to 2023.

Flame Retardants

Weight of evidence evaluation of the metabolism disrupting effects of triphenyl phosphate using an expert knowledge elicitation approach.

Pesticides

Network analysis of toxic endpoints of fungicides in zebrafish.

Metals/Metalloids

Mercury-induced toxicity: Mechanisms, molecular pathways, and gene regulation.

Environmental exposure to metal(loid)s and hypertensive disorders of pregnancy: A systematic review.

Microplastics/Nanomaterials

Gut microbiota, a key to understanding the knowledge gaps on micro-nanoplastics-related biological effects and biodegradation.

Micro/nano-plastics impacts in cardiovascular systems across species.

Microplastics in multi-environmental compartments: Research advances, media, and global management scenarios.

Adverse effects and potential mechanisms of polystyrene microplastics (PS-MPs) on the blood-testis barrier.

Compounding one problem with another? A look at biodegradable microplastics.

Human Health Studies

PFAS

Mitochondrial DNA copy number mediated the associations between perfluoroalkyl substances and breast cancer incidence: A prospective case-cohort study.

Positive Associations of Perfluoroalkyl and Polyfluoroalkyl Substances With Hypertension May Be Attenuated by Endogenous Sex Hormones: A Nationally Representative Cross-Sectional Study.

Flame Retardants

Polybrominated diphenyl ethers and gestational weight gain: a multi-center prospective cohort study.

Pesticides

Exposure to Pesticides and Breast Cancer in an Agricultural Region in Brazil.

Associations between exposure to pesticides mixture and semen quality among the non-occupationally exposed males: four statistical models.

Occupational Pesticide Exposure in Parkinson’s Disease Related to GBA and LRRK2 Variants.

Metals/Metalloids

Associations of serum lead, cadmium, and mercury concentrations with all-cause and cause-specific mortality among individuals with cardiometabolic multimorbidity.

Air Pollution

Ambient Air Pollution, Housing Context, and Birth Outcomes Among Wisconsin Mothers.

Accelerated aging and altered subclinical response to ozone exposure in young, healthy adults.

Reduced human fecundity attributable to ambient fine particles in low- and middle-income countries.

Long-term exposure to PM_2.5 air pollution and mental health: a retrospective cohort study in Ireland.

Miscellaneous

Seasonal variation in urinary PAH metabolite levels and associations with neonatal birth outcomes.

Laboratory Studies

BPA/Phenols

Bisphenol a accelerates the glucolipotoxicity-induced dysfunction of rat insulinoma cell lines: An implication for a potential risk of environmental bisphenol a exposure for individuals susceptible to type 2 diabetes.

Effects of bisphenol A and tauroursodeoxycholic acid on maturation of porcine oocytes and parthenogenetic development of embryos.

Evaluation of thyroid-disrupting effects of bisphenol F and bisphenol S on zebrafish (Danio rerio) using anti-transthyretin monoclonal antibody-based immunoassays.

ERβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the TPH2/5-HT pathway.

Melatonin and Resveratrol Alleviate Molecular and Metabolic Toxicity Induced by Bisphenol A in Endometrial Organoids.

Developmental effects and lipid disturbances of zebrafish embryos exposed to three newly recognized bisphenol A analogues.

Fetal Origin of Abnormal Glucose Tolerance in Adult Offspring Induced by Maternal Bisphenol A Analogs Exposure.

Postnatal maternal care moderates the effects of prenatal bisphenol exposure on offspring neurodevelopmental, behavioral, and transcriptomic outcomes.

Oral exposure to bisphenol S is associated with alterations in the oviduct proteome of an ovine model, with aggravated effects in overfed females.

The obesogen bisphenol A promotes adipogenesis in canine adipose-derived stem cells: Potential implication in dog obesity.

Effects of combined exposure to two bisphenol plasticizers (BPA and BPB) on Xenopus laevis development.

Phthalates

Identification of Key Blood Biomarkers Linking Di (2-ethylhexyl) Phthalate and Autoimmune Diseases in Adolescents Mice.

A computational analysis of the molecular mechanisms underlying the effects of ibuprofen and dibutyl phthalate on gene expression in fish.

DBP Exposure Affects Oocyte Fertilization Via Extracellular Vesicles-Derived miR-116-5p in Ovarian Granulosa Cells Through Downregulating FOXO3a Expression.

Thyroid and neurobehavioral effects of DiNP on GH3 cells and larval zebrafish (Danio rerio).

Parabens/Triclosan/Antimicrobials

Assessment of immunomodulatory effects of five commonly used parabens on human THP-1 derived macrophages: Implications for ecological and human health impacts.

Butylparaben induces glycolipid metabolic disorders in mice via disruption of gut microbiota and FXR signaling.

In vitro exposure of porcine spermatozoa to methylparaben, and propylparaben, alone or in combination adversely affects sperm quality.

PFAS

6:2 Cl-PFESA, a proposed safe alternative for PFOS, diminishes the gemcitabine effectiveness in the treatment of pancreatic cancer.

Developmental perfluorooctane sulfonic acid exposure exacerbates house dust mite induced allergic responses in adult mice.

Effects of long-chained perfluoroalkyl acids (PFAAs) on the uptake and bioaccumulation of short-chained PFAAs in two free-floating macrophytes: Eichhornia crassipes and Ceratophyllum demersum.

Male infertility and Perfluoroalkyl and poly-fluoroalkyl substances: Evidence for alterations in phosphorylation of proteins and fertility-related functional attributes in bull spermatozoa.

Perfluorooctane sulfonate induces ferroptosis-dependent non-alcoholic steatohepatitis via autophagy-MCU-caused mitochondrial calcium overload and MCU-ACSL4 interaction.

Legacy and alternative per- and polyfluoroalkyl substances (PFAS) alter the lipid profile of HepaRG cells.

Flame Retardants

Melatonin improves mouse oocyte quality from 2-ethylhexyl diphenyl phosphate-induced toxicity by enhancing mitochondrial function.

Pesticides

Sex-specific transgenerational effects on murine thyroid gland imposed by ancestral exposure to neonicotinoid thiacloprid.

Confirmation of the steroid hormone receptor-mediated endocrine disrupting potential of fenvalerate following the Organization for Economic Cooperation and Development test guidelines, and its estrogen receptor α-dependent effects on lipid accumulation.

Histological, biochemical and immunohistochemical assessments of Roundup®, atrazine, and 2,4-D mixtures on tissue architecture, body fluid conditions, nitrotyrosine protein and Na⁺/K⁺-ATPase expressions in the American oyster, Crassostera virginica.

Impact of imidacloprid exposure on gestational hyperglycemia: A multi-omics analysis.

Effects of glyphosate-based herbicide on gut microbes and hepatopancreatic metabolism in Pomacea canaliculata.

Glyphosate and its formulated product Roundup Transorb R® affect locomotor activity and reproductive and developmental parameters in Jenynsia lineata fish: an intergenerational study.

Farnesol prevents chlorpyrifos nephrotoxicity by modulating inflammatory mediators, Nrf2 and FXR and attenuating oxidative stress.

Chlormequat chloride induces hepatic steatosis by promoting mTOR/SREBP1 mediated lipogenesis via AMPK inhibition.

Metals/Metalloids

Induction of oxidative stress and cardiac developmental toxicity in zebrafish embryos by arsenate at environmentally relevant concentrations.

Microplastics/Nanomaterials

Effects of nanoplastic exposure during pregnancy and lactation on neurodevelopment of rat offspring.

Neurobehavioral toxicity induced by combined exposure of micro/nanoplastics and triphenyltin in marine medaka (Oryzias melastigma).

Mechanism insights into the histopathological changes of polypropylene microplastics induced gut and liver in zebrafish.

Polystyrene nanoplastics induce cardiotoxicity by upregulating HIPK2 and activating the P53 and TGF-β1/Smad3 pathways.

Effects of polystyrene nanoplastic size on zebrafish embryo development.

Ingestion of polyethylene terephthalate microplastic water contaminants by Xenopus laevis tadpoles negatively affects their resistance to ranavirus infection and antiviral immunity.

Polylactic acid microplastics cause transgenerational reproductive toxicity associated with activation of insulin and hedgehog ligands in C. elegans.

Miscellaneous

Oral exposure to phenanthrene during gestation disorders endocrine and spermatogenesis in F1 adult male mice.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Analysis of chemical exposures in racial populations in Canada: An investigation based on the Canadian health measures survey.

BPA/Phenols

Exposure characteristics and cumulative risk assessment of bisphenol A and its substitutes: the Taiwan environmental survey for toxicants 2013.

Environmental and occupational exposure to bisphenol compounds in Finland.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effects of persistent organic pollutants on telomere dynamics are sex and age-specific in a wild long-lived bird.

Persistent organic pollutants in feathers of various terrestrial and aquatic bird species: Interspecies difference and source apportionment.

PFAS

Serum concentrations of legacy, alternative, and precursor per- and polyfluoroalkyl substances: a descriptive analysis of adult female participants in the MIREC-ENDO study.

Occurrence of a “forever chemical” in the atmosphere above pristine Amazon Forest.

Flame Retardants

Influence of paternal factors on plastic ingestion and brominated chemical exposure in East Tropical Atlantic Procellariid chicks.

Pesticides

High-throughput screening of 222 pesticides in road environments in a megacity of northern China: A new approach to urban population exposure.

Metals/Metalloids

Toxic arsenolipids bioaccumulate in the developing brain of pilot whales.

Microplastics/Nanomaterials

Microplastics in Wastewater and Sludge from Centralized and Decentralized Wastewater Treatment Plants: Effects of Treatment Systems and Microplastic Characteristics.

Every breath you take: high concentration of breathable microplastics in indoor environments.

Miscellaneous

Watershed analysis of urban stormwater contaminant 6PPD-Quinone hotspots and stream concentrations using a process-based ecohydrological model.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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