EDC Science Weekly, June 30 – July 6, 2021

Post author:HEEDS
Post published:July 6, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

July 14: Inaugural PFAS Conference (EWG)

July 15 webinar: Throwaway Packaging, Forever Chemicals: European wide survey of PFAS in disposable food packaging and tableware and efforts to phase it out at top US Grocery and Fast-food Chains (EDC Strategies Partnership)

July 20, webinar: The Science on Toxic Chemicals in the Built Environment: Environmental Health Disparities and Equity-Driven Solutions (CHE)

Regulations/Policy

Finding essentiality feasible: common questions and misinterpretations concerning the “essential-use” concept.

Methods/Tools/Screening

Safer chemicals using less animals: kick-off of the European ONTOX project.

A Cumulative Framework for Identifying Overburdened Populations under the Toxic Substances Control Act: Formaldehyde Case Study.

Chemical interactions and mixtures in public health risk assessment: An analysis of ATSDR’s Interaction Profile database.

An Adverse Outcome Pathway on the disruption of retinoic acid metabolism leading to developmental Craniofacial Defects.

Varying-coefficient regression analysis for pooled biomonitoring. [PBDE]

Combined Naïve Bayesian, Chemical Fingerprints and Molecular Docking Classifiers to Model and Predict Androgen Receptor Binding Data for Environmentally- and Health-Sensitive Substances.

Commentaries

What Does CLARITY-BPA Mean for Canadians?

Calling a Rapid Response on Environmental Racism: Medical Students Sound the Alarm.

Time to Fix the Damage of Weakened Chemical Disaster Prevention Regulations.

Making It Count: How to Achieve Structural Change with Community-Based Participatory Research Projects. [EHP Science Selection re

Participatory Research for Environmental Justice: A Critical Interpretive Synthesis]

BPS and Cell Fusion in the Human Placenta: A Separate Mechanism of Action? [EHP Science Selection re

Bisphenol S and Epidermal Growth Factor Receptor Signaling in Human Placental Cytotrophoblasts]

Reviews

Numerous EDCs

Effects of Endocrine-Disrupting Chemicals on Endometrial Receptivity and Embryo Implantation: A Systematic Review of 34 Mouse Model Studies.

Environmental and occupational exposures associated with male infertility.

Mitochondrial DNA Copy Number and Developmental Origins of Health and Disease (DOHaD).

Pollution, Inflammation, and Vaccines: A Complex Crosstalk.

A Review of the Impact of Selected Anthropogenic Chemicals from the Group of Endocrine Disruptors on Human Health.

Why We Will Continue to Lose Our Battle with Cancers If We Do Not Stop Their Triggers from Environmental Pollution.

Endocrine Disrupting Chemicals, Hormone Receptors, and Acne Vulgaris: A Connecting Hypothesis.

BPA/Phenols

The Role of the Bisphenol A in Diabetes and Obesity.

Phthalates

Effect of prenatal phthalate exposure on childhood atopic dermatitis: A systematic review and meta-analysis.

Perfluoroalkyl Substances

PFOS in U.S. Ambient Surface Waters: A Review of Occurrence in Aquatic Environments and Comparison to Global Concentrations.

The degradation mechanisms of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) by different chemical methods: A critical review.

Pesticides

Reproductive Health Risks Associated with Occupational and Environmental Exposure to Pesticides.

Maternal exposure to pesticides during pregnancy and risk for attention-deficit/hyperactivity disorder in offspring: A protocol for systematic review and meta-analysis.

US Food and Drug Administration regulatory pesticide residue monitoring of human foods: 2009-2017.

Level of pesticides contamination in the major river systems: A review on South Asian countries perspective.

Non-Occupational Exposure to Pesticides: Experimental Approaches and Analytical Techniques (from 2019).

An Overview on the Potential Hazards of Pyrethroid Insecticides in Fish, with Special Emphasis on Cypermethrin Toxicity.

Assessment of risks to listed species from the use of atrazine in the USA: a perspective.

Potentially Toxic Elements

The possible role of arsenic and gene-arsenic interactions in susceptibility to breast cancer: a systematic review.

Evaluation of environmental contamination by toxic trace elements in Kazakhstan based on reviews of available scientific data.

Toxicity mechanisms of arsenic compounds in aquatic organisms.

Aluminum environmental pollution: the silent killer.

Sex-specific neurotoxic effects of heavy metal pollutants: Epidemiological, experimental evidence and candidate mechanisms.

Microplastics

The potential effects of microplastics on human health: What is known and what is unknown.

Time to Safeguard the Future Generations from the Omnipresent Microplastics.

A toxicological perspective of plastic biodegradation by insect larvae.

Co-occurrence of co-contaminants: Cyanotoxins and microplastics, in soil system and their health impacts on plant – A comprehensive review.

Air Pollution

Effects of air pollution exposure on social behavior: a synthesis and call for research.

PM_2.5 as a potential risk factor for autism spectrum disorder: its possible link to neuroinflammation, oxidative stress and changes in gene expression.

Air Pollution and COVID-19: A Possible Dangerous Synergy for Male Fertility.

Miscellaneous

Let’s Talk about Placental Sex, Baby: Understanding Mechanisms That Drive Female- and Male-Specific Fetal Growth and Developmental Outcomes.

Human Health Studies

Numerous Chemicals

Web-based behavioral intervention to reduce exposure to phthalate metabolites, bisphenol A, triclosan, and parabens in mothers with young children: A randomized controlled trial.

Mixture effects of prenatal exposure to per- and polyfluoroalkyl substances and polybrominated diphenyl ethers on maternal and newborn telomere length.

Gene Variants Determine Placental Transfer of Perfluoroalkyl Substances (PFAS), Mercury (Hg) and Lead (Pb), and Birth Outcome: Findings From the UmMuKi Bratislava-Vienna Study.

BPA/Phenols

Placental Glucose Transporters and Response to Bisphenol A in Pregnancies from of Normal and Overweight Mothers.

Association of maternal exposure to bisphenol A with her β-hCG level and neonatal anthropometric measures.

Phthalates

Prenatal Exposure to Di-Ethyl Phthalate (DEP) Is Related to Increasing Neonatal IgE Levels and the Altering of the Immune Polarization of Helper-T Cells.

Racial and Sex Differences between Urinary Phthalates and Metabolic Syndrome among U.S. Adults: NHANES 2005-2014.

Urinary Phthalate Levels Associated with the Risk of Nonalcoholic Fatty Liver Disease in Adults: The Korean National Environmental Health Survey (KoNEHS) 2012-2014.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Historical exposure to persistent organic pollutants and cardiovascular disease: A 15-year longitudinal analysis focused on pharmaceutical consumption in primary care.

Perfluoroalkyl Substances

Associations between exposure to perfluoroalkyl substances and body fat evaluated by DXA and MRI in 109 adolescent boys.

Pesticides

Acute and Cumulative Effects of Repeated Exposure to Chlorpyrifos on the Liver and Kidney Function among Egyptian Adolescents.

Assessment of Cytogenetic Damage and Cholinesterases’ Activity in Workers Occupationally Exposed to Pesticides in Zamora-Jacona, Michoacan, Mexico.

Comparison of Thyroid Hormone Levels between Women Farmers and Non-Farmers in Banten Indonesia.

Nanopesticides in Agriculture: Benefits and Challenge in Agricultural Productivity, Toxicological Risks to Human Health and Environment.

Potentially Toxic Elements

Cord serum elementomics profiling of 56 elements depicts risk of preterm birth: Evidence from a prospective birth cohort in rural Bangladesh.

Joint effect of urinary arsenic species and serum one-carbon metabolism nutrients on gestational diabetes mellitus: A cross-sectional study of Chinese pregnant women.

Potential liver damage due to co-exposure to As, Cd, and Pb in mining areas: Association analysis and research trends from a Chinese perspective.

Environmental cadmium exposure induces kidney tubular and glomerular dysfunction in the Myanmar adults.

Dose-response evaluation of urinary cadmium and kidney injury biomarkers in Chinese residents and dietary limit standards.

Association between Blood Mercury Levels and Non-Alcoholic Fatty Liver Disease in Non-Obese Populations: The Korean National Environmental Health Survey (KoNEHS) 2012-2014.

Combined exposure to multiple metals and cognitive function in older adults.

Urinary Nickel and Progesterone in Workers Exposed to Urban Pollutants.

Air Pollution

Portable HEPA filter air cleaner use during pregnancy and children’s body mass index at two years of age: The UGAAR randomized controlled trial.

Maternal PM_2.5 exposure associated with stillbirth: A large birth cohort study in seven Chinese cities.

Pharmaceuticals/Personal Care Products

Is Maternal Use of Paracetamol during Pregnancy Associated with Anogenital Distance in Male Newborns? The Results from the NELA Birth Cohort.

Laboratory Studies

BPA/Phenols

Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation.

Bisphenols disrupt thyroid hormone (TH) signaling in the brain and affect TH-dependent brain development in Xenopus laevis.

Coenzyme Q10 ameliorates BPA-induced apoptosis by regulating autophagy-related lysosomal pathways.

Prenatal Exposure to BPA: The Effects on Hepatic Lipid Metabolism in Male and Female Rat Fetuses.

Resveratrol Butyrate Esters Inhibit Obesity Caused by Perinatal Exposure to Bisphenol A in Female Offspring Rats.

Bisphenol a Interferes with Uterine Artery Features and Impairs Rat Feto-Placental Growth.

Role of cerium oxide nanoparticles in improving oxidative stress and developmental delays in Drosophila melanogaster as an in-vivo model for bisphenol a toxicity.

Hypothalamic Expression of Neuropeptide Y (NPY) and Pro-OpioMelanoCortin (POMC) in Adult Male Mice Is Affected by Chronic Exposure to Endocrine Disruptors. [BPA, TBT, DES]

Nonylphenol and cyproterone acetate effects in the liver and gonads of Lithobates catesbeianus (Anura) tadpoles and juveniles.

Phthalates

Effects of Di-Isononyl Phthalate (DiNP) on Follicular Atresia in Zebrafish Ovary.

The Long-Term DEHP Exposure Confers Multidrug Resistance of Triple-Negative Breast Cancer Cells through ABC Transporters and Intracellular ROS.

Parabens/Triclosan/Antimicrobials

In vitro and in vivo estrogenic activity of triclosan.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Impaired Morphogenesis and Function of Rat Adrenal Zona Glomerulosa by Developmental Low-Dose Exposure to DDT Is Associated with Altered Oct4 Expression.

Perfluoroalkyl Substances

Chemoproteomic Approach toward Probing the Interactomes of Perfluoroalkyl Substances.

Probiotic intervention mitigates the metabolic disturbances of perfluorobutanesulfonate along the gut-liver axis of zebrafish.

Developmental Perfluorooctanesulfonic acid (PFOS) Exposure as a Potential Risk Factor for Late-Onset Alzheimer’s Disease in CD-1 Mice and SH-SY5Y Cells.

Flame Retardants

Nonalcoholic Fatty Liver Disease Development in Zebrafish upon Exposure to Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate, a Novel Brominated Flame Retardant.

PXR-mediated organophorous flame retardant tricresyl phosphate effects on lipid homeostasis.

Pesticides

Developmental effect of parental or direct chronic exposure to environmental concentration of glyphosate on the larvae of rainbow trout, Oncorhynchus mykiss.

Epigenetic histone acetylation and Bdnf dysregulation in the hippocampus of rats exposed to repeated, low-dose diisopropylfluorophosphate.

Amisulbrom causes cardiovascular toxicity in zebrafish (Danio rerio).

Exposure to fomesafen alters the gut microbiota and the physiology of the earthworm Pheretima guillelmi.

Identification of long noncoding RNAs reveals the effects of dinotefuran on the brain in Apis mellifera (Hymenopptera: Apidae).

Protective effects of rutin against deltamethrin-induced hepatotoxicity and nephrotoxicity in rats via regulation of oxidative stress, inflammation, and apoptosis.

Polyphenols as Food Supplement Improved Food Consumption and Longevity of Honey Bees (Apis mellifera) Intoxicated by Pesticide Thiacloprid.

Chlorpyrifos caused necroptosis via MAPK/NF-κB/TNF-α pathway in common carp (Cyprinus carpio L.) gills.

Freshwater quality criteria of four strobilurin fungicides: Interspecies correlation and toxic mechanism.

Tissue distribution and sublethal effects of imidacloprid in the South American grayish baywing (Agelaioides badius).

Effects of Flutriafol Fungicide on the Lipid Accumulation in Human Liver Cells and Rat Liver.

Food Contaminants Effects on an In Vitro Model of Human Intestinal Epithelium.

Harmful effects of fipronil exposure on the behavior and brain of the stingless bee Partamona helleri Friese (Hymenoptera: Meliponini).

The organophosphate insecticide diazinon and aging: Neurobehavioral and mitochondrial effects in zebrafish exposed as embryos or during aging.

Missing Nurse Bees-Early Transcriptomic Switch From Nurse Bee to Forager Induced by Sublethal Imidacloprid.

Potentially Toxic Elements

Exposure to lead on expression levels of brain immunoglobulins, inflammatory cytokines, and brain-derived neurotropic factor in fetal and postnatal mice with autism-like characteristics.

The n-butanol fraction of the Xiao-Chai-Hu decoction alleviates the endocrine disturbance in the liver of mice exposed to lead.

Heavy metals in soil from gangue stacking areas increases children health risk and causes developmental neurotoxicity in zebrafish larvae.

Quercetin Protects Human Thyroid Cells against Cadmium Toxicity.

Microplastics/Nanomaterials

Basal Ti level in the human placenta and meconium and evidence of a materno-foetal transfer of food-grade TiO₂ nanoparticles in an ex vivo placental perfusion model.

Chronic exposure to UV-aged microplastics induces neurotoxicity by affecting dopamine, glutamate, and serotonin neurotransmission in Caenorhabditis elegans.

Effects of chemical and natural ageing on the release of potentially toxic metal additives in commercial PVC microplastics.

Dietary polystyrene nanoplastics exposure alters liver lipid metabolism and muscle nutritional quality in carnivorous marine fish large yellow croaker (Larimichthys crocea).

Polystyrene nanoplastics dysregulate lipid metabolism in murine macrophages in vitro.

Pharmaceuticals/Personal Care Products

Prenatal and pubertal exposure to 17α-ethinylestradiol cause morphological changes in the prostate of old gerbils.

Growth and gonadal development retardations after long-term exposure to estradiol in little yellow croaker, Larimichthys polyactis.

Developmental Neurotoxicity of Environmentally Relevant Pharmaceuticals and Mixtures Thereof in a Zebrafish Embryo Behavioural Test.

Effects of Diethylstilbestrol on Zebrafish Gonad Development and Endocrine Disruption Mechanism.

Mixtures

Co-exposure to BPA and DEHP enhances susceptibility of mammary tumors via up-regulating Esr1/HDAC6 pathway in female rats.

The combined toxicity of ultra-small SiO₂ nanoparticles and bisphenol A (BPA) in the development of zebrafish.

Assessing the combinatorial cytotoxicity of the exogenous contamination with BDE-209, bisphenol A, and acrylamide via high-content analysis.

Dose-Dependent Oxidative Damage in Erythrocytes and Hepatic Tissue of Wistar Rats Concurrently Exposed with Arsenic and Quinalphos: a Subacute Study.

Genotoxic activity of endocrine disrupting compounds commonly present in paper mill effluents.

Miscellaneous

UV aged epoxy coatings – Ecotoxicological effects and released compounds.

In Vitro Evaluation of the Individual and Combined Cytotoxic and Estrogenic Effects of Zearalenone, Its Reduced Metabolites, Alternariol, and Genistein.

Exposure/Environment Studies

Phthalates

Concentrations of Seven Phthalate Monoesters in Infants and Toddlers Quantified in Urine Extracted from Diapers.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Toxic organic pollutants in Greek house dust: Implications for human exposure and health risk. [PBDEs, PCBs, PAHs and NPAHs]

Fatty acids, persistent organic pollutants, and trace elements in small pelagic fish from the eastern Mediterranean Sea.

Dioxins and dioxin-like PCBs in buffalo milk from the Campania region (Italy): Decreasing trend and baseline assessment over 10 years (2008-2018).

Soil concentrations, compositional profiles, sources and bioavailability of polychlorinated dibenzo dioxins/furans, polychlorinated biphenyls and polycyclic aromatic hydrocarbons in open municipal dumpsites of Chennai city, India.

Organochlorines and Polycyclic Aromatic Hydrocarbons as fingerprint of exposure pathways from marine sediments to biota.DDT, Chlordane, and Hexachlorobenzene in the Air of the Pearl River Delta Revisited: A Tale of Source, History, and Monsoon.

Tracking POPs in Global Air from the First 10 Years of the GAPS Network (2005 to 2014).

Perfluoroalkyl Substances

Concentrations of perfluoroalkyl substances in donor breast milk in Southern Spain and their potential determinants.

Confirmatory Analysis of Per and Polyfluoroalkyl Substances in Milk and Infant Formula Using UHPLC-MS/MS

Hair determination of Per- and polyfluoroalkyl substances (PFAS) in the Italian population.

Legacy and alternative per- and polyfluoroalkyl substances (PFASs) in the West River and North River, south China: Occurrence, fate, spatio-temporal variations and potential sources.

Comprehensive adsorption behavior and mechanism of PFOA and PFCs in various subsurface systems in China.

Legacy and emerging per- and polyfluoroalkyl substances (PFAS) in the Bohai Sea and its inflow rivers.

Flame Retardants

Polybrominated diphenyl ethers in indoor dusts from industrial factories, offices, and houses in northern Vietnam: Contamination characteristics and human exposure.

Occurrence, distribution and risk assessment of organophosphate ester flame retardants and plasticizers in surface seawater of the West Pacific.

Pesticides

Urinary neonicotinoids level among pregnant women in Japan.

Liquid chromatography tandem mass spectrometry for the determination of nine insecticides and fungicides in human postmortem blood and urine.

Estimation of chronic dietary intake of pesticide residues.

The Risk Assessment of Pesticide Ingestion with Fruit and Vegetables for Consumer’s Health.

Assessment of the vulnerability to pesticide exposures across bee species.

Long-term field-realistic exposure to a next-generation pesticide, flupyradifurone, impairs honey bee behaviour and survival.

Epigenetic effects of parasites and pesticides on captive and wild nestling birds.

Occurrence of Chemical Contaminants in Peruvian Produce: A Food-Safety Perspective.

Chloro-s-triazenes – toxicokinetic, toxicodynamic, human exposure, and regulatory considerations.

Potentially Toxic Elements

A pilot study on the feasibility of testing residential tap water in North Carolina: implications for environmental justice and health.

Probabilistic Health Risk Assessment of Trace Elements in Baby Food and Milk Powder Using ICP-OES Method.

Bioaccumulation of Toxic Metals in Children Exposed to Urban Pollution and to Cement Plant Emissions.

Artisanal gold mining in the eastern Amazon: Environmental and human health risks of mercury from different mining methods.

Failure of chelator-provoked urine testing results to predict heavy metal toxicity in a prospective cohort of patients referred for medical toxicology evaluation.

Exposures and Health Risks Associated with Elements in Diets from a Gold Mining Area.

Diné citizen science: Phytoremediation of uranium and arsenic in the Navajo Nation.

Preliminary Study of Lead-Contaminated Drinking Water in Public Parks-An Assessment of Equity and Exposure Risks in Two Texas Communities.

Microplastics

The missing ocean plastic sink: Gone with the rivers.

Air Pollution

Taking a deep breath: a qualitative study exploring acceptability and perceived unintended consequences of charging clean air zones and air quality improvement initiatives amongst low-income, multi-ethnic communities in Bradford, UK.

Mixtures

Environmental Footprint of Wastewater Treatment: A Step Forward in the Use of Toxicological Tools.

Miscellaneous

Estimating mouthing exposure to chemicals in children’s products.

Analysis of polycyclic aromatic hydrocarbon intake in the US adult population from NHANES 2005-2014 identifies vulnerable subpopulations, suggests interaction between tobacco smoke exposure and sociodemographic factors.

So much for making this shorter…

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.