EDC Science Weekly, June 3 – 9, 2020

Post author:HEEDS
Post published:June 9, 2020
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies.

Regulations/Policy

Significance of and Challenges in Regulating Endocrine Disruptors – How Regulators and Industry can Conquer?

PBPK model reporting template for chemical risk assessment applications.

Methods/Screening

The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity. [the Int J of Mol Sci has recently published descriptions of the 8 Eurion Cluster projects on EDCs, including this project. For a list of all the projects and links to the publications, see the HEEDS.org Policy page.]

A validated search filter for the identification of endocrine disruptors based on the ECHA/EFSA guidance recommendations.

A statistical assessment of micropollutants occurrence, time trend, fate and human health risk using left-censored water quality data.

Reviews

Commentaries

Global solutions to a silent poison. [Comment in Science re arsenic]

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Occurrences, sources, and transport of organochlorine pesticides in the aquatic environment of Antarctica.

Perfluoroalkyl Substances

Strategies for grouping per- and polyfluoroalkyl substances (PFAS) to protect human and environmental health.

Pesticides

Global trends in pesticides: A looming threat and viable alternatives.

Potentially Toxic Elements

An Emerging Frontier: Metal(loid) Soil Pollution Threat under Global Climate Change.

Heavy Metal-Induced Cerebral Small Vessel Disease: Insights into Molecular Mechanisms and Possible Reversal Strategies.

Cadmium isotopes as tracers in environmental studies: A review.

Toxic heavy metals: impact on the environment and human health, and treatment with conducting organic polymers, a review.

Microplastics

Interaction of Environmental Pollutants with Microplastics: A Critical Review of Sorption Factors, Bioaccumulation and Ecotoxicological Effects.

Microplastics provide new microbial niches in aquatic environments.

Laboratory simulation of microplastics weathering and its adsorption behaviors in an aqueous environment: A systematic review.

Air Pollution

Oxidative stress pathways of air pollution mediated toxicity: Recent insights.

From air pollution to cardiovascular diseases: the emerging role of epigenetics.

Pharmaceuticals

Cardiovascular drugs and lipid regulating agents in surface waters at global scale: Occurrence, ecotoxicity and risk assessment.

Ibuprofen as an emerging organic contaminant in environment, distribution and remediation.

Numerous Chemicals

Endocrine-Disrupting Chemicals and Insulin Resistance in Children

Prenatal exposure to endocrine disrupting chemicals and asthma and allergic diseases.

Biomarker responses in terrestrial gastropods exposed to pollutants: A comprehensive review.

Environmental factors in epithelial barrier dysfunction.

The External Exposome and Food Allergy.

Human Health Studies

Phthalates

The levels of phthalate exposure and associations with obesity in an elderly population in China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Sex-specific DNA methylation differences in people exposed to polybrominated biphenyl.

Perfluoroalkyl Substances

Perfluoroalkyl substances exposure in early pregnancy and preterm birth in singleton pregnancies: a prospective cohort study.

PFAS (per- and polyfluoroalkyl substances) and asthma in young children: NHANES 2013-2014.

Associations of Perfluoroalkyl Substances with Incident Natural Menopause: the Study of Women’s Health Across the Nation.

Serum concentrations of perfluoroalkyl substances and their association with osteoporosis in a population in Jeddah, Saudi Arabia.

Does Low Maternal Exposure to Per- and Polyfluoroalkyl Substances Elevate the Risk of Spontaneous Preterm Birth? A Nested Case-Control Study in China.

Flame Retardants

Association of polybrominated diphenyl ether (PBDE) levels with biomarkers of placental development and disease during mid-gestation.

Pesticides

Residential pyrethroid insecticide use, urinary 3-phenoxybenzoic acid levels, and attention-deficit/hyperactivity disorder-like symptoms in preschool-age children: The Environment and Development of Children study.

Different working conditions shift the genetic damage levels of pesticide-exposed agriculture workers.

Potentially Toxic Elements

Association between 10 urinary heavy metal exposure and attention deficit hyperactivity disorder for children.

Cadmium, Smoking, and Human Blood DNA Methylation Profiles in Adults from the Strong Heart Study.

Elevated Hair Mercury Levels Are Associated With Neurodevelopmental Deficits in Children Living Near Artisanal and Small-Scale Gold Mining in Peru.

Are Heavy Metal Exposure and Trace Element Levels Related to Metabolic and Endocrine Problems in Polycystic Ovary Syndrome?

Erythrocyte Levels of Cadmium and Lead and Risk of B-Cell Non-Hodgkin Lymphoma and Multiple Myeloma.

Air Pollution

Improved asthma outcomes observed in the vicinity of coal power plant retirement, retrofit, and conversion to natural gas.

Respiratory Inflammation and Short-Term Ambient Air Pollution Exposures in Adult Beijing Residents with and without Prediabetes: A Panel Study.

Genome-Wide DNA Methylation in Peripheral Blood and Long-Term Exposure to Source-Specific Transportation Noise and Air Pollution: The SAPALDIA Study.

Impact of environmental pollution and weather changes on the incidence of ST-elevation myocardial infarction.

Particulate Air Pollution and Progression to Kidney Failure With Replacement Therapy: An Advanced CKD Registry-Based Cohort Study in Taiwan.

Associations between Vehicle Exhaust Particles and Ozone at Home Address and Birth Weight.

Association between exposure to ambient air pollution and thyroid function in Korean adults.

Biomass Fuel Use and Cardiac Function in Nepali Women.

Influence of air pollutants on pneumonia hospitalizations among children in a town in the Brazilian Legal Amazon region: a time series study.

Indoor air pollution concentrations and cardiometabolic health across four diverse settings in Peru: a cross-sectional study.

The acute effects of short term exposure to particulate matter from natural and anthropogenic sources on inflammation and coagulation markers in healthy young adults.

Associations between green space and preterm birth: Windows of susceptibility and interaction with air pollution.

Hyperactivity disorder in children related to traffic-based air pollution during pregnancy.

Air Pollution and temperature are associated with increased COVID-19 incidence: a time series study.

Exposure to air pollution and COVID-19 mortality in the United States: A nationwide cross-sectional study.

Urban Air Pollution May Enhance COVID-19 Case-Fatality and Mortality Rates in the United States.

Assessing the relationship between surface levels of PM2.5 and PM10 particulate matter impact on COVID-19 in Milan, Italy.

Pharmaceuticals

“Idiopathic” partial androgen insensitivity syndrome in 11 grandsons of women treated by diethylstilbestrol during gestation: a multi-generational impact of endocrine disruptor contamination?

Mixtures

Residential Proximity to Oil and Gas Development and Birth Outcomes in California: A Retrospective Cohort Study of 2006-2015 Births.

Cancer Incidence Trends in the Oil Shale Industrial Region in Estonia.

Miscarriage, stillbirth, and infant death in an oil-polluted region of the Niger Delta, Nigeria: A retrospective cohort study.

Miscellaneous

Untargeted Metabolomics Screen of Mid-pregnancy Maternal Serum and Autism in Offspring.

Association of aldehydes exposure with obesity in adults.

Laboratory Studies

BPA/Phenols

BPA toxicity during development of zebrafish embryo.

Bisphenol A in utero exposure induces ovary dysfunction in mice offspring and the ameliorating effects of Cuscuta chinensis flavonoids.

Endocrine disruption: Molecular interactions of environmental bisphenol contaminants with thyroid hormone receptor and thyroxine-binding globulin.

Luteolin-Supplemented Diets Ameliorates Bisphenol A-Induced Toxicity in Drosophila melanogaster.

Bisphenol A Diglycidyl Ether (BADGE) and Bisphenol Analogs, but Not Bisphenol A (BPA), Activate the CatSper Ca2+ Channel in Human Sperm.

Bisphenol-A exposure induced neurotoxicity and associated with synapse and cytoskeleton in Neuro-2a cells.

A prominent environmental endocrine disruptor, 4-nonylphenol, promotes endometriosis development via plasmacytoid dendritic cells.

Toxic effects of perinatal maternal exposure to nonylphenol on lung inflammation in male offspring rats.

Phthalates

Prioritizing phthalate esters (PAEs) using experimental in vitro/vivo toxicity assays and computational in silico approaches.

Recovery of BDNF and CB1R in the Prefrontal Cortex Underlying Improvement of Working Memory in Prenatal DEHP-Exposed Male Rats after Aerobic Exercise.

Effect of di(2-ethylhexyl) phthalate on Nrf2-regulated glutathione homeostasis in mouse kidney.

Metabolism of mono-(2-ethylhexyl) phthalate in Arabidopsis thaliana: Exploration of metabolic pathways by deuterium labeling.

Parabens/Triclosan/Antimicrobials/Personal Care Products

Combined approaches for evaluation of xenoestrogen neural toxicity and thyroid dysfunction: Screening of oxido-nitrosative markers, DNA fragmentation, and biogenic amine degradation.

Toxic effects and transcriptome analyses of zebrafish (Danio rerio) larvae exposed to benzophenones.

Perinatal Exposure to Triclosan Results in Abnormal Brain Development and Behavior in Mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Development of Proliferative Response of Thymic Lymphocytes to T-Cell Mitogen in Rats Exposed to Endocrine Disrupter DDT during Ontogeny.

Downregulation of Acat1 by miR-21 may participate in liver fibrosis upon chronic DDT exposure.

Perfluoroalkyl Substances

Perfluoroctanoic acid (PFOA) enhances NOTCH-signaling in an angiogenesis model of placental trophoblast cells.

Time-dependent biomolecular responses and bioaccumulation of perfluorooctane sulfonate (PFOS) in Daphnia magna.

Flame Retardants

Evaluation of the Effect of Selected Brominated Flame Retardants on Human Serum Albumin and Human Erythrocyte Membrane Proteins.

The impact of oral exposure to low-dose tris(2-butoxyethyl) phosphate in allergic asthmatic mice.

Organotins

Triphenyltin chloride reduces the development of rat adrenal cortex during puberty.

Pesticides

TCP structure intensified the chlorpyrifos-induced decrease in testosterone synthesis via LH-LHR-PKA-CREB-Star pathway.

The protective role of spirulina and β-glucan in African catfish (Clarias gariepinus) against chronic toxicity of chlorpyrifos: hemato-biochemistry, histopathology, and oxidative stress traits.

Toxicity of deltamethrin to Eriocheir sinensis and the isolation of a deltamethrin-degrading bacterium, Paracoccus sp. P-2.

Altered phagocytic capacity due to acute exposure and long-term post-exposure to pesticides used for vector-borne disease as dengue.

Over-gene expression in the apoptotic, oxidative damage and liver injure in female rats exposed to butralin.

Impairment of postnatal epididymal development and immune microenvironment following administration of low doses of malathion during juvenile and peripubertal periods of rats.

Exposure to Oxadiazon-Butachlor causes cardiac toxicity in zebrafish embryos.

Potentially Toxic Elements

Neonatal exposure to aluminum chloride disrupts branching morphogenesis and hormonal signaling of the ventral male prostate and female prostate of gerbils.

Cadmium exposure during prenatal development causes progesterone disruptors in multiple generations via steroidogenic enzymes in rat ovarian granulosa cells.

Low Doses of Arsenic in a Mouse Model of Human Exposure and in Neuronal Culture Lead to S-Nitrosylation of Synaptic Proteins and Apoptosis via Nitric Oxide.

Inflammasome/NF-κB translocation inhibition via PPARγ agonist mitigates inorganic mercury induced nephrotoxicity.

Microplastics/Nanomaterials

Assessment of cancer risk of microplastics enriched with polycyclic aromatic hydrocarbons.

Microplastics Lead to Hyperactive Swimming Behaviour in Adult Zebrafish.

Nanoparticles: An Experimental Study of Zinc Nanoparticles Toxicity on Marine Crustaceans. General Overview on the Health Implications in Humans.

Air Pollution

In vitro genomic damage induced by urban fine particulate matter on human lymphocytes.

Effects of early life exposure to traffic-related air pollution on brain development in juvenile Sprague-Dawley rats.

Embryonic gene expression altered by maternal exposure to air pollution in rats.

PM2.5 Exposure Induces Inflammatory Response in Macrophages via the TLR4/COX-2/NF-κB Pathway.

The association of subchronic exposure to low concentration of PM2.5 and high-fat diet potentiates glucose intolerance development, by impairing adipose tissue antioxidant defense and eHSP72 levels.

Pharmaceuticals

Environmental estrogen exposure disrupts sensory processing and nociceptive plasticity in the cephalopod, Euprymna scolopes.

Mixtures

Interactive Effects of Perinatal BPA or DES and Adult Testosterone and Estradiol Exposure on Adult Urethral Obstruction and Bladder, Kidney, and Prostate Pathology in Male Mice.

Organic extract of indoor dust induces estrogen-like effects in human breast cancer cells.

Single and combined effects of carbamazepine and copper on nervous and antioxidant systems of zebrafish (Danio rerio).

Gammarid exposure to pyriproxyfen and/or cadmium: what effects on the methylfarnesoate signalling pathway?

In utero cadmium and dibutyl phthalate combination exposure worsens the defects of fetal testis in rats.

Oxidative stress and genotoxicity of co-exposure of chlorpyrifos and aflatoxin B1 in HepG2 cells.

Ecotoxicological assessment of effluents from Brazilian wastewater treatment plants using zebrafish embryotoxicity test: A multi-biomarker approach.

Structure-based discovery of the endocrine disrupting effects of hydraulic fracturing chemicals as novel androgen receptor antagonists.

Miscellaneous

The synthetic progestin norethindrone causes thyroid endocrine disruption in adult zebrafish.

Exposure/Environment Studies

BPA/Phenols

The presence of bisphenol A in the thermal paper in the face of changing European regulations – A comparative global research.

Phthalates

Migration regularity of phthalates in polyethylene wrap film of food packaging.

Phthalates levels in olive oils and olive pomace oils marketed in Turkey.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Trophic transfer of micropollutants and their metabolites in an urban riverine food web.

Eighty years of chemical exposure profiles of persistent organic pollutants reconstructed through baleen whale earplugs.

Perfluoroalkyl Substances

Perfluorinated compounds are not necessary: pegylated organosilanes can endow good water sliding/removal properties.

Levels of Perfluoroalkyl Acids (PFAAs) in Human Serum, Hair and Nails in Guangdong Province, China: Implications for Exploring the Ideal Bio-Indicator.

Per- and polyfluoroalkyl substances in blood plasma – Results of the German Environmental Survey for children and adolescents 2014-2017 (GerES V).

Pesticides

Levels and inhalation health risk of neonicotinoid insecticides in fine particulate matter (PM2.5) in urban and rural areas of China.

Serum concentrations of pesticides including organophosphates, pyrethroids and neonicotinoids in a population with osteoarthritis in Saudi Arabia.

Potentially Toxic Elements

Biomonitoring of Lead Exposure in Children from Two Fishing Communities at Northern Colombia.

Subsistence fish consumption in rural Alaska: Using regional monitoring data to evaluate risk and bioavailability of dietary methylmercury.

Accumulation of pollutants in proglacial lake sediments: Impacts of glacial meltwater and anthropogenic activities.

Potential human health hazard due to bioavailable heavy metal exposure via consumption of plants with ethnobotanical usage at the largest chromite mine of India.

Mercury Exposure Among Artisanal and Small-Scale Gold Miners in Four Regions in Uganda.

Interactions of Dimethylarsinic Acid, Total Arsenic and Zinc Affecting Rice Crop Management and Human Health in Cambodia.

Survey of Methylmercury Exposures and Risk Factors Among Indigenous Communities in Guyana, South America.

Heavy Metals Bioaccumulation and Health Risks with Associated Histopathological Changes in Clarias gariepinus from the Kado Fish Market, Abuja, Nigeria.

Mercury Exposure Associated with Use of Skin Lightening Products in Jamaica.

Risks of consuming cadmium-contaminated shellfish under seawater acidification scenario: Estimates of PBPK and benchmark dose.

Microplastics

Factors influencing the spatial and temporal distribution of microplastics at the sea surface – A year-long monitoring case study from the urban Kiel Fjord, southwest Baltic Sea.

Microplastic particle emission from wastewater treatment plant effluents into river networks in Germany: Loads, spatial patterns of concentrations and potential toxicity.

Air Pollution

Global Estimates and Long-Term Trends of Fine Particulate Matter Concentrations (1998-2018).

Drop in urban air pollution from COVID-19 pandemic: Policy implications for the megacity of São Paulo.

Changes in U.S. air pollution during the COVID-19 pandemic.

Mixtures

Assessing the mixture effects in in-vitro bioassays of chemicals occurring in small agricultural streams during rain events.

Miscellaneous

Micro QuEChERS-based method for the simultaneous biomonitoring in whole blood of 360 toxicologically relevant pollutants for wildlife.

Legacy and contaminants of emerging concern (CECs) in tree swallows along an agricultural to industrial gradient: Maumee River, Ohio.

Perceptions and Attitudes of Gynecologic and Pediatric Professionals Regarding Dietary Exposure to Chemical Pollutants.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.