EDC Science Weekly, June 28 – July 3, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week. Sending early this week due to the U.S. holiday tomorrow.

Contents: Events, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: Water pollution, health, and medicine’s duty to engage; plastics: what the clinician needs to know and can do about it; exposure to PFAS via fish exceeds safety thresholds; are “green” tires also chemically green?

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More science highlights

Events

July 12 and 31: Virtual symposium: Measuring Microplastics register for July 12; register for July 31 [NYU Langone Center for the Investigation of Environmental Hazards (CIEH)]

July 23 webinar: CHE Café: Protecting scientists from industry intimidation [Collaborative for Health and Environment (CHE)]

July 24 webinar: 3M’s decades-long cover-up of the “forever chemicals” in your blood [Beyond Plastics]

Sept. 23-24: Plastics and Human Health Symposium [NYU Center for the Investigation of Environmental Hazards (CIEH), save the date]

Oct. 14-16: 8th Annual meeting of the U.S. DOHaD Society: exploring translational DOHaD science: from cells to communities in Chapel Hill, NC [abstracts due Aug. 1]

Oct. 28: Swiss Symposium on Endocrine Disrupting Chemicals [Food Packaging Forum and ETH Zurich, save the date]

More events

Methods/Tools/Screening

Advancing toxicity studies of per- and poly-fluoroalkyl substances (pfass) through machine learning: Models, mechanisms, and future directions.

An in vitro model system for testing chemical effects on microbiome-immune interactions – examples with BPX and PFAS mixtures.

Commentaries

Downstream — Water Pollution, Health, and Medicine’s Duty to Engage

The Role of Plastics in Allergy, Immunology and Human Health: What the Clinician Needs to Know and Can Do About It.

The perfect pesticide?

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Climate change, microplastics, and male infertility.

Environmental, Metabolic, and Nutritional Factors Concerning Dementia in African-Americans and Hispanic Populations.

Revisiting the focal role of endostatin and environmental factors in Alzheimer’s disease.

Environmental factors affecting female fertility.

BPA/Phenols

Emerging regulatory roles of noncoding RNAs induced by bisphenol A (BPA) and its alternatives in human diseases.

Bisphenol A (BPA) and neurological disorders: An Overview.

PFAS

Human exposure to per- and polyfluoroalkyl substances (PFAS) via the consumption of fish leads to exceedance of safety thresholds.

Flame Retardants

A Review of the Association between Exposure to Flame Retardants and Thyroid Function

Metals/Metalloids

The association between heavy metal exposure and obesity: A systematic review and meta-analysis.

Toxic impacts of arsenic bioaccumulation on urinary arsenic metabolites and semen quality: A systematic and meta-analysis.

Impact of oxidative stress induced by heavy metals on ovarian function.

Microplastics/Nanomaterials

A comprehensive review of urban microplastic pollution sources, environment and human health impacts, and regulatory efforts.

Air Pollution

Air pollution accelerates the development of obesity and Alzheimer’s disease: the role of leptin and inflammation – a mini-review.

Environmental Pollution and Cardiovascular Disease: Part 1 of 2: Air Pollution. [also see Environmental Pollution and Cardiovascular Disease: Part 2 of 2: Soil, Water, and Other Forms of Pollution.]

Miscellaneous

Environmental fate of tire-rubber related pollutants 6PPD and 6PPD-Q: A Review.

Human Health Studies

Numerous Chemicals/Mixtures

Association of metals and bisphenols exposure with lipid profiles and dyslipidemia in Chinese adults: Independent, combined and interactive effects.

Adverse impact of phthalate and polycyclic aromatic hydrocarbon mixtures on birth outcomes: a metabolome Exposome-Wide Association Study.

BPA/Phenols

Association of urinary bisphenol A with hyperlipidemia and all-cause mortality: NHANES 2003-2016.

High Levels of BPA and BPF Exposure during Pregnancy Are Associated with Lower Birth Weight in Shenyang in Northeast China.

Phthalates

Common genetic variants associated with urinary phthalate levels in children: A genome-wide study.

Phthalate exposure and markers of biological aging: The mediating role of inflammation and moderating role of dietary nutrient intake.

Association Between Urinary Phthalate Metabolites and Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Mortality and cancer incidence in a population exposed to TCDD after the Seveso, Italy, accident (1976-2013).

Gestational exposure to organochlorine compounds and metals and infant birth weight: effect modification by maternal hardships.

The Role of Tissue Persistent Organic Pollutants and Genetic Polymorphisms in Patients with Benign and Malignant Kidney Tumors.

PFAS

Association of Vitamin D with Perfluorinated Alkyl Acids in Women with and without Non-Obese Polycystic Ovary Syndrome.

Exposure to per- and polyfluoroalkyl substances and alterations in plasma microRNA profiles in children.

Flame Retardants

[A panel study on the association of organophosphate ester flame retardant exposure with thyroid function related hormones in healthy older adults]. [in Chinese]

Pesticides

Associations between urine glyphosate levels and metabolic health risks: insights from a large cross-sectional population-based study

Association between pesticide exposure and thyroid function: analysis of Chinese and NHANES databases.

Metals/Metalloids

A Novel Approach to Assessing the Joint Effects of Mercury and Fish Consumption on Neurodevelopment in the New Bedford Cohort.

Microplastics/Nanomaterials

Detection and analysis of microplastics in tissues and blood of human cervical cancer patients.

Air Pollution

A causal relationship between particulate matter 2.5 and obesity and its related indicators: a Mendelian randomization study of European ancestry.

Disparities in air pollution attributable mortality in the US population by race/ethnicity and sociodemographic factors.

Miscellaneous

Associations between urinary hydroxylated polycyclic aromatic hydrocarbon biomarker concentrations and measures of timing of delivery and infant size at birth.

Association between polycyclic aromatic hydrocarbon exposure and cognitive performance in older adults: a cross-sectional study from NHANES 2011-2014.

Laboratory Studies

Numerous Chemicals/Mixtures

Mitigating effect of gallic acid on zinc oxide nanoparticles and arsenic trioxide-induced spermatogenesis suppression, testicular injury, hormonal imbalance, and immunohistochemical changes in rats.

Folliculogenesis and steroidogenesis alterations after chronic exposure to a human-relevant mixture of environmental toxicants spare the ovarian reserve in the rabbit model.

BPA/Phenols

Structural Studies on the Binding Mode of Bisphenols to PPARγ

Early-life bisphenol A exposure causes neuronal pyroptosis in juvenile and adult male rats through the NF-κB/IL-1β/NLRP3/caspase-1 signaling pathway: exploration of age and dose as effective covariates using an in vivo and in silico modeling approach.

Environmental endocrine disrupting chemical 4-tert-butylphenol induced calcium overload and subsequent autophagy impairment via miRNA-363/CACNA1D Axis in epithelioma papulosum cyprini cells.

Human in vitro percutaneous absorption of bisphenol S: Assessment of the skin reservoir and occlusion effects.

Phthalates

Prenatal exposure to an environmentally relevant phthalate mixture alters serum cytokine levels and inflammatory markers in the F1 mouse ovary.

Effects of BBIBP-CorV vaccine on gut microbiota and short-chain fatty acids in mice exposed to bis (2-ethylhexyl) phthalate and dioctyl terephthalate.

Concerted monoamine oxidase activity following exposure to di-2-ethylhexyl phthalate is associated with aggressive neurobehavioral response and neurodegeneration in zebrafish brain.

Vascular endothelial effects of dibutyl phthalate: in vitro and in vivo evidence.

Di-(2-ethylhexyl) phthalate promotes benign prostatic hyperplasia through KIF11-Wnt/β-catenin signaling pathway.

PFAS

Transcriptomic re-analyses of human hepatocyte spheroids treated with PFAS reveals chain length and dose-dependent modes of action.

Insights into the Enhanced Bioavailability of Per- and Polyfluoroalkyl Substances in Food Caused by Chronic Inflammatory Bowel Disease.

Exacerbated interfacial impacts of nanoplastics and 6:2 chlorinated polyfluorinated ether sulfonate by natural organic matter in adult zebrafish: Evidence through histopathology, gut microbiota, and transcriptomic analysis.

The VDAC1 oligomerization regulated by ATP5B leads to the NLRP3 inflammasome activation in the liver cells under PFOS exposure.

Binary and quaternary mixtures of perfluoroalkyl substances (PFAS) differentially affect the immune response to influenza A virus infection.

In vitro screening of understudied PFAS with a focus on lipid metabolism disruption.

Flame Retardants

Potential Adverse Outcome Pathways of Chlorinated Organophosphate Flame Retardants.

Effects of organophosphorus flame retardant EHDPP on mouse retinal photoreceptor cells: Oxidative stress, apoptosis, and proinflammatory response.

Triphenyl phosphate (TPP) exposure promotes proliferation and migration capabilities of gastric cancer cells: Insights from gene expression and pathway analysis.

Organotins

Subacute tributyltin exposure alters the development and morphology of mammary glands in association with CYP19A1 expression in female rats.

Pesticides

Structural gonadal lesions observed in Japanese quail (Coturnix coturnix japonica) following exposure during puberty to the neonicotinoid pesticide, imidacloprid.

Association of Atrazine-Induced Overexpression of Aldo-Keto-Reductase 1C2 (AKR1C2) with Hypoandrogenism and Infertility: An Experimental Study in Male Wistar Rat.

Chlorpyrifos induces autophagy by suppressing the mTOR pathway in immortalized GnRH neurons.

A single dose of clothianidin exposure induces varying sex-specific behavioral changes in adulthood depending on the developmental stage of its administration.

Resveratrol ameliorates cyprodinil-induced zebrafish cardiac developmental defects as an aryl hydrocarbon receptor antagonist.

Cardiotoxicity of the diamide insecticide chlorantraniliprole in the intact heart and in isolated cardiomyocytes from the honey bee.

Effects of chronic oral exposure to insecticide teflubenzuron on the midgut of the honey bee Apis mellifera workers: histopathological insights into pesticide toxicity.

Metals/Metalloids

Betaine ameliorates arsenic-induced kidney injury in mice by mitigating oxidative stress-mediated inflammation.

Microplastics/Nanomaterials

CuO nanoparticles elicit intestinal immunotoxicity in zebrafish based on intestinal microbiota dysbiosis.

The combined effects of polystyrene of different sizes and cadmium in mouse kidney tissues.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Are eco-friendly “green” tires also chemically green? Comparing metals, rubbers and selected organic compounds in green and conventional tires.

Mass spectrometry analysis of environmental pollutants in breast and artificial milk for newborns.

Phthalates

Urinary metabolite concentrations of phthalate and plasticizers in infancy and childhood in the UNC Baby Connectome Project.

PFAS

The Total Mass of Per- and Polyfluoroalkyl Substances (PFASs) in California Cosmetics.

Quantifying levels of per- and polyfluoroalkyl Substances (PFAS) in water and serum after contamination from agricultural biosolid application.

Chickens’ eggs and the livers of farm animals as sources of perfluoroalkyl substances.

Pesticides

Accelerated farmland bird population declines in European countries after their recent EU accession.

Microplastics/Nanomaterials

Release of microplastic fibers from synthetic textiles during household washing.

Microplastic ingestion in five demersal, bathydemersal and bathypelagic fish species from the eastern Weddell Sea, Antarctica.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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