EDC Science Weekly, June 27 – July 3, 2025

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

A Chapter Closes at Environmental Health Perspectives.
The Cost Outcome Pathway Framework: Integrating Socio-Economic Impacts to Adverse Outcome Pathways for Supporting Policy Makers.
Extensive analysis of pollutant interactions: Identification of deleterious synergistic effects at environmentally relevant doses
U.S. EPA Conference on the State of Science on Development and Use of NAMs for Chemical Safety Testing
Exposures to Contemporary and Emerging Chemicals among Children Aged 2 to 4 Years in the ECHO Cohort.

Science summaries and highlights

Events

July 8 webinar: Communicating about EDCs & Health: Why words matter [CHE]

July 15 webinar: Defend Our Health: Authors & Friends with Kristina Marusic and Dr. Rachel Criswell [Defend Our Health]

July 28-30: DOHaD summer course [Developmental Origins of Health and Disease (DOHaD) Society]

July 30 – Aug. 1 conference: U.S. DOHaD Society Annual Meeting

July 31 webinar: Excellent Alternatives to Plastic Packaging [Beyond Plastics]

Aug. 17 in-person workshop: How to conduct gold-star systematic reviews [PRHE, at the ISEE-ISES conference]

Sept. 15: ECHO symposium: translating science to action [hybrid] [NIH Environmental Influences on Child Health Outcomes (ECHO)]

Sept. 22-23 save the date: Second Annual Scientific Symposium on Plastics and Human Health [NYU Langone Health Center for the Investigation of Environmental Hazards (CIEH)]

Methods/Tools/Screening

U.S. EPA Conference on the State of Science on Development and Use of New Approach Methods (NAMs) for Chemical Safety Testing

Ways to broaden the awareness, consideration and adoption of new approach methodologies (NAMs).

The Cost Outcome Pathway Framework: Integrating Socio-Economic Impacts to Adverse Outcome Pathways for Supporting Policy Makers.

A Machine Learning Approach to Molecular Initiating Event Prediction Using High-Throughput Transcriptomic Chemical Screening Data.

In Vivo Screening Evaluation of 12 Chemicals as Candidate Endocrine Disruptors Using Ovariectomized Mouse Uterotrophic Bioassay

Commentaries

A Chapter Closes at Environmental Health Perspectives.

Unlocking the past: Release of hazardous contaminants into water from thawing permafrost.

Microplastics and Nanoplastics and the Digestive System.

Plastics in health care: rethinking medical device innovation, use, and disposal for sustainability. [editorial in The Lancet re three articles, Can plastic waste from point-of-care diagnostics be reduced? Do medical masks have to be disposable? and Why are plastic syringes not being recycled?]

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

The Chemical Exposome on Ovarian Aging in Adult Women: a Narrative Review.

Estrogenic endocrine disruptors and cancer: a narrative review.

Relationship between endocrine disruptors and neurodegenerative diseases: Systematic review and meta-analysis.

Maternal exposure to specific endocrine-disrupting chemicals and gestational diabetes mellitus: systematic review and meta-analysis.

BPA/Phenols

The Silent Threat of BPA: Its Pervasive Presence and Impact on Reproductive Health.

PFAS

Human exposure and toxicity of per- and polyfluoroalkyl substances: Narrative review and perspectives.

Association between prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the incidence of infant and childhood respiratory infections: A systematic review.

Pesticides

Health risk resulting from pesticide residues in food of plant origin – a still valid challenge for health and ecological education.

Neurotoxic risks of long-term environmental exposure to pesticides: a review.

Microplastics/Nanomaterials

Risk Assessment of Microplastics in Humans: Distribution, Exposure, and Toxicological Effects.

From Harm to Hope: Tackling Microplastics’ Perils with Recycling Innovation.

Biosphere Plastic Contamination and Microbial Alternatives for a Sustainable Degradation of Plastic Waste.

Polystyrene microplastics (PS-MPs): A Review on metabolic disruptions and potential obesogenic implications using -omics approaches based evidences on zebrafish model.

Intestinal microplastic debris, flora dysbiosis, and insidious combined hazards across diverse aquatic and terrestrial organisms.

Miscellaneous

Next-Generation Bioplastics for Food Packaging: Sustainable Materials and Applications.

Risk assessment of tire wear in the environment – a literature review.

Human Health Studies

Numerous Chemicals/Mixtures

In utero exposure to a mixture of phthalates, parabens, and other phenols and menstrual cycle characteristics in adolescents.

Associations between prenatal exposure to a mixture of lead, mercury and polychlorinated biphenyls and executive function in Inuit adolescents.

Phthalates

Association of the Ratio of Second to Fourth Digit Length and Phthalate Exposure With Sexual Function in Japanese Men Seeking Fertility Treatment.

Parabens/Triclosan/Antimicrobials

Urinary parabens, advanced glycation end products and blood pressure in children: a longitudinal cohort study.

Association of urine parabens with liver function in US adolescents based on NHANES 2007-2016

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Association between in utero exposure to organochlorine pesticides and steroids in cord blood.

Mortality of individuals in a long-term cohort exposed to polybrominated biphenyls (PBBs).

PFAS

Modifying effects of vitamin D on associations between per- and polyfluoroalkyl substances exposure and risk of gestational diabetes mellitus: A prospective cohort study in Beijing, China.

Temporal changes in per and polyfluoroalkyl substances and their associations with type 2 diabetes.

Associations of prenatal per- and polyfluoroalkyl substances with whole blood folate levels in pregnant women in the Health Outcomes and Measures of the Environment (HOME) Study.

Per- and Polyfluoroalkyl Substances, Serum Lipidome, and Clinical Outcomes after Percutaneous Coronary Intervention in Type 2 Diabetic Patients: A Prospective Nested Case-control Study.

Impact of Per- and Polyfluoroalkyl Substances Exposure on Renal Dysfunction: Integrating Epidemiological Evidence with Mechanistic Insights.

Associations between per- and polyfluoroalkyl substance exposure and the prevalence of myopia in adolescents: the mediating role of serum albumin.

An assessment of maternal concentrations of per- and polyfluoroalkyl substances (PFAS) and trace elements during the second trimester of pregnancy in western Pennsylvania

Flame Retardants

The significance of organophosphate flame retardants in patients with esophageal squamous cell carcinoma.

Effect of the exposure to brominated flame retardants on hyperuricemia using interpretable machine learning algorithms based on the SHAP methodology.

Pesticides

Impact of prenatal and childhood exposure to pyrethroids and chlorpyrifos on motor skills in 7-year-old children from the Odense Child Cohort.

Occupational pesticide exposure and cognitive impairment among adult farmers in northern Thailand.

Distribution and Differential Associations of Neonicotinoids and Their Metabolites in Paired Urine and Serum with Liver Function.

Metals/Metalloids

Role of low-dose cadmium exposure to the pathogenesis of gestational diabetes mellitus.

Lifetime Water Arsenic, Genetic Susceptibility, And Bladder Cancer In The New England Bladder Cancer Study.

Milk intake reduced the prevalence of hypertension by decreasing total arsenic levels in fasting serum in Japanese residents.

Microplastics/Nanomaterials

Impact of urinary microplastic exposure on cognitive function in primary school children.

Exposure to placental microplastic and placental and umbilical cord blood telomere length.

Associations between microplastics in human feces and colorectal cancer risk.

Pharmaceuticals/Personal Care Products

Associations of pharmaceutical and personal care product chemical exposure with thyroid nodules and thyroid homeostasis.

Miscellaneous

Prenatal melamine, aromatic amine, and psychosocial stress exposures and their association with gestational diabetes mellitus in a San Francisco pregnancy cohort.

Associations between urinary polycyclic aromatic hydrocarbons and glycometabolic markers and potential mechanisms in healthy older adults: The China BAPE study.

Laboratory Studies

Numerous Chemicals/Mixtures

Extensive analysis of pollutant interactions: Identification of deleterious synergistic effects at environmentally relevant dose levels using Drosophila and mammalian cells.

Oxidative Stress in Zebrafish Gut Induced by Individual and Combined Exposure to Amoxicillin, Arsenic and Fluoride: Engagement of Nrf2-Keap1-ARE Pathway.

RNA-Seq Uncovers Association of Endocrine-Disrupting Chemicals with Hub Genes and Transcription Factors in Aggressive Prostate Cancer.

Genomic evidence based on EQTL data implicates endocrine disruptors as environmental risk factors for estrogen receptor-positive breast cancer.

Unveiling the integrated toxicological effects and underlying mechanisms of bisphenol A and cadmium, two hormesis-type endocrine disruptors, on Chromochloris zofingiensis.

BPA/Phenols

Integrated Network Toxicology and Experimental Validation Reveal the Mechanism of Bisphenol A-Induced Kidney Injury: Targeting Macrophage Esr1 Expression and Apoptosis.

High-Throughput Screening Identifies Bisphenol P as a Potent Cardiotoxin, Inducing Cardiotoxicity through Apoptosis and the NF-κB Pathway.

Exposure to Bisphenol S promotes renal damage via aryl hydrocarbon receptor and NF-κB pathways in a mice model of obesity.

Assessing the impact of 4-nonylphenol and 17β-estradiol on growth, steroidogenesis and vitellogenin expression in juvenile manila clams: Implications for endocrine disruption.

Phthalates

Impact of prenatal Di(2-ethylhexyl) phthalate exposure on pubertal development in female offspring rats: A focus on ERα-Mediated IGF-1/NKB crosstalk in the hypothalamus.

Comparison of in utero phthalate exposure on fetal rat testis transcript and endocrine alterations with apical reproductive alterations in male rats.

Diethylhexyl phthalate exposure promotes mitophagy through Drp1-mediated mitochondrial fission in neural crest cells of chick embryos.

Transcriptomic and network toxicology approaches reveal potential mechanisms of DEHP induced intrahepatic cholestasis during pregnancy

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Chronic exposure to organochlorine pesticide mixture induces type 2 diabetes mellitus-associated metabolic dysregulation in C57BL/6J mice.

PFAS

Single cell RNA sequencing reveals the reshaping effect of perfluorooctanoic acid on the intestinal microenvironment of mice.

Mitochondrial and inflammatory dysfunctions underlie perfluorooctane sulfonic acid (PFOS)-induced neurotoxicity in adult zebrafish.

Enhanced Ecological Risk of PFOA Degradation Products: Insights from Concentration-Dependent Transcriptomics, Adverse Outcome Pathways, and Biomarker Verification.

Elucidating environmental fate and toxicological mechanisms of ultrashort- and short-chain PFAS: Integrating machine learning, molecular modeling, and experimental validation.

Adapting Existing Toxicokinetic Models to Relate Perfluoroalkyl and Polyfluoroalkyl Intake to Biomarkers in Humans.

Network toxicology and immune-metabolic dysregulation: linking per- and polyfluoroalkyl substances exposure to osteoarthritis pathogenesis.

Exposure to “Forever Chemical” perfluorooctanoic acid induces depression-like behaviors in mice by activating the HPA axis.

Multi-level evidence reveals PANK2 as a potential target of PFOA/PFOS-induced bone metabolism disruption: From network toxicology to in vitro validation.

Gestational and Lactational Exposure to Perfluorohexanoic Acid Affects Behavior in Adult Male Mice: A Preliminary Study.

Apical effects of simulated maternal exposure of salmonid fishes to novel and typical per- and polyfluoroalkyl substances

Flame Retardants

Brominated Flame Retardants Exposure Promotes the Formation of Atherosclerotic Plaque in Aortic Roots of ApoE ^-/- Mice by Increasing Macrophage Recruitment and Foam Cell Formation.

Tris (1,3-dichloro-2-propyl) phosphate (TDCPP) aggravates Parkinson’s disease neurotoxicity through ferroptosis-related oxidative stress and neuroinflammation.

Exposure to tris(2,4-di-tert-butylphenyl) phosphate during adolescence induces testicular toxicity in mice: Autophagy-apoptosis interplay.

Exposure to BDE-209 triggers necroptosis by activating the JAK2/STAT3 signaling pathway, thereby exacerbating neuroinflammation.

Pesticides

Reproductive toxicity of glyphosate and its main metabolite aminomethyl phosphonic acid (AMPA) on zebrafish (Danio rerio).

Glyphosate and AMPA-Induced Apoptosis and Epigenetic Alterations in HepG2 Cells: Upregulation of p53-BAX-CASP Pathways.

Chronic exposure to low concentration of metamifop induces Reproductive Endocrine Disruption and Courtship behavior disorders in zebrafish (Danio rerio).

Metals/Metalloids

Mitigation effect of grape seed extract against cadmium-induced hormonal toxicity in common carp (Cyprinus carpio).

Microplastics/Nanomaterials

Polystyrene nanoplastics act as endocrine disruptors altering neurotransmitter levels and locomotor activity via estrogen receptor during early zebrafish development.

Effects of Polystyrene Nanoplastics on the Female Reproductive System in Mice: Implications for Ovarian Function and Follicular Development.

Impact of Environmental Microplastic Exposure on Caco-2 Cells: Unraveling Proliferation, Apoptosis, and Autophagy Activation.

Exploring the combined toxic effects of tri-n-butyl phosphate and polystyrene micro/nano-plastics on Daphnia magna under environmentally relevant concentrations.

Chronic Exposure to Microplastics Induces Blood-Brain Barrier Impairment, Oxidative Stress, and Neuronal Damage in Rats.

Oral exposure to PET microplastics induces the pancreatic immune response and oxidative stress in immature pigs.

Microplastics induce insulin resistance by causing mitochondrial dysfunction associated with mROS in skeletal muscle in vitro.

Early-life exposure to polypropylene nanoplastics induces neurodevelopmental toxicity in mice and human iPSC-derived cerebral organoids.

Pharmaceuticals/Personal Care Products

Biodegradation of progesterone and norgestrel in wastewater by functional bacterial gels: Perspectives from simultaneous reduction of transformation products and endocrine disrupting effects.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Exposures to Contemporary and Emerging Chemicals among Children Aged 2 to 4 Years in the United States Environmental Influences on the Child Health Outcome (ECHO) Cohort.

Dietary patterns and exposure to non-persistent endocrine-disrupting chemicals during pregnancy.

Exposure to mercury and polychlorinated biphenyls affects the thyroid function of an Australian seabird (Ardenna carneipes).

Phthalates

Characterization of phthalate esters (PAEs) in urban water supply system: PAE-degrading bacteria existed in the pipeline biofilm.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Peatland fires in Peninsular Malaysia act as primary source of dioxins, dioxin-like polychlorinated biphenyl, and particulate matter.

Chlorinated paraffins in plasma of healthy elderly adults: Method development, temporal variability, and exposure determinants.

PFAS

Multi-site study of communities with PFAS-contaminated drinking water: Methods, demographics, and PFAS serum concentrations.

Evidence mapping and scoping review of pathways for potential dietary exposure to per- and poly-fluoroalkyl substances (PFAS).

PFAS in drinking water, wastewater and surface water in Reykjavik, Iceland.

Polyfluoroalkyl substances in dedicated hazardous waste incinerators: Framework and industrial scale experimental estimation of destruction and removal efficiency.

Strong bioaccumulation of a wide variety of PFAS in a contaminated terrestrial and aquatic ecosystem.

Wide scope screening and target quantification of per- and polyfluoroalkyl substances (PFAS) in feed and feed ingredients to farmed salmonids.

PFAS in the Buzz: Seasonal Biomonitoring with Honey bees (Apis mellifera) and Bee-collected Pollen.

Pesticides

Pesticide exposure as prenatal exposome: A biomonitoring study in pregnant women from Argentina.

Evaluation of Pesticide Residues in Greenhouse Workers’ Blood Serum Using QuEChERS-UHPLC-MS/MS Method and Associated Health Risks.

Pyrethroid insecticides implicated in mass mortality of monarch butterflies at an overwintering site in California.

Availability and acute risk to birds of maize, sorghum, and soybean seeds treated with neonicotinoids.

Microplastics/Nanomaterials

Are we eating microplastics with our staple food? A pioneering study of microplastic contamination in store-bought rice and cooked rice in Bangladesh.

Mass and fate estimates of plastic waste dispersed globally to marine and terrestrial environments by three major corporations.

Microplastic contamination is widespread across invertebrate taxa frequently consumed by terrestrial vertebrates

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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Sarah Howard | she/her
HEEDS Program Manager
Environmental Health Sciences
showard@ehsciences.org
EHSciences.org
HEEDS.org