EDC Science Weekly, June 24 – 30, 2020

Post author:HEEDS
Post published:June 30, 2020
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Upcoming Webinars, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Upcoming Webinars

Endocrine Disrupting Chemicals and Metabolic Disruption July 1

Disparities and Cancer July 22

Agents of Change: Amplifying voices of future leaders in environmental health and justice July 30

Methods/Tools/Screening

A cross-platform approach to characterize and screen potential neurovascular unit toxicants.

Toward an AOP network-based tiered testing strategy for the assessment of thyroid hormone disruption.

Commentaries/Conference Summaries

Finding the Right Fit: Highly Selective Binding by the Thyroid Hormone Receptor. [Science Selection in Environmental Health Perspectives]

Microplastic in terrestrial ecosystems. [Perspective in Science]

Where Is the Evidence That Human Exposure to Microplastics Is Safe?

Go slow to go fast: A plea for sustained scientific rigor in air pollution research during the COVID-19 pandemic.

Clinical Epidemiology Studies on Potential Effects of Endocrine Disrupting Chemicals (EDCs) Should Exclude Subjects With Obesity as Determined by BMI

Reviews

Numerous EDCs

Is There a Role for Environmental and Metabolic Factors Predisposing to Severe COVID-19?

Lizards as model organisms to evaluate environmental contamination and biomonitoring.

Mixtures

Identification of component-based approach for prediction of joint chemical mixture toxicity risk assessment with respect to human health: A critical review.

Chemical Mixtures and Neurobehavior: A Review of Epidemiologic Findings and Future Directions

BPA/Phenols

Bisphenol A and Male Fertility: Myths and Realities

Bisphenols and Male Reproductive Health: From Toxicological Models to Therapeutic Hypotheses .

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Ah Receptor Ligands and Their Impacts on Gut Resilience: Structure-Activity Effects

Pesticides

Impact of Pesticide Exposure in Childhood

Pesticides and Herbicides.

Known Target and Non-target Effects of the Novel Neonicotinoid Cycloxaprid to Arthropods: A Systematic Review.

Influence of pesticides on respiratory pathology – a literature review.

Pesticide Residues in Honey and Their Potential Reproductive Toxicity

Potentially Toxic Elements

Counteracting arsenic toxicity: Curcumin to the rescue?

Lead Toxicity and Pollution in Poland.

Cadmium Exposure and Risk of Breast Cancer: A Dose-Response Meta-Analysis of Cohort Studies

Microplastics

Global trends and prospects in microplastics research: A bibliometric analysis.

Microplastics Exposure Routes and Toxicity Studies to Ecosystems: An Overview.

Are we underestimating the sources of microplastic pollution in terrestrial environment?

Air Pollution

Food chemoprevention and air pollution: the health comes with eating.

Health Effects of Asian Dust: A Systematic Review and Meta-Analysis.

Health effects of air pollution: a Southern European perspective.

Climate change, air pollution, and allergic respiratory diseases: a call to action for health professionals.

Short-term exposure to particulate matter (PM10 and PM2.5), nitrogen dioxide (NO2), and ozone (O3) and all-cause and cause-specific mortality: Systematic review and meta-analysis.

Attributable Risk to Assess the Health Impact of Air Pollution: Advances, Controversies, State of the Art and Future Needs.

Air Pollution and Covid-19: The Role of Particulate Matter in the Spread and Increase of Covid-19’s Morbidity and Mortality.

Pharmaceuticals

Poor And Unsatisfactory Disposal Of Expired And Unused Pharmaceuticals: A Global Issue.

Miscellaneous

Polycyclic Aromatic Compounds (PACs) in the Canadian Environment: Exposure and Effects on Wildlife

Human Health Studies

Numerous Chemicals

Early-Life Environmental Exposures and Childhood Obesity: An Exposome-Wide Approach. [air pollution, POPs, metals, phthalates, phenols, pesticides, smoking, built environment, etc.]

BPA/Phenols/Parabens

Maternal prenatal urinary bisphenol A level and child cardio-metabolic risk factors: A prospective cohort study.

Determination of urinary carnitine levels as a potential indicator of uterine fibroids caused by nonylphenol exposure.

Association of bone mineral density with nine urinary personal care and consumer product chemicals and metabolites: A national-representative, population-based study. [BPA, phenols, parabens]

Perfluoroalkyl Substances

A case-control study of perfluoroalkyl substances and the risk of breast cancer in Taiwanese women.

Perfluoroalkyl acids, hyperuricemia and gout in adults: Analyses of NHANES 2009-2014.

Maternal exposure to environmental endocrine disruptors during pregnancy is associated with pediatric germ cell tumors.

Pesticides

Prenatal Maternal Organophosphorus Pesticide Exposures, Paraoxonase 1, and Childhood Adiposity in the Mount Sinai Children’s Environmental Health Study

Insecticide use and risk of non-Hodgkin lymphoma subtypes: a subset meta-analysis of the North American Pooled Project.

Environmental and Occupational Risk Factors Associated with Chronic Kidney Disease of Unknown Etiology in West Javanese Rice Farmers, Indonesia.

Potentially Toxic Elements

Cadmium Is Associated With Type 2 Diabetes in a Superfund Site Lead Smelter Community in Dallas, Texas

Evaluation of different types of arsenic methylation and its relationship with metabolic syndrome in an area chronically exposed to arsenic.

Executive Functions in School Children From Montevideo, Uruguay and Their Associations With Concurrent Low-Level Arsenic Exposure

Arsenic exposure associated T cell proliferation, smoking, and vitamin D in Bangladeshi men and women.

Chronic kidney disease of unknown origin is associated with environmental urbanisation in Belfast, UK.

Low-level maternal exposure to cadmium, lead, and mercury and birth outcomes in a Swedish prospective birth-cohort.

Air Pollution

Adverse birth outcomes in Victoria, Australia in association with maternal exposure to low levels of ambient air pollution.

Prenatal Particulate Air Pollution Exposure and Expression of the miR-17/92 Cluster in Cord Blood: Findings From the ENVIRONAGE Birth Cohort

Quantile regression analysis of the socioeconomic inequalities in air pollution and birth weight.

Integrated study of genotoxicity biomarkers in schoolchildren and inhalable particles in areas under petrochemical influence.

Sub-Daily Exposure to Fine Particulate Matter and Ambulance Dispatches during Wildfire Seasons: A Case-Crossover Study in British Columbia, Canada.

Prenatal and postnatal exposures to ambient air pollutants associated with allergies and airway diseases in childhood: A retrospective observational study.

Prospective Association of Air-Purifier Usage during Pregnancy with Infant Neurodevelopment: A Nationwide Longitudinal Study-Japan Environment and Children’s Study (JECS).

Long-term exposure to air pollution and stroke incidence: A Danish Nurse cohort study.

Long-term exposure to ambient source-specific particulate matter and its components and incidence of cardiovascular events – The Heinz Nixdorf Recall study.

Association between ambient particulate matter (PM10) and incidence of diabetes in northwest of China: A prospective cohort study.

Effects of meteorological conditions and air pollution on COVID-19 transmission: Evidence from 219 Chinese cities.

Miscellaneous

An approach to estimating the environmental burden of cancer from known and probable carcinogens: application to Ontario, Canada.

Placental Levels of Polycyclic Aromatic Hydrocarbons (PAHs) and Their Association With Birth Weight of Infants

Laboratory Studies

BPA/Phenols

Mechanistic in silico modeling of bisphenols to predict estrogen and glucocorticoid disrupting potentials.

Bisphenol A induces Agrp gene expression in hypothalamic neurons through a mechanism involving ATF3.

Linoleic acid promotes testosterone production by activating Leydig cell GPR120/ ERK pathway and restores BPA-impaired testicular toxicity.

Chronic Exposure of Adult Male Wistar Rats to Bisphenol A Causes Testicular Oxidative Stress: Role of Gallic Acid

Phthalates

Maternal exposure to Di-(2-ethylhexyl) phthalate (DEHP) activates the PI3K/Akt/mTOR signaling pathway in F1 and F2 generation adult mouse testis.

The gut-microbiota-testis axis mediated by the activation of the Nrf2 antioxidant pathway is related to prepuberal steroidogenesis disorders induced by di-(2-ethylhexyl) phthalate.

Human Erythrocytes Exposed to Phthalates and Their Metabolites Alter Antioxidant Enzyme Activity and Hemoglobin Oxidation

Parabens/Triclosan/Antimicrobials

Triclosan has a robust, yet reversible impact on human gut microbial composition in vitro.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Developmental polychlorinated biphenyl exposure influences adult zebra finch reproductive behaviour.

Incubation temperature and PCB-126 exposure interactively impair shorebird embryo and post-hatch development.

Perfluoroalkyl Substances

Perfluorooctanoic acid activates the unfolded protein response in pancreatic acinar cells.

Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorononanoic acid (PFNA) increase triglyceride levels and decrease cholesterogenic gene expression in human HepaRG liver cells.

Toxicity of Balb-C Mice Exposed to Recently Identified 1,1,2,2-Tetrafluoro-2-[1,1,1,2,3,3-hexafluoro-3-(1,1,2,2-tetrafluoroethoxy)propan-2-yl]oxyethane-1-sulfonic acid (PFESA-BP2).

Flame Retardants

Formation of polybrominated dibenzofurans (PBDFs) and polybrominated diphenyl ethers (PBDEs) from oxidation of brominated flame retardants (BFRs).

Organotins

Histological and Behavioral Toxicity of Tributyltin in the Tropical Guppy Poecilia vivipara.

Pesticides

Impact of pesticide coexposure: an experimental study with binary mixtures of lambda-cyhalothrin (LCT) and captan and its impact on the toxicokinetics of LCT biomarkers of exposure.

Detrimental effects of temephos on male fertility: an in vitro study on a mouse model.

Absence of glyphosate-induced effects on ovarian folliculogenesis and steroidogenesis.

Sleep in Honey Bees Is Affected by the Herbicide Glyphosate

Phosmet bioactivation by isoform-specific cytochrome P450s in human hepatic and gut samples and metabolic interaction with chlorpyrifos.

Neurotoxicity assessment of triazole fungicides on mitochondrial oxidative respiration and lipids in differentiated human SH-SY5Y neuroblastoma cells.

Neonatal Exposure to a Glyphosate-Based Herbicide Alters the Uterine Differentiation of Prepubertal Ewe Lambs

Acute and Chronic Toxicity of Deltamethrin, Permethrin, Dihaloacetylated Heterocyclic Pyrethroids in Mice

Potentially Toxic Elements

Effect of lead exposure and nutritional iron-deficiency on immune response: A vaccine challenge study in rats.

Chronic cadmium exposure causes oocyte meiotic arrest by disrupting spindle assembly checkpoint and maturation promoting factor.

Influence of Prenatal Exposure to Mercury, Perceived Stress, and Depression on Birth Outcomes in Suriname: Results from the MeKiTamara Study.

Aluminum exposure promotes histopathological and pro-oxidant damage to the prostate and gonads of male and female adult gerbils.

In Vitro Administration of Sodium Arsenite in Mouse Prepubertal Testis Induces Germ Cell Loss and Apoptosis

Chronic and Acute Arsenic Exposure Enhance EGFR Expression via Distinct Molecular Mechanisms

Microplastics

Microplastics negatively impact embryogenesis and modulate the immune response of the marine medaka Oryzias melastigma.

Acute and chronic effects of polystyrene microplastics on brine shrimp: First evidence highlighting the molecular mechanism through transcriptome analysis.

Effects of microplastics and their adsorption of cadmium as vectors on the cladoceran Moina monogolica Daday: Implications for plastic-ingesting organisms.

Strong Influence of Surfactants on Virgin Hydrophobic Microplastics Adsorbing Ionic Organic Pollutants

Air Pollution

Chronic exposure to diesel exhaust particulate matter impairs meiotic progression during spermatogenesis in a mouse model.

Short-term exposure to air pollution (PM2.5) induces hypothalamic inflammation, and long-term leads to leptin resistance and obesity via Tlr4/Ikbke in mice.

Filtered air intervention reduces inflammation and hypothalamus-pituitary-adrenal axis activation in adult male and female rats after PM 2.5 exposure.

Mitochondrial alterations triggered by repeated exposure to fine (PM2.5-0.18) and quasi-ultrafine (PM0.18) fractions of ambient particulate matter.

Pharmaceuticals

Effect of short-term intermittent exposure to waterborne estradiol on the reproductive physiology of the round goby (Neogobius melanostomus).

Protective effect of a polyherbal bioactive fraction in propylthiouracil-induced thyroid toxicity in rats by modulation of the hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal axes.

Altered Biology of Testicular VSELs and SSCs by Neonatal Endocrine Disruption Results in Defective Spermatogenesis, Reduced Fertility and Tumor Initiation in Adult Mice. [DES]

Responses of Hydrocharis dubia (Bl.) Backer and Trapa bispinosa roxb. to tetracycline exposure.

Mixtures

Grouping of endocrine disrupting chemicals for mixture risk assessment – Evidence from a rat study. [BPA, phthalate, paraben, etc.]

Immunotoxicity of petroleum hydrocarbons and microplastics alone or in combination to a bivalve species: Synergic impacts and potential toxication mechanisms.

Modulation of Paraoxonase-1 and Apoptotic Gene Expression Involves in the Cardioprotective Role of Flaxseed Following Gestational Exposure to Diesel Exhaust Particles and/or Fenitrothion Insecticide.

Antagonistic effects of multi-walled carbon nanotubes and BDE-47 in zebrafish (Danio rerio): Oxidative stress, apoptosis and DNA damage.

Effects of multiwalled carbon nanotubes co-exposure with cadmium on zebrafish cell line: Metal uptake and accumulation, oxidative stress, genotoxicity and cell cycle.

Will temperature rise change the biochemical alterations induced in Mytilus galloprovincialis by cerium oxide nanoparticles and mercury?

Analysis of search strategies for evaluating low-dose heavy metal mixture induced cognitive deficits in rats: An early sensitive toxicological approach.

Toxicity of binary mixtures of Cu, Cr and As to the earthworm Eisenia andrei.

Joint Effects of Cadmium and Copper on Apis Mellifera Forgers and Larvae

Diazepam, metformin, omeprazole and simvastatin: a full discussion of individual and mixture acute toxicity. [all pharmaceuticals]

Miscellaneous

Benzo[a]pyrene induces microbiome dysbiosis and inflammation in the intestinal tracts of western mosquitofish (Gambusia affinis) and zebrafish (Danio rerio).

Mapping the Mitochondrial Regulation of Epigenetic Modifications in Association With Carcinogenic and Noncarcinogenic Polycyclic Aromatic Hydrocarbon Exposure.

Exposure/Environment Studies

BPA/Phenols

A Prospective Cohort Study of Bisphenol A Exposure from Dental Treatment.

Phthalates

Sources of Exposure to Urinary Phthalates Among Couples Undergoing Infertility Treatment

Parabens

Urinary Concentrations of Parabens in a Population of Iranian Adolescent and Their Association with Sociodemographic Indicators.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Sources of polychlorinated biphenyls to Upper Hudson River sediment post-dredging.

Evaluating polymeric sampling as a tool for predicting the bioaccumulation of polychlorinated biphenyls by fish and shellfish.

Polychlorinated biphenyls in settled dusts from an end-of-life vehicle processing area and normal house dusts in northern Vietnam: Occurrence, potential sources, and risk assessment.

Polybrominated dibenzo-p-dioxins and furans (PBDD/Fs) in Italian food: Occurrence and dietary exposure.

Perfluoroalkyl Substances

Temporal and spatial analysis of per and polyfluoroalkyl substances in surface waters of Houston ship channel following a large-scale industrial fire incident.

Occurrence of Legacy and Emerging Organic Contaminants in Snow at Dome C in the Antarctic [PFAS, organophosphates, PAHs]

Flame Retardants

A broad range of organophosphate tri- and di-esters in house dust from Adelaide, South Australia: Concentrations, compositions, and human exposure risks.

Characterization and health risk assessment of organophosphate esters in indoor dust from urban and rural domestic house and college dormitory in Nanjing, China.

Occurrence and partitioning of brominated flame retardants (BFRs) in indoor air and dust: a 15-month case study in a test home.

Temporal Trends in Polybrominated Diphenylethers (PBDEs) in Blubber of Ringed Seals (Pusa Hispida) From Ulukhaktok, NT, Canada Between 1981 and 2015

Pesticides

Occurrence of the insecticide fipronil and its degradates in indoor dust from South, Central, and North China.

Five degradates of imidacloprid in source water, treated water, and tap water in Wuhan, central China.

Pesticides Hazardous Hotspots: Empirical Evidences from North India.

Long-term effects of neonicotinoid insecticides on ants.

Analysis of triazines, triazoles, and benzimidazoles used as pesticides in different environmental compartments of the Formoso River and their influence on biodiversity in Tocantins.

Potentially Toxic Elements

Risk Assessment of Lead and Cadmium in Drinking Water for School use in Nakhon Si Thammarat Province, Thailand.

Arsenic in US correctional facility drinking water, 2006-2011.

Total mercury and methylmercury in rice: Exposure and health implications in Bangladesh.

Essential and toxic elements in human milk concentrate with human milk lyophilizate: A preclinical study.

Trace Elements in Breakfast Cereals and Exposure Assessment in Moroccan Population: Case of Lead and Cadmium.

Terrestrial mercury transformation in the Tibetan Plateau: New evidence from stable isotopes in upland buzzards.

Body mass, mercury exposure, biochemistry and untargeted metabolomics of incubating common eiders (Somateria mollissima) in three Baltic colonies.

Mercury isotopes as tracers of ecology and metabolism in two sympatric shark species.

Mercury concentrations in reared Atlantic bluefin tuna and risk assessment for the consumers: To eat or not to eat?

Resolving Atmospheric Mercury Loading and Source Trends From Isotopic Records of Remote North American Lake Sediments

Effect of toxic trace element detoxification, body fat reduction following four-week intake of the Wellnessup diet: a three-arm, randomized clinical trial.

Occupational Exposure of Foundry Workers Assessed by the Urinary Concentrations of 18 Elements and Arsenic Species

Anthropogenic Gadolinium in Freshwater and Drinking Water Systems

Microplastics

Plastics everywhere: first evidence of polystyrene fragments inside the common Antarctic collembolan Cryptopygus antarcticus

Freshwater insects of different feeding guilds ingest microplastics in two Gulf of Guinea tributaries in Nigeria.

The role of wet wipes and sanitary towels as a source of white microplastic fibres in the marine environment.

Distribution and characteristics of microplastics in the Yulin River, China: Role of environmental and spatial factors.

Air Pollution

Decline in PM2.5 concentrations over major cities around the world associated with COVID-19.

Exposure Assessment of Indoor Particulate Matter During Pregnancy: A Narrative Review of the Literature

Mixtures

Impact of Endocrine Disruptors on Vitellogenin Concentrations in Wild Brown Trout (Salmo trutta trutta).

Direct Evidence of Poison-Driven Widespread Population Decline in a Wild Vertebrate

First Observations of Intersex Development in Paddlefish Polyodon Spathula

Miscellaneous

Blood partitioning and whole-blood-based maternal transfer assessment of chlorinated paraffins in mother-infant pairs from South China.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.