EDC Science Weekly, June 13-18, 2025

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week. Sending a day early due to the Juneteenth U.S. holiday tomorrow.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: Systematic Evidence Map for the Per- and Polyfluoroalkyl Substances (PFAS) Universe.

Science summaries and highlights

Events

June 19 webinar: Key areas of regulatory challenge: research needs and opportunities [ECHA]

June 19 conference: Endocrine disruption: Perspectives from the 2024 ICEDA Awardees [Intersectoral Centre for Endocrine Disruptor Analysis (ICEDA)]

June 24 webinar: Environmental health research at EPA: What’s happening at ORD? [EDC Strategies Partnership]

June 25 online conference: TSCA reform- Nine years later [Environmental Law Institute]

July 8 webinar: Communicating about EDCs & Health: Why words matter [CHE]

July 28-30: DOHaD summer course [Developmental Origins of Health and Disease (DOHaD) Society]

July 30 – Aug. 1 conference: U.S. DOHaD Society Annual Meeting

Aug. 17 in-person workshop: How to conduct gold-star systematic reviews [PRHE, at the ISEE-ISES conference]

Sept. 15: ECHO symposium: translating science to action [hybrid] [NIH Environmental Influences on Child Health Outcomes (ECHO)]

Sept. 22-23 save the date: Second Annual Scientific Symposium on Plastics and Human Health [NYU Langone Health Center for the Investigation of Environmental Hazards (CIEH)]

More events

Regulations/Policy

Policy Gaps and Opportunities in Bio-Based Plastics: Implications for Sustainable Food Packaging.

Effects of global treaties on commercial chemicals widely used as additives: a meta-analysis of historical measurements of polybrominated diphenyl ethers.

Transforming the Evaluation of Agrochemicals: A Conceptual Model

More EDC policy, FPF’s regulations open for comment, Science’s Trump-Tracker, and links to preserved resources removed from U.S. federal websites

Methods/Tools/Screening

Workflow for Statistical Analysis of Environmental Mixtures.

Commentaries

Human reproduction in crisis: causes unknown.

Advancing Exposomics: From Concept to Practice in Environmental Health Sciences.

Invited Perspective: Air Pollution and Temperature Even Affects the Placenta-Revisiting Common Approaches.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Renin-Angiotensin System Role in Cardiovascular Effects of Plasticizers: A Systematic Review.

Novel Approaches in Establishing Chemical Food Safety Based on the Detoxification Capacity of Probiotics and Postbiotics: A Critical Review.

BPA/Phenols

Release of Bisphenol A from Dental Materials: Risks and Future Perspectives.

Phthalates

Ecotoxicological effects of phthalate esters: A review.

PFAS

Systematic Evidence Map for the Per- and Polyfluoroalkyl Substances (PFAS) Universe.

Pesticides

Toxic sprays, fragile brains: assessing pesticides exposure and disparities on neurodevelopment.

Microplastics/Nanomaterials

Human exposure to micro- and nanoplastics: a mechanistic perspective of health risks associated with metabolic and reproductive functions.

The Threat of Microplastics to Human Kidney Health: Mechanisms of Nephrotoxicity and Future Research Directions.

Nanoplastics and Immune Disruption: A Systematic Review of Exposure Routes, Mechanisms, and Health Implications.

Micro/Nanoplastics and Human Health: A Review of the Evidence, Consequences, and Toxicity Assessment.

A novel risk factor for dementia: chronic microplastic exposure.

Can Clear Aligners Release Microplastics That Impact the Patient’s Overall Health? A Systematic Review.

Human Health Studies

Numerous Chemicals/Mixtures

Association between gestational environmental chemical mixtures and folate exposures with autistic behaviors in a Canadian birth cohort.

Associations between environmental chemical mixtures and anthropometric measures in Korean girls: a cross-sectional study.

BPA/Phenols

Examining the association between gestational phenol exposure and infant non-nutritive suck in two Environmental influences on Child Health Outcomes cohorts.

Phthalates

Phthalate Metabolites and Their Relationship with Abdominal and General Obesity: Evidence from the Aragon Workers’ Health Study (AWHS).

Effects of exposure to phthalates and a phthalate substitute on food sensitization in children in China: evidence from a population study.

EXPRESS: Evidence-based biostatistics and value-based biostatistics practices in biomedical research: Application to evaluating the association between phthalate metabolites and sex hormones in US male adults.

Parabens/Triclosan/Antimicrobials

Paraben exposure profiles in pregnant women and association with changes in thyroid hormone levels.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Longitudinal study of temporal trends in urinary polycyclic aromatic hydrocarbon metabolites and their repeated cross-sectional association with oxidative stress.

PFAS

Prenatal Per- and Polyfluoroalkyl Substance Exposures and Longitudinal Blood Pressure Measurements in Children Aged 3 to 18 Years: Findings From a Racially and Ethnically Diverse US Birth Cohort.

Novel and legacy per- and polyfluoroalkyl substances in humans: Long-term temporal variability and metabolic perturbations.

Short-chain per- and polyfluoroalkyl substances associate with elevated alanine aminotransferase: Cross-sectional analysis results from the STRIVE cohort.

Association between per- and polyfluoroalkyl substances and unexplained recurrent spontaneous abortion: A case-control study in China.

Environmental exposure to mixtures of per- and polyfluoroalkyl substances in Northeast China: exploring links to nodular goiter and papillary thyroid carcinoma.

Pesticides

Longitudinal assessment of the association between pesticide exposure and lifestyle with Parkinson’s disease motor severity.

Correlation between urinary glyphosate levels and serum antioxidant vitamins and carotenoids in a representative sample of U.S. adults: NHANES 2017-2018.

Human biomonitoring of urinary neonicotinoids and their metabolites by ultra-high performance liquid chromatography tandem with mass spectrometry and their association with oxidative stress.

Metals/Metalloids

Public Water Arsenic and Birth Outcomes in the Environmental Influences on Child Health Outcomes Cohort.

Long-term arsenic exposure perturbs gut microbial diversity, composition and predicts metabolic dysregulation.

Risk of gestational diabetes mellitus in relation to serum metal mixtures and mediating effects of metabolites in Chinese population: A dual approach using bibliometric and epidemiological analyses.

Associations between metal exposure and metabolic syndrome: exploring the mediating role of biological ageing among US adults.

Investigating the potential risk of cadmium exposure on Osteoporosis: An integrated multi-omics approach.

Microplastics/Nanomaterials

Therapeutic apheresis: A promising method to remove microplastics?

Air Pollution

Exploring the causal relationship between long-term exposure to particulate matter 2.5 and risk of thyroid disorders: a Mendelian randomization analysis.

Exposure to fine particulate matter in adults is associated with immune cell gene expression related to inflammation, the electron transport chain, and cell cycle regulation.

The Role of Gut Microbiota in the Association Between Air Pollution and Cognitive Function in Older Adults.

Changes in the short-term relationship between air pollution and mortality in New York City, 1990-2019.

Neighborhood environmental vulnerability factors strongly drove COVID-19 fatality and excess all-cause mortality in New York City, while long-term air pollutant associations were weak and varied.

Laboratory Studies

Numerous Chemicals/Mixtures

Effects of an environmental chemical mixture on early-stage embryo development: In vitro evidence from human embryonic stem cells.

BPA/Phenols

Halogen Atoms in Bisphenol A Derivatives Enhance the Inhibitory Potency against Human and Rat Placental 3β-Hydroxysteroid Dehydrogenases.

Sex-specific neurotoxicity induced by long-term bisphenol A exposure: Single-cell sequencing reveals dual mechanisms involving hippocampal gliosis and neuronal apoptosis.

In utero exposure to estrogenic bisphenol analogues increases mammary tissue stiffness.

Synergistic effects of bisphenol A and elevated temperature on lipid metabolism and fatty acid synthase in the marine rotifer Brachionus plicatilis.

Gestational TCBPA exposure impairs placental function and fetal Development: Mechanisms of syncytialization disruption and fetal growth restriction.

Phthalates

Phthalates unleashed: decoding ovarian carcinogenesis through multi-omics networks, single-cell insights, and molecular docking.

Di (2-ethylhexyl) Phthalate decrease pregnancy rate via disrupting the microbe-gut-hypothalamic-pituitary-ovarian axis in mice.

Developmental and neurobehavioral toxicity of di-(2-ethylhexyl) phthalate (DEHP) in zebrafish larvae.

Parabens/Triclosan/Antimicrobials

A network toxicology approach to decipher paraben-induced molecular dysregulation in breast cancer pathogenesis.

Triclosan inhibits testosterone synthesis in male offspring by activating mitophagy.

PFAS

Mechanistic insights into PFOS-induced inflammatory bowel disease: a network toxicology and molecular docking study.

Pinobanksin ameliorates perfluorooctane sulfonate-evoked cardiotoxicity via targeting Nrf-2/Keap-1, oxidative damage and inflammation in Sprague Dawley rats.

Identification of Four Mechanisms for Per- and Polyfluoroalkyl Substances (PFAS) Through Transcriptomic Profiling from 24 PFAS-Exposed Human Liver Spheroids.

Perfluorooctanoic Acid and Its Short-Chain Substitutes Induce Cytotoxic and Prooxidative Changes in Human Peripheral Blood Mononuclear Cells: A Comparative Study.

Impact of per- and polyfluoroalkyl substances structure on oxidative stress and lipid metabolism disruption in HepG2 Cells.

Pesticides

Mobilization of the environmental toxicant chlorpyrifos during weight loss and its impact on liver and adipose tissue metabolism in mice.

Maternal α-cypermethrin and permethrin exert differential effects on fetal growth, placental morphology, and fetal neurodevelopment in mice.

Metals/Metalloids

Transgenerational diabetogenic effects of preconception exposure to inorganic arsenic in C57BL/6 mice are associated with dysregulation of DNA methylation and gene expression in G1 and G2 offspring.

Fecal microbiota transplantation alleviates female offspring’s ovarian inflammation in arsenic and fluoride co-exposed rats through the PI3K/ Akt /NF-κB pathway.

Microplastics/Nanomaterials

Microglial Clearance of Alzheimer’s Amyloid-Beta Obstructed by Nanoplastics.

Polystyrene microplastics internalization by term placental chorionic villi explants.

Following the fate of polystyrene micro and nanobeads during in vitro digestion.

Oral exposure to PLA microplastics induces time-dependent nanotoxicity via the gut-liver axis.

Impact of environmental microplastic exposure on HepG2 cells: unraveling proliferation, mitochondrial dynamics and autophagy activation.

Air Pollution

Effects of maternal PM2.5 exposure during pregnancy on cardiovascular maldevelopment in rat offspring

Tire Wear Particles

Gut microbiome contributes to 6PPD-Quinone induced cognitive impairment through PI3K/Akt signaling.

Chronic exposure to environmental concentrations of 6PPDQ induces neurotoxicity via perturbing multiple neurotransmission pathways in zebrafish.

Enantioselectivity in Metabolism and Toxicity of 6PPD-Quinone in Salmonids.

Blood-Brain and Blood-Gill Barrier Disruption in Coho Salmon Exposed to Roadway Runoff and 6PPD-Quinone.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Characterizing community water systems exposed to wildfire in the Western U.S.

Emerging contaminants in juvenile Chinook salmon: patterns of exposure and implications for conservation.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Improved sampling efficiency of volatile halomethoxybenzenes and persistent organic pollutants reveals increasing concentrations in Canadian air.

PFAS

Burden of per- and polyfluoroalkyl substances (PFAS) in human breast milk: Implications for maternal and infant health.

Chrome Plating Facility Siting Is Associated with Neighborhood Demographic and Socioeconomic Factors and Elevated Per- and Polyfluoroalkyl Substances in Blood in California.

Validation of dietary assessment methods for PFOS exposure using biomonitoring data in a senior population with metabolic syndrome.

Long term trends of legacy per- and polyfluoroalkyl substances (PFAS), their substitutes and precursors in archived wildlife samples from the German Environmental Specimen Bank.

Occurrence, Sources, and Prioritization of Per- and Polyfluoroalkyl Substances (PFASs) in Drinking Water from Yangtze River Delta, China: Focusing on Emerging PFASs.

Two Decades of Spatiotemporal Distribution of Per- and Polyfluoroalkyl Substances in the Yangtze River: A Meta-Analysis.

Flame Retardants

Size Distribution and Gas/Particle Partitioning of Organophosphorus Flame Retardants in Indoor and Outdoor Air of Garment Factories.

Pesticides

Occurrence of Current-Use Pesticides in Paired Indoor Dust, Drinking Water, and Urine Samples from the United States: Risk Prioritization and Health Implications.

Pregnancy, Childcare, and Pesticides: Understanding the Health Risks of Women and Children in Small-Scale Horticulture in Tanzania.

Children’s environmental and occupational exposures to pesticides in low- and middle-income countries rural areas – an elephant in the room.

Microplastics/Nanomaterials

Microplastics in surficial sediments from some UK rivers and canals: seasonal and spatial variation and relationship with concentrations of organophosphate esters.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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